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Results for “INTRAOCULAR PRESSURE”

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At least 739 records · Page 41Linked to original sources

PubMed1984

Intraocular pressure after intracapsular cataract extraction.

We studied the incidence of postoperative intraocular pressure elevations in 42 patients following intracapsular cataract extraction with alpha-chymotrypsin (1:5,000) and noted 17% to develop pressures greater than 30 mm Hg and 38% greater than 24 mm Hg within a 48-hour time interval. Additionally, we studied the effect of a single immediate postoperative instillation of timolol maleate 0.5%; this was associated with a slight reduction of intraocular pressure at the three- and six-hour time intervals, but did not eliminate the pressure spikes.

Aged↗

PubMed2000

Association between intraocular pressure and budesonide inhalation therapy in asthmatic patients.

BACKGROUND: The extent to which inhaled glucocorticoids increase the risk of intraocular pressure elevation has been controversial. OBJECTIVE: The authors attempt to assess such risk attributable to budesonide, an inhaled glucocorticoid for asthma therapy. METHODS: Data were pooled from four prospective, randomized, double-blind, parallel-group, placebo-controlled, multicenter clinical trials of 12 to 20 weeks in duration. One thousand two hundred and fifty-five patients, 6 to 70 years of age whose intraocular pressures (IOPs) were less than 23 mmHg at screening were randomized to receive placebo or inhaled budesonide at doses ranging from 100 to 800 microg, administered twice daily. Intraocular pressure was measured at screening and at the end of double-blind treatment. Intraocular change was compared between budesonide and placebo, accounting for the confounding effects of gender, race, age, history of diabetes, history of hypertension, clinical trial, systemic glucocorticoid use during the trials, ophthalmic glucocorticoid use during the trials, and prior oral glucocorticoid use. RESULTS: No budesonide treatment effect on the IOP was evident either in the crude analysis or after adjustment for possible confounding factors. For patients exposed to budesonide at a total daily dose of 1600 microg for 20 weeks, there was no difference in IOP change compared with the placebo controls. CONCLUSIONS: No association with an increased IOP was observed in asthmatic patients treated with budesonide at daily doses ranging from 200 to 1600 microg for durations of 12 to 20 weeks. The subgroup analysis, which focused on the highest dose and longer term therapy was reassuring, as was the overall result.

Administration, Inhalation↗

PubMed1987

An intraoperative intraocular pressure monitor.

An autoclavable instrument based on piezoelectric principles for intraoperative monitoring of the intraocular pressure is presented. Accurate and rapid recordings of intraocular pressure during various surgical techniques are discussed.

Humans↗

PubMed2003

Intraocular pressure development after cataract surgery: a prospective study in 50 dogs (1998-2000).

OBJECTIVE: To study the course of intraocular pressure (IOP) after cataract surgery in 50 dogs. DESIGN: Prospective study. ANIMALS: Fifty dogs without preoperative ocular hypertension were selected for cataract surgery. METHODS: All dogs underwent cataract surgery: 25 by manual extracapsular extraction and 25 by phacoemulsification. For each dog, intraocular pressure was measured before surgery, and 1, 3, 5, 18 h, 1 week and 1 month post surgery. RESULTS: No significant difference of mean intraocular pressure between the two surgical methods was observed for each time measurement. Nine dogs had postoperative hypertension (IOP > 25 mmHg) during the first 5 hours post surgery. Incidence of postoperative hypertension was not significantly different with manual extracapsular extraction (16%) vs. phacoemulsification (20%). A decrease of mean IOP was observed 1 h after surgery (8.49 mmHg vs. 10.91 mmHg), then an increase 3 and 5 h post surgery (12.3 and 13.32 mmHg, respectively). At 18 h, 1 week and 1 month post surgery, mean IOP decreased. Mean IOP was 10.38, 10.38 and 8.84 mmHg, respectively. CONCLUSION: In this study incidence of POH is not high. However, a follow-up of IOP in the first hours after cataract surgery is required to avoid complications of the retina and optic nerve and to administer hypotensive treatment if necessary.

