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PubMed1981

Age- and position-dependent effects of monaural acoustic deprivation in nucleus magnocellularis of the chicken.

The effect of a moderately severe monaural conductive hearing loss on the development of neuronal size in the avian nucleus magnocellularis (NM) was investigated. NM is considered to be the homologue of the mammalian anteroventral cochlear nucleus and receives large calyceal synaptic endings from the cochlear nerve. Silicone plastic earplugs which produce a 40 dB broadband conductive hearing loss were placed in one external auditory canal of chick embryos on the 18th day of incubation. After hatching, all animals were housed in communal brooders and sacrificed at 4, 10, 25, and 60 days of age. Nissl-stained sections from paraffin- and plastic-embedded brains were used to sample neuronal cross-sectional areas in NM on the deprived and nondeprived sides of the brain. These samples were obtained separately in each brain from three posterior-to-anterior percentage quartiles within NM. Statistical analyses of these data showed that the severity of deprivation-induced cell size changes in NM varied as a function of both age and position. In the 4- and 10-day groups, no significant deprived-versus-nondeprived differences in neuronal size were seen in any area of the nucleus. At 25 days after hatching, only the third posterior-to-anterior quartile (i.e., 50-74%) showed a significant difference; this difference was also significantly greater than those in the second and fourth quartiles at this age. By 60 days, all three sampled areas in NM showed highly significant differences (averaging 12%) in mean neuronal cross-sectional area. Cell size values from the deprived and nondeprived sides of 60-day-old experimental animals were also compared with values from 60-day-old control subjects. Whereas the deprived NM cells were significantly smaller than controls, there was no evidence for a reliable hypertrophy in the nondeprived cells. Thus, the principal effect of the acoustic deprivation produced was to retard continued growth of the deprived neurons after 4 days of age.

Animals↗
PubMed1987

Antagonistic effects of perilymphatic calcium and magnesium on the activity of single cochlear afferent neurons.

The dependence of the spontaneous and sound driven activity of single cochlear nerve fibers on the calcium and magnesium content of the perilymph was studied by perfusion of the perilymphatic space. It was possible to study these effects under steady-state conditions by continuously perfusing scala tympani at low rates while simultaneously recording from units in the chinchilla auditory nerve. Preparations were stable for many hours. As previously reported [Robertson and Johnstone (1979) Pflügers Arch. 380, 7-12], perfusion with solutions containing elevated concentrations of magnesium reduces both the spontaneous and driven activity. When calcium was eliminated from the perfusate, activity was completely abolished for stimuli with sound pressure levels below 100 dB. During partial blocks, a relatively frequency-independent threshold elevation was seen for frequencies well below the characteristic frequency (CF) of the unit, with greater elevations closer to CF. When the threshold elevation at CF was 30-40 dB, the width of the 'tip' portion of the tuning curve was reduced, resembling that of naturally-occurring units with low spontaneous rates of discharge. These effects are similar to that of raising the criterion for response during threshold measurement and are probably related to a frequency-dependent nonlinearity exhibited by the motion of the basilar membrane. The dynamic range for the growth of average rate with level was increased and saturation was shifted to higher stimulus levels during elevated magnesium perfusion. Raising the calcium content of the perfusate increased both spontaneous and driven rates, even in the saturated portion of the rate-intensity plot. Under these conditions, the response of the unit may more directly correspond to the intracellular potential of the presynaptic hair cell. It is argued that the primary site of divalent cation interaction is in the control of transmitter release. Inner hair cells of the mammalian cochlea apparently do not release transmitter in the absence of a calcium influx. The size of the pool of 'readily-available' transmitter appears to be influenced by divalent cations. Even though this synapse is probably specialized for the transmission of auditory signals, the mechanism of synaptic transmission is probably not fundamentally different from that of other well-characterized synapses.

Animals↗
PubMed1982

Cochlear microphonic evidence for mechanical propagation of distortion products (f2 - f1) and (2f1 - f2).

