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At least 811 records · Page 45Linked to original sources

PubMed2005

Evaluation of the Sinmed Mastercouch as replacement for a standard couch.

BACKGROUND AND PURPOSE: Introducing into practice a new carbon-fibre couch necessitates its evaluation with regard to the present clinical situation. MATERIALS AND METHODS: In this study, a geometric and dosimetric evaluation has been made for the Sinmed Mastercouch as a replacement for the Elekta C-arm couch with Mylar-tennis racket combination. Geometrically, feasible gantry angles with regard to collision and beam intersection were discriminated as function of isocentric table rotation for 10 treatment isocentres. Dosimetrically, the build-up distortion and attenuation by the aforementioned tabletops and a carbon-fibre tabletop of an Elekta Precise simulator was measured. Finally, the clinical implications of these influences were assessed for a 3-field prostate treatment in three configurations: Mastercouch, C-arm couch and no-intersection situation. RESULTS: With regard to collision, the largest advantages are observed for the Mastercouch with the Omega-shaped treatment module compared to the C-arm couch for isocentres located in the upper part of the body, thanks to its shape and the absence of any metal. Dosimetrically, one has to take into account the build-up loss and attenuation by beam intersection with Mastercouch and the carbon-fibre edges of the tennis racket (C-arm couch). The clinical relevance of these dosimetric aspects depends on the dose delivered by the compromised beams.

Equipment Design↗

PubMed1999

Evaluation of red light camera enforcement in Oxnard, California.

Red light cameras are increasingly being used to supplement police efforts to enforce against noncompliance with traffic signals--a substantial contributing factor in urban motor vehicle crashes. Camera enforcement is intended to modify driver behavior through both general deterrence and punishment of individual violators. A before/after quasi-experimental design with controls was employed to evaluate the influence of a red light camera enforcement program on red light violation rates in the city of Oxnard, CA. A total of 14 intersections (nine camera sites, three non-camera sites, and two control sites) were studied. Overall, the red light violation rate was reduced approximately 42% several months after the enforcement program began. Increases in driver compliance with red lights were not limited to the camera-equipped intersections but spilled over to nonequipped intersections as well. Results of public opinion surveys conducted approximately 6 weeks before, 6 weeks after, and 6 months after the camera enforcement program began indicated that nearly 80% of Oxnard residents support using red light cameras as a supplement to police efforts to enforce traffic signal laws.

Accidents, Traffic↗

PubMed2000

Explaining two-lane highway crash rates using land use and hourly exposure.

This paper describes the estimation of Poisson regression models for predicting both single and multi-vehicle highway crash rates as a function of traffic density and land use, as well as ambient light conditions and time of day. The study focuses on seventeen rural, two-lane highway segments, each one-half mile in length with varying land use patterns and where actual hourly exposure values are available in the form of observed traffic counts. Land-use effects are represented by the number of driveways of various types on each segment. Hourly exposure is represented for single-vehicle crashes as the total vehicle miles traveled and volume/capacity ratio; for multi-vehicle crashes it is the product of the hourly volumes on the main highway and the roads intersecting it along the study segment. For single-vehicle crashes, the following variables were found to be significant, with a positive or negative effect as noted: daytime (06:00-19:00 h, negative effect), the natural log of the segment volume/capacity ratio (negative), percent of the segment with no passing zones (positive), shoulder width (positive), number of intersections (negative), and driveways (mixed effects by type). Good multi-vehicle crash prediction models had quite different variables: daylight conditions from 10:00-15:00 and 15:00-19:00 h (positive), number of intersections (negative), and driveways (positive for all types). The results show that traffic intensity explains differences in crash rates even when controlling for time of day and light conditions, and that these effects are quite different for single and multi-vehicle crashes. Suggestions for future research are also given.

Accidents, Traffic↗

PubMed1998

Is visual anticipation of collision during self-motion related to perceptual style?

