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[The VCG in ventricular septal defect in the first two years of life. Qualitative and quantitative analyses (author's transl)].

A group of 37 patients, less than 2 years old, with a ventricular septal defect of variable degree, and a left to right shunt, were studied by vectorcardiography. The duration, the direction and the aspect of the QRS loop on the three orthogonal planes, the voltage of the 0.01; 0.02; 0.04 vectors, the right and the left maximum spatial vectors and their projection on the H and F planes were analyzed and correlated to the right ventricular systolic pressure and Qp/Qs. A clockwise or an eight-type loop on the frontal plane, regardless of RVSP, was observed; on the H plane the loop is, usually, counterclockwise when the pressure is low or medium, and can be of the eight-type but never clockwise when the pressure is systemic. Very interestingly, the quantitative analysis showed a consistent increase of the LMSV. A progressive relationship between the spatial vectors and the right ventricular pressure was noted. The diagnosis of combined ventricular hypertrophy depend upon the following findings: the majority of cases showed a large, counterclockwise and anterior QRS loop on the H with the maximum vector to the left and anteriorly; in all cases the 0.01; 0.02; 0.04 vectors were enlarged, thus warranting the diagnosis of combined ventricular hypertrophy in the first few months of life. 4 cases with low RVSP presented increased initial forces to the right and anteriorly directed, while the major portion of the loop was in the left posterior quadrant on the H plane, with a counterclockwise direction. In our view, the differential diagnosis between this type of aspect and that of diastolic overload of the left ventricle can rest only on the increased voltage of the 0,02 vector which means both systolic and diastolic overload of the right ventricle when accompanied by an increased 0.01 vector which indicates volume overload of left ventricle. Likewise only a quantitative analysis can help in differentiating a combined ventricular hypertrophy from a normal tracing in children under 6 months who show an eight-type loop on the H plane with initial and medium vectors directed anteriorly to the left and counterclockwise, and terminal vectors to the right, posteriorly and clockwise, or in those cases with an anterior clockwise loop on the H plane. Moreover, in the first month of life, the VCG of large VSD with increased pulmonary flux and pressure, can be differentiated from the normal by the QRS loop on the H plane which is clockwise, with initial vectors directed to the left and anteriorly with increased LMSV.

Age Factors↗

[Body surface isopotential mapping system by colored spatial mapping electrocardiography].

We developed a new body surface isopotential mapping system using a colored spatial mapping electrocardiographic technique based on Frank's vectorcardiography to be used with CERX CQ-3011 and NEC PC-100 computers. We assessed its usefulness in comparison with the conventional body surface mapping technique in 12 patients with old myocardial infarction (6 with anterior and 6 with inferior infarction), and in 10 healthy subjects. All distributions of positive and negative zones presented on body surface isopotential maps were obtained with this new technique, which corresponded well with the distribution of zones on conventional body surface isopotential maps. Although the maximum and minimum positions of the 2 maps did not coincide with one another, this new map aided in diagnosing anterior and inferior infarction from the minimum position determined 20 msec after the onset of QRS. This new mapping system allows a clear spatial representation of vectorcardiograms and requires less complicated procedure compared with the conventional body surface mapping technique. Thus, this body surface isopotential mapping system should be clinically useful.

Adult↗

[Indeterminate form of Chagas' disease. A polymorphic disease].

PURPOSE: To evaluate the association between the indeterminate form of Chagas' disease and abnormalities in non-invasive cardiovascular propedeutics. PATIENTS AND METHODS: Twenty-two patients in the indeterminate form of Chagas' disease, 17 female, with ages between 25 and 50 years were submitted to studies of: vectorcardiography, echocardiography, stress test, dynamic electrocardiography and scintigraphic studies (scintigraphic ventriculography and cardiac mapping with pyrophosphate of technetium), in a period of two months after first consultation. RESULTS: The analysis shows the percentual of altered exams: vectorcardiogram--68.2% (conduction disturbance--22.7%); echocardiogram--15.8% (apical hypokinesia); cardiac mapping 61.8%; scintigraphic ventriculography--68.2%; stress test--72.2% (reduced delta PS--50%, ventricular arrhythmia--50%); and dynamic electrocardiographic--50% (ventricular arrhythmias). We could observe also that the great majority of the patients has more than three exams altered (63.6%). The study of relation between methods, shows only association between reduced delta PS and ventricular arrhythmia, with concordant results in 72.7%. CONCLUSION: Indeterminate form of Chagas' disease appears to be a really chronic form, may be of attenuate aggressive potential, with indeterminate evolution and with polymorphic clinical exteriorization seeing only through invasive and non invasive propedeutic techniques.