The present cochlear microphonic (CM) study was undertaken to help resolve a conflict in the literature regarding cochlear nonlinear properties. The CM studies of Dallos and his coworkers have concluded that "(up to 70-80 dB SPL [re 20 mu Pa]), all orders of distortion components...do not seem to be accompanied by traveling waves of their own" (Dallos, P. (1973): The Auditory Periphery: Biophysics and Physiology. Academic Press, New York). However, studies of spatial distributions of cochlear nerve fiber responses, acoustic distortion products in the ear canal, and related modeling studies of Kim et al. (Kim, D.O. and Molnar, C.E. (1975): in: The Nervous System, Vol. 3: Human Communication and Its Disorders. Editor: D.B. Tower. Raven Press, New York; Kim, D.O., Molnar, C.E. and Matthews, J.W. (1980): J. Acoust. Soc. Am. 67, 1704-1721) have led to conclusions to the contrary. In the present study, CM data were obtained from the second and third turns of the chinchilla cochlea using fluid-filled glass micropipettes in scala media and nichrome wire electrodes in scala vestibuli and scala tympani. We sought responses containing predominant distortion products (f2 - f1) and (2f1 - f2) by fixing a distortion frequency (fD) near the characteristic frequency (CF) of the recording site and varying the stimulus frequencies f1 and f2 and SPLs (with L1 = L2). By subsequently varying the distortion frequency around the CF, e.g., fixing f1 well above the CF and varying f2, we measured the tuning characteristics of the distortion products (f2 - f1) and (2f1 - f2). Tuning characteristics of single-tone responses were measured by applying single-tone stimuli of various frequencies with a constant SPL at the eardrum. We have observed, with SPLs as low as 25 dB, that these distortion products in CM display tuning similar to the single-tone response which is consistent with above neural results. From these tuning similarities, we conclude that our CM data reflect the presence of mechanically propagated distortion products at low SPLs, in agreement with the above studies by Kim et al. Validity of our results is supported by the sensitivity and sharp tuning of our CM data and, in the case of the scala media recordings, by the presence of a normal d.c. endolymphatic potential. Plausible explanations for the opposing conclusions of previous studies of Dallos et al. and the present study are discussed.

Acoustic Stimulation↗
PubMed2006

Decorrelation sensitivity of auditory nerve and anteroventral cochlear nucleus fibers to broadband and narrowband noise.

Binaural neurons show remarkable sensitivity to temporal differences in the waveforms at the two ears. This ability obviously requires temporal coding of sound waveforms in the monaural afferents that converge on such binaural neurons. We introduce a new analysis to investigate how well responses of single monaural neurons support discrimination of decorrelations in waveforms. Spike trains from auditory nerve (AN) and anteroventral cochlear nucleus (AVCN) neurons of cats to many repetitions of a set of broadband and narrowband noise tokens were obtained. The normalized correlation between the noise tokens ranged from 0.99 to -1. A coincidence and signal detection analysis was used to perform a correlation discrimination task using the monaural spike trains. The correlation discrimination thresholds derived from AVCN neurons were lower than those derived from AN fibers and sometimes as low as human psychophysical just noticeable differences. Importantly, low detection thresholds required comparisons of spike trains at small internal delays. Bandwidth dependence of neural decorrelation thresholds agreed with psychophysical data when large internal delays contributed to the detection. We conclude that, in the context of correlation discrimination, coding by AVCN fibers is superior to that by AN fibers and that these discriminations require a distribution of internal or best delays in binaural processing that differs from the predictions from studies of discrimination in interaural time delays.

Acoustic Stimulation↗
PubMedDate not supplied

Preservation of vestibular nerves in surgery of the cerebellopontine angle: effect on hearing and balance function.

INTRODUCTION: Small tumors of the cerebellopontine angle (CPA) can frequently be removed with preservation of the auditory and the vestibular portion of the eighth cranial nerve. This study was undertaken to estimate the effect of vestibular nerve preservation on both balance and hearing following surgery. MATERIALS AND METHODS: A retrospective study of all cases of CPA lesions between 1987 and 1991 was undertaken. This identified 11 patients in whom either the superior and/or inferior vestibular nerves were preserved. This included eight acoustic neuromas and three meningiomas. The retrosigmoid approach and total tumor extirpation was undertaken in all cases. Patients undertook a vestibular questionnaire, audiometric testing, and evaluation of vestibulo-ocular responses preoperatively and postoperatively. Additionally, static and dynamic platform posturography was performed postoperatively in 9 of 11 patients. RESULTS: Follow-up ranged from 6 to 44 months. Of the eight patients with acoustic neuroma, four had a preoperative balance disorder that resolved postoperatively. One patient died of unrelated causes. Of the remaining seven patients with caloric testings, one maintained normal caloric responses. A persistent postoperative phase shift was noted in 4 of the 7 cases with rotatory testing. Three patients were treated for a meningioma. All had a preoperative balance disorder that resolved postoperatively. Two patients showed vestibular response indicative of residual but compromised function on the involved side. The third patient showed absent responses indicating an anatomically intact nerve that does not necessarily predict functional activity. Preservation of the vestibular nerve was associated with preservation of preoperative hearing in five of the patients. This included four of the eight acoustic patients and one of the three meningioma patients. CONCLUSIONS: Preservation of the vestibular nerve did not result in a chronic balance disorder in this patient population. This study does not allow the authors to conclude if vestibular nerve preservation improves overall hearing after CPA surgery; however, these data suggest that preservation of the inferior vestibular nerve may result in less damage to the cochlear nerve in some patients. Accordingly, preservation of the vestibular nerve in CPA meningioma surgery can be recommended.

