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PubMed1983

[Therapy of endocrine diseases in childhood and adolescence. 1. Goiter in childhood].

Euthyroid or hypothyroid goitre in childhood is due to hyperstimulation by TSH in iodine deficiency or inborn errors of thyroid hormone synthesis. Hyperthyroid goitre results from presence of LATS. Hashimoto's strumitis may be hypo- or hyperthyroid. Therapy consists of iodine, thyroxine in hypothyroid goitres or in thyrostatic suppression in hyperthyroid goitres. Whereas hypothyroidism requests lifelong therapy, hyperthyroidism requires therapy for 1 to 2 years if successful. Otherwise, operative procedures are necessary.

Adolescent↗
PubMed1984

[Therapy of endocrine diseases in childhood and adolescence. 4: Hypophyseal dwarfism].

A deficiency in growth hormone depresses growth and leads to dwarfism. The cause of hypopituitarism may be the destruction of the hypothalamus by a tumor infection or trauma. Birth trauma is often the underlying cause. Genetic forms or cerebral defects have also been described. Growth hormone may be completely lacking or partially reduced. Neurohormonal dysfunction is of particular interest. Administration, either intramuscular or subcutaneously, of human growth hormone leads initially to "catch-up" growth and to subsequent normal growth. Early treatment should be instituted if normal adult height is to be achieved.

Adolescent↗
PubMed1984

HLA, Gm and endocrine diseases.

Differences in the frequency rates of seven signs determined by locus HLA-A and of 14 signs controlled by the HLA-B locus and also differences in the rates of appearance of four signs of the Gm system and that of the Inv(1) sign were searched for between patients suffering from diseases of the thyroid gland and healthy subjects. No statistically significant differences in the HLA system could be demonstrated when healthy subjects were compared to the diseased patients. In simple goiter patients there was a significant difference in the frequency rates of the Gm (1, 4, 5) phenotypes and a highly significant difference in the frequency rates of the Gm (1, 2, 4, 5) phenotypes. No direct association could be demonstrated between the above mentioned systems and the studied disease.

Chromosome Mapping↗
PubMed1983

[Therapy of endocrine diseases in childhood and adolescence. 2. Connatal athyreosis. 3. Diabetes insipidus neurohormonalis].

Congenital athyreosis may be due to different though mostly unknown factors. It should be diagnosed by TSH-screening. Immediate therapy consists of supplementation of thyroxin. The dose should be adjusted to the child's needs controlled by normal growth and bone age advance, normalization of TSH and thyroxin levels in serum. The goal must be to reach normal intelligence. Therapy should be continued during the entire life. Absence of adiuretin is the cause for diabetes insipidus neurohormonalis due to genetic disorders, tumor or infection of the hypothalamo-pituitary system. The disorder is best treated with synthetic desamino-8-vasopressin (minirin, alternatively with an oily suspension of pitressin). Diabetes insipidus renalis and psychogenic polydipsia should be ruled out before this therapy is started.

Adolescent↗