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PubMed1996

Role of cementoenamel junction on the radicular penetration of 30% hydrogen peroxide during intracoronal bleaching in vitro.

Intracoronal bleaching of nonvital, teeth with 30% hydrogen peroxide is occasionally associated with external cervical root resorption. The exact mechanism by which bleaching induced root resorption occurs is not yet fully understood. The relationship of cementum to the enamel at the cementoenamel junction may have clinical significance. Seventeen single rooted human mandibular premolars extracted atraumatically for orthodontic reasons were used. The radicular hydrogen peroxide penetration in each tooth was measured in vitro by an indirect colorimetric method. Thereafter, the teeth were examined with a scanning electron microscope to determine the type of the cementoenamel junction. It was found that the radicular penetration of 30% hydrogen peroxide was related to the type of cementoenamel junction.

Adult↗
PubMed1995

Endodontic pathogens: propagation of infection through patent dentinal tubules in traumatized monkey teeth.

Periapical pathology indicating endodontic infection, when present in marginal periodontitis-affected teeth, has recently been shown to be an aggravating factor in progression of marginal destruction. This has been associated with patency of dentinal tubules in the tooth cervix, an area normally devoid of cementum following periodontal therapy. These studies are, however hampered by that only circumstantial evidence such as presence of periapical destruction have been applied as criteria of endodontic infection. The purpose of the present investigation was to study to what extent a predefined selection of endodontic pathogens inoculated in the root canal can influence periodontal pathology and healing in areas of the root covered by or devoid of cementum, using root resorption as a histomorphometric marker. Exposed dentine surfaces, in the present study showed significantly larger areas of resorption in infected roots compared to non-infected roots, while cementum surfaces showed an almost identical distribution of tissue reactions regardless of root canal infection or not. It was concluded that endodontic pathogens or their products were not able to penetrate the cementum barrier. The significantly larger areas of resorption on exposed dentine surfaces in infected roots compared to non-infected roots indicated that endodontic pathogens or their products could spread through dentinal tubules to a root surface void of cementum. Extrapolated to the marginal situation this indicated that endodontic pathogens in the root canal might be able to aggravate marginal infection in areas of root devoid of cementum.

Animals↗
PubMed1992

Immunocytochemical localization of cathepsins B and G in odontoclasts of human deciduous teeth.

For clarification of the mechanisms by which odontoclasts resorb deciduous teeth during physiological root resorption, cysteine-proteinases such as cathepsins B and G were immunocytochemically localized in odontoclasts at the ultrastructural level. Extracted human deciduous teeth undergoing root resorption were fixed with a mixture of formaldehyde and glutaraldehyde and processed for immunocytochemical detection of these enzymes. Sheep antisera, raised against either human cathepsin B or G, were used as primary antibodies. In odontoclasts, specific immunogold labeling of both anti-cathepsin B and G was clearly localized in lysosomes and pale vacuoles of various sizes, and in a portion of the extracellular canals of odontoclastic ruffled borders. In the presence of either antibody, the cytoplasmic matrix, mitochondria, and nuclei were minimally labeled by immunogold particles. The presence of these proteolytic enzymes in odontoclasts suggests that, during odontoclastic root resorption, these enzymes are involved in the formation of resorption lacunae by means of intra/extracellular degradation of collagen and other non-collagenous matrix proteins of deciduous teeth.

Cathepsin B↗
PubMed2004

Orthodontics. Part 6: Risks in orthodontic treatment.

Orthodontics has the potential to cause significant damage to hard and soft tissues. The most important aspect of orthodontic care is to have an extremely high standard of oral hygiene before and during orthodontic treatment. It is also essential that any carious lesions are dealt with before any active treatment starts. Root resorption is a common complication during orthodontic treatment but there is some evidence that once appliances are removed this resorption stops. Some of the risk pointers for root resorption are summarised. Soft tissue damage includes that caused by archwires but also the more harrowing potential for headgears to cause damage to eyes. It is essential that adequate safety measures are included with this type of treatment.

Dental Caries↗
PubMed1996

Orofacial radiological manifestations of systemic sclerosis.

OBJECTIVE: To ascertain the orofacial radiological manifestations of systemic sclerosis. METHODS: Twenty-one patients with known systemic sclerosis underwent panoramic, and where appropriate periapical, radiography parotid sialography and a labial gland biopsy. RESULTS: The prevalence of periodontal ligament space widening was 33%, bone resorption 9.5% and abnormal parotid gland sialographic findings 43%. Root resorption affected 4 (33%) of the 12 dentate patients. CONCLUSIONS: Orofacial radiological manifestations occur commonly in systemic sclerosis. Root resorption has not previously been reported.

Adult↗
PubMed1998

Autogenous free tooth transplantation by the two-stage operation technique. An analysis of treatment factors.