Adult↗

[The characteristics of the vectorcardiographic diagnosis of chronic cor pulmonale in middle and old age].

Spatial assay of the vectorcardiograms (VCG) was performed in 85 elderly and senile patients with chronic cor-pulmonale (CCP) and in 64 patients aged 30-49 years. In accordance with the VCG, CCP was diagnosed in 90.7% of patients aged 60-79 years and in 91.3% of patients aged 30-49 years in a stage of compensation as well as in all the cases with decompensation superaddition. Spatial vectorcardiography makes it possible not only to diagnose right ventricular hypertrophy in CCP patients but also to examine its formation over time, commencing from the early disease stages. Biventricular hypertrophy was one of the most characteristic features of cor pulmonale on ageing. A complex of the most informative VCG criteria for CCL are suggested for patients of different age groups.

Adult↗

[Significance of echo- and vectorcardiographic studies of the heart atrium in the assessment of intracardiac hemodynamics and myocardial contractility].

Seventy three patients with coronary heart disease (CHD) complicated by paroxysmal atrial fibrillation (PAF) were examined. Vectorcardiography developed by I. A. Akulinichev and M-mode echocardiography were used to assess the status of left atrial and ventricular myocardia. An interrelationship was examined between the electrophysiological and echocardiographic parameters of myocardial performance, depending on the stage of circulatory insufficiency (CI). The patients with PAF-complicated CHD, unlike those with CHD alone, showed more severe myocardial conduction abnormalities despite the stage of CI. There were signs of compensatory left ventricular overload in the absence of clinical signs of CI. Comparison of ultrasound examination findings with high performance atrial vectorcardiographic ones increases the possibility of accurately assessing the cardiac performance by using noninvasive tools of examinations.

Adult↗

[Vectorcardiographic diagnosis of the myocardial inactivatable zone].

Clinical importance of the vectorcardiographic exploration (distant and spatial) of the myocardial electrical phenomenon is emphasized. This technique constitutes a useful integration of electrocardiographic exploration (near and analytical). The more characteristic morphological and chronological changes due to an inactivatable area are discussed in the light of ventricular myocardial depolarization. Some typical vectorcardiographic features corresponding to the presence of a myocardial inactivatable zone are presented. The utility of the complementary elements which vectorcardiography can bring to electrocardiography is emphasized. Both of these procedures integrate a rational exploration of electrical activity of the myocardium, the solid base of prognostic and therapeutic decisions in cases of myocardial infarction.

Aged↗

[Regression of heart hypertrophy. Criteria of regression from the viewpoint of the clinician].

Regression of ventricular hypertrophy has been studied in cases of valvular disease after valve replacement, as well as in hypertension under drug treatment. All studies have focussed on the left ventricle. The right heart chamber has not been quantitatively assessed. Regression has been found in both conditions in the range of 15-40% of initial left ventricular muscle mass. In hypertrophic cardiomyopathy consistent results have not been obtained. The ECG, correlating with muscle mass only loosely, is but a semiquantitative, albeit reliable indicator of regression. Vectorcardiography seems to be useful and deserves further study and application. Echocardiography has been validated for both TM- and 3D-mode and allows quantitative estimation of LV-mass during regression. Further improvement can be achieved through the subcostal approach. Left ventriculography remains standard of comparison, but can be considered valid only if angulated biplane technique is used. Repeated application of this technique is limited, unless digital subtraction angiography is used. This technique, however, has not been applied for serial studies of LV-mass during the process of regression. Computed tomography and nuclear magnetic resonance have been used for estimation of muscle mass. The capability of NMR seems particularly high. First results are presented and show excellent quantitation of LV-mass.

Cardiomegaly↗

[Cartogram of 35 ECG leads in hypertrophy of the right ventricle of the heart].