Animals↗

PubMed1988

A double-crossover trial comparing the effects of topical carteolol and placebo on intraocular pressure.

The effect of topical carteolol 2% on the intraocular pressures of 12 patients suspected of having glaucoma was measured in a double-crossover trial of six weeks' duration. Carteolol produced a significant reduction in intraocular pressure (p less than or equal to 0.001), when compared with placebo. This represented reductions of 11% and 14%, after one and two weeks of treatment.

Administration, Topical↗

PubMed1989

Atrial natriuretic peptides. Effects on intraocular pressure, cGMP, and aqueous flow.

We report a significant decrease in intraocular pressure after intravitreal injection of atrial natriuretic peptide (AP). There is also an increase in cGMP in iris-ciliary body preparations after exposure to physiologic concentrations of AP in vitro. We present evidence that after intravitreal AP administration there is a decrease in aqueous humor flow associated with the decrease in intraocular pressure. The changes in aqueous humor flow were estimated by automated fluorophotometry and aqueous humor ascorbate concentrations.

Animals↗

PubMed1991

Effect of bunazosin hydrochloride on intraocular pressure and aqueous humor dynamics in normotensive human eyes.

We investigated the effects of topical administration of bunazosin hydrochloride, a new selective alpha 1-adrenergic antagonist, on intraocular pressure and aqueous humor dynamics in normal human eyes. In the single-dose study, all concentrations of bunazosin (0.025%, 0.05%, 0.1%, and 0.2%) significantly lowered intraocular pressure in a concentration-dependent manner. Administration of multiple doses of 0.1% bunazosin revealed no occurrence of tachyphylaxis after 1 week. Single application of 0.1% bunazosin had no significant influence on aqueous flow rate, tonographic outflow facility, or episcleral venous pressure, suggesting that bunazosin reduces intraocular pressure by increasing uveoscleral outflow. Aqueous protein concentration was found to be unaltered by bunazosin, indicating that blood-aqueous barrier permeability to protein molecules remained unchanged. We conclude that bunazosin may be a possible new antiglaucoma agent with a mechanism of action different from those currently in use for treating ocular hypertension.

Administration, Topical↗

PubMed2006

Intraocular pressure measurement-comparison of dynamic contour tonometry and goldmann applanation tonometry.

PURPOSE: The dynamic contour tonometer (DCT, Pascal tonometer, Swiss Microtechnology AG, Port, Switzerland) was recently introduced as a new method of intraocular pressure measurement, supposedly independent of corneal properties. In this study we analyzed the agreement and correlation of dynamic contour tonometry and Goldmann applanation tonometry (GAT) and investigated the influence of central corneal thickness (CCT) and corneal curvature. We also considered preferential patient groups for both methods. METHODS: In a prospective study of 100 eyes without glaucoma, intraocular pressure was measured using dynamic contour tonometry and Goldmann applanation tonometry, followed by measurements of central corneal thickness and corneal curvature. RESULTS: A clear correlation between dynamic contour tonometry and Goldmann applanation tonometry was found (r = 0.693; P < 0.001). Dynamic contour tonometry generally resulted in higher intraocular pressure measurements (median difference + 1.8 mm Hg, mean difference + 2.34 mm Hg). Unlike dynamic contour tonometry, Goldmann applanation tonometry was remarkably affected by central corneal thickness, but neither method was significantly influenced by corneal curvature. Bland-Altman graphs showed remarkable disagreement between dynamic contour tonometry and Goldmann applanation tonometry, which could be partially explained by the influence of central corneal thickness on Goldmann applanation tonometry. To obtain valid readings, dynamic contour tonometry required a more extensive selection of patients than Goldmann applanation tonometry. CONCLUSIONS: Dynamic contour tonometry seems to be a reliable method for intraocular pressure measurement, which unlike Goldmann applanation tonometry is not influenced by central corneal thickness. In clinical practice, advantages from dynamic contour tonometry can be expected for cooperative patients, outpatients, and patients with sufficient bilateral ocular fixation, whereas Goldmann applanation tonometry measurements are more reliable in case of patients with inadequate cooperation, poor vision, or nystagmus.