Adult↗
PubMed1998

Delayed facial weakness after microvascular decompression of cranial nerve VII.

BACKGROUND: Retromastoid craniectomy and microvascular decompression of cranial nerve VII for hemifacial spasm is a well accepted and effective treatment. Risks of the operation relate to the surgical approach in general and to the seventh nerve in particular. Delayed facial weakness is an unusual and little-described complication of the procedure. The purpose of this review is to describe this complication and the characteristics of the patients so affected. METHODS: Between 1972 and 1996, 985 patients have undergone microvascular decompression for hemifacial spasm. During this time, 28 patients (2.8%) undergoing decompression of the facial nerve and 1 patient undergoing decompression of the cochlear nerve for tinnitus developed delayed facial palsy. RESULTS: The weakness was at least a House Grade III or worse and was complete in 11 of the patients. The time to occurrence averaged 12 days, with a tight range of 7 to 16 days. There were no factors such as duration of symptoms, intraoperative findings, or preoperative botulinum injections that were predictive of this postoperative weakness. In all patients there was almost complete recovery (House Grade I or II). CONCLUSIONS: Delayed facial weakness after MVD of CN VII can occur in up to 3% of cases. The onset of weakness after operation is consistent in its timing, occurring on average 12 days after the procedure. Although the etiology of this complication is uncertain, the palsy spontaneously resolves with a good or excellent outcome.

Adult↗
PubMed2004

A phenomenological model of peripheral and central neural responses to amplitude-modulated tones.

A phenomenological model with time-varying excitation and inhibition was developed to study possible neural mechanisms underlying changes in the representation of temporal envelopes along the auditory pathway. A modified version of an existing auditory-nerve model [Zhang et al., J. Acoust. Soc. Am. 109, 648-670 (2001)] was used to provide inputs to higher hypothetical processing centers. Model responses were compared directly to published physiological data at three levels: the auditory nerve, ventral cochlear nucleus, and inferior colliculus. Trends and absolute values of both average firing rate and synchrony to the modulation period were accurately predicted at each level for a wide range of stimulus modulation depths and modulation frequencies. The diversity of central physiological responses was accounted for with realistic variations of model parameters. Specifically, enhanced synchrony in the cochlear nucleus and rate-tuning to modulation frequency in the inferior colliculus were predicted by choosing appropriate relative strengths and time courses of excitatory and inhibitory inputs to postsynaptic model cells. The proposed model is fundamentally different than others that have been used to explain the representation of envelopes in the mammalian midbrain, and it provides a computational tool for testing hypothesized relationships between physiology and psychophysics.

Acoustics↗
PubMed1991

Facial nerve stimulation with cochlear implantation. VA Cooperative Study Group on Cochlear Implantation.

The course of the facial nerve may place it within the current field generated by an activated cochlear implant to produce incidental facial movement. We investigated the presence of facial nerve stimulation associated with cochlear implants in the VA Cooperative Study of Advanced Cochlear implants. Twelve of 82 patients enrolled in this study demonstrated facial nerve stimulation within 2 years of implant activation. Facial nerve stimulation in six patients with multiple channel implants (Nucleus or ineraid devices) either resolved spontaneously (n = 2), or was eliminated by deactivating basal (n = 2) or apical (n = 2) electrodes. Two of six patients with single-channel electrodes (3-M/Vienna devices) demonstrated facial nerve stimulation that resolved spontaneously (n = 2), resolved with lowering current output (n = 2), or was refractory to processor adjustment (n = 2). Intraoperative assessment in one of the refractory cases indicated that facial nerve stimulation resulted from current spread through the modiolus to activate the facial nerve. A variety of factors, including implant design, stimulus parameters, and local tissue impedances, may interact to produce incidental facial stimulation. Low-impedance pathways between the scala tympani and the modiolus may deserve increased recognition as an interactive factor in cochlear implant performance.

Adult↗