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At least 721 records · Page 40Linked to original sources
PubMed2004

Specific cognitive deficits are common in children with Duchenne muscular dystrophy.

A neuropsychological assessment was conducted to study cognition, with emphasis on memory, information processing/learning ability, and executive functions in boys with Duchenne muscular dystrophy (DMD). A group of 20 boys with DMD, aged 7 to 14 years (mean age 9 years 5 months, SD 2 years 2 months), was contrasted with 17 normally developing age-matched comparison individuals, using specific neuropsychological tests (Block Span, Digit Span, Story Recall, Rey Auditory Verbal Learning Test, Rey Complex Figure Test, Spatial Learning Test, Verbal Fluency, Trail Making Test, Tower of London, Memory for Faces, and Raven's Coloured Progressive Matrices). The DMD group performed significantly worse on all aspects of memory, learning, and executive functions. There was no significant difference in general intellectual ability between the two groups. Analyses of group differences indicate that problems in short-term memory are the most apparent, suggesting specific cognitive deficits. The differences between the groups were similar for both verbal-auditory and visuospatial tests, thus contradicting the idea that cognitive deficits are related to type of stimulus presented. It is concluded from this study that short-term memory deficits might play a critical role in the cognitive impairment and intellectual development seen in those with DMD.

Adolescent↗
PubMed2000

What is extinguished in auditory extinction?

Extinction is a frequent sequel of brain damage, whereupon patients disregard (extinguish) a contralesional stimulus, and report only the more ipsilesional stimulus, of a pair of stimuli presented simultaneously. We investigated the possibility of a dissociation between the detection and the identification of extinguished phonemes. Fourteen right hemisphere damaged patients with severe auditory extinction were examined using a paradigm that separated the localization of stimuli and the identification of their phonetic content. Patients reported the identity of left-sided phonemes, while extinguishing them at the same time, in the traditional sense of the term. This dissociation suggests that auditory extinction is more about acknowledging the existence of a stimulus in the contralesional hemispace than about the actual processing of the stimulus.

Acoustic Stimulation↗
PubMed1979

[Recognition of onomatopoeias and animal cries during focalized lesions of the cerebral cortex (author's transl)].

The recognition of animal cries and their onomatopoeias was compared during the course of right or left unilateral cortical lesions. A double dissociation is noted; in left-sided affections there is a more severe deficiency to onomatopoeia than to cries, whereas in right-sided lesions the quality of the performances is reversed. These results suggest that the right hemisphere is dominant in the auditive recognition of familiar sounds, and supply information as to the linguistic value of onomatopoeias.

Animals↗
PubMed1983

Application of pattern evoked potential techniques for evaluating infant perceptual systems.

An evoked potential (EP) test was developed to aid in the diagnostic evaluation of a 16-week-old infant of initially unknown pathology and degree of perceptual deficit. Patterned stimuli were presented at two repetition rates to challenge the infant's visual and auditory information processing capabilities. The data were compared to those obtained from a "normal" infant of the same age and sex and, where possible, to normative population data. The EP data indicated the following: (1) the "suspect" infant's occipital response to visual pattern was abnormal in terms of waveform characteristics and in the relationship of its amplitude to spatial frequency of pattern; (2) in comparing brain response to 1 Hz and 6 Hz stimulation rates, the "suspect" infant's occipital EPs were abnormally attenuated for the faster presentation rate when a patterned visual display was part of the stimulus complex; (3) an auditory speech sound produced equivalent EP effects in both infants. These data indicated that the "suspect" infant's perceptual deficit was restricted to the processing of visual pattern information, possibly due to abnormal functioning of the geniculo-striate system. Subsequent tests and the diagnosis of ocular albinism corroborated the results of the abnormalities suggested by the EP procedure.

Auditory Perceptual Disorders↗
PubMed2004

Crossed Wernicke's aphasia: a case report.

Crossed aphasia is a phenomenon in which an individual sustains a lesion in the right hemisphere (typically non-language dominant), but who exhibits an aphasic syndrome. The authors present a case study of an individual with crossed aphasia (CA) in an attempt to provide anecdotal information for four questions posed by : (a). Is CA a reversal of the normal cerebral hemisphere pattern of language function? (b). Does the presence of aphasia following a right cerebral hemisphere lesion indicate that typical right hemisphere functions (e.g., visual perception) are intact? (c). How may the aphasia's presentation differ from typical left hemisphere aphasias? And (d). is the pattern of improvement following CA similar to that of typical left hemisphere aphasias? We longitudinally examined the communicative-cognitive performance of an adult man with crossed aphasia of the Wernicke's type following a cerebrovascular accident. A 21-week follow-up evaluation indicated improvements in his language functioning from our initial evaluation, but he continued to exhibit a classic, moderately severe Wernicke's aphasia.