Body Weights and Measures↗

PubMed1986

A comparison of the efficacy and toxicity of and intraocular pressure response to viscous solutions in the anterior chamber.

An intraocular-lens abrasion test, vital dye staining, and scanning electron microscopy were used for an in vitro comparison of endothelial protection offered by four viscous solutions of 1% sodium hyaluronate (Healon), 3% sodium hyaluronate (AmVisc), 4% chondroitin sulfate (Viscoat), and 2% methylcellulose. Wide-field specular microscopy with analysis of endothelial cell density and morphologic evaluation, pachymetry, and intraocular pressure measurements were also used to study the toxicity of the viscous solutions in an in vivo cat model with and without anterior chamber washout. All four solutions provided complete endothelial protection from mechanical trauma. Endothelial cell density and morphologic nature were unaffected during the in vivo toxicity study. A mild increase in intraocular inflammation occurred at one and two days after intraocular injection with all four viscous solutions. Intraocular pressure elevations peaked within four hours after instillation of the viscous solutions and were significantly reduced by anterior chamber washout.

Animals↗

PubMed1975

[The effect of repeated adrenaline application on intraocular pressure and pupil in the rabbit (author's transl)].

The effect of single and repeated topical application of adrenaline on the intraocular pressure and pupil in the rabbit eye was studied using a 2% adrenaline borate and a commercial preparation of 2% adrenaline hydrochloride. On the first day, the hydrochloride gave a more pronounced pressure reduction and pupil diladation than the borate. This was found to be due to the benzalkonium chloride in the chloride preparation causing a better permeability of the adrenaline into the eye. From the second to the fifth day of adrenaline treatment a marked pressure decrease was found from the previous application of the day before. The following adrenaline application gave a hypertensive phase of intraocular pressure lasting two or three hours and a subsequent hypotensive phase lasting more than 24 hrs. The pupil diladation on the second and following days of treatment was not essentially different from the first day considering the observation period of two hours. The hypertensive phase could not be influenced by intravenous or intramuscular propranolol, however, the topical application of propranolol inhibited it completely. Some aspects of adrenergic regulation of the intraocular pressure are discussed.

Animals↗

PubMed2002

Intraocular pressure determination in clinically normal red-footed tortoise (Geochelone carbonaria).

Intraocular pressure (IOP) reflects a balance between aqueous humor production and outflow and is often an essential ophthalmic diagnostic procedure in animals. The objective of this study was to estimate IOP in clinically normal red-footed tortoises (Geochelone carbonaria) of various sizes by using applanation tonometry. Intraocular pressures were estimated for 25 captive red-footed tortoises (10 males, 10 females, and 5 animals of unknown sex) by using an applanation tonometer after topical anesthesia. Body length ranged from 5.1 to 54.9 cm, measured from nuchal to anal scutes. Five measurements from each eye were obtained by a single observer in an ambient temperature of approximately 30 degrees C. Observer's reliability was good (intraclass r = 0.75), and IOP did not change over the ordered sequence of five replicate measurements. For individual tortoises the correlation for IOP between the left and right eyes was low (r = 0.20). The paired t-test did not show any statistical effect (P = 0.426) for the difference in IOP between the left and right eyes. Mean IOP determined for 10 confirmed males and 10 confirmed females did not differ between sexes (P = 0.244). The mean IOP of five small tortoises (< 10 cm long) was not significantly different (P = 0.244) from that of 20 large tortoises (> 10 cm long). In red-footed tortoises there does not appear to be any relation between carapace length and IOP.

Analysis of Variance↗

PubMed2005

[Effect of viscoelastic substances on postoperative intraocular pressure in phacoemulsification].

