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Sexual behaviors of intravenous drug users in treatment.

Sexual behaviors of a group of 313 intravenous drug users (IVDUs) (225 men, 88 women) were assessed by a structured interview at the start of an AIDS prevention project. Although the majority were celibate or monogamous during the prior year (men 52.5%, women 64.3%), many IVDUs had multiple sexual partners in that time, including 19.6% of men and 7.2% of women reporting five or more. Married male and female IVDUs were more likely to have multiple sexual partners than married people in general population samples. Only 38.5% of male and 35.4% of female IVDUs ever used condoms during the previous 5 years. Percentage of sexual encounters in which condoms were used correlated significantly with the number of partners for women (r = 0.37, p less than 0.01), but not for men (r = 0.03, ns). Use of intravenous drugs in the prior year, sharing of needles, use of stimulants, exchange of sex for money or drugs, and combining sexual events with drug use were all associated with greater numbers of sexual partners. A subset of male IVDUs engages in the dual-risk behaviors of needle sharing and unprotected intercourse with multiple partners. This group could act as a highly efficient vector for human immunodeficiency virus transmission and should become a focus of intensive preventive intervention.

Acquired Immunodeficiency Syndrome↗

Normal and abnormal sexual behavior.

This article includes a brief description of the reproductive patterns and specific behaviors comprising courtship and copulation in equids. The author then focuses on breeding behavior of the domestic stallion. Descriptions of normal breeding behavior under a variety of domestic management systems, comments on sexual behavior of donkeys and exotic equids, and the most common types and treatments of sexual behavior dysfunction are included.

Animals↗

Substance use and risky sexual behavior among homeless and runaway youth.

PURPOSE: To (a) characterize human immunodeficiency virus (HIV)-related risk behaviors of homeless youth; (b) determine whether substance use is associated with risky sexual behavior in this population; and, if so, (c) explore explanations for this relationship. METHODS: A purposive sample of 327 homeless youth (ages 14-21 years) in Washington, DC, were surveyed in 1995 and 1996. Survey items were adapted from items used in a national study of adult substance use and sexual behavior and measured global (lifetime) and event-specific (most recent sexual encounter) behaviors. RESULTS: Sexual activity with many partners, "survival" sex, and substance use were common. However, needle use was rare, and consistent condom use was evident in half the sample. Nearly all correlations between global measures of substance use and risky sex were statistically significant, but only a few of the event-specific correlations were significant. Marijuana use during the most recent sexual encounter was associated with nonuse of condoms, but this relationship disappeared in the multivariate model. However, crack use during the last encounter was associated with condom use; this relationship remained significant in the multivariate model. Lack of motivation to use condoms, longer histories of sexual activity and homelessness, symptoms of drug dependency, not discussing HIV risks with partner, and being female were also associated with nonuse of condoms. CONCLUSIONS: Homeless youth do use condoms, even within the context of substance use and casual sex. Results suggest that prevention and targeted intervention efforts have had some positive effect on this population, but young homeless women are in need of targeted prevention. Finally, additional research is needed to investigate the observed relationship between crack use and condom use in this sample.

Adolescent↗

Addictive sexual behavior.

Case material is presented from two patients suffering from addictive sexual behavior. The term addiction is used because of the intense, driven quality of the behavior and because of its mood-elevating effects. Psychodynamically, the patients' sexual acts helped to undo feelings of rejection at the hands of their mothers and to enhance feelings of lovability and of self-esteem. The behavior also helped to neutralize powerful feelings of rage toward the mother. In one patient, the acts also helped to ease inner turmoil related to an underlying attention deficit disorder. I speculate that some adults with addictive sexual behavior may have underlying attention deficit disorders. In both my patients, the sexual behaviors served the self-regulatory function of alleviating inner feelings of anhedonia and depression. When they decreased their sexual activities during the course of the treatment, they required adjunctive antidepressant medication. The underlying meaning of the medication and countertransference attitudes toward such patients are explored.