Automatedly-reproduced cartograms of 35 electrocardiographic leads in 27 cases of isolated right-ventricular hypertrophy (RVH) were analysed in relation to the latter's roentgenocardiometric markedness, and the obtained results were substantiated in terms of spacial vectorcardiography. A direct correlation was established between cartographic and roentgenocardiometric data in cases of moderate RVH that was absent in marked RVH. The correlation between cartographic and vectorcardiographic parameters was, on the contrary, only slightly expressed in moderate RVH and high in marked RVH cases. These results can be attributed to specific anatomical structure of the hypertrophic myocardium at different stages of RVH formation, with either the outflow-pathway hypertrophy proper prevailing at early stages of hypertrophic development, or the right-ventricular free wall hypertrophy prevailing at later stages which result in irregular thickening of individual compartments and distortion of cavity size characteristics and geometrical properties of the right ventricle proper, as well as the displacement of the center of gravity and heart rotation round its own axes.

Adolescent↗

Detection, prediction, and significance of perioperative myocardial infarction following aorta-coronary bypass.

One hundred consecutive patients undergoing aorta-coronary bypass grafting (ACBG) alone, without ventricular venting, were prospectively studied to determine the incidence and consequence of perioperative myocardial infarction (PMI) and the clinical variables that were predictive of PMI. Incidence was determined by serial electrocardiography (ECG) 100 patients; serum CK, GOT, and LDH (100 patients). CK isoenzymes (qualitative 100 patients, quantitated 50 patients); vectorcardiography (VCG) (78 patients); and 99mtechnetium pyrophosphate scintigraphy (TcPyp) (52 patients). The incidence of PMI by ECG was 9%; an additional 8% of cases was diagnosed by enzymes alone. The incidence of diagnostic change by VCG was 19% and by scintigraphy, 25%. Using at least one changed variable of the remaining three as the reference standard, the relative sensitivity and relative specificity of given variables in the diagnosis of PMI were as follows: ECG 67% and 100%, respectively; VCG 85% and 94%; scintigraphy 92% and 97%; and serum enzymes 86% and 96%. By univariate analysis, unstable angina was the only significant predictor of PMI. The operative mortality rate was 2% and the mortality rate at 12 months was 5%. There was a significantly greater mortality rate in patients with PMI diagnosed by ECG (p less than 0.01), in patients with unstable angina pectoris before operation (p less than 0.05), and in women (p less than 0.05).

Analysis of Variance↗

Estimation of myocardial infarct size by electrocardiographic and radionuclide techniques.

The Western Washington Intravenous Streptokinase in Acute Myocardial Infarction Trial was a randomized, experimental, multicenter clinical study comparing intravenous streptokinase therapy to conventional therapy of acute myocardial infarction. Myocardial infarct size was estimated by spatial vectorcardiography in 93 patients in the treatment group and 80 patients in the control group eight weeks post MI. The estimated infarct size for the treated group was smaller: 16 +/- 10% MI vs. 20 +/- 9% MI for the control group, P = 0.01. Four independent techniques to estimate infarct size were prospectively compared within the same day: Cowan's spatial VCG; the Selvestor/Wagner QRS score; 99m technetium synchronized ejection fractions and 201-Thallium Tomography. There was strong correlation between the two ECG techniques (r = 0.88) and between the two radionuclide techniques (r = 0.77). Statistically significant correlations (P = 0.0001) were described, respectively, among the four techniques, but the correlations were not clinically strong between electrocardiographic and radionuclide techniques: IAD vs. EF, r = -0.41; IAD vs. 201-Tl, r = 0.50; QRS Score vs. EF, r = -0.49; QRS Score vs. 201-Tl, r = 0.58.

Clinical Trials as Topic↗

A simple bedside technique in the study of the WPW syndrome.

A simple method for the study of the WPW syndrome, which can be performed at the patient's bedside, is presented. Using standard ECG, vagal maneouvers, ajmaline test, precordial mapping, vectorcardiography, electrode catheters positioned in the right atrium and esophageal catheters, the site of accessory pathways, and the complex arrhythmias occurring in these patients can be understood and medically treated.

Adult↗

[Colored spatial mapping electrocardiography for detecting myocardial infarction].

