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At least 793 records · Page 44Linked to original sources
PubMed2002

From pain research to pain treatment: role of human pain models.

There is no objective measure of pain; we can however measure different aspects of the pain perception. Earlier experimental pain models often only involved induction of cutaneous pain. Recently new experimental models have been developed eliciting deep muscle and visceral pain that may more closely resemble the clinical pain condition. It is imperative to use multi-modal and multi-structure pain induction and assessment techniques, as a simple model cannot describe the very complex and multi-factorial aspects of clinical pain. The importance of peripheral and central hyperexcitability for acute and chronic pain has been demonstrated in animals and to some extent in humans. But in spite of our immense knowledge we still do not know how to prevent and treat this hyperexcitability. Our understanding of nociceptive mechanisms involved in acute and chronic pain and the effects of anaesthetic drugs or combinations of drugs on these mechanisms in humans may also be expanded with experimental human models. This knowledge can then help us to develop and test therapeutic regimes in patients with acute and chronic pain.

Humans↗
PubMedDate not supplied

Effect of electronic dental anesthesia on pain threshold and pain tolerance levels of human teeth subjected to stimulation with an electric pulp tester.

The effect of electronic dental anesthesia on pain threshold and pain tolerance levels of human teeth subjected to stimulation with an electric pulp tester was evaluated. Subjects (n = 120) were randomly assigned to one of four experimental groups (baseline, placebo, square wave, and postsynaptic wave). Symptom-free right-sided maxillary incisor teeth were tested for anesthesia with an electric pulp tester. Electrostimulation significantly increased the pain perception threshold and pain tolerance level with both the square wave and postsynaptic wave. The postsynaptic wave was more effective than the square wave. Presented at the Satellite Symposium on Advances in the Management of Acute and Chronic Facial Pain associated with the 6th World Congress on Pain, Melbourne, Australia, 1990.

Adolescent↗
PubMedDate not supplied

Nurses' perceptions of their pain assessment skills, pain management practices, and attitudes toward pain.

Nursing pain assessments are influenced by the length of available tools, patient characteristics, patient pathology, concern about addictive behavior, and characteristics of the nurse. The relationship among these variables was explored in a sample of community hospital nurses (N = 59) and ONS members (N = 19). Although a number of interesting similarities were found in the two groups, age, professional and continuing education, and care setting appear to be related to differences in pain assessment practices. Implications for practice, research, and education include teaching nurses to: assess factors related to quality of life in the pain experience, assess and validate data from families, assess coping skills, and teach patients to use behavioral pain management strategies. The findings also suggest that further study is needed concerning the relationship between personal beliefs and experiences and the assessment and management of pain. Membership in professional organizations appears to be associated with comprehensive approaches to the assessment and management of cancer pain and should be addressed in further research.

Adult↗
PubMed1997

Coping strategies and laboratory pain in children with sickle cell disease.

Studies have found that coping strategies are significant predictors of pain report, health care use, and psychosocial adjustment in children with sickle cell disease (SCD); however, the mechanisms of the relationship are not clear. In this study, 41 children with SCD completed a laboratory pain task to analyze their pain perception under standardized conditions. Sensory decision theory analyses were used to analyze the pain perception data. Children and their parents also completed measures of coping strategies and adjustment. Hierarchical regression analyses controlling for the child's age indicated that children who reported using active cognitive and behavioral coping strategies had a lower tendency to report pain during the laboratory pain task. Results are discussed in terms of the utility of using laboratory pain models with children and the need for future intervention studies to target coping strategies in children with SCD pain.

Adaptation, Psychological↗
PubMed2000

The myth of the 'Mediterranean syndrome': do immigrants feel different pain?

There is a long tradition of assuming other way of pain perception in immigrants than in natives. This article discusses profound methodological problems to assess pain perception and behaviour between people of different cultural background, existing epidemiological data are reviewed and results of an own study regarding chronic pain syndromes are included. There is no clear evidence for existing differences in pain syndromes between natives and immigrants of any kind. In difference, there is some evidence, that clinicians and health workers frequently have other impressions about pain intensities as the patients themselves.

Chronic Disease↗
PubMed1998

Sex differences in temporal summation but not sensory-discriminative processing of thermal pain.

Gender differences in experimental pain sensitivity have been widely investigated, and the results generally indicate that females exhibit greater sensitivity to noxious stimuli than males. However, results using thermal pain procedures have been inconsistent, with some studies reporting greater responses among females and other studies reporting no gender differences. The present study investigated gender differences in thermal pain perception using several different psychophysical procedures. Twenty-seven females and 22 males underwent thermal testing, including: determination of thermal pain threshold and tolerance, a thermal discrimination procedure, real-time magnitude estimates of heat pulses, and temporal summation of thermal pain. The results indicated lower thermal pain threshold and tolerance and greater temporal summation of thermal pain among females, but no gender differences in thermal discrimination or real-time magnitude estimates of discrete heat pulses. These findings suggest that gender differences in thermal pain perception may be more robust for sustained, temporally dynamic thermal stimuli with a strong C-fiber component.