We have previously shown that during self-motion in car driving situations, the perception of another car's trajectory relies both on global visual information such as the optical flow field, and on local visual information such as the optical motion of the other car and the relative optical motion of the other car with respect to fixed elements in the environment. Here, we studied the environmental factors that contribute to perceptual judgements in relation to the observer's perceptual style (visual-field dependence vs. visual-field independence). In an experiment, observers were presented with visual scenes corresponding to the curvilinear self-motion of a driver approaching an intersection where another vehicle was arriving perpendicularly. The factors manipulated were the presence or absence of a spatial reference point (road sign near the intersection), environmental complexity ("road" or "spot" scenes), and the degree of field dependence/independence. Nine field-independent (FI) subjects and seven field-dependent (FD) subjects were asked to predict whether the other vehicle would reach the intersection before or after they would. Their responses were analyzed. Overall, subjects' judgements were more accurate with road environments and with a road sign, suggesting that the relative motion of the other vehicle with respect to fixed elements in the environment provides additional useful information. FI subjects were significantly more accurate than FD subjects, suggesting that the former are better at picking up relevant dynamic information in a complex environment.

Adult↗

PubMed1999

The role of working memory, field dependence, visual search, and reaction time in the left turn performance of older female drivers.

Older drivers have difficulties at intersections, especially in their performance of left turns. Older females are especially at risk in intersection maneuvers. Information processing abilities have been most promising in explaining the crash involvement of elderly drivers. This study examines the relationship of field dependence, visual search skills, and working memory to the decision to make a left turn at an intersection as well as to gap choice. Participants included thirty-three women ranging in age from 61 to 84 years. The results show that working memory plays a very important role in left-turn performance. Implications for appropriate interventions are discussed.

Accidents, Traffic↗

PubMed1999

Achieving incremental semantic interpretation through contextual representation.

While much work has been done investigating the role of context in the incremental processing of syntactic indeterminacies, relatively little is known about online semantic interpretation. The experiments in this article made use of the eye-tracking paradigm with spoken language and visual contexts in order to examine how, and when listeners make use of contextually-defined contrast in interpreting simple prenominal adjectives. Experiment 1 focused on intersective adjectives. Experiment 1A provided further evidence that intersective adjectives are processed incrementally. Experiment 1B compared response times to follow instructions such as 'Pick up the blue comb' under conditions where there were two blue objects (e.g. a blue pen and a blue comb), but only one of these objects had a contrasting member in the display. Responses were faster to objects with a contrasting member, establishing that the listeners initially assume a contrastive interpretation for intersective adjectives. Experiments 2 and 3 focused on vague scalar adjectives examining the time course with which listeners establish contrast for scalar adjectives such as tall using information provided by the head noun (e.g. glass) and information provided by the visual context. Use of head-based information was examined by manipulating the typicality of the target object (e.g. whether it was a good or poor example of a tall glass. Use of context-dependent contrast was examined by either having only a single glass in the display (the no contrast condition) or a contrasting object (e.g. a smaller glass). The pattern of results indicated that listeners interpreted the scalar adjective incrementally taking into account context-specific contrast prior to encountering the head. Moreover, the presence of a contrasting object, sharply reduced, and in some conditions completely eliminated, typicality effects. The results suggest a language processing system in which semantic interpretation, as well as syntactic processing, is conducted incrementally, with early integration of contextual information.

Adult↗

PubMed1992

Human disease mortality kinetics are explored through a chain model embodying principles of extreme value theory and competing risks.

