PubMed1999
As there are limitations in WB-MR angiography, so there are limitations in BB-MR angiography. Vessel morphology is visualized by means of the innermost nonattenuated layer of tissue, which, under ideal conditions, coincides with the luminal surface of the vessel wall. Vessel morphology may be depicted inaccurately whenever a portion of the vessel wall is undetectable with the MR imaging technique used. In such cases, vessel segments with exaggerated lumen diameter may result at locations where tissues with either a very short T2 or a low proton density are present. Another phenomenon that could potentially degrade the accuracy of vessel depiction with BB techniques is the effect of slowly flowing blood near the vessel walls. Residual blood signal would result in apparent vessel narrowing. Preliminary clinical experience in the brain, however, suggests that this adverse effect is less prominent with a turbo-SE-based BB technique than with a TOF WB technique. BB-MR angiography data sets may also present image postprocessing difficulties arising from the isointensity between the vessels and other dark structures such as bones and air-filled cavities. A limitation that is more specific to hybrid-SE-based BB-MR pulse sequences, particularly for very high spatial resolution applications, stems from the comparatively high RF specific absorption rates that result from the intensive use of 180 degrees refocusing pulses. GRASE-based BB-MR techniques that generate a fraction of the RF energy constitute a promising alternative for very high spatial resolution applications. In summary, to be effective, a BB technique must produce strong signal attenuation from flowing spins, ideally to the level of the baseline noise. Simultaneously it should produce good depiction of tissues with the comparatively short T2s characteristic of vessel walls and muscle, hence the need to operate with the shortest possible TE. Finally, high spatial resolution combined with fast data acquisition are requisites for imaging small vessels in the presence of motion, such as the carotid arteries. The flow properties of BB-MR angiographic sequences that meet these criteria were reviewed for different anatomic locations.