Maternal nutrition during pregnancy as it affects infant growth, development and health.
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Adolescent↗
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Results for “Infant Development”
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Development of vernier acuity in infants.
The development of vernier acuity in human infants aged 2-9 months was assessed by a preferential looking procedure using a vernier-motion display. The displacement of vernier offsets gives the impression of motion only when the vernier offsets are detected. Grating acuity of the same group of infants was also measured by a preferential looking procedure. Vernier acuity was found to be superior to grating acuity only after 3 months of age. This superiority of vernier acuity was compared with the superiority of stereoscopic acuity to grating acuity. The two classes of hyperacuity proved to be almost equivalent in terms of their developmental time-courses. A common physiological basis for the development of hyperacuities is suggested.
Child Development↗
Applicability of BSID-II in diagnosing developmental delay at Kaohsiung area.
The purpose of this study was to investigate the applicability of BSID-II in diagnosing children with developmental delay in Kaohsuing area. Five hundred and forty-four children, all who were patients of Developmental Delay Clinic of Kaohsuing Medical University, participated in this study. The instrument of this study was the Bayley Scales of Infant Development--second edition (BSID-II), the primary value of which was in diagnosing developmental delay and planning intervention strategies. The standardization and statistical properties of BSID-II made it one of the best measures of infant development available. The findings as follows: (1) the alpha coefficients were between .95 and .99, which were higher than data on manual of BSID-II; (2) the reproducibilities, which were different with each examiner, were between .9503 and .9633, that were good enough to be a developmental scale; (3) Standard Errors of Measurement were between 2.8589 and 3.8206. It was a restricted sample so that these also were lower than the data on manual of BSID-II. This evidence shows BSID-II is a highly reliable instrument of developmental assessment at Kaohsuing area. A special norm for developmentally delayed children and quality control of examiners are suggested.
Child, Preschool↗
Extremely immature infant who developed clitoromegaly during the second month of her postnatal life probably due to frequent whole blood transfusion from an adult male.
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Blood Donors↗
Genetic and environmental influences on atopic immune response in early life.
The purpose of our study was to carry out a prospective follow-up of 114 newborns at term (including three pairs of twins), regarding clinical manifestations for atopy during the first year of life. Their IgE levels in cord blood samples, at 3, 6, 9 and 12 months of age were measured and the influence of race, sex, breast-feeding, maternal smoking, family income, month of birth, family history and personal manifestations of atopic disease were evaluated. Total serum immunoglobulin E was quantified by microparticle enzyme immuno-assay (MEIA). The study group consisted of 60 (53%) male neonates, 67 (59%) Caucasians and 47 (41%) blacks. In the clinical follow-up, 32 (28.1%) infants developed obvious atopic disease: 29 infants presented recurrent wheezing, two had cow's milk allergy and one had atopic dermatitis. Probable atopic disease developed in 12 (10.5%) infants, whereas 70 (61.4%) infants showed no manifestations. Cord blood IgE levels in infants with obvious atopic disease was higher when compared to those without (p = 0.024), with 70.97% sensitivity and 46.2% specificity. IgE levels were also significantly different up to 12 months in these groups (p = 0.0001), when the sensitivity was 82.1% and the specificity 54.1%. At this age, the IgE levels were higher in infants with obvious atopy than nonatopic disease in relation to male sex (p = 0.015), black race (p = 0.009), breast-feeding for less than 6 months (p = 0.011) and when the family income was less than three times the minimum wage (about US $300) (p = 0.006). There was no association between IgE levels and family history of atopy. We concluded that immune response for atopy was in a large degree influenced by environmental factors and serum IgE at 12 months was a good marker for identifying infants with risk of atopic disease in early life.
Breast Feeding↗
Social and affective development in infants with a manic-depressive parent.
The authors observed seven infants who had a manic-depressive parent longitudinally in a structured laboratory setting with their mothers at ages 12, 15, and 18 months. The infants' attachment and affiliative behaviors and the patterning of their affective responses were assessed according to systematic measures and compared with those of a matched control group. The proband infants appeared to show a disturbance in the quality of their attachments to their mothers as well as a generalized disturbance in their capacities to regulate their emotions adaptively. There appeared to be an increasing severity of disturbance with increasing age. The authors discuss the implications of these findings.
Bipolar Disorder↗
Clinical studies of a quadrivalent rotavirus vaccine in Venezuelan infants.