Aged↗
PubMed2005

Poor hand-pointing to sounds in right brain-damaged patients: not just a problem of spatial-hearing.

We asked 22 right brain-damaged (RBD) patients and 11 elderly healthy controls to perform hand-pointing movements to free-field unseen sounds, while modulating two non-auditory variables: the initial position of the responding hand (left, centre or right) and the presence or absence of task-irrelevant ambient vision. RBD patients suffering from visual neglect, unlike RBD patients without neglect and healthy controls, showed a systematic rightward error in sound localisation, which was modulated by the non-auditory variables. Localisation errors were exacerbated by initial hand-position to the right of the body-midline, and reduced by the leftwards initial hand-position. Moreover, for the visual neglect patients, mere presence of ambient vision worsened localisation errors. These results demonstrate that although hand-pointing to sounds has often been considered a straightforward approach to investigate sound-localisation abilities in brain-damaged patients, in some patients it may actually reveal localisation deficits that reflect a combination of impaired spatial-hearing and spatial biases from other sensory modalities (i.e., vision and proprioception).

Aged↗
PubMedDate not supplied

Dichotic consonant-vowel (CV) perception in normal and learning-impaired children.

Two experiments were performed using dichotic presentation of the consonant-vowel (CV) syllables [pa], [ba], [ta], [da], [ka], and [ga]. The stimuli were constructed with no temporal offsets between channels (+/-2 msec) and with temporal offsets of 30, 60, and 90 msec between channels. Data were analyzed for ear asymmetry (right ear advantage), double-correct responses (auditory capacity), and the effects of temporal offsets (the lag effect). In experiment 1, 32 normal children (mean age at entry = 6 yrs 6 mos) were evaluated once each year over a 4-yr period. Results showed no significant change in ear laterality over the 4 yrs. However, there was a significant, age-related increase in auditory capacity. None of the subject groups showed a significant lag effect. In experiment 2 results from 17 children (mean age = 9.3 yrs) enrolled in a school for learning disability who were identified as having significant auditory processing problems were compared to age- and sex-matched normal controls. Results failed to show a significant group difference for ear asymmetry, auditory capacity, or the lag effect. Case studies are presented comparing two learning-disabled children with two normal children matched for age and sex to illustrate the results for the learning-impaired population. Overall, findings indicate that the dichotic CV syllables test has limited prognostic value in identifying auditory processing dysfunction in children classified as having "learning disability."

Adolescent↗
PubMed2005

Hallucinogen persisting perception disorder after psilocybin consumption: a case study.

The recurrence of flashbacks without acute or chronic hallucinogen consumption has been recognized in the DSM IV criteria as the hallucinogen persisting perception disorder (HPPD). Perceptual disturbances may last for 5 years or more and represent a real psychosocial distress. We reported here a case of a 18-year-old young man presenting HPPD after a mixed intoxication with psylocibin and cannabis. This report shows symptomatic recurrences persisting more than 8 months. Various differential diagnoses were evoked and our therapeutic strategies were described.

Adolescent↗
PubMed1985

Effects of mild hearing loss on auditory processing.

The impact on language learning of mild hearing loss due to otitis media with effusion has forced a new look at the dynamics of central auditory processing. A model of auditory deprivation that would produce the test results that define CAP deficits would be a mild conductive hearing loss. It is relevant to reexamine CAP theory in terms of such hearing loss.

Auditory Perceptual Disorders↗
PubMed1997

Semantic, phonological, and perceptual changes following left and right intracarotid injection (Wada) with a low amytal dosage.

Intracarotid injection of a low dosage of amobarbital (75 mg, 5% solution) was studied in 30 temporal lobectomy candidates while naming achromatic, incongruously, and congruously colored pictorial objects and reading real, nonsense, and embedded words. Semantic errors and phonological alexia followed the left injection, while the right injection induced visuoperceptual errors. When the contralateral hemisphere was anesthetized, the left brain formulated supraordinate categories for words and objects, while the right brain applied concrete labels. The basic language proficiency of patients influenced recovery and outcome; left temporal patients who were interictally anomic performed especially poorly after both injections. Codifying phonological and perceptual changes during the intracarotid amobarbital procedure can improve interpretations about language laterality and organization.

Adult↗
PubMed2002

Direction and position factors in performance of line extension task by unilateral neglect subjects.