Teeth were autogenously transplanted by the 2-stage technique in adult patients and examined up to 5 years after surgery for the prevalence of, and correlation between, tooth graft loss, root resorption, ankylosis, periodontal attachment loss, tooth mobility, and pain. The influence on the dependent variables of independent variables related to the patient, the donor tooth, the recipient site, and the transplantation procedure was examined. Pain was correlated to transplanted teeth, later extracted, and teeth with periodontal attachment loss. The expected correlation of root resorption to periodontal attachment loss was not verified owing to incomplete follow-up. The older the patient was, the less root resorption was found. Variables indicative of infection of the recipient bed and of traumatic injuries to the donor tooth at the transplantation were found to be detrimental to the tooth transplant.

Adolescent↗
PubMed1997

Alveolar bone turnover and tooth movement in male rats after removal of orthodontic appliances.

The purpose of this study was to acquire tooth movement, histomorphometric and biochemical data on oral tissues that had previously been loaded with calibrated orthodontic forces. One hundred and forty-four male Sprague-Dawley rats were randomly divided into two groups: Group I, orthodontic appliances placed for 16 days to mesially move maxillary first molars with an initial force of 40 gm, and group II, sham orthodontic treatment. Seven to twelve rats were killed at each of six times after removal of appliance. Tooth movement was measured cephalometrically, alveolar bone turnover by histomorphometry, and tissue phosphatase levels biochemically. Treated molars moved distally more rapidly than the shams (13.9 vs 5.0 microns/day). The appliance removal group had a persistent 10-fold elevation in root resorption on the mesial (p < 0.0001), as well as early elevations in osteoclasts on the mesial and osteoblasts on the distal (p < 0.001) that returned to control by 3 to 5 days. Acid, alkaline phosphatase, and tartrate-resistant acid phosphatase (TRAP) remained elevated in the tissues until 10 days (p < 0.0001). Changes in the dynamic measures of bone formation were characterized by low rates at days 1 and 3 (p < 0.01), elevating thereafter on the mesial and the converse on the distal. Orthodontic tooth movement relapses, and bone remodeling continues for several days after removal of appliance consistent with the direction of loading, orthodontic treatment stimulates root resorption at sites that were loaded in pressure without detectable recovery, and root resorption does not increase at the tension sites.

Acid Phosphatase↗
PubMed2003

Effects of maxillary molar intrusion on the nasal floor and tooth root using the skeletal anchorage system in dogs.

The skeletal anchorage system (SAS) was developed to provide intraoral absolute anchorage for the intrusion or distalization of molars. The purpose of this study was to verify the effects of remarkable molar intrusion on the tooth root and the maxillary sinus floor. Six adult female beagles with fully erupted dentition were used. Titanium miniplates were implanted bilaterally above the maxillary second premolar root apices using pentobarbital anesthesia. The second premolars were intruded for four or seven months after three months of healing after implantation. Standardized dental radiographs were taken periodically to evaluate the amount of tooth movement and root resorption. After the experimental animals were fixed by perfusion at the end of each experimental period, the second premolars were dissected along with the surrounding alveolar bone. Undecalcified (60 microm thick) and decalcified (five microm thick) sections were prepared. The average extent of intrusion was 1.8 mm after four months and 4.2 mm after seven months. The root apices of the intruded molars penetrated into the nasal cavity. Remodeled bone around the intruded molar toots was rich in woven bone on the buccal side, whereas that on the palatal side was rich in lamellar bone. Nasal floor membrane and a thin layer of newly formed bone, which lifted intranasally, covered the intruded molar root. Root resorption partly reached into the dentine without the formation of reparative cementum, and little or no serious pathological changes were seen in the pulp of the intruded molars. SAS effectively intruded maxillary molars, but some moderate root resorption was observed.

Animals↗
PubMed2004

Immunohistochemical localization of alphavbeta3 integrin receptor during experimental tooth movement.

During orthodontic treatment, multinucleated clast cells carry out the resorption of mineralized tissues. Adhesion of clast cells to the mineralized tissues is mediated by transmembrane cell-surface glycoproteins called integrins, specifically by the alphavbeta3 integrin, which plays an important role in the process of bone resorption. The role of the alphavbeta3 integrin in bone resorption leading to osteoporosis has been demonstrated, but its role in alveolar bone and root resorption during orthodontic tooth movement is unknown. This study examined the expression of the alphavbeta3 integrin during experimental tooth movement. Tooth movement was achieved in 16 male Sprague-Dawley rats (each weighing 120-200 g) with elastic bands between their maxillary first and second molars. The molar-bearing segments were dissected and processed for histologic and immunohistochemical examination. The expression of alphavbeta3 integrin was examined with 2 primary antibodies: a polyclonal anti-alphav integrin subunit antibody and a polyclonal anti-beta3 integrin subunit antibody. Negative controls were similarly processed but without incubation with primary antibodies. The alphavbeta3 integrin was expressed both by osteoclasts associated with alveolar bone resorption and by odontoclasts associated with root resorption during experimental tooth movement. Furthermore, the beta3 integrin subunit was expressed by the epithelial rests of Malassez in the periodontal ligament. Negative controls did not show immunolabeling. The alphavbeta3 integrin adhesion receptor is expressed during experimental tooth movement and might be involved in the process of mineralized tissue resorption and the functions of the epithelial rests of Malassez.