Adult↗
PubMed2003

History of neuroaugmentative procedures.

Neuroaugmentation, the use of chronic stimulation of the brain and spinal cord for pain management, developed during the past 30 years. It evolved, however, from concepts of pain treatment that were based on observations and clinical experience dating back an additional two decades or more. The appreciation of the role of the extralemniscal system and descending influences from the brain in modulation of pain perception led to the Melzack-Wall gate theory. The concept proposed in that theory, that pain perception could be lessened by increasing activity in neural structures not associated with pain, led to chronic stimulation of deep brain and spinal cord as a modality for the management of chronic pain. Both brain and spinal structures emerged as targets for neuroaugmentation.

Animals↗
PubMed2004

Biomechanics of musculoskeletal pain: dynamics of the neuromatrix.

Pain, due to mechanical stimuli, is a normal, indeed healthy, response of animals to potential or actual damage to tissues. Mammals in general, and humans in particular, have evolved a highly sophisticated system of pain perception, which is characterized in humans by complementary but distinct neural processing of the intensity and location of a noxious stimulus, and a motivational/emotional or affective response to the stimulus. The peripheral and central neurons that comprise this system, which has been called the 'neuromatrix', dynamically (temporally) respond and adapt to noxious biomechanical stimuli. However, phenotypic variability of the neuromatrix can be large, which can result in a host of musculoskeletal conditions that are characterized by altered pain perception, which can and often does alter the course of the condition. This neural plasticity has been well recognized in the central nervous system, but it has only more recently become known that peripheral nociceptors also adapt to their altered extracellular matrix environment. This work reviews the biomechanics of pain focusing on the relevant stimulus that initiates responses by nociceptors to the cognitive perception of pain.

Biomechanical Phenomena↗
PubMedDate not supplied

Pain management 2: the use of pyschological approaches to pain.

This article is the second of a two-part series looking at the psychological and social factors which affect pain perception. The first article (Vol 10(14): 903-11) examined neurophysiological and psychological factors of pain perception. This article considers the importance of the nurse-patient interaction in the management of patients' pain. It outlines the adoption of several psychological approaches which could be utilized by nurses when dealing with patients in pain. The need to encourage a feeling of control over pain is discussed in relation to the use of patient-controlled analgesia and the development of positive coping skills. The value of good communication skills is emphasized as being essential in encouraging patients in pain to utilize these psychological approaches.

Humans↗
PubMed2005

Implicit operant learning of pain sensitization.

Operant conditioning mechanisms have been demonstrated to be important in the development of chronic pain behavior, but it is not clear whether and how this extends to pain perception itself. The fear-avoidance theory suggests that hypersensitivity may be induced by anticipatory pain avoidance learned through negative reinforcement by acute reductions of pain and fear. But the precise mechanism of the assumed 'sensory decalibration' has not been specified. The present study with healthy subjects investigated whether operant learning of enhanced short-term sensitization may provide the 'proximal' mechanism and whether gradual learning of hypersensitivity can take place without subjects' awareness. We used an experimental model of implicit learning based on a behavioral adjustment method of sensitization measurement developed and validated previously, combining it with standard methods of operant response shaping of increased sensitization or habituation. Results indicated that operant discrimination training with reinforcement of short-term sensitization in the seconds range can produce gross up or down changes in sensitivity within an hour without subjects' awareness of reinforcement contingencies. Consequently, implicit learning of enhanced pain sensitization may be a suitable model to investigate operant plasticity of pain perception in addition to basic sensory and neuronal mechanisms and to link these with the clinical construct of pain-fear avoidance.

Adaptation, Physiological↗
PubMed2002

Gender, anxiety, and experimental pain sensitivity: an overview.

Our objective was to review human experimental studies to see if anxiety had a differential impact on the pain perceptions of men and women. We searched MEDLINE and PsycINFO for studies of anxiety and pain sensitivity in men and women published from 1966 to 2001. Research indicated that women are more sensitive to pain than men, and that anxiety may be partly responsible for the observed differences. Anxiety may also differentially affect men's and women's report of pain. Anxiety may be an important factor when considering sex differences in pain perception and warrants further investigation.

Anxiety↗
PubMed2003

Assessment and management of pain in infants.

Infants, including newborn babies, experience pain similarly and probably more intensely than older children and adults. They are also at risk of adverse long term effects on behaviour and development, through inadequate attention towards pain relief in early life. However, the issue of analgesia in young babies has been largely neglected in most clinical settings, despite subjecting them to painful diagnostic and therapeutic procedures. Several therapeutic and preventive strategies, including systemic and local pharmacological and non-pharmacological interventions, are reported to be effective in relieving pain in infants. A judicious application of these interventions, backed by awareness and sensitivity to pain perception, on the part of the caregivers is likely to yield the best results. This article is a review of the mechanisms of pain perception, objective assessment, and management strategies of pain in infants.