Adult↗

Parity and sexual behavior in pregnancy.

Correlation between parity and sexual behavior during pregnancy was studied in 106 pluriparous and 69 primiparous patients. Sexual desire, frequency of coitus, frequency of orgasm, which partner initiated sexual activity, and level of sexual satisfaction were analyzed in the year before pregnancy and during pregnancy. Sexual desire, frequency of coitus, and sexual satisfaction were qualitatively equal in both groups. The frequency of coitus in particular decreased progressively in the three trimesters of pregnancy and more evidently in the pluriparous. The partner who initiated sexual activity most frequently was the male in the pluriparous group.

Adolescent↗

Sexual behavior in the United States 1930-1990: trends and methodological problems.

BACKGROUND AND OBJECTIVES: Arguments for population-based research on patterns of sexual behavior are reviewed, and survey data are used to illustrate the insights that can be gained from such research. STUDY DESIGN: Reports of sexual behavior obtained in surveys of large probability samples of the U.S. population are analyzed and compared to make inferences about changes in the age of onset of sexual intercourse and the patterns of heterosexual and same-gender sexual behaviors of American men and women who entered adulthood during the period from 1930 to 1990. RESULTS: Strong trends are documented for both a decline in the reported age at first heterosexual intercourse and an increase in the numbers of heterosexual partners reported during adulthood. Similar evidence on patterns of same-gender contact indicate a relatively stable prevalence of reported male-male contact for cohorts of men born from the 1930s through the 1960s. Preliminary analyses suggest, however, that there has been a substantial increase in the proportion of women reporting female-female sexual contact during adulthood. Although the analyses require refinement, it appears that the prevalence of reported female-female contact may have increased by a factor of 3 to 4 for cohorts of women born between the 1930s and the 1960s. CONCLUSIONS: Although the trends in reported behaviors are robust, inferences about behavior, pre se, rest on the assumption that reporting biases were equivalent across cohorts. Methodological challenges in the interpretation of such findings and new technologies for conducting such research are described.

Adolescent↗

Monoamine levels in the nucleus accumbens correlate with male sexual behavior in middle-aged rats.

The correlation between monoamine levels in the nucleus accumbens (NAcc) and male sexual behavior was studied in middle-aged rats. Male rats (18-19months) were assigned to three groups: (1) Group MIE consisted of rats showing mounts, intromissions, and ejaculations; (2) Group MI was composed of rats showing mounts and intromissions, but no ejaculation; and (3) Group NC were non-copulators showing no sexual behavior. Young adult rats (4-5months), displaying complete copulatory behavior, were used as the control group. Levels of dopamine (DA), serotonin, and norepinephrine and their metabolites in the NAcc were measured by high-pressure liquid chromatography with electrochemical detection. No difference was seen in DA levels between MIE rats and young controls, whereas DA levels in NC rats were significantly lower than those in both MIE and MI rats. Serotonin levels in NC rats were significantly higher than those in MIE and MI rats. Conversely, norepinephrine levels in NC rats were lower than those in MIE rats. These results suggest that monoamine levels in the NAcc correlate with sexual performance in male rats and that changes in NAcc monoamine levels might affect male sexual behavior in middle-aged rats.

Animals↗

Changes in sexual behavior by young urban heterosexual adults in response to the AIDS epidemic.

Young adults residing in four States were enrolled in the period 1985-88 in a multicenter study of cardiovascular disease risk factors. In 1989, 2,729 members of the group were given a self-administered questionnaire that included questions on changes in sexual behavior that subjects had made in response to the epidemic of acquired immunodeficiency syndrome (AIDS). The final sample of 1,601 young, heterosexual, urban respondents included 412 white men, 568 white women, 224 black men, and 397 black women, all ages 21 to 40 years. Overall, nearly 50 percent of the sample reported having made at least one change in their sexual behavior in response to the AIDS epidemic to decrease their risk of becoming infected by the human immunodeficiency virus. The mean number of changes was 0.8 for white men, 1.1 for white women, 1.6 for black men, and 1.5 for black women. Change was reported more frequently by black respondents than white, with no significant sex differences. The categories of respondents reporting behavior changes were more often young, with a history of recreational drug use, with more sex partners, or having had anal intercourse. The most commonly reported behavior changes were reducing the number of sex partners and being more careful in partner selection. Of the 54 percent of respondents who did not report any change in sexual behavior, about 70 percent reported unprotected sex with more than one partner in the previous year. Significant sexual behavior change in response to the AIDS epidemic remains a goal for health education efforts.