The distributions for human disease-specific mortality exhibit two striking characteristics: survivorship curves that intersect near the longevity limit; and, the clustering of best-fitting Weibull shape parameter values into groups centered on integers. Correspondingly, we have hypothesized that the distribution intersections result from either competitive processes or population partitioning and the integral clustering in the shape parameter results from the occurrence of a small number of rare, rate-limiting events in disease progression. In this report we initiate a theoretical examination of these questions by exploring serial chain model dynamics and parameteric competing risks theory. The links in our chain models are composed of more than one bond, where the number of bonds in a link are denoted the link size and are the number of events necessary to break the link and, hence, the chain. We explored chains with all links of the same size or with segments of the chain composed of different size links (competition). Simulations showed that chain breakage dynamics depended on the weakest-link principle and followed kinetics of extreme-values which were very similar to human mortality kinetics. In particular, failure distributions for simple chains were Weibull-type extreme-value distributions with shape parameter values that were identifiable with the integral link size in the limit of infinite chain length. Furthermore, for chains composed of several segments of differing link size, the survival distributions for the various segments converged at a point in the S(t) tails indistinguishable from human data. This was also predicted by parameteric competing risks theory using Weibull underlying distributions. In both the competitive chain simulations and the parametric competing risks theory, however, the shape values for the intersecting distributions deviated from the integer values typical of human data. We conclude that rare events can be the source of integral shapes in human mortality, that convergence is a salient feature of multiple endpoints, but that pure competition may not be the best explanation for the exact type of convergence observable in human mortality. Finally, while the chain models were not motivated by any specific biological structures, interesting biological correlates to them may be useful in gerontological research.

Computer Simulation↗

PubMed1998

Dichromacy characterized by chrominance planes.

Dichromacy is described in terms of dichromatic opponent colour spaces. By means of the perceptual criteria 'equally bright', 'neither blue nor yellow' and 'neither red nor green' and embedding in a three-dimensional colour space, it is possible for each type of dichromat to quantify a null-chrominance plane and a null-luminance plane, both of which intersect in the missing colour. These two null planes (or the trace of their intersection with the chromaticity chart) are the chromaticities of the dichromatic opponent primaries. Since a null-luminance plane contains only colour ('chrominance'), it is simply a chrominance plane. Under the assumption that the retinal short-wavelength cones do not contribute to luminance, the chrominance planes of the three types of dichromats intersect in a common straight line, the 'blue' fundamental primary vector. This constellation may serve as a general characterisation of dichromacy.

Color↗

PubMed1998

Nonrandom sequence of slope-intercept estimates in longitudinal gompertzian analysis suggests biological relevance.

The significance of intersections in age-specific mortality rate distributions could be attributed to a fundamental statistical relationship between estimates of slope and intercept. A strong negative correlation between estimates of slope and intercept is often observed in simple linear regression problems. The net result is that the family of lines generated by repetitive estimates of slope and intercept in a static experimental situation will tend to intersect at a common point. This statistical relationship between slope and intercept, however, should be random with respect to the time-ordered sequence of slope and intercept estimates. Annual paired slope and intercept estimates derived using the method of longitudinal Gompertzian analysis of age-specific mortality rates for men and women in the United States from 1900 to 1988 were analyzed to determine if they varied randomly. The probability that the observed sequence in these annual paired slope-intercept estimates was random is less than 10(-50) for both men and women. This finding essentially excludes the possibility that intersections in age-specific mortality rate distributions reflect a fundamental statistical relationship between slope and intercept and further suggests biological relevance for the method of longitudinal Gompertzian analysis.

Female↗

PubMed2002

Do sperm cells remember?

Spontaneous alternation behavior (SAB) is the universal tendency of animals, including unicellular organisms, to alternate directional choices at consecutive left/right branchings while traversing a maze. Occurrence of SAB implies short-term memory, as a current decision is statistically dependent on previous ones. We developed a procedure to assess SAB in human spermatozoa. A total of 1302 progressively motile spermatozoa from healthy donors were observed as they entered one of two mazes, both fabricated by eximer laser ablation. The control maze was a simple T-maze (width=depth=20 microm, distance between entrance and free choice T-intersection=600 microm). The experimental maze was identical to the control maze except for a forced right-turn 600 microm before the T-intersection. We recorded individual sperm cells' left/right decisions at the T-intersections in both mazes. Of the 714 spermatozoa entering the control maze, 49.1% turned to the left (not significantly different from the chance expectation of 50.0%). Of the 588 spermatozoa entering the experimental maze, 58.6% turned left after the initial forced right turn (significant SAB; P=0.041, Wilcoxon). The statistical dependency of a directional decision on a previous one suggests a physiological 'memory' in human spermatozoa. Among the possible underlying mechanisms are refractory processes in structures responsible for flagellar beating, a postulation which deserves further scrutiny with video-monitored single-cell testing.

