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At least 811 records · Page 45Linked to original sources
PubMed1977

Effect of topical application of fluoride on the healing rate of experimental calvarial defects in rats.

The effect of the local application of fluoride on the healing process of experimental calvarial defects in rats was studied. A total of 172 male rats, 6 weeks old, weighing 100 to to 160 gm, were used in the experiments. Two standard defects, each approximately 2.8 mm in diameter, were drilled through the parietal bones on either side of the sagittal suture. In one half of the rats that were operated on, a 20-minute topical application of 2% acidulated (0.1 M H3PO4) NaF solution was used. The control rats underwent the same local treatment with saline solution. Groups of 9 to 13 rats were killed at 4, 5, 7, 9, and 12 weeks after the operation. Radiographs of each calvarium demonstrated the healing area in the bone. Linear bone apposition was measured from histological sections. Fluoride content was determined in ashed calvaria with an Orion electrode. The results indicate that all fluoride-treated groups had increased bone gain compared with the control group. The histological examination revealed no major differences in the structure, number, and size of the cells of the newly formed bone in either group. The mean fluoride concecreased until completion of the experiment.

Administration, Topical↗
PubMed1983

Effect of topical application of stannous fluoride, stannous chloride and stannous tartrate on rat caries.

Topical application of 10 mM aqueous solutions of stannous fluoride inhibited caries in rats to a higher degree than 20 mM sodium fluoride, although the difference was not statistically significant. Furthermore, stannous fluoride reduced the number of Strep. mutans in plaque significantly; stannous ions have an antibacterial effect. Stannous chloride and stannous tartrate did not reduce caries in the rats, probably because of the low concentrations of available stannous ions in these solutions at low pH. The high concentration of stannous ions in solutions of stannous fluoride is probably partly due to the reduced hydroxide formation resulting from the buffering effect of HF formed at low pH in this solution.

Administration, Topical↗
PubMed1999

Fluoride concentration in whole saliva and separate gland secretions after topical treatment with three different fluoride varnishes.

Fluoride concentration in whole saliva and in separate gland secretions was determined after a single application of each of 3 different fluoride varnishes with contrasting levels of fluoride in a randomized crossover design. The study group comprised 8 healthy schoolchildren aged 10-12 years treated with A: Bifluorid 12 (6% F); B: Duraphat (2.26% F); and C: Fluor Protector (0.1% F). Unstimulated and stimulated whole saliva, as well as stimulated parotid and submandibular-sublingual saliva, were collected at baseline and 1, 6, 12, and 24h after the varnish treatments. The fluoride concentrations were determined with an ion-selective electrode. Time- and dose-dependent concentration curves were obtained in all the collected secretions, A > B > C. In whole saliva, the fluoride levels were significantly elevated (P<0.01) 1 h after the A and B varnish applications compared with baseline, while the increase was insignificant for varnish C. Similar patterns were unveiled in the parotid and submandibular-sublingual secretions, although the increase in fluoride concentration was modest. The elevated levels did not exceed 6 h for any of the varnish tested. The results of this study suggest a correlation between the concentration of fluoride of the varnish and fluoride levels obtained in saliva after application.

Calcium Fluoride↗
PubMed1977

The effect of topical application with an organic and inorganic fluoride compound on the inhibition of dental plaque in humans.

Accumulation of dental plaque for 3 and 7 days respectively was determined by calculating the difference between the postcollection and precollection weights of enamel slabs attached to orthodontic bands cemented to the upper first molars of 3 subjects. Pretreatment of the enamel slabs with amine-fluoride or -chloride respectively-at an equivalent amine concentration-prevented plaque deposition on the slabs, whereas pretreatment with sodium monofluorophosphate was less effective. The fluoride concentrations of all fluoride-pretreated enamel slabs were similar. No convincing demonstration of significant differences between the treatments could be predicted in view of the discrepancy in results at the 3- and 7-day test periods.

Adult↗
PubMed2002

Treating root-surface caries.

This article summarizes the effectiveness of restorative materials used to restore root surfaces, the mechanisms by which these materials reduce caries, and placement techniques for restoring root-surface lesions. Patients may be classified into low, medium, and high caries risk groups for root caries, and specific dental restorative material recommendations are made for each category. Effective plaque control, xylitol-containing chewing gums, antimicrobial agents, fluoride-releasing restorative materials, topically applied fluoride, and fluoride-containing toothpastes provide maximum protection for the high caries risk patient.

Age Factors↗
PubMed1980

A clinical caries evaluation of a stannous fluoride prophylactic paste and topical solution.

A three-yr caries study was conducted to evaluate an SnF2 prophylactic paste and topical solution professionally applied to children on a semi-annual basis. The topical solution imparted a significant decrease in caries incidence while the prophylactic paste was without significant effect. The combination of treatments was not significantly more effective than the topical application alone.

Adolescent↗
PubMed1976

In vivo uptake of fluoride by surface enamel of cleaned and plaque-covered teeth.

Utilizing a newly developed biopsy method, the F uptake in the outer 3 mum of enamel from a single topical application of neutral NaF or amine F solution was tested on cleaned and plaque-covered premolars in 12- to 14-year-old children. Cleaned teeth treated with neutral NaF acquired only insignificant amounts of F. The presence of plaque seemed to enhance the deposition of F in surface enamel. The findings were discussed in relation to the possible mechanisms of action of topically applied fluorides. Topical treatments with amine F increased surface enamel F considerably more than the NaF. The F uptake was similar in cleaned and plaque-covered teeth. It was suggested that the usually performed plaque-removing procedures prior to topical F applications are superfluous and may even be disadvantageous.

Adolescent↗