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At least 739 records · Page 41Linked to original sources

Computer-integrated finite element modeling of human middle ear.

The objective of this study was to produce an improved finite element (FE) model of the human middle ear and to compare the model with human data. We began with a systematic and accurate geometric modeling technique for reconstructing the middle ear from serial sections of a freshly frozen temporal bone. A geometric model of a human middle ear was constructed in a computer-aided design (CAD) environment with particular attention to geometry and microanatomy. Using the geometric model, a working FE model of the human middle ear was created using previously published material properties of middle ear components. This working FE model was finalized by a cross-calibration technique, comparing its predicted stapes footplate displacements with laser Doppler interferometry measurements from fresh temporal bones. The final FE model was shown to be reasonable in predicting the ossicular mechanics of the human middle ear.

Acoustic Stimulation↗

The relationship between housing characteristics, emotional well-being and the personal empowerment of psychiatric consumer/survivors.

In this research, we examine the relationships between the housing characteristics and dimensions of community adaptation for 107 psychiatric consumer/survivors. Hypotheses about which housing characteristics best predict which dimensions of adaptation were made based on previous research and theory. Using a longitudinal research design, we found, after controlling for demographic variables and prior adaptation, that the number of living companions, housing concerns, and having a private room all significantly predicted different dimensions of community adaptation. The findings partially support our theoretical expectations and illuminate the relationship between physical, social and organizational aspects of community-based housing and the adaptation of psychiatric consumer/survivors. We discuss the implications of the results for policy and practice in providing housing for this population.

Activities of Daily Living↗

A structured approach to occupational hygiene in the design and operation of fine chemical plant.

In order to ensure appropriate occupational hygiene controls can be incorporated in the design and operation of fine chemical plant, a structured scheme has been developed based upon the intrinsic hazard of the materials in use. The scheme provides guidelines for managing the inherent risks to health presented by the operation of such plant, including basic recommendations on the selection and operation of selected plant equipment. Although the scheme has focused on a carcinogenic ranking system for aromatic amines and nitro compounds, with suitable modifications its underlying philosophy and principles should be capable of application to any toxicological scheme for ranking the relative hazard of chemical substances.

Carcinogens↗

[Efficacy evaluation of preventive interventions: experience and proposal for road accident prevention strategies].

OBJECTIVE: To supply the local administrators with a tool for a preventive evaluation of the improvements in road safety brought about by specific interventions which are planned. It is one of the first Italian experiences in the area. STUDY DESIGN: The database consists of the accidents occurring in three municipalities of the province of Modena characterized by accidents of high severity. Models were used to simulate changes related to possible interventions. The goodness of the model-based estimates has been evaluated after the implementation of interventions. RESULTS: Scenario analyses indicate which actions are most effective. Preliminary estimates of efficacy suggest a good agreement with model-based forecasts. CONCLUSION: Results encourage the adoption of methods of preventive evaluation of the efficacy of preventive actions.

Accidents, Traffic↗

TRI2SOLID: an application of reverse engineering methods to the creation of CAD models of bone segments.

For many biomechanical engineering activities it would be useful to have the three dimensional (3D) geometry of bone segments available in form of vectorial models within computer aided design (CAD) environments. In this paper a new method for the semi-automatic conversion of a stack of CT images of a femur into a CAD solid model is described. This method is relatively simple, accurate, and requires only a 3D CAD plus a few additional programs available in the public domain. The proposed method was used to convert the CT scan data set of a human femur into a valid CAD model; the resulting solid was two times more accurate than that obtained using the commonly used procedure based on 2D segmentation.

Algorithms↗

Work redesign: an overview.

The process of redesign offers many opportunities to staff and leadership; it can be an exciting process with the potential for positive outcomes for staff, management, and patients. The key to success is to work together as a team to design new care teams and revised systems to enhance the quality of care provided. Changes will be and are taking place in health care. Nurses have the opportunity to use their creativity and innovation to help shape the future of health care. Emergency nurses can help accomplish this transformation and maintain our tradition as patient advocates for access to care and safe, quality patient care. This article has provided an overview of the major issues that should be addressed in a redesign project. Future articles will describe the redesign projects of specific emergency departments, highlighting strategies for planning and implementation.

Emergency Nursing↗

Genetics of asthma: current research paving the way for development of personalized drugs.

