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At least 739 records · Page 41Linked to original sources
PubMed1985

PUVA combination therapy.

Various adjunctive treatments are now frequently used in combination with PUVA therapy with the aims of limiting adverse effects, improving efficacy and decreasing the cost of treatment. In the management of psoriasis, PUVA plus retinoids, PUVA plus methotrexate and PUVA plus UVB phototherapy are the most frequently used combinations. PUVA plus topical corticosteroids and PUVA plus anthralin are also efficacious but adverse effects and poor acceptance by patients are limiting factors. Combinations of PUVA plus nitrogen mustard and ionizing radiation are used in mycosis fungoides to treat tumors and residual disease in secluded sites. In the management of photodermatoses with PUVA therapy, prednisone is often required to prevent exacerbation of disease. A combination of prednisone and PUVA therapy can also be useful in lichen planus and atopic eczema. The selection of a suitable combination treatment, will depend upon the preferences of the clinician, the disease being treated, and the characteristics of the patient.

Adrenal Cortex Hormones↗
PubMed1984

[Side effects and risks of phototherapy].

Interference factors of UV-therapy are among others the absolutely unknown biological activities of visible and ultra red wavelengths, which represent the main part of the energy emitted from all UV-sources. They produce a rise of the skin surface temperature up to 42-44 centigrades immediately followed by a reticulate erythema as well as a proliferative response of basal cells, which goes synchronously with that after SUP or UVA application but does not result in hyperproliferation. Acute side effects are direct toxic activities of UV-light with sunburn, up to severe bullous reaction, but without scarring; exacerbation of UV-sensitive dermatoses, internal diseases, and modulations of the immune system.

Collagen↗
PubMed1994

[Use of different methods of quantum hemotherapy in the treatment of suppurative wounds in middle-aged and aged patients].

The experience with the use of the different methods of quantum hemotherapy in the treatment of elderly and senile patients with purulent-inflammatory diseases of the soft tissues has been summarized. Comparative characteristic of their effectiveness is presented. The authors consider the most expedient the use of intravascular quantum hemotherapy and combined methods.

Aged↗
PubMed1976

[The treatment of psoriasis].

The therapeutic possibilities for psoriasis are multiple; they are based on experience and on empiricism and are harmless for the patient, or on the known pharmacodynamic action which limit their use. It should be remembered that psoriasis is not incurable, since it can be treated. But the definitive curative treatment will be discovered only when the cause of the disease is discovered.

Administration, Oral↗
PubMed1998

[The treatment of wounds of the anal canal and perineum].

Analysis of processes of wound healing in 215 patients after operations for hemorrhoids, anal fissures and rectal fistulas was carried out. Clinico-cytologic control of healing of postoperation wound has shown that ultra-violet irradiation of wound surface is most effective at early stages of wound healing due to its pronounced bactericidal and antiinflammatory action. Low frequency laser irradiation intensifies tissue reparative and hastens healing of wounds. The proposed method for treatment of wounds by successive use of ultra-violet and laser irradiation of wound surface combined with conventional ointment medications, improves the results of treatment and decreases the rate of purulent complications 2 times, promotes rapid healing of wounds.

Anal Canal↗
PubMed1999

The time-course of psoralen ultraviolet A (PUVA) erythema.

The time-course for the development of ultraviolet A-induced erythema in psoralen-sensitized skin differs from that caused by ultraviolet B or ultraviolet A but objective data are not available. During psoralen ultraviolet A therapy, the minimal phototoxic dose is determined 72 h after exposure, when psoralen ultraviolet A erythema is assumed to be maximal. This measurement is of fundamental importance in optimizing the therapeutic regimen. We examined a detailed time-course for development of psoralen ultraviolet A erythema in 16 subjects. The erythemal responses to ultraviolet B, ultraviolet A and psoralen ultraviolet A were assessed visually and using a reflectance device. Ultraviolet B erythema was maximal 24 h after exposure compared with subsequent time-points. Psoralen ultraviolet A erythema was evident at 24 h, with reduction in the median ultraviolet A minimal erythema dose from 14 to 5 J per cm2 in the presence of psoralen (p < 0.01; n = 9). Peak psoralen ultraviolet A erythema, assessed by minimal phototoxic dose, did not occur until 96 h or later in 75% of subjects. Using individual dose- response curves, we determined that only 67% of mean maximum psoralen ultraviolet A erythemal intensity had developed by 72 h. Furthermore, at the time of maximal erythema, the slope of the psoralen ultraviolet A dose-response curve was approximately 2-fold shallower than that for ultraviolet B-induced erythema. If assessment of psoralen ultraviolet A erythemal sensitivity had been made at 96 h instead of the conventional 72 h time-point, peak erythemal responses would not have been missed in any of the subjects. Based on these findings, it seems appropriate to consider whether psoralen ultraviolet A minimal phototoxic dose measurements should be performed 96 h after exposure.

Adult↗
PubMed1986

Treatment of psoriasis. Results achieved by the Johannesburg Hospital Psoriasis Clinic.

Eighty patients with severe and widespread psoriasis who had not responded to treatment at the Dermatology Outpatient Department were referred for specialized therapy to the Johannesburg Hospital Psoriasis Clinic. Here treatment consisted of phototherapy (topical coal tar or dithranol plus ultraviolet light (UVL], psoralen and ultraviolet A (PUVA) therapy or chemotherapy with methotrexate or etretinate (Tigason; Roche). The best results were obtained with etretinate, either given alone or together with UVL (midrange sunbeam spectrum) or PUVA. Most patients required the use of two or more treatment regimens for successful control.

Adult↗