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Expanding the role of the infection control professional in the cost-effective use of antibiotics.

There is a growing demand that health care expenses be contained and that excessive and inappropriate use of antibiotics be eliminated. At the University of California, San Diego Medical Center, strategies aimed at controlling drug usage and subsequently reducing costs have been implemented and found to be effective. Mechanisms designed to achieve such goals without diminishing quality of care involve expanding the role of the infection control professional (ICP) while implementing antibiotic control stratagems such as antimicrobial utilization teams, antibiotic order sheets, audits of use, automatic stop orders, computer-assisted management, drug use reviews, educational efforts, formulary practice, restricted drug policies, and target drug monitoring. The infection control professional, as well as other members of the antimicrobial utilization team, contributes to the promotion of the appropriate use of antibiotics in part by identifying individual cases in which antibiotics might be used inappropriately, such as for the treatment of colonization rather than infection or when appropriate microbiologic testing has not been carried out.

Academic Medical Centers↗

Infection control issues in critical care: an update.

NIs continue to be a frequent and serious complication in the critically ill patient. Although not all NIs can be prevented, two essential components of health care practice that are aimed at protecting both patients and staff have been discussed--isolation techniques and handwashing. We have also discussed the infectious complications of intravascular therapy, one of the most essential and common treatments for the critically ill patient. An effective infection control program for critical care must have certain elements: established standards of infection control practice, continual surveillance and feedback regarding infection rates, adequate physical facilities including personnel to maintain a clean environment, orientation and continuing education for personnel, but most important, a staff with a high level of awareness about the need to prevent NI. This awareness is developed by a leader who communicates his/her concern about the issue of infection control.

Attitude of Health Personnel↗

Evaluation of an antimicrobial-impregnated continuous ambulatory peritoneal dialysis catheter for infection control in rats.

Infection is the most serious complication arising in long-term continuous ambulatory peritoneal dialysis (CAPD), specifically peritonitis and exit-site infection. The initial weeks after implantation is the crucial period during which bacterial colonization of the catheter results in maximal morbidity, with Staphylococcus aureus being the most virulent organism. We developed an antimicrobial-impregnated CAPD catheter by impregnating the cuff and tubing with chlorhexidine, silver sulfadiazine, and triclosan in a polymer matrix. The antimicrobial spectrum and duration were shown by measuring zones of inhibition to various bacteria and fungi over the course of 5 to 10 days. Activity also was assessed subsequent to soaking in trypticase soy broth containing 20% bovine serum over the course of 1, 3, and 7 days. Significant antimicrobial activity was shown against all organisms tested for, with particular efficacy against gram-positive bacteria. Catheters were implanted in rats followed by inoculation of the exit site with S aureus. Seven days postimplantation, 0% of the impregnated catheters were colonized intraperitoneally compared with 100% of the control catheters. Similarly, 12.5% of the impregnated catheters were colonized at the exit site, whereas 100% of the controls were colonized. Histologic analysis showed that this combination and concentration of antimicrobials did not retard healing or cause increased inflammation compared with control catheters after 3, 10, and 24 days postimplantation in noninoculated rats.

Animals↗

Infection control programmed instruction: an alternative to classroom instruction in baccalaureate nursing education.

The purpose of this study was to determine whether self-managed learning in the form of a programmed unit of instruction (PUI) in the basic principles of infection control is an acceptable alternative to a standard lecture format for teaching infection control to nursing students. A sample of 108 subjects was selected from third-year baccalaureate nursing students at two universities. The subjects were randomly assigned to two groups. The experimental group was given the pretest, the PUI (treatment), the post-test, and a Likert scale opinionnaire of the PUI. The control group was pretested and presented the same content in a lecture format, then post-tested. A pretest-post-test control group design was used for data analysis and a one-way analysis of covariance was performed on the post-test means of the groups. Analysis of covariance (ANCOVA) was applied to the post-test means of the groups, with pretest scores and educational setting as covariates. Results indicate that nursing students who complete an infection control PUI score higher on post-tests than those who attend a lecture (p less than .001), regardless of pretest scores and educational setting. Subjects using the PUI also preferred this format and found the content manageable.

Cross Infection↗

A comparison of infection control software for use by hospital epidemiologists in meeting the new JCAHO standards.

To choose a microcomputer software package for our hospital epidemiology division, the two leading commercial software packages for infection control, AICE (ICPA, Inc., Austin, Texas) and NOS0-3 (Epi Systematics, Inc., Ft. Meyers, Florida), were compared for the types of epidemiologic analysis likely to be required to satisfy new Joint Commission on Accreditation of Healthcare Organizations (JCAHO) 1990 Infection Control Standards. The test dataset was a surgical database of 3,235 operations with 292 (9%) wound infections. Though NOSO-3 was more flexible in terms of the amount of data items one could record, it required seven times longer to learn, nine times more disk space to store and two times as long to enter cases than AICE. Six simple infection control reports (i.e., line listings, crosstabulations, stratified rates and graphs) required only seven computing steps and approximately 11 minutes to process with AICE, but 22 steps and over two hours with NOSO-3. All analytic results from AICE agreed with the results obtained with the Statistical Analysis System (SAS, SAS Institute, Inc., Cary, North Carolina), but analyses such as service-specific rates performed with NOSO-3 differed because of a design flaw in the NOSO-3 data structure.