Acquired Immunodeficiency Syndrome↗

Sexual behavior of college women in 1975, 1986, and 1989.

To compare sexual practices in college women before and after the start of the current epidemics of Chlamydia trachomatis, genital herpesvirus, and human immunodeficiency virus type 1 infection, we surveyed 486 college women who consulted gynecologists at a student health service in 1975, 161 in 1986, and 132 in 1989 at the same university. There were no statistically significant differences in age, age at menarche, or reason for visiting the gynecologist. The percentages of women in this population who were sexually experienced were the same in all three years (88 percent in 1975, 87 percent in 1986, and 87 percent in 1989). Oral contraceptives were used by 55 percent of the women in 1975, 34 percent in 1986, and 42 percent in 1989; the use of condoms as the usual method of birth control increased (6 percent in 1975, 14 percent in 1986, and 25 percent in 1989; P less than 0.001). In 1975, only 12 percent reported the regular use of condoms during sexual intercourse, in some cases in conjunction with other methods of contraception, as compared with 21 percent in 1986 and 41 percent in 1989 (P = 0.0014). No significant differences were found in the three surveys in the number of male sexual partners or the frequency of fellatio, cunnilingus, or anal intercourse. An additional sample of 189 college women who did not consult the health service was surveyed in 1989, and similar sexual behavior was reported by those who were sexually experienced (65 percent). We conclude that in this population there has been little change in sexual practices in response to new and serious epidemics of sexually transmitted diseases, with the exception of an increase in the use of condoms (which still does not reach 50 percent).

Adolescent↗

[Qualitative study of drug-using and sexual behaviors of drug users in Guangxi].

OBJECTIVE: To understand where and how drug-using and sexual behaviors occurred among drug users. METHODS: Twenty-five drug users were recruited from detoxification centers and communities. In-depth interview was used to collect information about drug-using and sexual behaviors. Each subject was interviewed separately and privately for about 2 - 3 hours. RESULTS: Most drug users shifted from oral taking drugs to injecting drugs in order to reduce economic burden and look for "high feeling". Reasons for not injecting among few drug users included 'perceiving information on harm of injection', 'over-dose death' or 'infection with HIV'. Most drug users knew that HIV transmit through sharing needles or having sexual intercourse without using a condom. However, needles were shared at night when drug or needles were scarce. Promiscuous sexual relationship was common among drug users. Most female drug users had engaged in prostitution but few used condoms. CONCLUSION: High-risk drug injecting behaviors and high-risk sexual behaviors were prevalent among drug users despite knowledge on HIV transmission and prevention. Thus, education alone would not work unless specific intervention programs are taken.

Adolescent↗

Changes in sexual behavior among women in studies evaluating the dapivirine vaginal ring for HIV prevention.

