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PubMed1987

[A case of malignant paraganglioma arising from the retroperitoneum].

We report the case of 38-year-old male with a malignant and functional paraganglioma arising from the retroperitoneum. He was admitted to our hospital with a pathological fracture of the right femur, A diagnosis of paraganglioma was made after taking a biopsy specimen and discovering a hypervascular retroperitoneal tumor. The level of catecholamine in his urine was greatly increased, accompanied with hypertension, rapid pulse and sweating. He was treated with chemotherapy, radiotherapy and surgical therapy. However, he died from pulmonary metastasis.

Adult↗

PubMed1988

[Immunohistologic findings in paragangliomas in the area of the head and neck].

30 patients with paraganglioma of the head and neck region were subjected to surgery at the Department of Otorhinolaryngology during 1978-1985. Histological classification of the obtained specimens was performed using also immunocytochemical methods to detect more details. The site of origin of the tumours was the glomus tympanicum in 18 cases, 7 times the glomus caroticum and 5 times the glomus jugulare. Antibodies against neuronal components (S-100 protein), endothelial cells (UEAI) and endocrine activity (NSE) were used for subtyping by PAP-method (Figs. 1-3). Immunocytochemistry provided for an easy subtyping of the tumours and showed an increase in severe progress forms in adenomatous variants of paragangliomas.

Adult↗

PubMed1988

Therapeutic effectiveness of iodine-131 MIBG metastases of a nonsecreting paraganglioma.

This case report describes the treatment of the bone metastases of a nonfunctioning sympathetic paraganglioma, with [131I]MIBG. After primary tumor excision and unsuccessful external radiotherapy, the patient received three therapeutic doses of [131I]MIBG, resulting in a reduction of the number and volume of metastases, and an improvement of the general condition. At 3 yr following [131I]MIBG therapy, the patient remained in remission. [131I]MIBG appears to be an efficient and safe agent for treating malignant sympathetic paraganglioma.

3-Iodobenzylguanidine↗

PubMed1988

Urinary bladder paragangliomas. An immunohistochemical study.

The immunohistochemical characteristics of three cases of urinary bladder paragangliomas are presented. These are compared with similar studies on paragangliomas from other anatomic sites and the clinical and pathologic implications are discussed.

Adolescent↗

PubMed1978

Intrasellar paraganglioma associated with hypopituitarism.

A 37-year-old with a history of postpubertal arrest of sexual development and delayed growth was found to have an enlarged sella turcica. The clinical and biochemical features were consistent with hypopituitarism. A tumor was removed transsphenoidally that, through light microscopy, histochemistry, and electron microscopy, proved to be a paraganglioma. We report the possible origin of intrasellar paraganglioma, as well as the pathogenesis of hypopituitarism.

Adult↗

PubMed1987

[Malignant paraganglioma of the retroperitoneal space developing with increased arterial pressure].

Brief literature data on clinico-morphologic manifestation of retroperitoneal paraganglioma and its differential diagnosis with ectopic pheochromocytoma is presented. A female 31-year old patient is described with a rapid growth of retroperitoneal neoplasm and a concomitant increase of arterial blood pressure, first paroxysmal and then permanent. After the tumor excision (10 X 13 X 16 cm in size), not connected with the adrenal, the blood pressure recovered. The morphologic study provided the evidence for malignant paraganglioma different from ectopic pheochromocytoma in structural polymorphism and small size of neurosecretory granules. The arterial blood pressure increase is suggested to be due to tumor compression on the left kidney vessels.

Adrenal Gland Neoplasms↗

PubMed1985

[A non-secreting bladder paraganglioma. A case report].

The authors report the case of a 43 year old patient hospitalized for hematuria extending over eight years. Cystoscopy revealed an endovesical lesion which was resected and diagnosed as a non-secreting vesical paraganglioma. At operation, the cervical localization of the lesion was treated by total cystoprostatectomy. Starting out from this case report, the authors discuss the difficulties of diagnosing non-secreting vesical paragangliomas, the difficulties of assessing their malignancy and therefore the difficulties of treating them.

Humans↗

PubMed1985

[Nasopharyngeal paraganglioma extending to the middle cranial fossa].

A case report of a 15-year-old boy with a nasopharyngeal paraganglioma extended to middle cranial fossa is presented. We are reporting the fifteenth patient with a primary nasopharyngeal paraganglioma and reviewing the pertinent literature. The unusual initial presentation of oculomotor palsy and response to radiotherapy is described. The possible origin and radiosensitivity of this tumor discussed. Although the choice of therapy for this tumor remain controversial, the preferred treatment has been radiotherapy, in conjunction with surgical procedures for the mass of middle cranial fossa.

Adolescent↗

PubMed1985

[Arterial hypertension caused by mediastinal paraganglioma. Description of a case and review of the literature].

The Authors describe a case of artery hypertension caused by the secretion from the mediastinal paraganglioma and they emphasize the importance of correct diagnostic approach to patients with hypertension. This particular case is extremely rare, in literature, in fact, there are only 25 known cases of paraganglioma arising from the sympathetic trunk in the posterior mediastinum.

Adult↗

PubMed1981

Paraganglioma of the orbit - an exercise in diagnosis. A case report.

A case is described of a child presenting with an extremely large orbital tumour, which had an alveolar pattern on histological examination. The differential diagnosis, which included alveolar rhabdomyosarcoma, alveolar soft-part sarcoma and non-chromaffin paraganglioma, could only be made on electron microscopic examination. Exact diagnosis was important because of prognostic and therapeutic implications. The presence of neurosecretory granules in tumour cells was demonstrated on electron microscopy, confirming the diagnosis on non-chromaffin paraganglioma, a benign tumour which is extremely rare in this site.