Cross Infection↗

Recommendations for optimizing an infection control practitioner's effectiveness in an ambulatory care setting.

As the trend toward ambulatory care increases, the infection control practitioner's (ICP) role and responsibilities in this setting are continually expanding. Implementation of mandated governmental regulations, such as the Occupational Safety and Health Administration (OSHA) Bloodborne Pathogen Standard, has markedly increased the ICP's workload. Analysis reveals that much of the ICP's time is being spent on clerical tasks that encompass a variety of nonclinical functions. Clerical support would allow the ICP to use his or her time to implement essential components of an infection control program in the most cost-effective manner.

Ambulatory Care Facilities↗

[Ethical issues linked to the professional practice of nurses in a hospital infection control committee].

This qualitative work was developed according to Bardin's method of content analysis. It aimed at finding out the perceptions of nurses that are members of a Hospital Infection Control Commission about ethical issues that are inherent to their professional practice as well as understanding the clinical nurses opinion regarding the professional practice of the nurses that are members of the Hospital Infection Control Commission, considering the ethical aspects. In order to achieve an ethical, efficient and effective professional practice, there is a need for governmental changes and professional recognition through autonomy, respect and exclusivity in the Service of Hospital Infection Control, as well as improvements regarding information, the care provided to the patient and professional secret. The predominance of bureaucratic activities and team work were mentioned by the clinical nurses as differentiating factors of the activities performed by nurses that are members of the Commission.

Adult↗

Experiential teaching: infection control for certified nurse's aides.

This article has described a self-care model of teaching infection control to CNAs in nursing homes. How the CNAs know and detect illness in themselves becomes the basis for learning about the presentation of acute illness in nursing home residents. This model begins with a discussion of the different meanings of feelings, then the awareness of changes during acute illness, and the factors affecting nursing home residents that change their perceptions of acute illness. With this knowledge, CNAs empathically detect the changes of common acute infectious illnesses in elderly nursing home residents to accomplish infection control. This model uses self-care as a motivational tool, blending greater knowledge with self-confidence.

Aged↗

Guideline for Hand Hygiene in Health-Care Settings. Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force. Society for Healthcare Epidemiology of America/Association for Professionals in Infection Control/Infectious Diseases Society of America.

The Guideline for Hand Hygiene in Health-Care Settings provides health-care workers (HCWs) with a review of data regarding handwashing and hand antisepsis in health-care settings. In addition, it provides specific recommendations to promote improved hand-hygiene practices and reduce transmission ofpathogenic microorganisms to patients and personnel in health-care settings. This report reviews studies published since the 1985 CDC guideline (Garner JS, Favero MS. CDC guideline for handwashing and hospital environmental control, 1985. Infect Control 1986;7:231-43) and the 1995 APIC guideline (Larson EL, APIC Guidelines Committee. APIC guideline for handwashing and hand antisepsis in health care settings. Am J Infect Control 1995;23:251-69) were issued and provides an in-depth review of hand-hygiene practices of HCWs, levels of adherence of personnel to recommended handwashing practices, and factors adversely affecting adherence. New studies of the in vivo efficacy of alcohol-based hand rubs and the low incidence of dermatitis associated with their use are reviewed. Recent studies demonstrating the value of multidisciplinary hand-hygiene promotion programs and the potential role of alcohol-based hand rubs in improving hand-hygiene practices are summarized. Recommendations concerning related issues (e.g., the use of surgical hand antiseptics, hand lotions or creams, and wearing of artificial fingernails) are also included.

Alcohols↗

A clinical data repository enhances hospital infection control.

We describe the benefits of a relational database of hospital clinical data (Clinical Data Repository; CDR) for an infection control program. The CDR consists of > 40 Sybase tables, and is directly accessible for ad hoc queries by members of the infection control unit who have been granted privileges for access by the Information Systems Department. The data elements and functional requirements most useful for surveillance of nosocomial infections, antibiotic use, and resistant organisms are characterized. Specific applications of the CDR are presented, including the use of automated definitions of nosocomial infection, graphical monitoring of resistant organisms with quality control limits, and prospective detection of inappropriate antibiotic use. Hospital surveillance and quality improvement activities are significantly benefited by the availability of a querable set of tables containing diverse clinical data.

Bacteremia↗

Infection control and bone marrow transplantation.

BACKGROUND: Bone marrow transplantation for the treatment of malignancies is on the increase. Unfortunately, there are no well-validated infection control guidelines for this highly susceptible population. METHODS: Literature was reviewed concerning infection risks and interventions to decrease risks for bone marrow transplant recipients. RESULTS: Definitive information was generally lacking. However, basic "common sense" infection control recommendations for bone marrow transplantation were made in the following areas: air ventilation systems, design issues, environmental services, patient care issues, barrier precautions, nosocomial surveillance, and discharge planning. Recommendations must be tailored to each facility or setting. CONCLUSION: We conclude that validation of many of these recommendations is necessary to provide optimum care for bone marrow transplant recipients.

