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At least 739 records · Page 41Linked to original sources
PubMed1998

Cafeteria diet-induced sleep is blocked by subdiaphragmatic vagotomy in rats.

Feeding rats a cafeteria diet results in increased food intake and excess sleep. Furthermore, vagal afferent activity is altered by a variety of gastrointestinal factors, and vagal stimulation can induce sleep. We investigated, therefore, the hypothesis that the vagal nerve plays a critical role in mediating the sleep-inducing effects of cafeteria feeding. We examined the effects of a cafeteria diet on sleep, electroencephalographic (EEG) slow-wave activity (SWA), and brain temperature (Tbr) in control and vagotomized rats. EEG, electromyogram, and Tbr were recorded for 7 consecutive days. Day 1 was considered a baseline day; normal rat chow was available ad libitum. On days 2-4, the animals were fed, in addition to normal chow, a mixed, energy-rich diet (cafeteria diet). On days 5-7, the rats were again fed only normal rat chow. In control rats, the cafeteria diet resulted in an increase in non-rapid eye movement sleep (NREMS), which was the result of a significant lengthening of the NREMS episodes. In contrast, feeding vagotomized rats the cafeteria diet resulted in a decrease in NREMS. Cafeteria feeding decreased REMS and EEG SWA and increased Tbr in both control and vagotomized rats. These results suggest that an intact vagus plays a key role in the NREMS-inducing effects of the cafeteria diet.

Afferent Pathways↗
PubMed2003

A temporally asymmetric Hebbian rule governing plasticity in the human motor cortex.

Synaptic plasticity is conspicuously dependent on the temporal order of the pre- and postsynaptic activity. Human motor cortical excitability can be increased by a paired associative stimulation (PAS) protocol. Here we show that it can also be decreased by minimally changing the interval between the two associative stimuli. Corticomotor excitability of the abductor pollicis brevis (APB) representation was tested before and after repetitively pairing of single right median nerve simulation with single pulse transcranial magnetic stimulation (TMS) delivered over the optimal site for activation of the contralateral APB. Following PAS, depression of TMS-evoked motor-evoked potentials (MEPs) was induced only when the median nerve stimulation preceded the TMS pulse by 10 ms, while enhancement of cortical excitability was induced using an interstimulus interval of 25 ms, suggesting an important role of the sequence of cortical events triggered by the two stimulation modalities. Experiments using F-wave studies and electrical brain stem stimulation indicated that the site of the plastic changes underlying the decrease of MEP amplitudes following PAS (10 ms) was within the motor cortex. MEP amplitudes remained depressed for approximately 90 min. The decrease of MEP amplitudes was blocked when PAS(10 ms) was performed under the influence of dextromethorphan, an N-methyl-d-aspartate-receptor antagonist, or nimodipine, an L-type voltage-gated calcium-channel antagonist. The physiological profile of the depression of human motor cortical excitability following PAS(10 ms) suggests long-term depression of synaptic efficacy to be involved. Together with earlier findings, this study suggests that strict temporal Hebbian rules govern the induction of long-term potentiation/long-term depression-like phenomena in vivo in the human primary motor cortex.

Adolescent↗
PubMed1987

Computation, rhythm, and cerebral slow waves.

The trajectories of data and modelling from formerly divergent research efforts now seem to be converging to an unexpected region of the phase space of neuroscience. Computational network theory and simulation assume that temporal rhythm may be a significant parameter for the successful organization of nonlinear analog computation effected by hierarchical sets of biological neurons and of nonbiological circuitry alike. For neurobiology, the apparently chaotic rhythms of cerebral compound field potentials--the electroencephalogram (EEG) and slow waves of event related brain potentials (ERBP)--have long been a phenomenological embarrassment, of only marginal clinical utility. But recent data from molecular biophysics, nonlinear dynamics, artificial intelligence, and scalp-conducted human electrocorticography suggest a possible functional role in the serial gating of neural network computations for the familiar theta-alpha-beta rhythms of the EEG clinic.

Auditory Perception↗
PubMed1975

[Dynamics of changes in the cerebral and erythrocyte ATPase activity of rats with hypoxic hypoxia].