BACKGROUND: Access to novel HIV prevention technologies often raise concerns of risk compensation. This analysis examined changes in the sexual behaviors of MTN 020/ASPIRE participants, a placebo controlled randomized control trial, who subsequently enrolled in MTN-025/HOPE, an open-label extension using the dapivirine vaginal ring. METHODS: Both studies enrolled healthy, sexually active, HIV-negative women from Malawi, South Africa, Uganda and Zimbabwe. Longitudinal data on participants' sexual behaviors, specifically sex with a nonprimary partner (past 3&#xa0;months), and use of male or female condoms at the last vaginal sex act were compared between ASPIRE and HOPE. Conditional and mixed ordinal logistic regression models evaluated associations between study and sexual behaviors at enrollment,&#xa0;and quarterly over the first 12&#xa0;months. RESULTS: Of the 2629 individuals enrolled in ASPIRE, 1456 (55%) participated in HOPE. At enrollment, the proportion of participants who reported sex with a nonprimary partner and condom use at last vaginal sex act did not differ by study. Across all quarterly follow-up visits, sex with a nonprimary partner was more common in HOPE (13.9-18.7%) than ASPIRE (10.7-12.6%); adjusted OR&#xa0;1.47, 95% CI 1.24-1.75, P&#xa0;<&#xa0;0.001. There was no difference in condom use at the last vaginal act across all quarterly follow-up visits between ASPIRE (36.5-42.7%) and HOPE (43.6-46.7%); adjusted OR&#xa0;1.05, 95% CI 0.94-1.18. CONCLUSION: More women reported sex with nonprimary partners in HOPE, with little change in condom use over time between the two studies. Understanding behavior changes during PrEP use allows for tailored, holistic reproductive health programming.

Humans↗

GABAergic control of masculine sexual behavior.

Drugs affecting the GABAergic transmission were injected into the medial preoptic anterior hypothalamic area (MPOA) and the masculine sexual behavior analyzed. Antagonizing GABAergic neurotransmission by (+) bicuculline methiodide (30 ng/cannula), or 3-mercaptopropionic acid (10 or 20 micrograms/cannula) resulted in a drastic shortening of the postejaculatory intervals and a shortening of the ejaculation latency. Injection of compounds causing an increase in GABAergic activity, muscimol (25 ng/cannula) or ethanolamine-O-sulphate (80 micrograms/cannula) depressed masculine sexual behavior. Systemic treatment or injection into the nucleus caudatus putamen of compounds affecting the GABAergic transmission did not cause any alteration in the mating pattern. It is suggested that the GABAergic neurotransmission is involved in inhibitory processes underlying the masculine sexual behavior.

3-Mercaptopropionic Acid↗

Sexual behavior of HIV-seropositive young men with congenital coagulopathies. Hemophilia Behavioral Intervention Projects (HBIEP) Study Group.

PURPOSE: To describe the self-reported sexual behaviors of human immunodeficiency virus (HIV)-seropositive youths with congenital coagulopathies in order to guide the development of interventions to prevent secondary transmission. SUBJECTS: A total of 297 HIV-seropositive males, 12-24 years of age, were sampled from 11 hemophilia treatment centers and 28 affiliated subsites. METHODS: Review of clinical records and self-administered survey of HIV-related knowledge, attitudes and behaviors. Subjects were classified and compared by self-reported sexual behavior over the lifetime and the prior 6 months into five mutually exclusive groups (G1-5). RESULTS: A total of 42% of subjects were virgins who never had oral, vaginal, or rectal sex (G1); 10% were nonvirgins who had abstained (G2); 13% were virgins and nonvirgins who had intimate touch only (G3); 21% had intercourse and always used condoms (G4); and 13% had had unsafe intercourse (G5). Among the groups, G5 was the oldest, least likely to forego sex, most angry and anxious when reminded of HIV, and most reluctant to disclose serostatus to friends. CONCLUSIONS: Most subjects (87%) had safer sex or abstained in the last 6 months. A relatively small group of HIV-seropositive youth with bleeding disorders were engaged in unprotected intercourse and in need of intensive help with HIV risk reduction.

Adolescent↗

Dopamine release in the nucleus accumbens during sexual behavior in prenatally stressed adult male rats.

