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PubMedDate not supplied

Effects of illicit drug use on adherence to prescribed antiretroviral medication.

This exploratory analysis compared adherence to antiretroviral medication on days that illicit drugs were used and on matched abstinence days in twelve subjects who used MEMS caps during participation in a clinical trial. Adherence on drug use days was lower in seven subjects, higher in one, and the same in four. Three subjects maintained 100% adherence despite illicit substance use on studied days. Thus, in a subset of patients, the actions involved in procuring drugs and the acute effects of using them contribute to non-adherence on those specific drug use days, associated with substance abuse. (Am J Addict 2003;12:455-458)

Adult↗
PubMedDate not supplied

Is there a general tendency to become addicted?

The tendency to become addicted across a number of different substances or activities was determined for a sample of 573 subjects, including college students and their parents. Four components of addiction were defined: craving, tolerance, withdrawal and lack of control. Subjects rated the extent to which each of these components characterized their relationships to each of ten substance/activities: coffee, tea, cola beverages, favorite alcoholic beverage, chocolate, nonchocolate sweets, hot chili pepper on food, cigarettes, gambling and video games. An "addiction score" was computed for each subject and each substance/activity, by summing the scores on the four components. Correlations in addiction scores for almost all activities were positive, but low (between 0 and .30), with the exception of chocolate and nonchocolate sweets, where the correlation was higher. The results suggest, at best, a weak tendency to become addicted, across a wide range of substances or activities. Other explanations for the low positive correlations are available, besides the notion of a general tendency to become addicted. There were a few significant mother-father correlations in various addiction scores, but none between mid-parent and child values. Three of the four components of addiction (craving, lack of control and withdrawal), were highly correlated. We conclude that there is little basis for the assumption of a general tendency to become addicted, a conclusion which casts doubt on the derivative notion of an addictive personality.

Adolescent↗
PubMed2000

[Treatment of cocaine dependence. Intoxication, withdrawal and prevention of relapse].

The aim of this review article is to evaluate the treatment of cocaine-withdrawal, cocaine-intoxication and long-term relapse prevention of cocaine-addicts. Some 25% of police recognized first time drug users in Germany consume cocaine. However, there is an increasing number of cocaine-abusers and -addicts in the USA. The withdrawal of cocaine can be divided into three phases dominated mainly by psychiatric symptoms. Life-threatening condition can occur in cocaine-intoxication mainly in combination with other drug-use. A high risk of relapse is seen in follow-up trials of cocaine-addicts. Intensive craving, high cocaine- and substance-abuse is reported regularly in cocaine-addicts after detoxification therapy. Recommendations in the treatment of cocaine-intoxication, withdrawal and long-term relapse prevention are made. The use of antidepressives, anticonvulsants, dopaminergic and serotonergic medications as well as behavioural, psychoanalytical and combined therapies and their efficacy in clinical and trails is evaluated. A short review of new experimental therapies in the treatment of cocaine-dependence is shown.

Cocaine↗
PubMed1989

[Neurologic complications of drug addiction. General aspects. Complications caused by cannabis, designer drugs and volatile substances].

When a patient presents a neurological disorder, it is important to consider drugs is a possible cause. The risk to suffer neurological complications by drugs is unknown. It is difficult to calculate the number of drug addicts or the number of occasional drug users. It is important take into account that some patients are using more than one drug. The acute use of cannabis induces important changes in cognition and psychomotor performance. No signs of neurotoxicity were found in chronic marihuana users. Some "designer drugs" can induce neurotoxicity. MDMA, that have hallucinogenic activity, is a neurotoxin in animals. MPTP kill dopaminergic neurons in the substantia nigra, inducing Parkinson's disease. Volatile substances containing toluene or n-hexane are usually abused by young people. They can produce neurological damage when are used chronically (p. ex. cerebral atrophy or peripheral neuropathies).

Cannabis↗
PubMed2000

The Ohio Substance Abuse Monitoring Network: constructing and operating a statewide epidemiologic intelligence system.

Working with the Ohio Department of Alcohol and Drug Addiction Services (ODADAS) and researchers at the University of Akron, Wright State University's Center for Interventions, Treatment, and Addictions Research developed the Ohio Substance Abuse Monitoring (OSAM) Network to provide a statewide summary of substance abuse trends. Ten key informants across the state collect qualitative and statistical data on substance abuse trends in their regions and prepare biannual reports. The OSAM network has a rapid response capability through which key informants can investigate special issues related to substance abuse identified by ODADAS and provide policymakers with timely, statewide reports. Within 12 months after operations began, the key informants produced reports on drug abuse trends and rapid response issues for the state. These reports prepared policymakers to respond more effectively to prevention and substance abuse treatment needs.

Costs and Cost Analysis↗
PubMed1995

Anxiety and addiction: a clinical perspective on comorbidity.

Substance use disorders and the anxiety disorders, the two most prevalent mental disorders in the United States, are often comorbid, undiagnosed, and poorly treated. Confusion and controversy over comorbidity can complicate the treatment of both disorders. The author reviews the connections between addiction and anxiety and offers four practical guidelines for clinicians dealing with this comorbidity.

Anxiety Disorders↗
PubMedDate not supplied

Outcomes for children exposed to drugs in utero.

Substance abuse among pregnant women remains a national health issue. The incidence of infants born addicted to licit and illicit substances is increasing. The long-term outcomes have not been consistently documented. These appear to include mild to severe developmental and cognitive problems, depending upon the substance used. Central nervous system problems, behavioral dysfunction, and safety issues are major parental concerns for these children as they grow. Interventions must be aimed at thorough assessments, including an accurate maternal history, use of supports for positive neurodevelopment, parent education about infant/child cues, and encouragement of educational environments that are highly structured and safe. Consistent, long-term follow-up is essential to optimize long-term outcomes.

Child Abuse↗
PubMed1954

Barbiturism.

Explore the source record for details and available documents.

Barbiturates↗
PubMed1993

Overview of substance abuse: implications for the primary care nurse practitioner.

NPs in primary care can expect a significant percent of their patient population to have a substance abuse disorder. This article provides the practitioner with foundational information on the epidemiology and neurophysiology of substance abuse, models and theories of addiction, and the physical and psychological effects of commonly abused substances. The commonly abused legal substances, nicotine and alcohol, are highlighted.

Humans↗
PubMedDate not supplied

Economic modelling of the gateway effect.

Although a significant number of empirical studies provide evidence of sequencing in drug use, economic theory remains focused on addiction to a single substance. This paper presents a general model of substance use that allows for the possibility of multi-commodity habit formation and can be used to analyse the intertemporal relationship between the consumption of legal and illicit drugs, or the gateway effect. A simple two-drug model is analysed and conditions for the existence of multi-commodity habit formation are examined. It is found in the case of multi-commodity habit formation that the marginal utility of initiating a new drug is higher when there is prior consumption of the other drug. Further, it is found that the individual will initiate drug consumption with that drug that has the lowest marginal cost. The particular sequencing of drug use that is observed in empirical data is explained by differences in the marginal cost of consuming legal and illegal drugs.

Alcoholism↗