A long-term (for 3 hours) hypoxic hypoxia was accompanied in rats by wave changes of the brain tissue Na++K+-ATPase activity. This activity decreased after a 15-minute exposure; it increased after 2 hours and fell again after a 3-hour hypoxia (decompensation period). The membrane transport enzymes of erythrocytes proved to be more resistant to hypoxia than the brain cell enzymes.

Adenosine Triphosphatases↗
PubMed2003

[Physiopathology of periventricular leukomalacia].

The term "periventricular leukomalacia" (PVL) usually covers necrotic and/or gliotic lesions from perinatal origin occurring in the periventricular ring of telencephalic white matter. However focal white matter necrosis is often associated to a diffuse white matter disease and to brainstem and grey matter lesions, making up the basis of a true encephalopathy. PVLs are diagnosed in 4% to 10% of infants born before 33 weeks of gestation. The proportion of PVLs from prenatal origin is estimated around one third of cases. Recent progresses in neuroepidemiology, developmental neurobiology and imaging methods permitted to revisit the pathophysiology of PVLs on a multifactorial basis. The end result of these multiple factors seems to be calcium influx due to glutamatergic overactivation triggered by cytokines, free radicals, and deficits in neurotrophic factors. Periventricular topography can be explained by properties of the brain at this specific step of brain development. Carrying motor and neuropsychological consequences, PVLs could be the most severe danger for very premature brains. Positive rolandic sharp waves recorded on EEG and precocious abnormally echogenous periventricular images on ultrasound suggest prospective periventricular cysts. Cystic periventricular cavitations certify the diagnosis of PVL. More subtle lesions of PVL do not reach the cystic grade and their diagnosis is confirmed by MRI. Treatment of infections is already available and potentially a tool for prevention. When the overwhelming glutamatergic signal has been triggered, neuroprotective agents turning off the excitotoxic cascade, including calcium blockers, growth factors and others, are promising therapeutic tools.

Humans↗
PubMed2004

Relationship between sleep and eye state in Cetaceans and Pinnipeds.

We recorded EEG from both hemispheres and documented the state of the two eyes in two species of Cetaceans (one beluga and one bottlenose dolphin) and one species of Pinnipeds (two northern fur seals). In the dolphin and beluga we found that episodes of unihemispheric slow wave sleep (USWS) were associated with asymmetry in eye state. During USWS and asymmetrical SWS the eye contralateral to the sleeping hemisphere was mostly closed or in an intermediate state while the eye contralateral to the waking hemisphere was more often open or in an intermediate state. Bilateral eye opening indicated waking in about 80% cases and unilateral eye closure indicated USWS with an accuracy of about 75%. Bilateral eye closure was rare (< 2% of the observation time) and was not necessarily associated with high amplitude SWS. In fur seals, episodes of one eye briefly opening usually occurred in the beginning of sleep episodes and lasted several minutes. Those episodes were frequently associated with lower amplitude EEG slow waves in the contralateral brain hemisphere. During most of their sleep on land, fur seals had both eyes tightly closed. No EEG asymmetry was recorded at this time. Although eye state and EEG stage are correlated in the bottlenose dolphin, beluga and fur seals, short episodes of EEG synchrony (less then 1 min) occur contralateral to an open eye and waking (a more activated EEG) activity can be present contralateral to a closed eye. The available data suggest that two functions of USWS/EEG asymmetry during SWS in Cetaceans and fur seals are multisensory control of the environment and maintenance of motion and postures of sleep. The adaptive advantages of USWS throughout the evolution of Cetaceans and Pinnipeds from terrestrial mammals to present forms could include 1) the avoidance of predators and maintenance of contact with other animals of the same species; 2) continuance of regular breathing; 3) and effective thermoregulation in the water environment.

Adaptation, Physiological↗
PubMed1997

Computer analysis of human depth EEG in different sleep stages.

This study compares delta (< 4 Hz), theta (4-8 Hz), alpha (8-12 Hz) and beta (12-20 Hz) band EEG signals during wakefulness, rapid-eye-movement (REM) sleep, and stage 1 and stage 2 non-REM sleep recorded from both surface and depth electrodes in patients with drug-resistant partial seizures. Computer analysis utilizing Fast Fourier Transforms (FFT) was performed with the Neurovision software developed for this purpose. Mean amplitudes were calculated for each of the frequency bands. Preliminary analysis was performed with emphasis on the presence and characteristics of theta activity in the hippocampus of the brain. Results demonstrate theta wave activity in the hippocampus with an increase of theta activity in REM sleep as compared to non-REM sleep (stages 1 and 2).

