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At least 757 records · Page 42Linked to original sources
PubMed1988

Role of immunoglobulin and peritoneal phagocytes in the protection of rats against salmonella infection.

Intradermal vaccination of rats with heat-killed Salmonella dublin protected against an intraperitoneal challenge of live S dublin. Serum from vaccinated animals administered intraperitoneally protected normal rats against intraperitoneal challenge with S dublin and four other serotypes. Protection was attributed to opsonic antibodies which promoted phagocytosis by mononuclear phagocytes. The opsonin was identified as IgG2a which prevented lysis of macrophages and enabled them to contain the pathogen at the site of infection. In vitro, mononuclear phagocytes killed S dublin for up to two hours after phagocytosis in the presence of immune rat serum.

Animals↗
PubMed1987

Salmonella infections of the abdominal aorta cured with prolonged antibiotic treatment.

Three cases of endovascular infection of atherosclerotic aneurysm of the abdominal aorta due to Salmonella spp. are described. 'Breakthrough' or relapsing bacteraemia were major clues for diagnosis in each case. They were treated with a prolonged course of bactericidal antibiotics before surgery. Resection with an interposed graft was performed in all cases and antibiotic treatment continued. Two of our patients have survived for more than two years and the other for 18 months without evidence of relapse. Thus, it would appear possible at times to treat successfully mycotic aneurysm of the abdominal aorta with antimicrobial agents plus resection of the aneurysm followed by in situ bypass grafting. Extra-anatomical grafts should be kept for infections due to antimicrobial-resistant organisms or when periaortic infection is widespread.

Aged↗
PubMed1995

Schistosomal glomerulopathy: a putative role for commonly associated Salmonella infection.

A total of 190 patients were selected after being subjected to hemoculture for detecting Salmonella spp, coproscopy for Schistosoma mansoni eggs and ELISA testing for anti schistosomal sero-reactivity. They made up 4 group; The first comprised 31 febrile patients with positive hemoculture, coproscopy and ELISA, 13 of them with hepatic fibrosis and received combined anti- typhoid and antibilharzial therapy. The second comprised 53 febrile patient with the same criteria; 18 with hepatic fibrosis, and received anti typhoid & antibilharzial alternatively. The third group comprised 46 febrile patients with positive hemoculture and negative coproscopy but with positive ELISA 20 were hepatosplenic & received anti typhoid treatment. The fourth comprised 60 afebrile patients with negative hemoculture and positive coproscopy and ELISA 35 were hepatosplenic, and received anti-bilharzial treatment. 50 healthy individuals were selected as control. The controls and the patients; before and after treatment underwent investigation for determining levels of serum complement3 as a marker of immune complex precipitation activity and creatinine clearance, and urinary proteins excretion in 24 hours as measurements of glomerular function. The specific treatment either combined or alternative or single in the first 3 groups consequently showed marked improvement in the above criteria with insignificant additive pattern in the second. The fourth group showed non-significant difference in the above criteria after anti-bilharzial therapy among the hepatosplenic, meanwhile it improved these criteria significantly among the non-hepatosplenic--in the four groups--whose criteria were significantly higher than among the hepatosplenic before treatment.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