Child↗

PubMed1982

[Multiple paragangliomas of the neck localized in the thyroid region. Papillary thyroid cancer associated with parathyroid adenoma].

A 58 years-old woman has had a goiter for many years. She was treated by neck irradiation for "lymphadenopathy" 20 years-ago. She is now operated on for bilateral carotid body paragangliomas and a similar tumor of the thyroid gland near the midline. She also presents a papillary carcinoma of the left thyroid lobe with lymph node metastasis and a chief-cell parathyroid adenoma. The diagnosis of thyroid paraganglioma is discussed. Then the authors raise the hypothesis of radiation-induced papillary carcinoma. They try to set a link between thyroid tumors and parathyroid adenoma.

Adenoma↗

PubMed1983

Diagnosis of jugular paraganglioma by radionuclide angiography: concise communication.

Jugular paraganglioma is a highly vascular tumor, slowly growing, extending into the surrounding structures and causing otologic and/or neurologic symptoms according to its location in the jugular bulb region or the middle-ear. In our study, modified vertex and posterior head scintiangiography was used in seven cases. Scintiangiography was positive in all seven, whereas concomitant radiographic studies were limited: four of the seven gave positive findings by transmission computerized tomography (TCT). Only four patients underwent angiography, with positive results in two. Hypocycloidal tomography was positive in three cases. However, some radiographic studies, particularly TCT, may be useful in detecting local extension, bone destruction, and soft-tissue infiltration. Radionuclide angiography proved highly reliable and should be used initially whenever a jugular paraganglioma is suspected.

Aged↗

PubMed1984

Meta-[I-131]iodobenzylguanidine uptake in a nonsecreting paraganglioma.

In a patient with a paraganglioma at the carotid bifurcation, intense uptake of meta-[I-131]iodobenzylguanidine (I-131 MIBG) in the tumor was found. There was no clinical or biochemical evidence for catecholamine secretion by the tumor, although analysis of the tissue revealed that catecholamine biosynthesis took place. We conclude that accumulation of I-131 MIBG may occur in a paraganglioma, but does not necessarily indicate endocrine activity of the tumor.

3-Iodobenzylguanidine↗

PubMed1983

[A case of paraganglioma of the urinary bladder].

A very rare case of paraganglioma of the bladder is reported. The patient was a 51-year-old man. He was admitted to our hospital on June 18th, 1981, with the complaint of gross hematuria. He had no attack of hypertension and we could not find in him any parasympathetic symptom except hematuria. Upon urological examination, he was suspected to have stage B cancer of bladder. He received partial cystectomy with uneventful course during the operation on June 30th, 1981 and was discharged on the 15th postoperative day. The postoperative histological diagnosis was paraganglioma of the urinary bladder. He was confirmed to have normal levels of catecholamine and its metabolites in the urine after 4 months postoperatively. At present, he is asymptomatic.

Catecholamines↗

PubMed1983

[A case of paraganglioma of the urinary bladder].

Herein we report a case of primary paraganglioma of the urinary bladder. A 21-year-old woman was admitted to an emergency hospital, because of gross hematuria, dysuria and complete urinary retention. Pelvic CT scan and ultrasonic examination revealed a bladder tumor and coagulated blood mass, then she was referred to our clinic for further treatment. On cystoscopy a dark brown lobular tumor was seen on the anterior wall. The bladder tumor was removed by partial cystectomy. The operative specimen measured 6 X 4 X 3 cm and weighed 50 g. Histological examination showed it to be a paraganglioma of the urinary bladder, which was chromaffin positive. Her serum and urinary catecholamine level were within the normal range after operation. She is now ten months postoperative, free from hematuria, and showing no other symptoms or signs of disease including metastasis.

Adult↗

PubMed1984

[Intravascular growth of the tympanojugular paraganglioma in the internal jugular vein].

The different forms of intrajugular extension of tympanojugular paraganglioma, their symptoms, signs, diagnosis, differential diagnosis and hormonal activity are described. The craniocervical venous system requires particular emphasis in descriptions of surgical technique. Intravascular growth of a paraganglioma deserves particular attention because it may be overlooked, and it may be necessary to take precautions during surgical resection.

Adult↗

PubMed1984

Paraganglioma of the common hepatic duct.

A case of paraganglioma arising in the common hepatic duct is reported. The patient presented with obstructive jaundice. At operation, a soft mass, 5 X 2 X 1.8 cm, was found firmly adherent to the intraluminal surface of the common hepatic duct. At cholecystectomy, exploration of the common hepatic duct was performed and the mass was partially removed. T-tube choledochostomy and operative cholangiography were performed. The final pathological report was paraganglioma of the common hepatic duct. The patient was clinically improved on discharge.

Bile Duct Neoplasms↗

PubMed1981

Gastric tumors in patients with pulmonary chondroma or extra-adrenal paraganglioma: an ultrastructural study.

The histogenesis of a distinctive metastasizing intramural gastric tumor found in patients with extra-adrenal paragangliomas, pulmonary chondromas, or both, is unknown. By light microscopy, it has appeared to be of smooth-muscle derivation, and it has been interpreted as being epithelioid leiomyosarcoma. For further clues to its nature, we studied three examples by electron microscopy (two obtained from patients with extra-adrenal paragangliomas and one from a patient with pulmonary chondroma). Ultrastructurally, they were characterized by interdigitating cytoplasmic processes, plasma membrane-associated dense patches, an incomplete basement membrane, junctional complexes, randomly oriented filaments without periodicity, cytoplasmic dense bodies, pinocytotic vesicles, clustering of mitochondria, and rare cilia-features of normal smooth muscle or of smooth-muscle tumors with classic histologic patterns. Thus, the findings suggest that the three tumors we studied are of smooth-muscle derivation.

Adolescent↗