Colored spatial mapping electrocardiography (ECG) was developed for practical use from Frank lead vectorcardiography using a microcomputer system (CERX-CQ3001). Compared to body surface electrocardiography this new device facilitated easy recording and analysis for display on eight-colored spatial mapping electrocardiography at points equivalent to those on a terrestrial globe at intervals of 20 degrees longitude and 10 degrees latitude. In this study, the extent and direction of the Q waves were easily recognized with the aid of a colored display and mapping electrocardiography. To quantitatively evaluate infarct size, the total Q wave area (sigma Aq) was calculated from the mapping electrocardiograms of 12 patients with anteroseptal myocardial infarction, and compared with thallium defect scores obtained by single photon emission CT (SPECT) and the left ventricular ejection fraction (EF). Defect scores were calculated using short-axis images. Sigma Aq was correlated with defect scores and EF (r = 0.83, 0.45, respectively). This new type of colored spatial mapping electrocardiography proved useful for detecting myocardial infarction and for evaluating infarct size.

Color↗

[The electrocardiomultigraphimeter and the Commodore-64. How to use the home computer with great skill].

The drop in hardware costs has fostered the widespread use of home-computing systems. Because of this situation, the home-computer can be profitably employed in some highly specialized fields. We believe electrocardiographic instrumentation to be one of such fields. We have built an electrocardiomultigraphimeter (ECXGM), which can be considered as a development of the traditional electrocardiograph that fulfills some additional functions. Our prototype features vectorcardiography, polar coordinate tracing, automatic measurements between fiducial points selected by the user with a joystick and cursor on the screen and trace filing by patient, on labelled floppy disks. The conventional hardware consists of a Commodore 64 console, a monitor, two floppy disk drives and an Epson HI-80 plotter, all of them readily available. The special hardware consists of an A/D converter, which receives the electrocardiographic signal downstream of the amplifying stage which is a standard feature of any electrocardiograph. Prototype development mostly involved the software. Difficulties were posed by the limited resources available on home-computers, an important point in view of the problem to be tackled. The solutions adopted are based on the use of the ASSEMBLER language, overloading techniques and on minimizing the interconnections among the software modules defined in a compactly built program. The result is an instrument having significantly advanced clinico-scientific capabilities as compared to current electrocardiographic instruments. This factor, and the class of the hardware used and special software built confer originality to this work.(ABSTRACT TRUNCATED AT 250 WORDS)

Computer Graphics↗

[Vectorcardiographic analysis of late potentials].

We analyzed by high amplification vectorcardiography the morphology of the QRS ending loop and the ST segment of patients with previously recorded Lown 4A, 4B ventricular arrhythmias and the healthy subject. Eight patients were affected by ischemic heart disease and 7 by arrhythmogenic right ventricular dysplasia. All had some irregularities at the end of the QRS or in the ST segment, on the standard ECG. The VCG showed one or more of these three morphologies: complete or incomplete ring, rapidly inscripted isodi-triphasic potentials, sinusoidal irregularities. In the 20 healthy subjects, the loop corresponding to the last 30 msec of the QRS, till the end of the afferent portion of T, was regular, without any particular morphology. We think that these aspects could be related to delayed fragmentation of the ventricular depolarization.

Arrhythmias, Cardiac↗

[Deep Q waves in the ECG of children--an electro-, vector- and echocardiographic study].

Out of 9557 children we found 120 children (1,26%), who showed deep Q-waves of greater than or equal to 0.4 mV in 3 consecutive ECG's at least in one of the leads I, aVL, V4, V5 and V6. 70 children were investigated additionally by echocardiography, 45 by vectorcardiography according to Frank. Echocardiography revealed an increased septal thickness in 5 patients, a borderline thickness in 8, an increased septal/posterior wall ratio in 4. In the vectorcardiogram 51,1% of the patients had no Q-waves in lead y, mostly in combination with deep Q-waves in a VL or left axis deviation. Q-waves in lead y were combined with Q-waves in V 5/6. The determination of the main axis coincided in 80% of ECG and VCG. Looking for the various heart diseases, 30% of the children with Q-waves had a ventricular septal defect, 23,3% an endocardial cushion defect, 10,8% a patent ductus arteriosus, 3,3% a bradycardia, 2,5% a Bland-White-Garland syndrome and 1,6% a hypertrophic cardiomyopathy. 17,5% of the children had an innocent heart murmur, 5,8% no cardiac symptoms. Other diseases were found in 5%. The most frequent cause of Q-waves in children were volume-overload of the left ventricle (35%) and left axis deviation (33,3%), whereas myocardial infarction and septal hypertrophy (3,3 and 4,1%) were of minor importance. In healthy children (23,3%) we could not find any pathomechanism.

