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PubMed1979

Uterine leiomyosarcoma.

A series of uterine leiomyosarcomas was reviewed in an attempt to assign prognostic significance to clinical and pathologic features. Extension of the sarcoma at the time of initial diagnosis was associated with a dismal outcome; no patient with disease beyond the confines of the uterus survived. Histologic grade was a useful prognostic feature, although low-grade sarcoma can be associated with metastases. Mitotic count was also useful in prognosis, although it did not correlate as well with clinical outcome as did histologic grade. There was no number of mitoses below which the diagnosis of leiomyosarcoma was excluded.

Adult↗

PubMed1992

Phase II trial of ifosfamide and mesna in leiomyosarcoma of the uterus: a Gynecologic Oncology Group study.

OBJECTIVE: The purpose of this study was to evaluate the activity of ifosfamide (isophosphamide) in patients with advanced or recurrent leiomyosarcoma not previously exposed to chemotherapy. STUDY DESIGN: This is a phase II groupwide study of the Gynecologic Oncology Group. Thirty-five patients were treated with ifosfamide 1.5 gm/m2 daily intravenously for 5 days with mesna (mercaptoethane sodium sulfonate). Fifty-six patients had received prior abdominal hysterectomy and 15 prior radiotherapy. The dose was reduced to 1.2 gm/m2 daily in patients who had received prior radiotherapy. RESULTS: Gynecologic Oncology Group grade III or IV granulocytopenia occurred in 4 (11%) patients, and none had grade IV thrombocytopenia. One (2.8%) patient had grade IV neurotoxicity. Partial responses were observed in 6 of 35 (17.2%) patients. The 95% confidence interval for response was 6.6% to 33.7%. CONCLUSION: These results indicate that ifosfamide has modest activity in patients with advanced or recurrent leiomyosarcomas of the uterus.

Adult↗

PubMed1993

Successful resection of a recurrent leiomyosarcoma of the pulmonary trunk.

We successfully performed a total resection of the pulmonary artery trunk and replaced it with an equine pericardial xenograft roll in a patient with a recurrent leiomyosarcoma. We believe, based on anatomic and embryologic principles, total rather than partial resection of the pulmonary artery trunk should be the treatment of choice for primary leiomyosarcomas of the pulmonary artery.

Aged↗

PubMed1995

Leiomyosarcoma of the superior vena cava and azygos vein.

A 40-year-old woman presented with facial swelling and pressure sensation of the ears and sinuses. Chest roentgenography revealed a right paratracheal mass, which was confirmed by a venogram, and transjugular biopsy showed low-grade leiomyosarcoma. The superior vena cava was resected and reconstructed using a spiral vein graft. Pathologic evaluation revealed a low-grade leiomyosarcoma arising from both the superior vena cava and the azygos vein with clear margins.

Adult↗

PubMed1975

Leiomyosarcoma of the mediastinum.

A case of leiomyosarcoma of the posterior mediastinum is presented; 2 other malignant and 7 benign smooth muscle tumours of the mediastinum have been collected from the literautre. The tendency for blood-borne and local recurrence in the leiomyosarcomas is demonstrated. Various theories for the origin of these tumours are examined.

Cell Nucleus↗

PubMed1985

Leiomyosarcoma of the vagina.

A 46-year-old woman, who had very interesting tumor of the vagina microscopically, was presented. The removed tumor (40 g) in the upper lateral wall of the vagina was composed of two nodules. The cut surface of one nodule (20 g) was separated into two parts and they were diagnosed as necrosis and borderline case of leiomyomata microscopically. The other nodule (20 g) was diagnosed as leiomyosarcoma with interlacing bundles of spindle-shaped cells with large hyperchromatic, irregularly shaped nuclei and abundant mutases. These bindings suggest a possibility that leiomyoma of the vagina may undergo malignant change to become leiomyosarcoma.

Female↗

PubMed1985

Primary leiomyosarcoma of the vagina.

A case of primary leiomyosarcoma of the vagina is described and discussed. The tumor recurred and the patient died 8.5 years after the diagnosis and primary treatment. This is the longest survival time reported in the literature for a primary vaginal leiomyosarcoma.

Adult↗

PubMed1980

Leiomyosarcoma of the anterior maxillary alveolar ridge.

A case of leiomyosarcoma of the anterior maxillary alveolar ridge, including ultrastructural examination findings, in a 39-year-old woman is reported. The patient was clinically free of tumor 34 months later. The twenty-three previously reported cases of oral leiomyosarcoma are reviewed briefly.

Adult↗

PubMed1992

Primary hepatic leiomyosarcoma in a child with the acquired immunodeficiency syndrome.

We report the first case of acquired immunodeficiency syndrome (AIDS)-related primary hepatic leiomyosarcoma in a 9-year-old girl. The pathologic diagnosis was made on a partial hepatectomy specimen and was confirmed by immunohistochemistry and electron microscopy. No human immunodeficiency virus-related nucleic acid was identified in tumor cells by in situ hybridization. Review of the AIDS-related literature reveals a rising incidence of tumors of smooth muscle origin in human immunodeficiency virus-infected patients. This case study details the eighth pediatric AIDS patient with a tumor of smooth muscle origin and represents the 20th and the youngest patient with primary hepatic leiomyosarcoma to be reported in the world literature.

Acquired Immunodeficiency Syndrome↗

PubMed1981

Leiomyosarcoma of renal vein and inferior vena cava.