Phase I studies of an oral quadrivalent rotavirus vaccine were conducted in 130 Venezuelan infants 10 to 20 weeks of age. The vaccine consists of a mixture of equal amounts of rhesus rotavirus (RRV) vaccine (serotype 3 [VP7]) and each of three human rotavirus-RRV reassortant strains: D x RRV (serotype 1 [VP7]), DS1 x RRV (serotype 2 [VP7]), and ST3 x RRV (serotype 4 [VP7]). Three different doses of the quadrivalent vaccine (0.25 x 10(4), 0.5 x 10(4), and 10(4) PFU of each component) were evaluated sequentially for safety and antigenicity in placebo-controlled, double-blind trials. Starting the day after vaccination, the infants were monitored by daily home visits for 7 days. Only minor reactions were observed during this period; these were limited to mild transient febrile episodes which began day 2 or 3 after vaccination and lasted 1 to 2 days in 15 to 30% of the infants. Serological studies demonstrated that 68 to 96% of the infants developed a rotavirus serum immunoglobulin A response following vaccination. However, when tested by plaque reduction neutralization assay against individual human rotavirus serotype 1, 2, 3, or 4, the response rates ranged from 4 to 23% with the low dose, 21 to 33% with the medium dose, and 32 to 58% with the high dose. Most (73 to 79%) infants developed neutralizing antibodies to RRV following administration of each dose schedule. Vaccine virus shedding was analyzed by utilizing tissue culture isolation of virus from stool. All of the infants who received the lower of medium dose and 89% of those fed the high dose shed one or more components of the vaccine. Analyses of rotavirus serotypes isolated from the stool of infants who received the 0.25 x 10(4) -PFU dose revealed that DS1 x RRV was the most commonly shed vaccine component, followed by RRV, D x RRV, and ST3 x RRV in that order.
Administration, Oral↗
Developmental outcome of patients with hypoplastic left heart syndrome treated with heart transplantation.
OBJECTIVE: To describe the outcome of children treated for hypoplastic left heart syndrome (HLHS) with heart transplantation. STUDY DESIGN: We evaluated outcomes in 26 children treated for HLHS in a single center; 13 children were evaluated with the Bayley Scales of Infant Development, Child Behavior Checklist (CBCL), and Vineland Adaptive Behavior Scales (VABS), and 13 were seen after 36 months of age and were evaluated with the Wechsler Preschool and Primary Scale of Intelligence, CBCL, and VABS at 36 to 72 months or the Wechsler Intelligence Scale for Children-III, CBCL, and VABS for those older than 72 months of age. RESULTS: Bayley Scales of Infant Development results revealed a median Mental Developmental Index of 88 (range <50 to 102) and a Psychomotor Developmental Index of 86.5 (<50 to 113), both significantly lower than expected in the general population. Intelligence quotient results on either the Wechsler Preschool and Primary Scale of Intelligence or Wechsler Intelligence Scale for Children-III were also significantly lower than expected, with a mean verbal score of 90.5 +/- 12.4, performance score of 88.9 +/- 14.5, and full scale score of 88.5 +/- 13.0. On the Vineland scales, 39% scored >1 SD below the mean on measures of daily living scales, 22% on the socialization subscale, 48% on the communication subscale, and 52% on the adaptive behavior scale. CONCLUSIONS: In this small population of children treated for HLHS with heart transplantation, both cognitive deficits and adaptive/behavioral abnormalities are described. Early identification with appropriate referral for services could potentially enhance the outcomes for these children.
Child↗
[The physical development of infants and young children. 5. Body height--a longitudinal study].
As a result of a longitudinal study (1979-1982) distance values increments and growth velocity of the body length of 84 male and 91 female children are presented for the first three years of life. As compared to earlier longitudinal for the first three years of life. As compared to earlier longitudinal studies performed by other authors and to the G.D.R.-study of 1970/71, the investigated children are taller, in spite of a smaller body length at birth.
Body Height↗
A quantitative measure of myelination development in infants, using MR images.
The objective of this study was to measure myelination of frontal lobe changes in infants and young children. Twenty-four cases of infants and children (age range 12-121 months) were evaluated by a quantitative assessment of T2-weighted MR image features. Reliable quantitative changes between white and gray matter correlated with developmental age in a group of children with no neurological findings. Myelination appears to be an increasing exponential function with the greatest rate of change occurring over the first 3 years of life. The quantitative changes observed were in accordance with previous qualitative judgments of myelination development. Children with periventricular leukomalacia (PVL) showed delays in achieving levels of myelination when compared to normal children and adjusted for chronological age. The quantitative measure of myelination development may prove to be useful in assessing the stages of development and helpful in the quantitative descriptions of white matter disorders such as PVL.
Aging↗
Infant growth, development and tooth emergence patterns: A longitudinal study from birth to 6 years of age.
OBJECTIVE: To test the association of child's growth/development status and socioeconomic variables with dental emergence patterns. DESIGN: A sample of 359 children belonging to a birth cohort of over 5000 children born in 1993 in Pelotas (Brazil) was studied in 1998-1999. Previously trained observers collected birthweight, head circumference at birth, birth height, gestational age, smoking during pregnancy, child's sex and skin colour, height by age at 6 months of age, caries experience in the deciduous teeth, number of emerged teeth at 6 and 12 months of age and emergence stages of the first permanent molars at 6 years of age. Family income, parental educational attainment and anthropometric measurements were collected at children's homes. Poisson regression models were applied in order to select best predictors of pairs of emerged teeth at 6 and 12 months of age and emerged (yes/no) first permanent molars at 6 years of age. RESULTS: Children shorter than 49cm had, on average, less pairs of emerged teeth at 6 months of age. Twelve-month-old children with birth height < or =49cm, presenting height-for-age deficit at 6 months of age and the females also presented less pairs of emerged teeth. Stunted children at 6 months of age were more likely to have non-emerged first upper left and lower right permanent molars at 6 years of age. CONCLUSIONS: Important developmental and nutritional variables at birth and throughout the early life may predict the numbers of emerged teeth children have in their oral cavity.