The Influence of the Type of Viscoelastic Substances on the Level of Intraocular Pressure after Phacoemulsification The aim of study was to asses the influence of the type of viscoelastic substances on the level of intraocular pressure (IOP) after cataract surgery and intraocular lens (IOL) implantation. In the study group of 100 patients Viscoat was used at 32 operated eyes, Provisc at 14 eyes and Duovisc in 54 eyes during phacoemulsification and IOL implantation. IOP was measured before surgery, one day after surgery and one week after surgery. Mean IOP level 1. day postoperatively was 24.94 mmHg in the Viscoat group of eyes, 24.65 mmHg in the Provisc group and 21.09 mmHg in the Duovisc group. The type of viscoelastic substance used during the surgery significantly influenced the level of IOP in the first postoperative day. The level of IOP was significantly lower in the Duovisc group comparing to Viscoat and Provisc. The level of IOP did not differ significantly between the Viscoat and Provisc group. One week after surgery the level of IOP was not significantly different between all types of viscoelastic device. Duovisc was the most profitable viscoleastic substance in the point of view of the course of phacoemulsification, IOL implantation and postoperative level of IOP.

Aged↗

PubMed1999

Elevation of human intraocular pressure at night under moderate illumination.

PURPOSE: An endogenous elevation of intraocular pressure (IOP) occurs at night in healthy young adults. The authors studied whether or not this IOP elevation can be detected under moderate illumination. METHODS: Twenty-five healthy volunteers, ages 18 to 25 years, were housed overnight in a sleep laboratory under a strictly controlled light-dark environment. Intraocular pressure was measured in the supine position every 2 hours, using a pneumatonometer. An 8-hour sleep period was assigned to each volunteer according to individual's accustomed sleep cycle. In the early part of this assigned period, sleep was encouraged with room lights off. Researchers performed IOP measurements at two time points with the aid of night vision goggles. In the middle to the late part of the assigned period, lights were turned on twice for a 1-hour interval. The light intensity was the same as before the bedtime. At the ending of each light period, IOP was measured under illumination. RESULTS: Average IOP was significantly higher in the assigned sleep period versus outside the period. The trough of mean IOP occurred just before the bedtime, and then IOP gradually increased and peaked at the end of the 8-hour assigned sleep period. The difference between the trough and peak IOP was 3.5 +/- 0.7 mm Hg (mean +/- SEM, n = 25). Within the assigned sleep period, the average IOP determined under illumination was significantly higher than the average IOP preceding the illumination. CONCLUSIONS: Elevation of IOP occurred during the assigned sleep period with two 1-hour light exposures of moderate intensity. Environmental light at night had no significant effect on the nocturnal IOP elevation in healthy young adults.

Adolescent↗

PubMed1998

Ultrastructural changes and immunocytochemical localization of microtubule-associated protein 1 in guinea pig optic nerves after acute increase in intraocular pressure.

PURPOSE: To investigate ultrastructural changes and localization of microtubule-associated protein 1 (MAP 1) in optic nerves of guinea pigs in conditions of acute increase in intraocular pressure (IOP). METHODS: Intraocular pressure was increased acutely in 40 guinea pig eyes, and 40 eyes were examined in 20 normal control animals. Analytic methods included quick-freezing and deep-etching (QF-DE) and conventional fixation. Microtubule-associated protein 1 immunocytochemistry was performed. RESULTS: In conventional ultrathin sections, an alteration of the axoplasmic ultrastructure was seen only at the level of the lamina cribrosa sclerae. The number of microtubules was significantly decreased in the axoplasm that exhibited accumulations of membranous organelles. Cross-bridged filaments on microtubules were significantly reduced in number when determined by the QF-DE method. The immunostaining of tubulin or MAP 1 was less positive than in other samples with normal IOP, revealed by light microscopic immunocytochemistry. Immunoelectron microscopy demonstrated that MAP 1 was significantly decreased in the axoplasm that showed accumulations of membranous organelles. CONCLUSIONS: The acute alteration of axoplasmic ultrastructures in some parts of the optic nerves at the level of the lamina cribrosa involves a decrease in the amount of MAP 1 and a decrease in the number of axonal cross-bridges on microtubules in a condition of acutely increased IOP, which could be related to microtubule instability and abnormal organelle transport in the axoplasm.

Acute Disease↗

PubMed1985

Ocular instillation of naloxone increases intraocular pressure in morphine-addicted patients: a possible test for detecting misuse of morphine.