A case of leiomyosarcoma of the right renal vein and inferior vena cava causing total obstruction of the vena cava is reported. This rare condition was treated successfully after two previous operations had deemed it unresectable. Treatment consisted of a right nephrectomy and resection of the vena cava and ligation of the left renal vein. Because of the slow growth of the well-differentiated leiomyosarcoma, there was no problem with venous return from the left kidney, and the patient recovered promptly without evidence of renal function impairment. Postoperatively, she received chemotherapy consisting of doxorubicin (Adriamycin) and vincristine. She is well and free of tumor over four years postoperatively. The good result, in this case, is attributed to complete surgical excision and multimodal therapy.

Adult↗

PubMed1986

Leiomyosarcoma of penile prepuce with ultrastructural study.

A case of a leiomyosarcoma developing in a penile prepuce of a young patient is presented with ultrastructural studies. The firm, well-circumscribed nodule was present for several years. Histologically and ultrastructurally the excised nodule showed features of a leiomyosarcoma. The incidence and morphology of this rare tumor is discussed.

Humans↗

PubMed1987

Leiomyosarcoma of kidney.

The case of a seventy-one-year-old woman with leiomyosarcoma of the kidney capsule is presented. Despite lack of invasion into surrounding tissues and few mitoses, the tumor recurred thirteen months after nephrectomy. A full subjective response and an almost complete objective regression lasting eight months were achieved using a short course of combination chemotherapy. The literature on leiomyosarcoma of the kidney is reviewed.

Aged↗

PubMed1984

Primary leiomyosarcoma of the vagina: a study of five cases.

The clinical and light and electron microscopic features of five cases of primary vaginal leiomyosarcoma, representing 2.9% of all vaginal malignancies registered at the Swedish Cancer Registry, are presented. The ages of the patients ranged from 31 to 69 years. The most common clinical presentation was an increasing mass and/or local tenderness. The tumor was located in the anterior wall in three cases and in the lateral wall in two. The size of the tumors ranged from 2 to over 10 cm. Four patients had tumors of high histologic malignancy grade and were all dead within 36 months. One patient had a tumor of low grade and is still alive 10 years after the initial excision. The ultrastructural observations of abundant myofilaments with focal elongated densities in primary paraffin-embedded material conform with the light microscopic diagnoses in all cases and indicate the usefulness and value of such material for electron microscopy in order to arrive at the diagnosis of leiomyosarcoma. The therapeutic and diagnostic aspects are discussed.

Adult↗

PubMed1986

Malignant osteoclast-like giant cell tumor associated with a uterine leiomyosarcoma.

An unusual case of osteoclast-like giant cell tumor associated with a leiomyosarcoma of the uterus is described. The mononuclear cell component of the giant cell tumor was cytologically malignant and the giant cell tumor was present in a biopsy of vaginal recurrence. The patient expired 17 months after diagnosis with extensive tumor despite surgical and radiation treatment. This is the first report of malignant osteoclast-like giant cell tumor associated with a uterine leiomyosarcoma and only the third report of osteoclast-like giant cell tumor in the uterus.

Aged↗

PubMed1990

Radioimmunodetection of uterine leiomyosarcoma with 111In-labeled monoclonal antimyosin antibody Fab fragments.

Radioimmunodetection of uterine leiomyosarcoma in a 64-year-old woman with a palpable local recurrence is described. Pathological abdominal, pelvic, and thoracic accumulation of monoclonal 111In-labeled antimyosin was observed. Afterward, these lesions were examined by whole-body X-ray computed tomography. With a double-tracer technique (pulmonary and hepatic/splenic subtractions) the lesions were delineated better and SPECT (radioisotope tomography) was used for more accurate localization of the abdominal and pelvic lesions. These findings indicate that antimyosin scintigraphy might be useful in staging and follow-up of uterine leiomyosarcoma.

Antibodies, Monoclonal↗

PubMed1990

Perineal leiomyosarcoma.

Perineal leiomyosarcomas are rare aggressive tumors for which the therapy remains to be defined. These tumors may be extensively infiltrating and therapy may require radical surgery. The problems encountered in treating these tumors are similar to those for retroperitoneal sarcomas. Namely, delay in diagnosis, lack of distinct anatomic boundaries, and close proximity to and encroachment on multiple organs prevents resection with adequate surgical margins. We discuss the current literature and present our management of perineal leiomyosarcomas.

Combined Modality Therapy↗

PubMed1991

Nongenital pelvic leiomyosarcoma metastatic to the heart.

A patient who had a 5-year history of a low-grade nongenital pelvic leiomyosarcoma was evaluated for worsening dyspnea, hypertension, and jugular venous distension. An echocardiogram revealed a large right atrial mass. At surgical exploration, metastatic leiomyosarcoma was found within the inferior vena cava extending from below the renal veins up into the right atrium. Using cardiopulmonary bypass with profound hypothermia and circulatory arrest, the inferior vena cava was opened below the renal veins, and the tumor was transected. That portion of the tumor above this transection was then extracted through a right atriotomy. Resection of the pelvic tumor was not thought to be feasible. The patient remains asymptomatic with stable pelvic tumor 1 year after the procedure.

Female↗

PubMed1986

Cytogenetic findings in a primary leiomyosarcoma of the prostate.

Cytogenetic analysis of a primary leiomyosarcoma of the prostate revealed a clonal chromosomal rearrangement involving chromosomes #2, #3, #9, #11, and #19. The results are discussed in relation to the cytogenetic findings in other solid tumors, especially those of the prostate and leiomyosarcoma at other sites.

Adult↗