Asthma is a complex genetic disorder involving the interplay between various environmental and genetic factors. In this review, efforts have been made to provide information on the recent advances in these areas and to discuss the future perspective of research in the area of developing personalized drugs using pharmacogenomic approach. Atopic asthma is found to be strongly familial, however the mode of inheritance is controversial. A large number of studies have been carried out and a number of candidate genes have been identified. In addition, a number of chromosomal regions have been identified using genome-wide scans, which might contain important unknown genes. It has been shown in studies carried out in different populations that the genetic predisposition varies with ethnicity. In other words, genes that are associated with asthma in one population may not be associated with asthma in another population. In addition to the involvement of multiple genes, gene-gene interactions play a significant role in asthma. The importance of environmental factors in asthma is beyond doubt. However, it remains controversial whether a cleaner environment or increased pollution is a trigger for asthma. Despite the increasing prevalence of the disorder, only a limited number of therapeutic modalities are available for the treatment. A number of novel therapeutic targets have been identified and drugs are being developed for better efficacy with less side-effects. With the rapid progress in the identification of genes involved in various ethnic populations combined with the availability in future of well-targeted drugs, it will be possible to have appropriate medicine as per the genetic make-up of an individual.

Anti-Asthmatic Agents↗

Virtual reality in the assessment of selected cognitive function after brain injury.

OBJECTIVE: To assess selected cognitive functions of persons with traumatic brain injury using a computer-simulated virtual reality environment. STUDY DESIGN: A computer-simulated virtual kitchen was used to assess the ability of 30 patients with brain injury and 30 volunteers without brain injury to process and sequence information. The overall assessment score was based on the number of correct responses and the time needed to complete daily living tasks. Identical daily living tasks were tested and scored in participants with and without brain injury. Each subject was evaluated twice within 7 to 10 days. A total of 30 tasks were categorized as follows: information processing, problem solving, logical sequencing, and speed of responding. RESULTS: Persons with brain injuries consistently demonstrated a significant decrease in the ability to process information (P = 0.04-0.01), identify logical sequencing (P = 0.04-0.01), and complete the overall assessment (P < 0.01), compared with volunteers without brain injury. The time needed to process tasks, representing speed of cognitive responding, was also significantly different between the two groups (P < 0.01). CONCLUSION: A computer-generated virtual reality environment represents a reproducible tool to assess selected cognitive functions and can be used as a supplement to traditional rehabilitation assessment in persons with acquired brain injury.

Activities of Daily Living↗

How cigarette design can affect youth initiation into smoking: Camel cigarettes 1983-93.

CONTEXT: Internal industry documents may shed light on how cigarettes are designed to promote youth smoking. OBJECTIVE: To determine changes in the design of Camel cigarettes in the period surrounding the "Smooth Character" advertising campaign and to assess the impact of these changes on youth smoking. DATA SOURCES: Internal documents made available through the document website maintained by RJ Reynolds, manufacturer of Camel cigarettes. STUDY SELECTION: Electronic searches using keywords to identify relevant data. DATA EXTRACTION: A web based index search of documents targeting "smoothness" or "harshness" and "younger adult smokers" ("YAS") or "first usual brand younger adult smokers" ("FUBYAS") in the 10 year period surrounding the introduction of the "Smooth Character" campaign was used to identify Camel related product design research projects. A snowball methodology was used: initial documents were identified by focusing on key words, codes, researchers, committees, meetings, and gaps in overall chronology; a second set of documents was culled from these initial documents, and so on. DATA SYNTHESIS: Product design research led to the introduction of redesigned Camel cigarettes targeted to younger adult males coinciding with the "Smooth Character" campaign. Further refinements in Camel cigarettes during the following five year period continued to emphasise the smoothness of the cigarette, utilising additives and blends which reduced throat irritation but increased or retained nicotine impact. CONCLUSIONS: Industry competition for market share among younger adult smokers may have contributed to the reversal of a decline in youth smoking rates during the late 1980s through development of products which were more appealing to youth smokers and which aided in initiation by reducing harshness and irritation.

Adolescent↗

ATLes: the strategic application of Web-based technology to address learning objectives and enhance classroom discussion in a veterinary pathology course.

A case-based program called ATLes (Adaptive Teaching and Learning Environments) was designed for use in a systemic pathology course and implemented over a four-year period. Second-year veterinary students working in small collaborative learning groups used the program prior to their weekly pathology laboratory. The goals of ATLes were to better address specific learning objectives in the course (notably the appreciation of pathophysiology), to solve previously identified problems associated with information overload and information sorting that commonly occur as part of discovery-based processes, and to enhance classroom discussion. The program was also designed to model and allow students to practice the problem-oriented approach to clinical cases, thereby enabling them to study pathology in a relevant clinical context. Features included opportunities for students to obtain additional information on the case by requesting specific laboratory tests and/or diagnostic procedures. However, students were also required to justify their diagnostic plans and to provide mechanistic analyses. The use of ATLes met most of these objectives. Student acceptance was high, and students favorably reviewed the online ''Content Links'' that made useful information more readily accessible and level appropriate. Students came to the lab better prepared to engage in an in-depth and high-quality discussion and were better able to connect clinical problems to underlying changes in tissue (lesions). However, many students indicated that the required time on task prior to lab might have been excessive relative to what they thought they learned. The classroom discussion, although improved, was not elevated to the expected level-most likely reflecting other missing elements of the learning environment, including the existing student culture and the students' current discussion skills. This article briefly discusses the lessons learned from ATLes and how similar case-based exercises might be combined with other approaches to enhance and enliven classroom discussions in the veterinary curriculum.

