[BEHAVIOR OF MINUTE-OUTPUT OF THE HEART, STROKE VOLUME AND CIRCULATION TIME IN HEART DISEASE PATIENTS DURING PHYSICAL EXERTION].
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Little information is available regarding left ventricular (LV) functional recovery from treadmill exercise. Accordingly, we used a recently described ultrasound index of LV function, the isovolumic index (IVI), to assess LV performance before and after exercise in 9 normal middle-aged men and 12 male patients with coronary artery disease (CAD). The IVI was measured at rest and at each minute for at least 10 min after completion of the Bruce protocol; normals had maximal tests and CAD patients had symptom limited studies. At rest the IVI value for normals was 26.2 +/- 2.1 (SD) and it was 43.5 +/- 8.2 for CAD patients (p less than 0.001); isovolumic times were longer in CAD patients (137 +/- 26 vs. 89 +/- 8 ms, p less than 0.001). The rate of recovery from exercise did not differ between normals and CAD patients. We conclude that despite depression of resting LV performance in CAD patients, the time course of functional recovery of the left ventricle from exercise is not different from normal subjects.
Hemodynamic parameters using Swan Ganz catheter were studied in 17 patients with end stage renal disease. The acute effects of radiocephalic AV fistula on the hemodynamic parameters were studied at 24 hours of surgery. The chronic effects were studied in 8 of these patients at 6 weeks of arteriovenous (AV) fistula. The AV fistula matured in 3 to 4 weeks time and blood flow was sufficient for hemodialysis (400 mL/min). Patients with chronic renal failure had normal or high normal hemodynamic parameters. Six weeks after the AV fistula, the cardiac index and the stroke volume index slightly increased along with a significant increase in systolic and mean systemic arterial pressure. None of the patients had significant increase in cardiac filling pressures. Although there was some fall in systemic vascular resistance index and rise in cardiac index and stroke volume index, these changes were physically small and unlikely to put any extra hemodynamic load. Thus, AV fistula in dialysis patients is not an appreciable cause of circulatory or pulmonary congestion.
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Compared with the cardiopulmonary function of the healthy adults on the plateau at an altitude of 4475 m and of 2500 m, the HR was faster, LVET was shorter, PEP/LVET rate was larger (P less than 0.05 or P less than 0.01) in the former. Besides the FEV1% and FEF25%, the FVC, FEV1.0, MMF, PEFR, FEF75% and FEF50% were all elevated (P less than 0.05 or P less than 0.01). After the villagers at the altitude of 2500 m area entered the area at the altitude of 4475 m, their LVETI became shorter, PEPI became longer, and PEP/LVET rate was increased (P less than 0.05 or P less than 0.01). Besides FEV1% and PEFR, other values of pulmonary function were increased obviously (P less than 0.05 or P less than 0.01). The Shengmaiyin could efficiently protect the villagers from the plateau reaction described above, while the Danshen-Chuanxiong decoction was not satisfactory.
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The physical activity capacity (W170) was twofold determined in 26 soldiers, aged about 20 by the method of three-stage loading (25,50 and 75 W) upon mechanic veloergometer and with the aid of regression extrapolation- at the release from the hospital after treatment for acute pneumonia and after 28+/-11 days of home sick leave. W170 was established not change significantly after the sick leave in spite of the favourable evolution towards further normalization of the remaining X-ray changes of the pneumonia and RES. The possible explanations are discussed for that W170 decrease after acute pneumonias and the conclusion is that further investigators in the field are necessary.
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Hemodynamic studies at rest, at exercise and during oxygen breathing (FiO2 99.6%) were carried out in 12 patients with severe chronic obstructive lung disease and cor pulmonale without congestion (NOCA). All lived in Mexico city (2,240 meters). Our data confirm the concept of a spectrum of ventricular behaviour, from normal to the one when right ventricular pressure abnormalities exist and blood flow is restricted. The right ventricular stroke work index was considerably higher due mainly to the increase in pressure work. Grossly right ventricular performance at altitude is not different from the described at sea level. When stroke index (SI) is related to the right ventricular end diastolic pressure (RVEDP), patients with NOC at sea level show depressed right ventricular function. This relation was different for NOC-A and it could be related indirectly to higher altitude. On the basis of the relation found for SI-RVEDP at our altitude we could not conclude that NOC-A show depressed right ventricular function.