In this study was investigated the influence of direction and position in the performance of a line extension task by patients with unilateral neglect, with the aim of exploring the role of perceptual and premotor factors in this task. Twenty-three right brain damaged patients (14 patients with left unilateral neglect) were asked to extend horizontal lines both leftward and rightward; lines were presented in three different positions (left, right and central). Patients with neglect significantly overextended the lines in all conditions, but particularly toward the sagittal mid plane of the body and leftward when the line was presented on the right. The global overextension seem to be related to concomitant hemianopsia. A crucial finding in neglect group was that left extensions reduced progressively on passing from right through central to left presentation, particularly in patients with lesions involving frontal regions or the basal ganglia. The last finding supports the hypothesis that left overextension does not exclude the coexistence of both perceptual and premotor factors (causing directional hypometria) in left unilateral neglect.

Aged↗
PubMedDate not supplied

Auditory processing abilities in children with previous middle ear effusion.

The present study was designed to determine whether auditory processing disorders are present in children with documented middle ear effusion (MEE) that required surgical treatment. Children with previous MEE and control subjects, in two age groups, were studied using five tests of auditory processing abilities: low-pass filtered speech, staggered spondaic word test, speech in noise, auditory sequential memory, and sound blending. Results found differences in groups at mean age 7 on the filtered speech tests, but no statistical differences were found on any other test at age 7 or on any test at mean age 9. The results indicate that well-managed MEE appears to have no long-term effects on children acquiring this disease.

Auditory Perceptual Disorders↗
PubMed1983

Residual sensorimotor deficits in the adult head-injured patient. A treatment approach.

Deficits in sensorimotor integration, cognition, and psychosocial behavior may lead to a characteristic set of problems in the head-injured adult. An inpatient Sensorimotor Integration Class for ambulatory head-injured patients was developed to introduce challenging sensorimotor activities before these patients established avoidance patterns. The class includes perceptual motor, sensory integration, and sports activities. Clinical observations suggest that the class leads to improved quality of movement for participants. Objective research is needed to document clinical observations.

Adult↗
PubMed1982

Clinical and audiological findings in a case of auditory agnosia.

A case is reported of severe agnosia for verbal and non-verbal sounds without associated aphasic disorder. A CT scan revealed bilateral, temporal lobe lesions from two ischaemic accidents that had occurred 9 months apart. The search for subtle deficits in the patient showed normal sensitivity to changes in the intensity and frequency of simple sounds; in contrast, his ability to discriminate sound duration and musical note sequences was severely impaired. The simultaneous recording of the whole auditory-evoked response pattern revealed no abnormality in the early components, which reflect the activation of the auditory nuclei and pathways of the brain stem. However, the middle and late components were delayed and slowed. These results and others in the literature suggest that the neocortex in man, as in other mammals, plays an essential role in the temporal aspects of hearing. Also, the two main ingredients commonly recognized in auditory agnosia, i.e. word deafness and the inability to interpret non-verbal sounds, are caused by the disruption of elementary, bilaterally represented cortical functions which start the processing of every kind of auditory information.

Agnosia↗
PubMed2002

The use of the QNST-II as a measure for the identification of children with perceptual-motor deficits.

This study aimed to examine the ability of the Quick Neurological Screening Test QNST II) (Mutti et al., 1998) to discriminate between children with and without perceptual-motor deficits and to further clarify its psychometric characteristics. Ninety-four children aged six to seven years were tested on the QNST-II. Out of this pool of subjects, 63 children had perceptual-motor deficits and 31 were typical controls. The children with perceptual-motor deficits scored significantly lower than the control children on the total score and on each of the subtest' s scores of the QNST II. Inter-rater reliability indicated a high degree of correlation between both evaluators' total scores of the QNST II. In terms of the test' s sensitivity and specificity, QNST II scores correctly classified 97% of the children with perceptual-motor deficits and 84% of the children from the control group. The findings of this study support the capability of the QNST II to discriminate between children with perceptual-motor deficits and typical children; thereby suggesting its usefulness as a screening measure to identify children at risk for difficulties in school performance.

Child↗
PubMed1986

Auditory brain stem responses and nonsense monosyllable perception test findings for patients with auditory nerve and brain stem lesions.

A nonsense monosyllable audiometric test was administered to 15 patients with eighth nerve or brain stem disorders caused by tumor, hemorrhage, encephalitis, and degenerative disease. Auditory brain stem responses (ABR) were abnormal in all patients. ABR abnormalities were defined by the absence of some or all waves or by prolongation of the wave V-I interval. The discrimination scores of the nonsense monosyllables were significantly lower in patients with completely absent ABR, with partial ABR series involving wave I, or with severely prolonged wave V-I intervals (over 3 SD). However, in patients with wave I only or with only moderately prolonged wave V-I intervals (less than 3 SD), test scores were within normal range. It is concluded that: 1. perception of nonsense monosyllables could be, though need not be, affected in patients with brain stem lesions; 2. eighth nerve lesions severely disrupt auditory comprehension as well as perception of nonsense monosyllables.

Adult↗