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At least 739 records · Page 41Linked to original sources
PubMed1986

Serial analysis of fibronectin concentration in plasma of patients with benign and malignant breast diseases.

The serial levels of fibronectin (FNp) in plasma from 65 patients with benign and malignant breast disease and from 74 healthy control women were assayed by the use of the rocket immunoelectrophoresis procedure. Mean FNp levels in patients with breast cancer were age-matched with control subjects, but no clear correlation was found between FNp levels and the presence of primary tumor. Mean FNp values for fibroadenoma patients did not differ either from controls or from patients with malignant disease. Patients were also categorized according to TNM classification, to the number of positive axillary nodes, to the histologic grade of malignancy, and to the presence of estrogen receptors. Although differences were not significant, a higher number of patients with levels greater than the normal 95% percentile were found only in the group with four or more positive axillary nodes and in the group with a greater number of histologic malignancies. Marked fluctuations in FNp concentrations were found in individual patients during the follow-up period, independently of the treatment received. FNp seems unsuitable as a tumor marker because, besides its apparent lack of specificity for cancer, it reflected neither the host-tumor burden nor the response to treatment.

Adenofibroma↗
PubMed1975

Benign breast disease and cancer.

We report the necessity for thoroughly understanding the physiopathology of benign breast lesions in order to treat each type of lesion adequately. Three groups of women are outlined as a practical approach to this problem. Subadipose mastectomy is proposed to treat heteronodular mastopathy. This operation is compared with the subcutaneous mastectomy proposed by plastic surgeons.

Breast↗
PubMed1977

The incidence and management of female breast disease in a general practice.

A retrospective study is reported of 180 women with breast symptoms consulting at a group practice during a 27-month period. The management policies of the general practitioners are discussed in the light of the observed short-term outcomes and of proposals to introduce screening clinics for breast cancer.

Adolescent↗
PubMedDate not supplied

MRI's role in assessing and managing breast disease.

As medical imaging techniques become more sensitive and treatment regimes become focused on "cure" for Stage I and Stage II breast cancers, it is essential that screening and diagnostic techniques become more specific. Mammography is the primary imaging modality used to detect early, clinically occult breast cancer. However, limitations in the sensitivity and specificity of mammograms have stimulated exploration into alternative or adjunctive imaging methods. This article discusses magnetic resonance imaging as a technology for assessing and managing breast disease.

Adult↗
PubMed2000

Detection of circulating epithelial cells after surgery for benign breast disease.

BACKGROUND: Cytokeratins are predominantly expressed in epithelial cells and their malignant counterparts. Ultrasensitive methods for cytokeratin messenger RNAs (mRNAs) can detect rare circulating tumor cells consistent with hematogenous dissemination in epithelial-derived malignancies, including breast carcinomas. Intraoperative tumor-cell shedding may contribute to this process; this hypothesis is based on the assumption that only tumor cells can be mobilized during surgical manipulation. METHODS AND RESULTS: The present study addresses this issue by using cytokeratin 19 mRNA detection by reverse transcription-polymerase chain reaction (RT-PCR) in preoperative and postoperative blood samples from 54 patients undergoing excisional biopsy for benign breast disease; 22 healthy volunteers represented the control group. No cytokeratin RT-PCR positivity was found in the control or preoperative samples. Cytokeratin RT-PCR positivity was found in 21 postoperative samples (39%). CONCLUSIONS: This finding shows that benign epithelial cells can be mobilized during breast surgery; this effect of surgical manipulation warrants caution in the interpretation of RT-PCR positivity for cytokeratin mRNA in the peripheral blood of patients undergoing surgery for breast cancer.

Adult↗
PubMed1992

The gynecologist and breast disease.

The designation of the obstetrician-gynecologist as a principal physician for women may impose new responsibilities on them, but in reality it merely reaffirms what most obstetrician-gynecologists have long regarded as standard practice. The gynecologist has always insisted that breast examination is an integral part of the evaluation of every patient and the basic knowledge of breast disease is certainly as essential as any understanding of obstetric and gynecologic problems. The obstetrician-gynecologist should follow certain guidelines that will help achieve in making an early diagnosis. These include: Integrate breast examination into the routine gynecologic examination of all patients. Instruct patients in the technique of life-long, periodic breast self-examination. Develop proper ambulatory surgical facilities suitable for performing breast biopsies. Perform biopsy for all true, solid, three-dimensional masses. The final diagnosis of pathologic condition rests on a careful histologic examination of a biopsy specimen. Encourage research, both basic and clinical, and etiology, diagnosis and treatment of breast lesions including innovative screening programs for high risk patients. Include obstetric and gynecologic residency programs with specific instructions in early breast cancer detection techniques. Previously, breast cancer was viewed as a stereotype disease that progressed from the breast to the nodes to the systemic area. This has changed. Breast cancer is now viewed as a systemic disease, which spreads to local and distant sites at the same time. Breast cancer is best viewed as occultly metastatic at the time of presentation. Therefore, dissemination of tumor cells has occurred by the time of surgery in many patients, and it is not surprising that radical mastectomy and local irradiation do not prevent metastatic disease.

