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Effect of consumption of food cooked in aluminium or stainless-steel pots on Bangladeshi children with calcium-deficient rickets: an eight month trial.

The putative role of aluminium intake in young Bangladeshi children (1.5 to 4 years of age) with calcium-deficient rickets was evaluated in a non randomised controlled eight month trial. The effects of aluminium or stainless-steel cooking pots on bone metabolism were assessed by measuring blood calcium, phosphorus, alkaline phosphatase, parathyroid hormone, 1,25 dihydroxy vitamin D, aminoterminal propeptide of type 1 collagen (PINP), cross-linked carboxyterminal telopeptide of type 1 collagen (ICTP), aluminium and albumin, and by analysis of wrist radiographs. In both groups, blood alkaline phosphatase, 1,25 dihydroxy vitamin D and aluminium decreased significantly, white serum albumin increased (p < 0.01). These results suggest that the nutrition may well be of major importance, whereas the role of aluminium appears to be insignificant.

Aluminum↗

Study of serum intestinal alkaline phosphatase isoenzyme in correlation with the ABO blood group system and secretory status in ulcer patients.

Serum alkaline phosphatase (AP) electrophoretic phenotype and the level of its activity inhibited by l-phenylalanine 5 mM (the stereospecific inhibitor of the intestinal AP isoenzyme) were investigated in 312 subjects (132 healthy controls, 89 patients with duodenal ulcer, 31 with gastric ulcer and 60 family members of the duodenal ulcer patients) in correlation with the ABO blood group system and secretory status. In the control subjects, those with A(II) blood group showed a predominance of the p degrees electrophoretic phenotype while phenotypes p+ and p++ were more frequent in the controls with O(I) and B(III) blood groups and in the secretory ones. In the patients with duodenal ulcer and their family members the frequency of phenotypes p+ and p+ was significantly higher than in the controls. The same distribution of frequencies was observed for the level of AP activity inhibited by l-phenylalanine. The results obtained are discussed in the light of a possible genetic linkage.

ABO Blood-Group System↗

[Alanine and aspartate transaminase and acid and alkaline phosphatase activities in the blood serum in relation to the protein and energy levels in the pigs' feeds].

The activity of alanine and asparagine transaminase and of acid and basic phosphatase was studied in blood serum of 72 porkers of the Polish large-white breed, fed with PT-2 feeds of various protein and energy levels. It was found that the activity of both transaminases in blood serum depended on the protein-energy level of the diet. The activity of transaminases was not found to increase at the protein content compatible with the standard and at increased energy value of the feeds, whereas the same protein level and decreased energy amount caused a decrease in the activity of alanine and asparagine transaminase. At a decreased protein content in the diet the activity of transaminases in plasma was lower than in the porkers on a diet containing protein according to the standard. An increased amount of energy with a decreased protein content in the diet did not affect the activity of asparagine transaminase but slightly stimulated alanine transaminase, whereas a decrease in the amount both of energy and protein in the diet caused an increase in the activity of both transaminases. Acid and basic phosphatase were not adequate indices of changes in the organism of the porkers in relation to the protein-energy level of their diet.

Acid Phosphatase↗

Honey ameliorates influence of hemorrhage and food restriction on renal and hepatic functions, and hematological and biochemical variables.

The objectives were to assess the effects of various diets, including total food restriction with 50% honey feeding, total food restriction with 50% dextrose feeding or adlibitum (control group) commercial regular diet, on the hematology and biochemical variables, and to assess the effects of the various diets on the influence of acute blood loss on the same parameters. Thirty Sprague-Dawley albino rats were divided into three groups, 10 rats each: group A, fed a commercial regular diet; group B, total food restriction with 50% dextrose feeding; and group C, total food restriction with 50% honey feeding. After 8 days of feeding, rats were subjected to acute blood loss (6 ml/kg) and blood investigations were performed. After acute blood loss, the same feedings were continued for a further 8 days and the blood tests were repeated at day 8 post-bleeding. Total food restriction with 50% dextrose feeding compared with commercial regular diet reduces hematological and biochemical variables. Total food restriction with 50% honey feeding compared with total food restriction with 50% dextrose feeding causes a greater reduction in fasting blood glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and triacylglycerol. Acute blood loss causes elevation of white blood cells, lymphocyte percentage, fasting blood sugar, blood urea nitrogen, alkaline phosphatase and triacylglycerol, and a reduction in serum albumen, protein, cholesterol, AST, serum creatinine and hemoglobin; the results are significant (P<0.05) concerning fasting blood glucose, AST, alkaline phosphatase, serum albumin and protein. A significant reduction in fasting blood glucose, white blood cells, BUN, AST, ALT, alkaline phosphatase and triacylglycerol, and a significant elevation of hemoglobin and serum albumin are obtained after acute blood loss in rats on total food restriction with 50% honey feeding as compared with the other two groups. Total food restriction with 50% honey feeding increases serum albumin, serum protein, fasting blood glucose, and causes lower reduction in hemoglobin as compared with the other groups. Conclusively, honey feeding during total food restriction significantly modifies and ameliorates biochemical and hematological changes observed after acute blood loss. This will pave the way to use honey as part of bleeding management and during a food restriction regimen.

Alanine Transaminase↗

[On the effect of imipramine on blood composition, glucose level and alkaline phosphatase activity of leucocytes in non-emotive Wistar rats and animals of inbred TMB strain (author's transl)].

The acute effect of imipramine (Tofranil) on the composition of blood, blood sugar level and activity of alcaline phosphatase in leucocytes was studied in an experiment with 30 adult male TMB-rats. These findings were compared with those in non-emotive Wistar rats (the scores without stress and under the condition of psycho-pharmacological effects) as far as corresponding motor activity in both strains was concerned. Hematological findings in a non-stress condition are considered to be identical in both strains studied. Under the acute effect of imipramine only about 50% of the compared parameters are similar to each other. The differing course of the hematological reaction within the other 50% points to the presence of non-identical control mechanisms in both strains.

Alkaline Phosphatase↗