The effect of conjunctival instillation of naloxone on intraocular pressure has been examined in morphine-addicted patients as compared to non-addicted healthy volunteers. Morphine-addicted subjects showed a lower basal value of intraocular pressure as compared to the control volunteers. The instillation of naloxone caused a normalization of intraocular pressure to a level similar to that of control volunteers. This test seems to be a useful screening method for detecting morphine addiction.

Adolescent↗

PubMed2004

[Intraocular pressure after cyclophotocoagulation with the diode laser].

BACKGROUND: The reduction of intraocular pressure (IOP) following a single cyclophotocoagulation (CPC) procedure with a diode laser was investigated retrospectively. METHOD: CPC was performed on 150 eyes with a diode laser using standard parameters. The decrease of IOP between the 1st and 3rd day after surgery, after 6 months and after 1 year was investigated for different types of glaucoma and complications were documented. RESULTS: Overall and also in the individual groups the mean reduction of IOP within the first 3 days postoperation was 35%. The main effect, however, occurred within the 1st day after CPC. In the long-term results for 6 months and 1 year, the mean pressure values remained relatively stable but with a high standard deviation. A postoperative inflammatory reaction in the anterior chamber was observed in 15 eyes, 1 eye showed a temporary hypotension and 2 eyes a phthisis. Success of CPC was almost identical in all treatment groups with a 38% decrease of IOP after the 1st year. Additionally IOP was stable at a low level during the 1st year after CPC. After 1 year 42% of all eyes were still successfully treated: 38% of eyes needed further CPC treatment. CONCLUSIONS: CPC is an effective procedure for surgical reduction of intraocular pressure. The initial pressure-reducing effect of CPC was not related to the type of glaucoma. The individual predictability of the effect of CPC, however, is difficult because of the high interindividual differences. The rate of complications is low.

Ciliary Body↗

PubMed1977

Intraocular pressures in children with glaucoma during halothane anesthesia.

Thirty measurements of intraocular pressure (IOP) were performed on 10 children either with congenital or secondary glaucoma, before and after halothane anesthesia. In 7 normal eyes, IOP decreased a mean of 3 mm Hg, while in 23 glaucomatous eyes, mean IOP decreased from 43 to 34 mm Hg. In 5 of the 23 glaucomatous eyes, IOP decreased below 25 mm Hg and in only one patient below 21 mm Hg. Our findings indicate that an abnormally elevated IOP during halothane anesthesia suggests a glaucomatous process. A normal IOP during halothane does not absolutely preclude the absence of glaucoma. Intraocular pressure greater than 21 mm Hg during halothane anesthesia should be viewed with suspicion when coupled with other clinical observations of pathologic significance. Awake, sedated IOP measurements appeared to provide a reliable index of glaucoma in the population studied.

Anesthesia, Inhalation↗

PubMed1985

Acute intraocular pressure response to argon laser iridotomy.

Argon laser iridotomy (ALI) was performed in 50 eyes for prophylactic treatment of anatomically narrow iridocorneal angles and in 50 eyes for therapy of chronic angle-closure glaucoma. Intraocular pressure was increased 6 mmHg or more 1 to 2 hours after ALI in 19 of 50 eyes with anatomical narrow iridocorneal angles and in 23 of 50 eyes with chronic angle-closure glaucoma. Increases greater than 20 mmHg over baseline value occurred in 5 of 50 eyes with narrow iridocorneal angles and in 7 of 50 eyes with chronic angle-closure glaucoma. A clinically significant increase in intraocular pressure (defined as a pressure 30 mmHg or greater and 40% or more increased over the pre-laser value) occurred 1 to 2 hours after ALI in 11 of 50 eyes with narrow iridocorneal angles and in 17 of 50 eyes with chronic angle-closure glaucoma. There was no statistical difference (chi square P greater than 0.3) in the incidence of this complication in the two groups. Additional medical therapy was effective in lowering the acute laser-induced elevation in intraocular pressure. Patient diagnosis, patient demographics, preoperative glaucoma medication and laser treatment parameters did not predict which eyes would develop this complication. Eyes which did not have a clinically significant elevation in intraocular pressure 1 to 2 hours after ALI did not show a later increase at 24 hours.

Female↗