Breast Neoplasms↗
PubMed1982

Controlled trial of the antigonadotropin danazol in painful nodular benign breast disease.

In a double-blind crossover study of the effects of the antigonadotropin danazol on pain and nodularity in 28 women with cyclical mastalgia danazol was given at doses of 200 mg/day and 400 mg/day, and the responses were assessed both subjectively and objectively. Danazol caused a significant and progressive decrease in breast pain and nodularity when compared with placebo. Symptoms responded more quickly with the 400 mg/day dose of danazol than with the 200 mg dose, but the larger dose also caused greater side-effects. Danazol is a useful addition to the range of antihormones that can be used to suppress the symptoms of severe hormone-related benign breast disease.

Adult↗
PubMed1980

[Relevance of CEA in benign breast disease (author's transl)].

Serum CEA-concentrations were measured in patients with various benign breast tumors; in addition, CEA levels were determined in the fluid of mammary cysts present. Patients with proliferating mastopathia with and without atypia had CEA values exceeding 25 ng/ml in the cystic fluid (= 46). No significant correlation existed between serum and cystic fluid concentrations. CEA determination allows for a differentiation between simple and proliferating mastopathias.

Breast Diseases↗
PubMedDate not supplied

Teaching clinician-patient communication in the treatment of breast diseases.

In 1998, some 179,000 women in the United States were newly diagnosed with breast cancer, and 48,500 women died from it. Early detection by mammography, physical examination, and breast self-examination improves survival rates and can decrease mortality. The clinician's level of comfort with discussing education and prevention with patients can influence patients' adherence to preventive measures. Improved clinician-patient interpersonal communication has a demonstrated positive impact on adherence and health outcomes. We developed and pilot tested a core curriculum on breast health aimed at primary care community physicians and resident house staff. The goal was to improve interpersonal communication between clinician and patient. Two groups of participants attended either a week-long or a 2-week-long training program consisting of four components: a brief demonstration of an interview and breast examination, interviews and breast examinations with a standardized patient, and two separate workshops of varying length. This pilot program had a significant impact on clinician behavior and knowledge. We recommend further investigation of this area with larger sample sizes.

Breast Diseases↗
PubMed1980

[Drug treatment of benign breast diseases].

During the last decade many new experimental and clinical data were published demonstrating the inclusion of estrogens, progestagens, androgens, corticosteroids, prolactin, growth hormone and of insulin in the endocrine control of normal mammary tissue. Different hormonal disorders, such as lowered progesterone-estrogen-index (P.E.I.), anovulation, hyperprolactinemia, or increased prolactin-sensitivity of mammary tissue, are often responsible for the induction and/or maintenance of benign breast disease. therefore the endocrine treatment possesses deciding importance for the improvement or removal of breast symptoms. The present paper evaluates the role of progestagens, prolactin-inhibitors or anti-gonadotropins in the differentiated therapy of mastodynia, mastopathia, mammary secretion, mastitis, mammary hyperplasia, premenstrual syndrome and other disturbances. Dose levels and side effects of the various drugs are reviewed. The relation to other therapeutic procedures, as non-hormonal preparations or operative methods, is discussed.

Breast Diseases↗
PubMed1998

Information needs of nurses regarding breast disease.

The purpose of this study was to identify the information needs of nurses regarding benign breast conditions and breast cancer. One hundred and five Ontario nurses who are directly involved in providing information to women were interviewed. The majority of nurses indicated feeling either somewhat or very comfortable during their discussions with women and perceived their knowledge was sufficient for answering women's questions. Nurses rated existing information concerning discovery of breast abnormalities and the diagnostic phases the highest in terms of quality, quantity and accessibility. Overall, a large proportion of nurses did not perceive gaps in information for nurses about breast disease. This work raises interesting practice questions for nursing in light of the reports by patients that they experience difficulties obtaining information.

Breast Neoplasms↗