Humans↗

PubMedDate not supplied

[Estimation of the use of seat belts: an observational study and a telephone survey].

OBJECTIVE: To estimate the prevalence of safety-belt use in a telephone survey and an observational survey. PATIENTS AND METHODS: Observational survey. Trained interviewers studied 4,067 front-seat occupants, at ten intersections of Madrid, according to "National Highway Traffic Safety Administration" guidelines. TELEPHONE SURVEY: We selected 433 front seat occupants from the Madrid city residential telephone directory. The questionnaire was completed by trained interviewers. RESULTS: Prevalence by the observational survey was 58.5%, and was significantly higher at interurban intersections (OR = 2.1) than city intersections. In the telephone survey, the overall prevalence was 94% at interurban area and 64% at city area and it was associated with no history of lines and positive opinion of effectiveness of safety belts. CONCLUSIONS: The safety belt prevalence observed is low, especially in the urban area. The telephone survey overestimates the safety belt use, but contributes with useful information for planning strategies.

Adult↗

PubMed1997

Particle-bound PAH content in ambient air.

Ambient air samples from a traffic intersection, an urban site and a petrochemical-industrial site (PCI) were collected by using several dry deposition plates, two Microorifice uniform deposited impactors (MOUDIs), one Noll Rotary Impactor (NRI) and several PS-1 (General Metal Work) samplers from March 1994 to June 1995 in southern Taiwan, to characterize the atmospheric particle-bound PAH content of these three areas. Twenty-one individual polycyclic aromatic hydrocarbons (PAHs) were analyzed primarily by using a gas chromatograph/mass spectrometer (GC/MS). In general, the sub-micron particles have a higher PAH content. This is due to the fact that soot from combustion sources consists primarily of fine particles and has a high PAH content. In addition, a smaller particle has a higher specific surface area and therefore may contain more organic carbon, which allows for more PAH adsorption. For a particle size range between 0.31 and 3.2 microm, both Urban/Traffic and PCI/Traffic ratios of particle-bound total-PAH content have the lowest values, ranging from 0.25 to 0.28 (mean = 0.26) and from 0.07 to 0.13 (mean = 0.10), respectively. This indicates that, during the accumulation process, the PAH mass shifted from a particle phase to a gas phase, or the particles aggregated with lower PAH-content particles, resulting in a reduction in particle-bound PAH content. By using the particle size distribution data, the dry deposition model in this study can provide a good prediction for the PAH content of dry deposition materials. In general, lower molecular weight PAHs had a larger fraction of dry deposition flux contributed by the gas phase; for 2-ring PAH (50.4, 46.3 and 28.4%), 3-ring PAHs (15.2, 15.4 and 11.7%) and 4-ring PAHs (13.0, 3.60 and 5.01%) for the traffic intersection, urban and PCI sites, respectively. For higher molecular weight PAHs-5-ring, 6-ring and 7-ring PAHs-their cumulation fraction (F%) of dry deposition flux contributed by the gas phase was lower than 3.26%. At the traffic intersection, urban and PCI sites, the mass median diameter of dry deposition materials (MMD(F)) of individual PAHs was between 25.3 and 49.6 microm, between 27.6 and 43.9 microm, and between 19.1 and 41.9 microm, respectively. This is due to the fact that PAH dry-deposition primarily resulted from gravitational settling of the coarse particulates (> 10 microm).

Journal Article↗

PubMed2003

Three-dimensional visual guidance improves the accuracy of calculating right ventricular volume with two-dimensional echocardiography.

