PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “METHOTRIMEPRAZINE”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 721 records · Page 40Linked to original sources
PubMed1982

[In-patient withdrawal treatment of heroin addicts with neuroleptics (author's transl)].

The results are reported of 144 abrupt withdrawal treatment in heroin addicts (102 in males, 42 in females). Neuroleptics were given intravenously (partly via subclavia catheter) or orally and the results compared with one another. Parenteral treatment needed much more specialist supervision and control and had a much higher complication rate. It should be used only on the individual special case. The initial withdrawal lasts about 4 days with an oral dosage of 270 mg levopromazine in males and 240 mg in females or 540 mg chlorprothixene in males and 520 mg in females per 24 hours. The only side effects encountered were tachycardia and the occasional occurrence of extrapyramidal signs. The liver function tests did not show any significant changes during the treatment.

Adolescent↗
PubMed1984

Inhibition of bacterial plasmid replication by stereoselective binding by tricyclic psychopharmacons.

Several dibenzazepines, thioxanthene, and phenothiazine stereoisomers were studied for their abilities to inhibit plasmid replication, intracellular transfer of R-plasmid, bacterial ATP-ase, and mouse serum cholinesterase isoenzyme. Partially saturated derivative of desipramine inhibited plasmid replication and transfer, but the fully saturated derivative was inactive. The inhibition of plasmid curing and transfer patterns did not correlate with the inhibition of ATP-ase and cholinesterase. Trans-clopenthixol was more effective in plasmid elimination than the cis-isomer. On the other hand, the cis-isomer inhibited ATP-ase and cholinesterase more than the trans-isomer. The levo- and dextro-methoxytrimeprazine also inhibited plasmid replication and enzyme activity. We believe that the tricyclic configuration of the drugs tested for stereospecific binding to bacterial receptors is more important than its side chain orientation. We believe that there is a similarity between bacterial receptor sites and neural receptor sites. Therefore, this model may be useful in the study of neuropharmacological agents as potential antibacterial agents.

Adenosine Triphosphate↗
PubMedDate not supplied

Interactions of propranolol with some analgesics.

The duration of the analgesic effect of levomepromazine was prolonged in mice when associated with propranolol. The administration of morphine to animals treated with propranolol resulted in an increase of morphine toxicity with death of some animals.

Animals↗