Arrhythmias, Cardiac↗

[Importance of the atrial vectorcardiogram in evaluating the myocardial functional state in ischemic heart disease].

The results of examination of 61 patients suffering from ischemic heart disease are analysed. All were subjected to catheterization of the right and left parts of the heart, left ventriculography, and selective coronarography. Some parameters of intracardiac hemodynamics, including the end diastolic pressure in the left ventricle, were determined. Atrial vectorcardiogram was recorded after I. T. Akulinichev's system (with mV = 100 mm). Comparison of the parameters of the atrial P loop of the vectorcardiogram with the findings of heart catheterization showed a direct dependence between the atrial changes recorded on the vectorcardiogram and the value of the left ventricular end diastolic pressure. Signs of overexertion of the left atrium grow with an increase in the end diastolic pressure. Quantitative dependence between these parameters is demonstrated. When the end diastolic pressure grows higher, overexertion of the left atrium is naturally joined by overexertion of the right atrium. Atrial vectorcardiography may be an important invasive method for appraising the functional condition of the left ventricular myocardium in patients with ischemic heart disease.

Adult↗

[Assessment of the dimensions and dynamics of the necrosis zone in acute myocardial infarct].

In 165 patients with myocardial infarction admitted to the clinic within the first 24 hours of the disease, the size of the zone of affection and its dynamics in the immediate 4--5 days were appraised. Three methods were used for this purpose: cartographic analysis of the ECG in 35 precordial leads; vectorcardiography and serial determination of creatine phosphokinase activity (CPK) in blood plasma with calculation of the size of the necrosis in units of weight (grams). It is shown that ECG-cartography and serial determination of serum CPK activity are valuable methods in quantitative appraisal of the size of the necrotic focus in patients with myocardial infarction. Study of the ECG-cardiogram and vectorcardiogram in dynamics and analysis of CPK activity curves enables one to appraise the spreading of the zone of the necrosis in the first days of the infarction. According to the results of these methods, in most patients (68 to 82%) with macrofocal myocardial infarction the zone of the necrosis spreads in length and in depths in the first days of the disease.

Adult↗

[Cardiologic aspects of Friedreich type heredoataxia].

The authors performed ambulatory electro-vectorcardiography polycardiography and echocardiography in 18 patients with typical Friedreich's disease, and 6 patients with atypical forms of hereditary spino-cerebellar ataxia classified on e basis of the degree of neurological involvement, without clinical signs of cardiocirculatory failure. The ECG and VCG recording commonly showed appearances suggestive of myocardial "necrosis" and were of little value in the differential diagnosis between typical and atypical forms of Friedreich's ataxia. This limitation also applied to the kinetocardiogramme which was sometimes pathological confirming the echocardiographic diagnosis of symmetric LV hypertrophy and of septal hypokinesia despite normal ECG and VCG. The systolic time intervals and echocardiographic parameters of the interventricular septum were more helpful in the differential diagnosis. Hypertrophic cardiomyopathy, usually symmetric, was observed in about 70 p. 100 of typical and only rarely in atypical forms of Friedreich's disease. The symmetric or asymmetric hypertrophy was associated with reduced left ventricular performance in less than 20 p. 100 of typical Friedreich's disease, systolic anterior motion of the mitral valve and other signs of dynamic left ventricular outflow tract obstruction were not observed in any of these patients. The correlations between the degree of neurological disability and the cardiac abnormalities, were, in general, disappointing compared with other reported series. The cardiac investigation of patients with Friedreich's disease remains valuable from the point of view of recent pathological hypotheses of a metabolic abnormality with eventual therapeutic implications.

Adolescent↗