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At least 721 records · Page 40Linked to original sources
PubMed1983

[Thrombocytopenia induced by heparin. Apropos of 10 cases].

The authors report ten observations of thrombocytopenia induced by heparin complicated with two arterial thrombosis and four deep venous thrombosis. Two deaths and two amputations are to mention. This retrospective study leads to a review of literature: this iatrogenic disease, which frequency is variously estimated, has no relation with the dose and the mode of administration of Heparin. It's mechanism might be immuno-allergic. It's diagnosis depends mainly on the repetition of platelet numerations at the outset period of treatment, and on the rapid and lasting climbing of platelet countings when heparin is stopped. This uncommon and unforeseeable complication indicates to stop Heparin and to start K antivitamin's if necessary.

Adult↗
PubMedDate not supplied

Prevention and treatment of complications and sequelae of tracheal resection anastomosis.

Deaths following tracheal resection anastomosis for tumoral or iatrogenic disease have become fairly rare (four deaths in 122 cases in our experience). Complications can usually be prevented or treated successfully. The most common of these were: infectious lesions of the operated area (6 cases), infection of the tracheal anastomosis with subsequent disruption (1 case), erosion of the innominate artery (no case), granulomatous lesions and recurrence of stenosis (3 cases). The risk of complications can be greatly reduced by meticulous preparation, both anti-infectious and anti-inflammatory, which is always possible even in cases of acute respiratory deficiency. The use of non-sclerogenic sutures is also important.

Asphyxia↗
PubMed1978

Delayed onset chloroquine retinopathy: case report.

A patient presented with decreased visual acuity and retinal findings compatible with chloroquine retinopathy 5 years after discontinuing regular usage of chloroquine for rheumatoid arthritis. A review of the literature on chloroquine retinopathy is outlined. In addition, the characteristic findings including fluorescein angiography, retinal physiologic studies, and symptoms are reviewed. Chloroquine retinopathy is dose related and essentially irreversible and often progressive once typical findings are noted. To our knowledge very delayed onset of chloroquine retinopathy is a relatively rare phenomenon but the medical and ophthalmic communities must be alerted to the possibly severe complications of this iatrogenic disease entity.

Chloroquine↗
PubMed1982

Problems in the treatment of peptic ulcer.

Although apparently very successful, the treatment of peptic ulcers remains unsatisfactory because therapy is still symptomatic. Consequently, debate continues about the proper objectives of therapy. Some clinicians consider it best to treat the patients' subjective symptoms, while others focus on the "objective" sign of mucosal ulceration. The latter seems more appropriate, since mucosal ulceration may result in lethal complications. It is therefore necessary not only to heal ulcers, but to keep them healed. The choice of optimal treatment of present ulcer relapse is determined not only by therapeutic success, but also by the frequency and severity of the iatrogenic diseases produced by the treatment. At the present time, maintenance treatment of proven efficacy is provided only by H2 receptor antagonists and is superior to operative therapy because it is accompanied by a lesser incidence of death and adverse reactions.

Duodenal Ulcer↗
PubMed1981

Liver injury due to drugs.

Although hepatic injury due to drugs plays only a minor role in comparison with the incidence of viral or alcoholic hepatitis, it is important to know about this form because it is an iatrogenic disease which the physician causes by the medical treatment he administers without being conscious of it. Yet awareness of the physician can prevent or rapidly reverse such injury.

Acetaminophen↗
PubMed1981

Repeat prescription card--'pink' card.

A prescription card which will prevent duplication of drugs, thus helping to control both polypharmacy and iatrogenic disease, is described. Has the time come to compel all members of the public to carry such a card for presentation every time a patient sees a doctor or pharmacist? Such a scheme could have great merit.

Drug Prescriptions↗
PubMed1995

[Hypertrophic cardiomyopathy: place and limitations of medical therapy].

The development of echocardiography and kindred studies have enabled the detection of an increasing number of asymptomatic forms of hypertrophic cardiomyopathy. Drug therapy, by far the commonest therapeutic method of managing this condition, has only been shown to be effective on the symptoms. Therefore, due to the risk of iatrogenic disease, medication is only proposed to symptomatic patients: high dose betablockers is the usual treatment; when ineffective or contra-indicated, verapamil may be prescribed at progressively increasing doses under strict medical control. These products may need to be given at high doses in order to be effective but excessive bradycardia may be a limiting factor. Amiodarone alone or in association, may be preferred in forms with arrhythmias. The comparative efficacy of the different drugs, especially in preventing sudden death, requires well designed, controlled, therapeutic trials. Their results, if positive, would question the dogma of only treating symptomatic patients.

Adrenergic beta-Antagonists↗
PubMedDate not supplied

[The efficacy of restoring the professional health of flight personnel in a combat unit].

It is shown in the paper that sanitary and rehabilitative measures (graded physical exercise, saunas, manual massage with the elements of biodynamic correction of the spinal column, relaxation exercises in the framework of remedial gymnastics, electrotranquilization of the central nervous system, psychosomatic self-regulation, functional music, video programmes, self-massage of biologically active points, specific diet) taken under conditions of drill by command of the flying personnel, tend to lead to lowering of the general morbidity rate (by a factor of 1.7), work losses (by a factor of 1.8), probability of occurring of iatrogenic diseases (by a factor of 1.6), thereby promoting rise in the level of functional efficiency of the pilot and safety of flights.

Adult↗
PubMed1994

[Sleep disorders in the elderly].