In vivo microdialysis experiments were performed on the nucleus accumbens (NAc) during observation of sexual behavior (including motivation and copulation) to determine if there were any changes in NAc dopamine (DA) transmission in prenatally stressed (PS) adult male rats. Approximate 37% of control males and 83% of PS males did not exhibit copulation during the sexual behavior tests and no significant changes in NAc DA release were seen during exposure to estrous females. In contrast, both control and PS males that displayed copulatory behavior showed a marked increase in NAc DA release when presented with a sexually receptive female behind a screen and this increased further during actual copulation. The increase in DA release in copulatory PS males was not significantly different from that in sexually active control males. In addition, a similar extent in DA release induced by high potassium perfusate was observed in all rats. These results suggest that prenatal stress may result in a deficit in DA neurotransmission in the NAc and this deficit may possibly cause impaired male sexual behavior in rats.

3,4-Dihydroxyphenylacetic Acid↗

Apomorphine, deprenyl, and yohimbine fail to increase sexual behavior in rhesus males.

Various doses of apomorphine, deprenyl, and yohimbine were administered to old (20-26 years) rhesus males that had been sexually active when younger and to younger (6-17 years) males that were characteristically sexually sluggish. These neuropharmacological agents have been reported to increase sexual behavior in male rats. In Experiment 1, 10 old intact rhesus males were tested after injection of vehicle and apomorphine, and 6 old testosterone-treated castrated males were tested after treatment with deprenyl and yohimbine and the vehicles for each drug. In experiment 2, the 5 younger males were tested after treatment with each of the drugs and with the vehicles for each drug. There were a few minor changes in behavior associated with certain doses of each of the drugs and as many depressive as facilitative effects on sexual behavior. This suggests that there are basic differences between rats and rhesus macaques in the systems mediating sexual behavior.

Age Factors↗

The effect of naloxone on sexual behavior in female rats depends on the site of injection.

Intraperitoneal injections of the opiate receptor antagonist naloxone (0.1, 1, 5 or 10 mg) had no effects on sexual behavior in ovariectomized female rats made either partially or fully receptive by injections of ovarian hormones. Intracerebroventricular (i.c.v.) injections of naloxone (10, 50 or 100 micrograms) had no effects on the behavior of partially receptive rats and in fully receptive rats an i.c.v. injection of a high dose of naloxone (100 micrograms) inhibited the behavior. Intrathecal (i.t.) injections of naloxone (50 or 100 micrograms) facilitated sexual behavior in partially receptive rats while i.t. injections of even very high doses of naloxone (500 micrograms) had no behavioral effects in fully receptive rats. Thus, the effects of naloxone on female sexual behavior depend on the site of injection.

Animals↗

Prepuberal social rearing conditions and sexual behavior in control and neonatally castrated male rats.

Male and female sexual behaviors were assessed in control and neonatally castrated male rats that had been housed with a female, a control male, or a neonatally castrated male from day 16 until adulthood. Prepuberal housing conditions had no differential effect on lordosis or ejaculatory potentials of neonatally castrated males tested as adults. A smaller percentage of control males raised with a neonatal castrate ejaculated than did animals housed with a female or a control male. However, a greater proportion of control males caged with a female showed lordosis than did those living with another control male or with a neonatal castrate. The data demonstrate the modulating effects which specific types of social stimulation experienced during early life have on sexual behaviors displayed in adulthood.

Androgens↗

Sexual behavior, heterosexual transmission, and the spread of HIV in sub-Saharan Africa: a simulation study.

A stochastic simulation model has been used to assess the extent to which variation in sexual behavior and transmission characteristics can explain the striking spatial heterogeneity in the prevalence of HIV among different geographical locations in sub-Saharan Africa. Of the various parameters describing sexual behavior the most important determinant of the spread of HIV is the proportion of men engaging in sexual relationships with people other than spouses, including contacts with sex workers and short-term partners. Considering factors other than sexual behavior the model shows that this heterogeneity in HIV prevalence could be the result of differences in the transmission probability of HIV or in the prevalence of other sexuality transmitted diseases. These factors could play a key role in determining the patterns of spread of HIV in sub-Saharan Africa and should be considered in the design of intervention strategies.

Adult↗