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At least 721 records · Page 40Linked to original sources
PubMed1976

Comparison of the acceleration and velocity of shortening of the ventricular radius. Their potential applicability of noninvasive measurements of ventricular performance.

The maximal rate and maximal acceleration of shortening of the radius of the minor axis of the ventricle were correlated with various indices of ventricular performance in 20 patients with angina. The maximal acceleration of shortening showed a closer correlation with the ejection fraction, rate of change of flow, and ejection rate of change of power than did the maximal rate of shortening. It also distinguished more sharply between patients with normal and abnormal values of these indices, showing no overlap of values. The maximal rate of shortening showed a less distinct separation. These observations suggest that the acceleration of shortening of the ventricular radius reflects ventricular performance more closely than does the rate of shortening of the radius. These results are relevant in regard to potential applications of these indices by noninvasive techniques, particularly echocardiography.

Angiocardiography↗
PubMed1986

Solitary beta-blocker therapy for idiopathic life-threatening ventricular tachyarrhythmias.

To determine the clinical characteristics of patients with life-threatening ventricular tachyarrhythmias with no identifiable heart disease, we analyzed six patients who presented with either cardiac arrest or syncope associated with documented ventricular tachycardia or fibrillation. Electrocardiographic and echocardiographic examination and cardiac catheterization results were normal in all patients. Electrocardiographic monitoring revealed ventricular tachycardia in all patients. Exercise testing did not provoke sustained ventricular tachycardia in any patient. Programmed extrastimulation did not induce ventricular tachycardia in any patient. Isoproterenol infusion facilitated provocation of sustained ventricular tachycardia in only one patient. All six patients were treated with solitary beta-blocker therapy. Following treatment, there was a significant reduction in the incidence of ventricular tachycardia, couplets and total ventricular ectopic beats. During a follow-up period ranging from 16 to 36 (mean 22) months, all patients remain alive without clinically significant recurrence. Therefore, patients with life-threatening ventricular tachyarrhythmias without identifiable heart disease may respond to solitary beta-blocker therapy.

Adrenergic beta-Antagonists↗
PubMed1978

Post-exertion restitution of left ventricular systolic time intervals in healthy subjects.

The left ventricular systolic function was studied in 123 healthy men aged 23-24 years under the influence of exercise and during a two-hour restitution period. Left ventricular systolic time intervals (LVSTI) were evaluated by means of the Blumberger method with Holldack's modification before the exercise, immediately after its termination and after 30, 60 and 120 minutes. After exercise, a decrease was found in the absolute values of LVSTI and of the diastolic stage. During two-hour restitution, the authors found a decrease of left ventricular ejection time, total mechanical systolic time, total electromechanical systolic time, total ventricular electrical stimulation time and of the diastolic stage. A statistically highly significant decrease of all mentioned intervals was related to persisting, still after 2 hours, increased heart rate with which these intervals significantly correlated. The share (in percent) of LVSTI in the total cardiac cycle increased after exercise and was still increased after 2 hours following its termination. The relative increase of systolic time intervals was accompanied by a decrease in the duration of the diastolic stage.

Adult↗
PubMed1984

Radionuclide assessment of right and left ventricular function during bicycle exercise in young patients with cystic fibrosis.

Right and left ventricular performance during exercise was evaluated in 31 patients with cystic fibrosis using equilibrium radionuclide cineangiography. There were 21 males and 10 females (mean age 17, range 10.4 to 34.9 yr) with a wide range of clinical involvement. Thirteen patients had arterial desaturation at rest and an additional 4 became desaturated with exercise. Nine patients (29%) were unable to increase their right ventricular ejection fraction more than 5% during exercise. Left ventricular ejection fraction at rest was normal (greater than 55%) in all but 2, and with exercise, performance was impaired in 9 (29%). No relationship was found between resting or exercise radionuclide ejection fraction, M-mode echocardiography or pulmonary function studies. This study suggests that both right and left ventricular dysfunction may occur during stress in patients with cystic fibrosis without other conventional clinical signs or symptoms. Radionuclide cardiac angiography appears to be a safe method of assessing cardiac response to exercise in patients with chronic lung disease, and may be useful in evaluating therapeutic interventions.

Adolescent↗
PubMed2005

[Assessment of cardiopulmonary function at rest and during exercise in patients with pulmonary hypertension].

Pulmonary hypertension is diagnosed by various investigations that are essential for making the diagnosis. Following a careful history and physical examination, an electrocardiogram, a chest X-ray, lung function studies, blood tests and an echocardiogram form the basis of the diagnostic algorithm. Following these studies, a right and sometimes additional left heart catheterization are carried out to establish the diagnosis and to perform acute vasodilator testing. Most of these studies are performed at rest. However, exercise studies are an important part of the functional assessment in this group of patients. Exercise capacity can be estimated by functional class, measured with the 6-min walk test or comprehensively assessed by cardiopulmonary exercise testing with gas exchange analysis. Once the diagnosis and etiology of pulmonary hypertension have been established, several parameters can predict outcome in these patients: functional class, right ventricular function, pulmonary hemodynamics, and certain laboratory parameters (uric acid, brain natriuretic peptide, troponin, endothelin-1). In addition, exercise parameters such as walking distance, peak oxygen uptake or peak systolic blood pressure can reliably predict prognosis in these patients.

Blood Pressure Determination↗
PubMed1983

Assessment of ventricular function by combined noninvasive measures: factors accounting for methodologic disparities.

We studied the predictive accuracy and disparities among cineventriculographic ejection fraction, pre-ejection period over left ventricular ejection time (PEP/LVET) obtained from the systolic time intervals and the percent shortening of the internal echocardiographic diameter (% delta D) in assessing left ventricular performance in 453 consecutive patients without valvular heart disease. In 308 patients all three tests were normal, and in 78 patients all three tests were abnormal. Overall agreement (predictive accuracy) among ejection fraction (normal greater than or equal to 57), % delta D (normal greater than or equal to 28%) and PEP/LVET (normal less than or equal to 0.42) was 85%. In 67 patients disparities among the tests as measures of global left ventricular performance were found. The major mechanisms accounting for such disparities were: (a) large segmental contraction abnormalities which selectively distort the % delta D and ejection fraction and (b) diminished isovolumic pressure (less than 45 mmHg) which distorts PEP/LVET. When patients with segmental contraction abnormalities and low isovolumic pressure were excluded the agreement between PEP/LVET and ejection fraction was 97%, ejection fraction and % delta D 98% and PEP/LVET and % delta D 97%. The combined uses of systolic time intervals and echocardiogram minimizes error due to segmental contraction abnormalities and isovolumic pressure. If both PEP/LVET and % delta D are concordant the agreement with ejection fraction is 94% for normal and 99% for abnormal left ventricular function.

Adult↗