[Oral manifestations of trisomy 21 syndrome (Down's syndrome--mongolism)].
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A case of Recklinghausen's neurofibromatosis of predominantly buccal localization is reported, lesions being apparent on gums and tongue. The rareness of such localizations is emphasized, results of surgical excision and histology of lesions described and manifestations of the disease outlined.
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The clinical, radiological and histological aspects of acute histiocytosis X of Letterer-Siwe disease are reviewed after personal observation of such cases. In spite of many advanced hypotheses the etiopathogenesis of Histiocytosis X is wide open to research. The diagnosis became possible by the discovery of histiocyte cells of a special order, the X-bodies, under the E. M. Recent research allows a classification of Letterer-Siwe disease, Hand-Schüller-Christian disease, and the eosinophilic granuloma under the same nosologic grouping. Finally, the prognosis of the Letterer-Siwe disease-so far much in the dark-may be improved by a properly conducted therapy.
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