Alveolar Process↗
PubMed2005

Evaluation of various root canal filling materials in primary molar pulpectomies: an in vivo study.

PURPOSE: To evaluate the clinical and radiographic success of zinc oxide-eugenol (ZOE), Calcicur, Sealapex and Vitapex in primary molar pulpectomies. METHODS: 80 primary molars, showing signs of pulpal and/or periapical involvement, with no abnormal mobility, were selected from 76 children aged between 4-9 years-old, free from systemic disease. Radiographic evaluation was done to exclude teeth showing internal or pathological external root resorption and/or inadequate bone support. The selected teeth (20 in each group) were randomly treated with ZOE, Sealapex, Calcicur and Vitapex. The procedure involved primarily a one-visit pulpectomy. The teeth were evaluated clinically and radiographically every 2 months for a period of 18 months. RESULTS: In the ZOE group, all pulpectomies were successful. In the Sealapex group, two pulpectomies and in the Calcicur group, four pulpectomies showed complete resorption of the material in the root canal. Although re-treatment was performed, those teeth had to be removed due to pathological root resorption. In the Vitapex group, although six pulpectomies showed resorption of the filling material within the canals, this had no effect on the clinical and radiographical success of the treatment.

Child↗
PubMed2002

The role of endodontics in the treatment of luxated permanent teeth.

Pulp necrosis is a common complication following traumatic dental injuries and is related to the type and severity of the injury, as well as to the stage of development of the injured tooth. Endodontic intervention is required when there are clinical and radiographic signs of pulpal infection and its sequelae. Arrested tooth development with periradicular pathosis, external inflammatory root resorption, sinus tract formation and pain on percussion are indicative of root-canal infection in the post-traumatized teeth, and require immediate endodontic treatment. The use of calcium hydroxide in the treatment of teeth with post-traumatic pulp necrosis and its sequelae has been shown to be extremely beneficial for the long-term retention of the injured teeth. Calcium hydroxide has been shown to arrest and repair external inflammatory root resorptive defects, eliminate the endodontopathic microorganisms from the root canal system and induce hard-tissue barrier formation at the apex of non-vital immature teeth. This paper reviews the endodontic treatment required by post-traumatic non-vital permanent teeth.

Calcium Hydroxide↗
PubMed1981

Effect of extra-alveolar period and storage media upon periodontal and pulpal healing after replantation of mature permanent incisors in monkeys.

The effect of extra-alveolar period and storage media upon periodontal and pulpal healing after replantation was studied in green Vervet monkeys (Cercopithecus aethiops). Mandibular lateral incisors were extracted. The extra-alveolar period before replantation was 0, 18, 30, 60, 90, and 120 min. The storage media for the extracted teeth were tap water, physiologic saline, saliva or dry storage. The animals were sacrificed 8 weeks after replantation and the replanted teeth were examined histometrically. The following histologic parameters were registered for each tooth: surface resorption, inflammatory resorption, replacement resorption (ankylosis), periapical inflammatory changes, the extent of vital pulp and downgrowth of pocket epithelium. A significant relationship was found between the frequency of root resorption, extra-alveolar period and storage medium. This was especially evident after dry storage. Surface resorption was found with approximately the same frequency irrespective of extra-alveolar period and storage media. Inflammatory root resorption was especially common after dry storage and was related to the length of the extra-alveolar period. Already after 30 min dry storage, this resorption type was very prominent. Teeth stored in tap water, saline or saliva showed about the same frequency of inflammatory resorption, which increased slightly with increased extra-alveolar periods. Replacement resorption showed a strong relationship to dry storage and became very prominent after 60 min. Replacement resorption was rarely found among teeth stored in saline or saliva; whereas it was significantly increased among teeth stored in tap water. It is concluded that saline and saliva offer good protection against root resorption during the extra-alveolar period.

Animals↗
PubMedDate not supplied

Aneurysmal bone cyst of the maxilla--an association with tooth resorption.