Insomnia dominates the sleep disorders of the elderly. Sleep apnea, the restless legs syndrome and nocturnal agitation represent other facets. After eliminating the possibility of painful or degenerative organic disease, iatrogenic cause and mode of life, other symptoms should be sought, namely mental and personality-related. Investigation requires polysomnogram recording, supported by careful history-taking, including objective and subjective factors. Treatment includes notions of diet, biological rhythm and desynchronisation. It should take into consideration the deleterious effects of prolonged use of certain psychotherapeutic agents.

Aged↗
PubMed1993

A survey on drug-related hospitalization in a community teaching hospital.

We retrospectively studied 2,695 patients admitted to the Department of Medicine over a 10-month period in 1990 to determine the incidence of drug-related hospitalization. A drug-related problem was identified as the primary cause of hospitalization in 109 (4.0%) admissions. The incidence was significantly greater in the elderly group as compared with the non-elderly group (5.2% vs 3.2%). Non-steroidal anti-inflammatory drugs, hypoglycemic agents, herbal medicine, adrenocorticosteroids and antihypertensive drugs were most often involved. The five most common adverse events were upper gastrointestinal tract bleeding, skin rashes, hypoglycemia, hypercorticism and hepatitis. Iatrogenic disease was fatal in 2 cases. Patients used drugs without medical supervision in 45 cases. In view of the increasing complexity of modern pharmacotherapy and the popularity of self-medication in our society, educational efforts should be enhanced for medical professionals and the general population to reduce the risk of drug-related hospitalization.

Adolescent↗
PubMed1977

Rational drug therapy of common illnesses in children.

Experience with the care of over 7,000 children with acute illnesses has shown that most need either no medication at all or can be adequately managed from a choice of but a handful of drugs precisely prescribed. A knowledge of rational therapeutics can decrease polypharmacy, the high cost of illness, and the risk of iatrogenic disease.

Acute Disease↗
PubMed1977

[The anti-epileptic drugs].

It is no longer acceptable to prescribe anticonvulsants on the basis of empirical rules. Pharmacological studies have made it possible to measure the absorption, distribution and excretion of these drugs. Complete understanding of this data is neccessary if anticonvulsant prescribing is to be fully effective and to avoid iatrogenic disease.

Age Factors↗
PubMed1997

Management of the incidentally discovered adrenal mass or "incidentaloma".

The prevalence of an incidentally discovered adrenal mass or "incidentaloma" by abdominal computerized tomography (CT) scan is 1% to 2%. The majority of patients with incidentalomas do not have clinical manifestations nor require further treatments of their incidentalomas. Thus the goal for their management is two-fold: 1) To identify and treat the hormonally hyperactive adrenal adenoma and the rare adrenal carcinoma, and 2) To avoid creating an iatrogenic disease of medical progress. An adrenal mass > or = 6 cm, excluding metastatic malignant disease, needs to be surgically resected due to the risk for carcinoma. The risk of primary adrenal cancer for a hormonally inactive lesion < or = 3 cm is extremely low and can be safely observed. Treatment for the hormonally inactive lesion between 3 and 6 cm must be individualized, based on age, specific scan characteristics (irregular border, local invasion, metastasis), and clinical status of the patient. All hormonally active adrenal adenomas should be surgically resected. In this article, we review the data to support the above recommendations.

Adenoma↗
PubMed1997

Prevention and treatment considerations in patients with drug-induced gingival enlargement.

Drug-induced gingival overgrowth is an iatrogenic disease caused by the use of phenytoin, cyclosporine, nifedipine, and other medications in the susceptible patient. The gingival overgrowth can be due to three causes: noninflammatory, hyperplastic reaction to the medication; chronic inflammatory hyperplasia; or a combined enlargement due to chronic inflammation and drug-induced hyperplasia. Drug-induced gingival enlargement can be minimized, but not prevented, by elimination of local irritants, meticulous oral hygiene, and regular periodontal recall. If gingival enlargement interferes with function, speech, esthetics, or oral hygiene, tissue reduction can be accomplished by gingivectomy or a flap procedure. Gingival enlargement may recur, especially in the patient with poor oral hygiene.

Anticonvulsants↗
PubMed1998

[Corticosteroid-induced epidural lipomatosis. Efficacy of medical treatment].

We describe a further case of cauda equina compression secondary to steroid-induced epidural lipomatosis in a patient treated for IBD. The diagnosis was rapidly confirmed by MRI allowing conservative management by corticosteroid withdrawal as well as use of hygiene and dietary measures. Therapeutic efficacy was noted on a clinical basis and confirmed by repeated follow-up MRI exams which showed regression of fat accumulation. Symptomatic epidural lipomatosis is probably underestimated because physicians concerned by steroid treatment are not fully informed about this potentially severe and usually iatrogenic disease. Also, proper medical attention to the first neurological symptom in these patients might help limit therapeutic management to a medical measurer, before requiring surgical decompressive surgery.

Adult↗
PubMed2006

Iatrogenic Creutzfeldt-Jakob disease: the waning of an era.

The outbreaks of iatrogenic Creutzfeldt-Jakob disease (CJD) from cadaveric human growth hormone and dura mater are winding down and, like the only other environmentally acquired form of CJD (variant CJD due to infection with the agent of bovine spongiform encephalopathy), iatrogenic disease seems to have reached its high water mark during the 1990s. The total number of cases has reached 405, and the diminishing number of new cases is due to extremely long incubation periods from infections acquired before 1985 (up to 23 years for dura mater and 36 years for growth hormone). Although no cases associated with surgical or other invasive procedures have been identified during the past several decades, the recent discovery of three transfusion-associated variant CJD infections has provoked new concerns about the possibility of further secondary transmissions from operative procedures as well as blood and tissue donations. Therefore, at least in those countries in which variant CJD has occurred, precautionary measures must continue for the indefinite future.

Animals↗