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At least 793 records · Page 44Linked to original sources
PubMed1979

Interactions of complement with the red-cell membrane.

Interactions of the complement components with the red-cell membrane are, as delineated, many and complex. Much is known about the nature of the complement components that take part in these interactions, but relatively little is known about the membrane or the components of the membrane with which they interact. Such understanding will be essential if we are to be able to explain the great resistance to complement lysis shown by normal red cells or the abnormalities that result in increased or decreased interacition of complement with abnormal red cells.

Antibodies↗
PubMed1979

Electron-dense subepithelial glomerular deposits in Henoch-Schönlein purpura syndrome.

A case of Henoch-Schönlein purpura (HSP) with renal lesions is presented. The clinical, laboratory, and morphologic findings revealed features commonly described in HSP. A renal biopsy revealed diffuse, generalized, proliferative glomerulonephritis. The unusual findings in this case were numerous electron-dense subepithelial deposits ("humps") and a few small intramembranous deposits in the glomerular capillaries without deposits in the mesangium, mimicking those of acute poststreptococcal glomerulonephritis. The electron-dense deposits were well correlated with deposits of IgG, IgA, C3, C4, C1q, and fibrin-fibrinogen demonstrated by immunofluorescent microscopy.

Child↗
PubMedDate not supplied

The biological role of the complement system and the clinical importance of complement measurements.

Properties of serum proteins belonging to the complement system, two pathways of the complement activation (classical and alternative pathway) as well as the physiological role of the complement system are discussed. Complement has essential importance in some physiological processes: In the induction of the humoral immune response, in the elimination of immune complexes and in the protection against bacterial and viral infections. After a short discussion of the genetics of the complement system, the principle and possibilities of clinical applications of the complement measurements are described. Finally, different approaches to the therapeutic manipulation of the complement system are discussed.

Angioedema↗
PubMed1979

[Circulating immune complexes and necrotizing vasculitis].

55 patients with necrotizing and with various forms of lymphocytic vasculitis were investigated for the presence of vascular deposits of immunoglobulins (Ig) and C3 by immunofluorescence testing of skin biopsies and with a 125I-Clq-binding assay for the presence of circulating immune complexes. Vascular deposits of Ig and C3 were found frequently both in patients with necrotizing and with lymphocytic vasculitis. In contrast, C1q binding activity was found almost exclusively in sera of patients with systemic necrotizing vasculitis. With one exception, all sera with C1q binding activity were from patients with vascular deposits of Ig and C3. The implications of these findings for our understanding of the development of system involvement in necrotizing vasculitis are discussed.

Antigen-Antibody Complex↗
PubMed1985

[Complement fixation activity of immunoglobulin G in ethylene glycol solutions].

Affinity of IgG to the first complement factor C1q was found out to increase in 10-30% glycol solutions. Analytical ultracentrifugation and turbidity data showed that IgG molecules do not aggregate at such concentrations of glycol. The complement-binding effect may be caused by a conformational transition in the IgG molecules.

Animals↗