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String revival.

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News↗

Fiddling the string of carbon nanotubes with amphiphiles.

The field of carbon nanotube-amphiphile self assembly has been reviewed to address the ongoing debate regarding their binding. Based on our spectrophotometry and transmission electron microscopy studies, this report shows the binding of lysophospholipids onto carbon nanotubes is dependent on the charge and geometry of the lipids and the pH of the solvent, and independent of solvent temperature. From molecular dynamics simulations, the binding of lysophospholipids onto carbon nanotubes does not fully obey any of the models proposed in the literature. We also studied carbon nanotube diffusion using single-molecule fluorescence microscopy, and carbon nanotube-lipid binding and dissociation using the technique of fluorescence resonance energy transfer. The use of carbon nanotube-lipid assembly for enabling nanotoxicological studies is demonstrated by the uptake of the assembly in the living organism Daphnia magna.

Computer Simulation↗

Hair on a gene string: recent advances in understanding the molecular genetics of hair loss.

The hair follicle is finally, after remaining a mystery for many years, beginning to yield some of its molecular secrets. The past decade has seen unprecedented and ever quickening advances in understanding the molecular genetics of the many single gene disorders, which have alopecia as a major feature. This article reviews recent novel clinical and experimental observations, which have shed new light on the basic molecular mechanisms underlying hair morphogenesis, differentiation, keratinization and cycling. We consider recent progress in understanding structural hair defects and complex traits and consider where future developments are likely to occur.

Alopecia↗