Birth Weight↗
[The physical development of infants and small children. 3. Head circumference, head length, length-width index--a longitudinal study].
The head breadth and head length of 175 children (84 boys, 91 girls) were investigated from birth up to the age of three years. Boys were shown to have greater distance values. Growth increments and velocity did not differ between boys and girls. The velocity was highest in the first trimenon. The children of this study had a greater head length, therefore the value of their cephalic index was lower as described in previous investigations. The phenomenon of debrachycephalisation observed in our populations confirms previous observations.
Cephalometry↗
Fatty acid and cholesterol in eggs: a review.
Elevated serum cholesterol, a major cause of vascular disease, has been strongly correlated with eating greater than normal amounts of cholesterol and saturated fatty acids. The role at omega-3 polyunsaturated fatty acids (PUFA), especially eicosa pentanoic acid (EPA) and decosahexaconic (DHA), has been associated with the prevention of degenerative disease. Breast milk and eggs fulfill the human requirement for DHA, however the DHA level is influenced by lactation levels and the maternal diet. Omega-3 PUFA are derived mainly from fish, eggs, and certain plants. Epidemiological observations, population studies, and basic research indicate the importance of these fatty acids for the membranes of the brain, for the retina in developing infants, and for the possibility of controlling coronary heart disease and other diseases by the ingestion of these fatty acids. Linolenic acid (LNA) enriched eggs may be an excellent source of dietary omega-3 PUFA and an ideal food ingredient for developing infants.
Cholesterol↗
A longitudinal follow up of development of preterm infants.
A prospective study was undertaken to determine the development of preterm (PT) babies (gestation less than 37 weeks). One hundred and seventy two preterm babies and 36 control babies were followed up for a period of 18-24 months. Psychomotor development was assessed using the Bayley Scales of Infant Development at 3, 6, 9, 12, 18, 24 months, using the corrected or post conceptional age. Preterm babies, as a group, caught up with normal babies between 18-24 months, both on the motor and mental scale. Higher the birth weight, better was the mean motor development quotient at 18 months. Uncomplicated preterm babies showed higher mean development quotients at 18 months than preterm babies with additional complications and they also caught up earlier (12-18 months) than the latter group who caught up between 18-24 months. Similarly, PT appropriate for gestational age (AGA) babies showed, earlier 'catch up' than PT small for gestational age (SGA) babies. The incidence of cerebral palsy was low (4%).
Birth Weight↗
[Birth weight and motor development of infants with Turner's syndrome].
There were analysed 61 cases of Turner's syndrome, in this group--48 cases with 45,X karyotype. Author confirmed, that mean birth weight of these children was lower (2920 g), than in healthy girls (3400 g), especially in cases with 45,X karyotype (2894 g). The 1st birth order in 45,X cases decreased birth weight of these children (mean 2693 g). The most retardation of motor development--3 months--in locomotion was observed. Between two genotype groups 45,X (mean 2894 g) and 45,X/46,XX (mean 3015 g) the difference was statistically significant.
Age Factors↗
Grating acuity and visual field development in infants following perinatal asphyxia.
Grating acuity and visual fields were assessed in 66 children who had had perinatal asphyxia (ASPH). Also tested were 41 healthy preterm children (H-PT). Subjects were tested at birth to one month, and four, nine, 12, 17, 24, 30 and 36 months corrected age. The mean acuity scores of the ASPH group were lower than those of the H-PT group at most test ages, and significantly so at 30 and 36 months. The mean visual field size of the infants in the ASPH group was significantly smaller than that of the H-PT group at nine, 12, 30 and 36 months. No significant effects were found for preterm vs term birth, gestational age at birth, degree of asphyxia and presence of strabismus. However, central nervous system abnormalities (intraventricular haemorrhage and periventricular leukomalacia) were related to deficits in acuity and visual field size.
Asphyxia Neonatorum↗
[Hypocalcemia and electroencephalographical modifications in the infant; regressive development of electrical anomalies and of the convulsive syndrome (when it exists) coincident with blood calcium normalization].
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Calcium↗
Early development of infants exposed to drugs prenatally.
This article includes a summary and critique of methodological limitations of the peer-reviewed studies of developmental outcome during the first 2 years in children prenatally exposed to the most commonly used drugs of abuse: tobacco, alcohol, marijuana, heroin/methadone, and cocaine. Reported effects vary by specific drug or drug combinations and amount and timing of exposure; however, few thresholds have been established. Drug effects also appear to be exacerbated in children with multiple risks, including poverty, and nonoptimal caregiving environments. Although prenatal exposure to any one drug cannot reliably predict the outcome of an individual child, it may be a marker for an array of variables that can impact development. Appropriate intervention strategies require future research that determines which factors place exposed children at risk and which are protective for optimal development.
Alcoholism↗