Three-dimensional guidance programs have been shown to increase the reproducibility of 2-dimensional (2D) left ventricular volume calculations, but these systems have not been tested in 2D measurements of the right ventricle. Using magnetic fields to identify the probe location, we developed a new 3-dimensional guidance system that displays the line of intersection, the plane of intersection, and the numeric angle of intersection between the current image plane and previously saved scout views. When used by both an experienced and an inexperienced sonographer, this guidance system increases the accuracy of the 2D right ventricular volume measurements using a monoplane pyramidal model. Furthermore, a reconstruction of the right ventricle, with a computed volume similar to the calculated 2D volume, can be displayed quickly by tracing a few anatomic structures on 2D scans.

Adult↗

PubMedDate not supplied

Three-dimensional echocardiography: the influence of number of component images on accuracy of left ventricular volume quantitation.

One approach to three-dimensional echocardiography is to reconstruct the surface of cardiac structures from two-dimensional images positioned in three-dimensional space. This approach has yielded accurate measures; however, the relationship between the number of nonparallel images used in three-dimensional echocardiographic reconstruction to the accuracy of the volume calculated has not been determined. With a canine model in which instantaneous left ventricular volume could be measured in vivo, images were obtained from intersecting long- and short-axis scans and stored with their spatial coordinates. The left ventricle was reconstructed and its volume calculated. The difference between three-dimensional echocardiographic and true volume was determined in 84 different cavitary volumes (4 to 85 ml). In each case, long- and short-axis images were deleted serially from the original data set (maximum of 27) until there were only three images left in the reconstruction. After each set of deletions, left ventricular volume was recalculated with the remaining images. Three-dimensional echocardiography accurately quantified ventricular volume with eight to 12 intersecting images, with a mean error of less than 1 ml and an SD of 5 ml. With a reduction of component images below eight, there were progressive increases in both absolute and mean percentage error. Accurate assessment of stroke volume and ejection fraction in this beating heart model also required eight to 12 images. Left ventricular volume and systolic function can be quantitated by three-dimensional echocardiography with as few as eight to 12 intersecting or nonparallel images.

Analysis of Variance↗

PubMedDate not supplied

Emergency medical vehicle collisions and potential for preventive intervention.

BACKGROUND: Emergency medical vehicle collisions (EMVCs) cause significant injury, death, and property damage every year in the United States and result in significant delays in transporting patients to the hospital. OBJECTIVE: To identify factors associated with EMVCs that are potentially amenable to preventive intervention. METHODS: The authors reviewed data from the Paramedic Division of the Denver Health and Hospital Authority (DHHA) on all EMVCs occurring from 1989 through 1997. RESULTS: A T-bone mechanism, collision at an intersection, and alcohol intoxication of the civilian driver were all significant predictors of collisions resulting in injury (odds ratios of 29.7, 4.3 and 6.1, respectively, p<0.05, multiple logistic regression). Although only 75% of the division's responses are run with warning lights and sirens (WLS), a disproportionate 91% of response mode collisions were during a WLS response. The responsible EMV driver had a history of multiple EMVCs in 71% of the collisions. CONCLUSIONS: Potential interventions suggested by this study include the need for EMV drivers to visually clear the intersection before entering it, alerting other drivers with visual and auditory warning systems, and attempting to make eye contact with them at an intersection. The authors recommend continued public education regarding the risks of drunk driving. The authors feel that the WLS driving mode is best reserved for patients in whom the benefits of shorter response and return times outweigh the risk of collision. Finally, the authors advocate careful review of drivers' collision history, frequent emergency vehicle operator's course retraining, and appropriate discipline when necessary.

Accidents, Traffic↗

PubMedDate not supplied

Zigzags, railroads, and knots in fullerenes.