Adult↗

Infection control measures for operative procedures in severe acute respiratory syndrome-related patients.

BACKGROUND: Singapore reported its first case of Severe Acute Respiratory Syndrome (SARS) in early March 2003 and was placed on the World Health Organization's list of SARS-affected countries on March 15, 2003. During the outbreak, Tan Tock Seng Hospital was designated as the national SARS hospital in Singapore to manage all known SARS patients. Stringent infection control measures were introduced to protect healthcare workers and control intrahospital transmission of SARS. Work-flow processes for surgery were extensively modified. METHODS: The authors describe the development of infection control measures, the conduct of surgical procedures, and the management of high-risk procedures during the SARS outbreak. RESULTS: Forty-one operative procedures, including 15 high-risk procedures (surgical tracheostomy), were performed on SARS-related patients. One hundred twenty-four healthcare workers had direct contact with SARS patients during these procedures. There was no transmission of SARS within the operating room complex. CONCLUSIONS: Staff personal protection, patient risk categorization, and reorganization of operating room workflow processes formed the key elements for the containment of SARS transmission. Lessons learned during this outbreak will help in the planning and execution of infection control measures, should another outbreak occur.

Cross Infection↗

Regulation of clinical microbiology and infection control--is the gain worth the pain?

In the USA, decreasing money for health has led medical professionals and the public to wonder whether cost containment is hurting patient care. In response to this, several regulatory bodies have instituted extensive review procedures under the label of 'quality assurance'. Anxiety in healthcare workers about the risk of HIV infection and chemical exposures has led to a profusion of rational and less-rational proposals, guidelines, and standards for employee protection. Concern about the validity of laboratory diagnostic tests has triggered laws, codes and rubrics about procedures and proficiency testing. A major premise of government now seems to be that 'an unregulated industry is an unsafe industry'. As a result, US hospitals find themselves reviewed, surveyed, examined, regulated and codified to a degree never before experienced. This quantity of review has been accompanied by problems of review quality, in the form of conflicting, vague and wasteful standards and regulations. What is at issue is finding the most efficient ways to address these problems. We must campaign for close cooperation between regulatory groups, clear distinction between sociopolitical and scientific justification for regulation, and cost-benefit analysis of the regulations and their impact. Laboratory and hospital infection control personnel are important to this effort because the epidemiological skills required for these tasks are the same abilities used to make clinical microbiology and hospital infection control effective and efficient. Similar problems and solutions may exist in other countries as well. The issue is particularly pertinent to the discussion of standards for hospital infection control in the European countries now preparing for economic unification.

Communicable Disease Control↗

Effect of delayed infection control measures on a hospital outbreak of methicillin-resistant Staphylococcus aureus.

All patients positive for methicillin-resistant Staphylococcus aureus (MRSA) at the University Hospitals of Geneva, Switzerland, between 1989 and 1997 (N = 1771) were included in a cohort study to evaluate the consequences of delayed containment of a hospital-wide outbreak occurring during a 4-year absence of MRSA control measures. The effects of efforts to control both the MRSA reservoir and the number of bacteraemic patients were assessed. Intensive infection control measures were initiated in 1993 and included patient screening, on-site surveillance, contact isolation, a computerized alert system, and hospital-wide promotion of hand hygiene. An increase in the rate of new MRSA-infected or -colonized patients was observed between 1989 and 1994 (from 0.05 to 0.60 cases per 100 admissions), which subsequently decreased to 0.24 cases in 1997 (P<0.001). However, the proportion of laboratory-documented methicillin-resistant isolates among all S. aureus showed little variation in the years from 1993 onwards (range, 19-24%), reflecting the result of an increase in the number of screening cultures. The annual number of patients with MRSA bacteraemia strongly correlated with the hospital-wide prevalence of MRSA patients (R(2)= 0.60; P = 0.01) and the rate of new MRSA patients (R(2)= 0.97; P<0.001). Consequently, the attack rate of nosocomial MRSA bacteraemia served as an excellent marker for the MRSA patient reservoir. In conclusion, despite delayed implementation, infection control measures had a substantial impact on both the reservoir of MRSA patients and the attack rate of MRSA bacteraemia.

Cohort Studies↗

Ophthalmology operating room standards and infection control concerns.

Postoperative infection is a rare complication of intraocular surgery. Although the incidence is low, the morbidity is high in terms of long-term sequelae. Because some ophthalmologists have requested separate operating rooms to reduce the risk of exogenous sources of infection, ophthalmology training program directors were surveyed to determine national standards of practice. Among the 100 centers responding, most were university affiliated (73%), had more than 500-bed hospitals (67%), and had fewer than 50 practicing ophthalmologists (92%). A single operating room was used in 50 centers and only 33 did not permit nonophthalmology cases in the ophthalmology operating rooms. Centers with a greater ophthalmology volume did not differ from low-volume centers in the scheduling of ophthalmology and nonopthalmology clean or infected cases. Program directors from larger centers, however, were more frequently of the opinion that a separate ophthalmology operating room was needed: 86.2% vs. 63.5% (p = 0.04).

Cross Infection↗