Adult↗
PubMed1992

Cortical mechanisms mediating asterixis.

We describe a patient with chronic renal failure who suffered multifocal action-induced jerks. Electromyography (EMG) recorded the typical silence of asterixis. Back-averaging the EEG activity preceding the EMG silent periods in the forearm showed a biphasic wave antedating the asterixis by 23 ms. Somatosensory evoked potentials (SEPs) after median nerve stimulation were pathologically enlarged on both hemispheres. Brain-mapping of the biphasic wave preceding asterixis and the giant SEPs indicated a common origin in the sensorimotor cortex. This observation provides further documentation of a cortical origin for some types of asterixis in humans.

Brain Mapping↗
PubMed2003

Three-dimensional laser-induced photoacoustic tomography of mouse brain with the skin and skull intact.

Three-dimensional laser-induced photoacoustic tomography, also referred to as optoacoustic tomography, is developed to image animal brain structures noninvasively with the skin and skull intact. This imaging modality combines the advantages of optical contrast and ultrasonic resolution. The distribution of optical absorption in a mouse brain is imaged successfully. The intrinsic optical contrast reveals not only blood vessels but also other detailed brain structures, such as the cerebellum, hippocampus, and ventriculi lateralis. The spatial resolution is primarily diffraction limited by the received photoacoustic waves. Imaged structures of the brain at different depths match the corresponding histological pictures well.

Animals↗
PubMed1988

The effects of brain bilirubin deposition on auditory brain stem evoked responses in rats.

Auditory brain stem evoked responses (ABR) in newborn infants are altered by elevated serum bilirubin levels and may be used as an indicator of bilirubin toxicity. The hypothesis of our study was that hyperbilirubinemia may affect ABR's because of bilirubin deposition in the brain stem. We examined this hypothesis by studying 21 male adult rats divided into three groups: group A, control (n = 8); group B, low bilirubin (n = 6); and group C, high bilirubin (n = 7). Each experimental group was studied over 150 min. The control group received a buffer solution. The low bilirubin group received a low dose bilirubin bolus of 50 mg/kg followed by continuous infusion of 20 mg/kg/h. The high bilirubin group received a bolus of 100 mg/kg bilirubin followed by continuous infusion of 40 mg/kg/h. All groups received sulfisoxazole (50 mg/kg X 3) during the second hour of the study. Auditory evoked potentials were recorded at 0 and 150 min. At the end of the study, the brains were analyzed for bilirubin content. Bilirubin deposition in the 3 groups was 0.6 +/- 0.28 micrograms/g, 0.93 +/- 0.07 micrograms/g and 3.2 +/- 2.2 micrograms/g for the control, low bilirubin and high bilirubin groups, respectively. Bilirubin deposition in the brain was associated with a significant amplitude reduction of Wave I and III, but had no effect on absolute latencies and interpeak latencies. Very high brain bilirubin concentrations were associated with absence of Waves I and IV. Wave I was also significantly reduced in the low bilirubin group where there was slightly increased bilirubin deposition in the brain. We conclude that ABR changes in the form of wave amplitude reduction were associated with brain stem and cerebellum bilirubin deposition. We speculate that previously reported observations of abnormal ABR changes in hyperbilirubinemic newborn infants are associated with bilirubin deposition.

Animals↗
PubMed2003

Short-term reorganization of auditory analysis induced by phonetic experience.