Computer-Assisted Instruction↗

Why the elderly fall in residential care facilities, and suggested remedies.

OBJECTIVE: To study precipitating factors for falls among older people living in residential care facilities. DESIGN: Prospective cohort study. SETTING: Five residential care facilities. PARTICIPANTS: 140 women and 59 men, mean age +/- SD 82.4 +/- 6.8 (range, 65-97). MEASUREMENTS: After baseline assessments, falls in the population were tracked for 1 year. A physician, a nurse, and a physiotherapist investigated each event, and reached a consensus concerning the most probable precipitating factors for the fall. RESULTS: Previous falls and treatment with antidepressants were found to be the most important predisposing factors for falls. Probable precipitating factors could be determined in 331 (68.7%) of the 482 registered falls. Acute disease or symptoms of disease were judged to be precipitating, alone or in combination in 186 (38.6%) of all falls; delirium was a factor in 48 falls (10.0%), and infection, most often urinary tract infection, was a factor in 38 falls (7.9%). Benzodiazepines or neuroleptics were involved in the majority of the 37 falls (7.7%) precipitated by drugs. External factors, such as material defects and obstacles, precipitated 38 (7.9%) of the falls. Other conditions both related to the individual and the environment, such as misinterpretation (eg, overestimation of capacity or forgetfulness), misuse of a roller walker, or mistakes made by the staff were precipitating factors in 83 (17.2%) of falls. CONCLUSION: Among older people in residential care facilities, acute diseases and side effects of drugs are important precipitating factors for falls. Falls should therefore be regarded as a possible symptom of disease or a drug side effect until proven otherwise. Timely correction of precipitating and predisposing factors will help prevent further falls.

Accidental Falls↗

Effectiveness of crime prevention through environmental design (CPTED) in reducing robberies.

OBJECTIVE: The objective of this study was to determine the effectiveness of the Crime Prevention Through Environmental Design (CPTED) approach in reducing robberies. METHODS: CPTED evaluations were obtained through a comprehensive search mechanism. Two sets of inclusion criteria were used: 16 primary studies evaluated a CPTED program with a comparison period; 12 secondary studies presented some evidence of CPTED effects but were not required to have the same level of scientific rigor. The percentage change in pre- and post-intervention events was the outcome examined. Studies were stratified by programs implementing multiple components, a single component, and through ordinances. MAIN RESULTS: All primary multiple-component CPTED programs experienced a percentage change in robberies ranging from -84% to -30%. Single-component program effects ranged from -83% to +91%, and ordinances ranged from -65% to +130%. Secondary studies reported robbery changes ranging between -92% and +7.6%. Robbery reductions were larger for interventions comprising basic store design, cash control, and training components compared to those including equipment systems. No associations were found between robbery decreases and either the follow-up period or the number of program components. Studies examining nonfatal injuries found a median pre-post change of -61%; those examining homicides found changes ranging from 0% to +11%. CONCLUSIONS: The broad nature of the CPTED approach allows its adaptation to any setting, and results indicate that it is an effective approach to reducing robbery. However, most interventions were not evaluated independently of other factors contributing to robbery risk. More research is needed on individual components and effects in various business settings.

California↗

A house is a center is a house: participatory design for a community counseling center.

Using an environmental-design concept called pattern language, an architectural design group worked with five mental health center staff members to locate, design, and move into a setting for a satellite counseling center. The group first identified environmental problems, especially the lack of privacy, that existed in the counselors' previous setting, a remodeled storefront. However, in their new quarters, a two-story house, staff decided against having private offices; they used the upstairs rooms for counseling and the downstairs for shared spaces and work stations--inexpensive, individual cabinets with desk space that were placed to allow privacy for the user, yet permitted the communication essential for work as a team. After 18 months of use, staff's and clients' reactions to the setting continued to be favorable.

Community Mental Health Services↗

Sun protection policies and environmental features in US elementary schools.