Two connections between fullerene structures and alternating knots are established. Knots may appear in two ways: from zigzags, i.e., circuits (possibly self-intersecting) of edges running alternately left and right at successive vertices, and from railroads, i.e., circuits (possibly self-intersecting) of edge-sharing hexagonal faces, such that the shared edges occur in opposite pairs. A z-knot fullerene has only a single zigzag, doubly covering all edges: in the range investigated (n </= 74) examples are found for C(34) and all C(n)() with n >/= 38, all chiral, belonging to groups C(1), C(2), C(3), D(3), or D(5). An r-knot fullerene has a railroad corresponding to the projection of a nontrivial knot: examples are found for C(52) (trefoil), C(54) (figure-of-eight or Flemish knot), and, with isolated pentagons, at C(96), C(104), C(108), C(112), C(114). Statistics on the occurrence of z-knots and of z-vectors of various kinds, z-uniform, z-transitive, and z-balanced, are presented for trivalent polyhedra, general fullerenes, and isolated-pentagon fullerenes, along with examples with self-intersecting railroads and r-knots. In a subset of z-knot fullerenes, so-called minimal knots, the unique zigzag defines a specific Kekulé structure in which double bonds lie on lines of longitude and single bonds on lines of latitude of the approximate sphere defined by the polyhedron vertices.

Journal Article↗

PubMed2005

Ab initio studies on the radiationless decay mechanisms of the lowest excited singlet states of 9H-adenine.

The mechanisms that are responsible for the rapid deactivation of the (1)npi and( 1)pipi excited singlet states of the 9H isomer of adenine have been investigated with multireference ab initio methods (complete-active-space self-consistent-field (CASSCF) method and second-order perturbation theory based on the CASSCF reference (CASPT2)). Two novel photochemical pathways, which lead to conical intersections of the S(1) excited potential-energy surface with the electronic ground-state surface, have been identified. They involve out-of-plane deformations of the six-membered aromatic ring via the twisting of the N(3)C(2) and N(1)C(6) bonds. These low-lying conical intersections are separated from the minimum energy of the lowest ((1)npi) excited state in the Franck-Condon region by very low energy barriers (of the order of 0.1 eV). These properties of the S(1) and S(0) potential-energy surfaces explain the unusual laser-induced fluorescence spectrum of jet-cooled 9H-adenine, showing sharp structures only in a narrow energy interval near the origin, as well as the extreme excess-energy dependence of the lifetime of the singlet excited states. It is suggested that internal-conversion processes via conical intersections, which are accessed by out-of-plane deformation of the six-membered ring, dominate the photophysics of the lowest vibronic levels of adenine in the gas phase, while hydrogen-abstraction photochemistry driven by repulsive (1)pisigma states may become competitive at higher excitation energies. These ultrafast excited-state deactivation processes provide adenine with a high degree of intrinsic photostability.

Adenine↗

PubMed2005

A study of pore blockage in silicalite zeolite using free energy perturbation calculations.

Binary systems consisting of large coadsorbed molecules (n-hexane, cyclohexane, and benzene) with smaller penetrant molecules (methane) were simulated to investigate the mechanisms of pore blockage in the zeolite silicalite. Benzene and cyclohexane trap the methane molecules in the zeolite channels on the time scales of molecular dynamics simulations. Minimum energy paths for methane diffusion past the blocking molecules were determined, and free energy perturbation calculations were carried out along the paths to get the rate constants of methane hopping past coadsorbed benzene and cyclohexane molecules, which adsorb in the channel intersections. Three principal diffusion pathways were found in both the methane/benzene and methane/cyclohexane systems. Minima which were connected by low-energy pathways were grouped together into macrostates. Using the calculated hopping rates between macrostates, kinetic Monte Carlo was then used to obtain the diffusivity of methane with a coadsorbate benzene loading such that all channel intersections are filled by benzene - conditions where molecular dynamics simulations fail. Passage of methane across cyclohexane molecules involved pushing the cyclohexane molecules into the channels from their preferred channel intersection positions.

Journal Article↗