Sine wave replicas of spoken words can be perceived both as nonphonetic auditory forms and as words, depending on a listener's experience. In this study, brain areas activated by sine wave words were studied with fMRI in two conditions: when subjects perceived the sounds spontaneously as nonphonetic auditory forms ("nïve condition") and after instruction and brief practice attending to their phonetic attributes ("informed condition"). The test items were composed such that half replicated natural words ("phonetic items") and the other half did not, because the tone analogs of the first and third formants had been temporally reversed ("nonphonetic items"). Subjects were asked to decide whether an isolated tone analog of the second formant (T2) presented before the sine wave word (T1234) was included in it. Experience in attending to the phonetic properties of the sinusoids interfered with this auditory matching task and was accompanied by a decrease in auditory cortex activation with word replicas but not with the acoustically matched nonphonetic items. Because the activation patterns elicited by equivalent acoustic test items depended on a listener's awareness of their phonetic potential, this indicates that the analysis of speech sounds in the auditory cortex is distinct from the simple resolution of auditory form, and is not a mere consequence of acoustic complexity. Because arbitrary acoustic patterns did not evoke the response observed for phonetic patterns, these findings suggest that the perception of speech is contingent on the presence of familiar patterns of spectral variation. The results are consistent with a short-term functional reorganization of auditory analysis induced by phonetic experience with sine wave replicas and contingent on the dynamic acoustic structure of speech.

Adolescent↗
PubMed1996

Lymphocyte targeting of the central nervous system: a review of afferent and efferent CNS-immune pathways.

The central nervous system (CNS) in considered to be an immunological privileged site. However, inflammatory reactions in response to virus infections, in multiple sclerosis (MS) and in experimental autoimmune encephalomyelitis (EAE) suggest that there are definite connections between the CNS and the immune system. In this review, we examine evidence for afferent and efferent pathways of communication between the CNS and the immune system, the pivotal role of regional lymph nodes in T-cell mediated autoimmune disease of the CNS, and the factors involved in lymphocyte targeting of the CNS. Afferent pathways of lymphatic drainage of the brain are well established in a variety of species, especially rodents. Fluid and antigens appear to drain along perivascular spaces populated by immunocompetent perivascular cells. Drainage pathways connect directly via the cribriform plate to nasal lymphatics and cervical lymph nodes. Soluble antigens draining from the brain induce antibody production in the cervical lymph nodes. Using a model of cryolesion-enhanced EAE, we review the role of lymphatic drainage and cervical lymph nodes in the enhancement of cerebral EAE. If a brain wound in the form of a cryolesion is produced 8 days post inoculation (dpi) of antigen in the induction of acute EAE, there is a 6-fold increase in severity of cerebral EAE by 15 dpi. Removal of the cervical lymph nodes significantly reduces such enhancement of EAE. These findings suggest that drainage of antigens from the brain to the cervical lymph nodes, in the presence of activated lymphocytes in the meninges or CNS, results in an enhanced second wave of lymphocytes targeting the brain. In examining the efferent immune pathway by which lymphocytes home to the CNS, several studies have characterized the phenotype of infiltrating T lymphocytes by the use of immunocytochemistry or FACS analysis. T-cells infiltrating the CNS are recently activated/memory lymphocytes typified by their high expression of CD44, LFA-1 and ICAM-1 and low expression of CD45RB in the mouse. Following the induction of EAE in susceptible mice, ICAM-1 and VCAM-1 are dramatically upregulated on CNS vessels; lymphocytes bind to such vessels via the interaction of their known ligands, LFA-1/Mac-1 and alpha 4-integrins, at least in vitro. It appears that alpha 4-integrin plays a key role in lymphocyte recruitment across the blood-brain barrier and may be a major factor in lymphocyte targeting of the CNS. Definition of factors involved in the afferent and efferent connections between the CNS and the immune system may clarify mechanisms involved in immune privilege of the CNS and may open significant therapeutic opportunities for multiple sclerosis.

Afferent Pathways↗
PubMed1988

[Response latency characteristics for ENT medical assessment of auditory brain stem evoked response].

A schematic description of the correlation between the various types of hearing disorders and the behaviour of auditory brain stem responses (ABR) is presented. Conductive pathology and high-frequency cochlear hearing loss prolong wave component latency due to energy loss and hair cell dysfunction. Latency is not affected in flat cochlear hearing loss. Prolonged interwave latencies between wave I and wave V indicate eighth nerve and brain stem disorders. An algorithm in the form of a flow chart was developed for location of the malfunction. Families of characteristics of wave V intensity-latency functions were designed for faster detection and more precise evaluation of conductive and cochlear hearing losses.

Audiometry, Evoked Response↗