Analgesics↗
PubMedDate not supplied

Pain management 1: psychological and social aspects of pain.

This two-part article presents psychological and social factors which affect pain perception and response and the implications of these for nursing practice. In this article, the complex interactions between neurophysiological and psychological factors are outlined and theories of pain perception and ways in which the pain experience can be modulated are presented. The role of psychological factors, attitudes, beliefs and expectations of both patient and practitioner, pain behaviours and ability to cope are discussed. In the second part, these are further elaborated with particular reference to the nurse-patient interaction. The use of psychological approaches to augment clinical practice, such as education, reduction of anxiety and improving coping ability, are suggested. Finally, the importance of communication skills in pain management is addressed.

Acupuncture Therapy↗
PubMed2005

Acute and persistent pain modulation of attention-related anterior cingulate fMRI activations.

The anterior cingulate cortex (ACC) has been implicated in both sustained attention (SA) and pain perception. Nonetheless, only a small body of literature has examined the relationship between SA and pain perception. This study utilized fMRI to examine activation patterns that emerged in the ACC in healthy participants and participants with chronic pain (due to osteoarthritis (OA) of the knee) while completing a sustained attention task with and without exposure to an acute painful stimulus. Independent component analysis (ICA) was used to determine groups of voxels within the ACC that covaried with performance on the SA task completed with and without exposure to a painful stimulus. In all participants, two distinct spatial patterns within the ACC were isolated that reflected (1) disrupted ACC activity when a painful stimulus was applied, or (2) emergent ACC activity when a painful stimulus was applied. In the healthy group, there were broadly distributed clusters of voxels within the ACC that were modulated by painful stimulation. But in the chronic pain group, a discrete focal region of the ACC was modulated by pain. These results demonstrate that ACC activity is modulated differently during tasks of SA and pain, and that acute pain in healthy participants and participants with chronic pain result in significantly different ACC activation patterns.

Aged↗
PubMed2005

The A118G single nucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans.

Responses to painful stimuli are characterized by tremendous interindividual variability, and genetic factors likely account for some proportion of this variability. However, few studies have identified genetic contributions to experimental pain perception in humans. This experiment investigated whether the A118G single nucleotide polymorphism of the mu-opioid receptor gene ( OPRM1 ) was associated with responses to three different experimental pain modalities in a sample of 167 healthy volunteers (96 female, 71 male). Responses to thermal, mechanical, and ischemic pain were assessed in all subjects, and genotyping of OPRM1 was performed, which revealed that the rare A118G allele occurred in 24 females (25%) and 12 males (17%). Statistical analyses indicated that subjects with a rare allele had significantly higher pressure pain thresholds than those homozygous for the common allele. Also, a sex by genotype interaction emerged for heat pain ratings at 49 degrees C, such that the rare allele was associated with lower pain ratings among men but higher pain ratings among women. These data indicate an association of a common single nucleotide polymorphism of OPRM1 with mechanical pain responses and that this genotype may be associated with heat pain perception in a sex-dependent manner. This study examines the association of the A118G SNP of OPRM1 to experimental pain sensitivity. The results indicate that the rare allele is associated with higher pressure pain thresholds. These results support previous contentions that OPRM1 may be a pain-relevant gene; however, replication of these findings is needed.

Adult↗
PubMed1988

Pain insensitivity in schizophrenic patients. A surgical dilemma.

Some schizophrenic patients have decreased pain perception while others have decreased pain expression. These factors frequently lead to difficulties in the diagnosis of acute intra-abdominal surgical emergencies. Increasingly large numbers of schizophrenic patients are being cared for in the community. It is therefore imperative that surgeons be acutely aware of the diagnostic dilemmas presented by this group of patients so that misdiagnosis is avoided and appropriate surgical therapy is instituted in a timely manner.

Abdomen, Acute↗
PubMed2002

Cortical representation of first and second pain sensation in humans.

Single painful stimuli evoke two successive and qualitatively distinct sensations referred to as first and second pain sensation. Peripherally, the neural basis of this phenomenon is a dual pathway for pain with Adelta and C fibers mediating first and second pain, respectively. Yet, the differential cortical correlates of both sensations are largely unknown. We therefore used magnetoencephalography to record and directly compare first and second pain-related cortical responses to cutaneous laser stimuli in humans. Our results show that brief painful stimuli evoke sustained cortical activity corresponding to sustained pain perception comprising early first pain-related and late second pain-related components. Cortical activity was located in primary (S1) and secondary (S2) somatosensory cortices and anterior cingulate cortex. Time courses of activations disclosed that first pain was particularly related to activation of S1 whereas second pain was closely related to anterior cingulate cortex activation. Both sensations were associated with S2 activation. These results correspond to the different perceptual characteristics of both sensations and probably reflect different biological functions of first and second pain. First pain signals threat and provides precise sensory information for an immediate withdrawal, whereas second pain attracts longer-lasting attention and motivates behavioral responses to limit further injury and optimize recovery.

Adult↗