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At least 739 records · Page 41Linked to original sources
PubMed1989

Antimicrobic susceptibility testing. A personal perspective.

The development of antimicrobic susceptibility testing is outlined with particular reference to standardization of procedures and organizational developments that have led to substantially improved performance. Special problems continue to be posed by increased proportions of opportunistic pathogens and newly recognized mechanisms of resistance, and these require updating. The role of automated procedures and technical problems in MBC and serum bactericidal testing are considered.

Automation↗
PubMed1983

[Differentiation between micrococci and staphylococci by the study of the sensitivity to nitrofurantoin [N(5 nitro - 2-furfurylidene - 1-amino - hydantoin)]].

The authors have studied the sensitivity to the nitrofurantoïne of 3 328 strains of staphylococci and of 232 strains of micrococci. They have noticed that 100% staphylococci strains are sensitive and that 100% micrococci strains are resistant. They propose this sensitivity test as a simple means of differentiation between micrococci and staphylococci.

Bacteriological Techniques↗
PubMed1980

[Bacteriological study on cefadroxil in vitro. Correlation between diameter of inhibition zone and inhibitory concentration (author's transl)].

There are only slight differences between the geometrical means of minimum inhibitory concentrations of (6R,7R)-7-[(R)-2-amino-2-2(p-hydroxyphenyl)-acetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (cefadroxil, Bidocef) and cefalexin against gram-positive and gram-negative bacteria freshly isolated from clinical material. Enterococci are more susceptible to cefadroxil. Considering the different break point, cefadroxil is on the whole more effective than cefalexin, in particular so against Proteus mirabilis, Enterobacter, Citrobacter and Escherichia coli. With the aid of the described regression analysis a meaningful interpretation of the results of the cefadroxil agar diffusion test is possible.

Bacteria↗
PubMed2003

Differentiation of Staphylococcus sciuri strains isolated from free-living rodents and insectivores.

Twenty-nine Staphylococcus sciuri strains isolated from free-living insectivores and rodents were comparatively analysed for their biochemical capacities and their SmaI macrorestriction patterns. The 29 S. sciuri isolates represented 21 different biotypes and 22 different SmaI macrorestriction types. This observation confirmed that S. sciuri isolates obtained from insectivores and rodents living in natural environments constituted a heterogeneous population. Cluster analysis revealed that the macrorestriction patterns and the biochemical profiles matched in some cases. However, S. sciuri isolates that exhibited the same or closely related biochemical profiles were also found to be associated with different macrorestriction patterns. Analysis of the 29 S. sciuri isolates for their plasmid content and their sensitivity to antimicrobial agents showed that most of the isolates were plasmid-free and susceptible to all antimicrobial agents tested.

Animals↗
PubMed1987

Determination of methicillin-resistance in Staphylococcus aureus by agar dilution and disc diffusion methods.

Four-hundred and seventy-six isolates of Staphylococcus aureus from patients in Hong Kong were tested for methicillin-resistance by agar dilution and disc diffusion methods, using heavy inocula. With Mueller-Hinton agar incubated at 30 degrees C for 24 h, 216 (MRSA) isolates were resistant to 8 mg/l of methicillin and grew up to the edge of a 10 micrograms methicillin disc, and 260 strains were susceptible to greater than or equal to 4 mg/l methicillin and produced inhibition zones of at least 20 mm diameter. Incubation for 48 h, the addition of sodium chloride, or the use of a 5 micrograms disc had little effect on these results, but a significant number of MRSA strains produced inhibition zones when disc diffusion tests were incubated at 35 degrees C, and many sensitive strains showed scanty growth on salt-containing agar at high methicillin concentrations in agar dilution tests. Iso-Sensitest agar did not appear to support the growth of the minority resistant populations of MRSA unless supplemented with menadione and thiamine, and even with supplemented Iso-Sensitest medium a few presumptively resistant strains appeared methicillin-sensitive in both disc diffusion and agar dilution tests.

Diffusion↗
PubMed1990

Laboratory identification and sensitivity testing of yeast isolates.

Methods used for identification and sensitivity testing of yeasts are presented. Identification depends on both morphologic features and biochemical characteristics. The germ tube test is a simple test for the identification of the commonest yeast pathogen, Candida albicans. Species not identified by this method can be identified by means of several other tests, the most important being the carbohydrate assimilation test. Several kits are commercially available and most appear to be satisfactory. Antifungal susceptibility tests are not standardized, and results are often subject to considerable variation. Until improved methods are developed, it might be advisable that smaller laboratories only do a preliminary screening test for flucytosine susceptibility and, if indicated, also for amphotericin B susceptibility. Important isolates should be sent to laboratories with a special interest in antifungal susceptibility testing for more extensive testing.

Antifungal Agents↗
PubMed1997

Microbiological diagnostics in periodontics.

Microbiological tests in periodontics can be of great help in determining the characteristics of a pathogenic infection, prescribing the optimal antibiotic regimen, and monitoring the effectiveness of treatment. However, they are not without potential pitfalls. Current microbiological tests vary considerably in sensitivity and specificity. A false-positive test result may lead to unnecessary therapy and patient distress. A false-negative test result may prompt the withholding of necessary therapy and the subsequent progression of disease. Also, diagnostic tests can be relatively expensive and uncomfortable for patients. This article attempts to determine the usefulness of various microbiological testing systems for the management of periodontitis patients.

Adult↗
PubMed1978

[Routine test for sensitivity (author's transl)].

The agar diffusion test is a simple but in most instances reliable method for the determination of the sensitivity of pathogenic bacteria, if it is performed under controlled standardised conditions and evaluated by defined criteria. The accuracy of the test results can be achieved by a permanent control of the test with control strains during routine testing.

Anti-Bacterial Agents↗