Cardiovascular tests (CT) of autonomic function and non-invasive ambulatory blood pressure (BP) and heart rate (HR) monitoring were performed in 17 patients with multiple system atrophy (MSA) (mean age 61 +/- 9 years) and in 12 healthy subjects matched for sex and age. CT showed severe autonomic dysfunction with orthostatic hypertension (OH) in eight patients with MSA (47%) (Group I). The remaining nine out of the 17 patients didn't show BP abnormalities during CT but an impaired HR reflex response was found (Group II). BP monitoring showed a reversed circadian BP rhythm in Group I with higher night-time than day-time values, a blunted circadian BP pattern in Group II and a normal day-night BP reduction in controls. Day-night HR reduction was poor in Group II and absent in Group I. Post-prandial hypotension was evaluated after a standard meal. In Group I systolic/diastolic BP fell within 30 minutes after meal (from 135 +/- 16/89 +/- 13 to 118 +/- 17/73 +/- 12 mmHg; p < 0.05) and after two hours had not returned to basal levels. In Group II a reduction of only systolic BP was found within 45 minutes after meal and persisted for one hour. OH clinically identifies a subgroup of MSA patients with a more severe BP dysregulation characterized by severe post-prandial hypotension and reversed circadian BP rhythm. CT and ambulatory BP monitoring are useful tools in identifying early stage of cardiovascular autonomic impairment.
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The objective of this study was to develop and test a technique to allow dynamic cardiac function to be studied during exercise in the horse. Blood pressure waveforms in the exercising horse are difficult to interpret because of the large influence of stride and respiration. A method has been devised to study dynamic right ventricular variables during high-speed exercise in the horse. A Fast Fourier Transform was performed on the digitised pressure waveforms and the frequency components associated with stride and respiration were removed. An inverse Fourier Transform was then performed to generate a time-domain pressure signal. Several dynamic right ventricular variables were calculated using the derived signal. Various parameters associated with removing frequencies from the frequency-domain pressure signal were changed to determine their influence on the variables. Most of the variables were not sensitive to these parameters. When compared during separate exercise bouts, some variables differed among runs, while others were not significantly different. Using the signal separation technique described here, right ventricular function of an exercising horse can be critically analysed.
Exercise stresses the primary function of the cardiovascular system, which is the supply of O2 and removal of CO2 from the cells of the body. Even ordinary walking requires an increase in O2 consumption and CO2 production by the exercising muscles of 20 times the resting level. While pulmonary dysfunction may affect arterial blood gas tensions, the dynamics of O2 uptake and CO2 output by the lungs depend on the circulatory responses to exercise. Thus, measurement of the dynamics of O2 uptake in response to exercise has been shown to reflect cardiovascular function. Inability of the circulatory responses to meet an increased O2 requirement may be reflected in abnormalities in O2 uptake dynamics, and an early increase in CO2 output relative to O2 uptake consequent to bicarbonate buffering of lactic acid. Application of currently available technology for the continuous measurement and analysis of pulmonary gas exchange can afford the practicing or investigative cardiologist with a noninvasive and inexpensive means for assessing cardiovascular function.
Certain results are gives which show that the frequency spectrum of the heart rhythm during the fulfillment of static muscle effort to refusal, distinguishes significantly the way in which this test is performed by experienced persons: at complete motivation (physiological refusal) and in incomplete motivation (psychological refusal). The second type of answer is unwanted in practical application of the test in industry, that's why a conclusion is made, that the frequency spectrum of the heart rhythm could serve as criterium of correctness for putting the test into practice.