The aneurysmal bone cyst is an uncommon lesion of the jaws. Cases involving the maxilla have been reported infrequently. Despite uncertainty as to the aetiology of the aneurysmal bone cyst, it is regarded as a benign lesion. Conservative surgical treatment with regular postoperative follow-up is recommended. The case described here presented with tooth mobility resulting from extensive root resorption. A review of the literature reveals that significant root resorption is not a commonly reported feature of aneurysmal bone cysts. For the present case we interpret the evidence as supporting a diagnosis of idiopathic root resorption complicated by the formation of a aneurysmal bone cyst.

Adult↗
PubMed1998

Later orthodontic appliance reactivation stimulates immediate appearance of osteoclasts and linear tooth movement.

BACKGROUND: Delays in the appearance of osteoclasts at compression sites occur after orthodontic appliance reactivation, when this is done during both the period of osteoclast recruitment and the peak expansion in the osteoclast population. This experiment examines osteoclasts and tooth movement in alveolar bone after appliance reactivation coinciding with alveolar bone formation and the time when reactivation osteoclasts first appear (ie, 10 days after initial appliance activation). METHODS: Bilateral orthodontic appliances were activated to mesially tip maxillary molars with 40 cN in 144 rats. After 10 days, all rats were randomized into two groups of 72. Group I had appliances reactivated in precisely the same manner as the first activation. Group II had appliances sham-reactivated. Nine to 12 rats were then sacrificed at 1, 3, 5, 7, 10, and 14 days in both groups (eg, day 1 represents an interval of 11 days after the first appliance activation and 1 day after either sham or real reactivation). Orthodontic movement was measured cephalometrically; changes in osteoclasts and root resorption were assessed at both compression and tension sites histomorphometrically. RESULTS: Teeth in the reactivated group (Group I) displayed linear tooth movement (62.6 micrometers/day), and 0.9 mm tooth movement by day 10. Significant increases in osteoclast numbers, osteoclast surface percentage, and surface per individual osteoclast were evident in these animals by 1 day postreactivation (P <.01). Significant treatment-related increases in root resorption were not evident at compression sites at any time. CONCLUSIONS: These findings indicate that, after appliance reactivation during the time when reactivation osteoclasts appear, a second cohort of osteoclasts can be recruited immediately, along with immediate and substantial tooth movement and no greater risk of root resorption.

Alveolar Process↗
PubMed2001

Gingival overgrowth as the initial paraneoplastic manifestation of Hodgkin's lymphoma in a child. A case report.

BACKGROUND: The purpose of this paper is to present the first case of gingival overgrowth, premature root resorption, and alveolar bone loss, which preceded the diagnosis of a stage IVB Hodgkin's lymphoma (HL) in a 9-year-old boy. METHODS: The child presented complaining of gingival pain which first appeared 3 months prior. Clinical examination revealed inflamed, hyperplastic gingivae, while x-ray showed premature root resorption and alveolar bone loss. Medical work-up was significant for cervical lymphadenopathy. Gingival biopsy, followed by lymph node resection, was performed twice. RESULTS: Histological examination of both gingival biopsies disclosed a mixed inflammatory infiltrate, while classical Hodgkin's lymphoma of the nodular sclerosis type was diagnosed from the second lymph node biopsy. Chemotherapy was instituted with mustard-vincristine-procarbazine-prednizone and adriamycine-bleomycine-vinblastine-dacarbazine. Remission of the lymphoma was observed with concomitant regression of the gingival overgrowth. CONCLUSIONS: The inflammatory gingival overgrowth, premature root resorption of deciduous teeth, and alveolar bone loss in this case, in conjunction with the regression of gingival overgrowth which followed the completion of chemotherapy, are strongly indicative of a paraneoplastic manifestation of HL. The postulated mechanism for the development of the manifestation is the constitutive activation of the transcription factor NF-kB. The gingival inflammatory reaction was probably further aggravated by the bacterial-stimulated cytokine secretion released by monocytes.

Alveolar Bone Loss↗
PubMed2006

[Changes of orthodontic tooth in different healing extraction sites].

OBJECTIVE: To compare the canines root resorption and alveolar bone height when they were moved into different healing extraction sites. METHODS: Twenty patients with overjet were treated by extracting the maxillary first premolars. By random determination, distalization of different lateral upper canines started after 1 week and 12 weeks. Every 4 weeks use a force of approximately 100 g to distalize the canines. The experiment was ended when bilateral canines have contacted with the second maxillary bicuspids completely. Periapical radiography of the canine in the end of the distalization was made. RESULTS: External apical root resorption and alveolar bone height of the canines have no significant difference between the different healing extraction sites. CONCLUSION: Tooth extraction site healing has not much effect on the canine external apical root resorption and alveolar bone height, when it was distalization. In practice, tooth movement into extraction sites can start early.

Adolescent↗