OBJECTIVE: To assess current sun protection policies and the receptiveness to new policies at elementary schools in the United States. DESIGN: A cross-sectional telephone survey. SETTING: General educational community. PATIENTS OR OTHER PARTICIPANTS: In 1998, a random sample of 1000 public elementary schools in the United States was selected (proportional to population size) from 27 metropolitan areas chosen from the 58 US cities regularly reporting the UV index in 1997. A final sample of principals from 412 elementary schools completed the survey. INTERVENTION: None. MAIN OUTCOME MEASURES: Only 3.4% of schools had a sun protection policy. The most common reasons for not having a policy included the principal's lack of awareness (n = 113) or organizational barriers in the school districts (n = 77). Most principals (84.2%) said that students were outdoors during midday hours. Many principals (48.3%) were willing to adopt a sun protection policy. Most schools (72.8%) had shade structures but the majority (67.3%) reportedly covered less than one fifth of the grounds. Most principals (76.4%) were willing to increase the amount of shade structures. CONCLUSIONS: The low frequency of sun protection policies and shade structures calls for national efforts to change policies and environments to increase sun protection at US schools. Research is needed to demonstrate the efficacy of these changes.

Child↗

Effects of environmental design and police enforcement on violations of a handicapped parking ordinance.

This study presents two experiments that evaluate strategies to reduce violations of a handicapped parking ordinance. The first experiment compared effects of upright versus ground handicapped parking signs on percentage of intervals in which cars were parked illegally. Introducing upright signs produced an immediate reduction in the percentage of intervals of inappropriate use of parking spaces. The second experiment examined effects of a police enforcement program on percentage of intervals of inappropriate use of parking spaces and frequency of inappropriately parked cars. Results showed consistent reductions in percentage of intervals of inappropriate use and number of inappropriately parked cars compared with a control site where no enforcement program was introduced. Implications of the research data for law enforcement and public policy are discussed.

Architectural Accessibility↗

Effectiveness and cost-effectiveness of a multidisciplinary intervention programme to prevent new falls and functional decline among elderly persons at risk: design of a replicated randomised controlled trial [ISRCTN64716113].

BACKGROUND: Falls are common among community-dwelling elderly people and can have a considerable impact on quality of life and healthcare costs. People who have sustained a fall are at greater risk of falling again.We replicated a British randomised controlled trial which demonstrated the effectiveness of a multidisciplinary intervention programme to prevent falls. The objective is to describe the design of a replication study evaluating a multidisciplinary intervention programme on recurrent falls and functional decline among elderly persons at risk. The study consists of an effect evaluation, an economic evaluation and a process evaluation. METHODS/DESIGN: The programme is aimed at community-dwelling elderly people aged 65 years or over who have visited an accident and emergency department (A&E department) or a general practitioners' cooperative (GP cooperative) because of a fall. The design involves a two-group randomised controlled trial. Participants are followed for twelve months after baseline. The intervention programme consists of a detailed medical and occupational therapy assessment with referral to relevant services if indicated. People in the control group receive usual care. The main outcome measures of the effect evaluation are number of falls and daily functioning. The economic evaluation will be performed from a societal perspective. A process evaluation will be carried out to evaluate the feasibility of the intervention programme.

Accidental Falls↗

Learning outcomes in medical informatics: comparison of a WebCT course with ordinary web site learning material.

OBJECTIVE: The purpose of this study is to compare whether students' learning outcomes would be better in a designed learning environment (WebCT) than in a conventional web site (WWW) with similar course material but without special learning tools. CONTEXT: Third-year medical students in an introductory course on medical informatics at the University of Helsinki, Finland. METHODS: Students were randomly assigned to a WebCT group (n=39) and a WWW group (n=46). The students in the WebCT group utilized the course material in general discussion groups, special discussions about lectures, quizzes and students' own notes. The WWW group had access only to the course material. The learning outcome was assessed by administering an on-line examination and the learning experience of the students was assessed by an on-line quiz. RESULTS: The course grade was significantly higher in the WebCT group as compared to the WWW group. This finding was more prominent among females. The students of the WebCT group also experienced significantly more improvement in collaboration with the use of computers than the students in the WWW group. CONCLUSIONS: Based on our results, web-based learning seems to be more effective when students are provided with specially designed learning tools.

Education, Distance↗

Enclosure design and reproductive success of baboons used for reproductive research in Kenya.

Three 125mz enclosures were designed to enable collection of urine from female baboons (Papio sp.) during early pregnancy, while maintaining them in close continuous social contact to permanent breeding groups. Attached to each enclosure were individual cages to which females were confined for urine collections. Over the 18-month period following group formation, 60 of 67 females became pregnant and then 51 reconceived following surgical termination of pregnancy. A total of 181 pregnancies were recorded. Over 75% of reconceptions occurred within the first two cycles following surgery. The enclosures have proved to be extremely versatile, allowing sampling of individual animals maintained in group conditions with the ability to interact socially.

Abortion, Induced↗