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Transsphenoidal microsurgery for selective removal of functional pituitary microadenomas.

The transphenoidal approach to the pituitary gland is emerging as the safest and most efficacious procedure for the management of pituitary tumors. With the aid of the microscope large tumors producing visual symptoms can be removed and microadenomata producing only signs and symptoms of endocrinopathies can be safely and adequately approached. The procedure is described in this report. The results of its use in 29 patients with selected illustrative case reports are described.

Acromegaly↗

Microsurgery of tumours of diencephalic region.

A report about the microsurgical treatment of large tumours involving or displacing the diencephalon (craniopharyngiomas 150, pituitary adenomas 450 out of 1100, meningiomas 200, and rare tumours as epidermoids and gliomas of the third ventricle). It is mandatory to save the floor of the third ventricle, the pituitary stalk and even the small vessels. The technical procedure is described in detail depending on the extent of the tumour. Craniopharyngiomas can be within the sella and above it, suprasellar and extraventricular or combined intraventricular and extraventricular. In each case the origin and extent of the tumour decide the approach, which can be unilateral or bilateral frontal, subtemporal, transtentorial, transventricular or any combination of these. In intraventricular tumours the approach by incising the lamina terminalis proved to be the best procedure in 50 cases. Radical removal was possible in 80%, but with a high mortality of 17%. In giant adenomas with involvement of the third ventricle the approach through the lamina terminalis is dangerous. In doing an intracapsular removal of the "intraventricular" portion of the tumour it is of great assistance to use a stomatological reverse mirror. The mortality of giant adenomas could be reduced from 30% to 11%. In meningiomas of the medial third of the sphenoidal wing and tuberculum sellae the microsurgical separation of the floor of the third ventricle and the stalk is the most important problem and has become possible in most cases. Some gliomas of the third ventricle can be separated completely via the lamina terminalis or the foramen of Monro without touching the floor of the third ventricle.

Adenoma↗

Microsurgery of the hypothalamus with special reference to craniopharyngioma.

After a short survey of microanatomy, microtopography, neurophysiology and neuropathophysiology of the hypothalamus the surgical approaches to the hypothalamus with special reference to the craniopharyngiomas are described in detail. Based on 100 personal cases (1954-1979) the special procedure, depending on the site and extent of the tumour and its involvement of the hypothalamus, is discussed. Primary radical excision (19 cases) with a mortality rate of 10.5% seems to be the method of choice, as late mortality recurrences and secondary operations are frequent after non-radical procedures. Modern microsurgical technique promises to achieve primary radical excision more frequently and with less risk.

Cerebral Angiography↗

Microsurgery of teratoma and germinoma involving the diencephalon and the brain stem.

The authors encountered 95 cases of germinoma (two-cell pattern pinealoma) and teratoma involving the third ventricle and the pineal region from 1962 to 1980. Germinoma is radiosensitive. However, removal (extensive or total) of the tumour followed by postoperative irradiation showed better results than simple radiotherapy. In the recent 62 cases, 5-year and 10-year survival rates were 80.2% and 69.3% respectively (in children under 15 years, both were 86.9%). Teratoma is not radiosensitive and requires operation. For operating on a pineal germinoma, either an infratentorial supracerebellar approach or an occipital transtentorial approach is indicated. A teratoma, however, is sometimes too large for these approaches, when exposed, and therefore, the author prefers the transcallosal approach (for huge tumours the frontal transcallosal approach). Technical details will be reported and discussed.

Adolescent↗

Anatomical principles of microsurgery of the tubal arteries.

Topographical relationships and size of the arteries of the mesovarium and mesosalpinx were evaluated from the point of view of their usefulness in microsurgical operations on the oviduct (tuba uterina). The results of our investigations showed that reconstitution of the continuity of the arterial vessels during oviduct transplantation seems to be anatomically warranted with respect to the uterine artery (arteria uterina). During ampullar salpingostomy the artery passing from the ovarian artery (arteria ovarica) should be saved and anastomosed with the uterine artery or its tubal branch (ramus tubarius arteriae uterinae) or with the artery passing under the serous membrane of the isthmus. Isthmic salpingostomy does not require a separate procedure in order to retain arterial blood supply to the oviduct.

Adult↗

Brachycephalic, serrated curettes for anterior cervical spinal microsurgery. Technical note.

Modified spinal fusion curettes with two unusual features on the tip are described for anterior cervical procedures. The features are: 1) an elliptical, long sidewise ("brachycephalic") scoop at the tip and 2) a serration equipped on the distal scoop edge. These designs allow reliable manipulation and significant removal of the intervertebral space contents in the deep operative field under the microscope.

Cervical Vertebrae↗

Microsurgery of gliomas.

The author describes his microsurgical operative technique used since 1980 for gliomatous tumours. Instead of extensive resection and lobectomy, a pergyral or intergyral persulcal approach with partial gyrectomy, interhemispheric, transsylvian and transventricular exposure of the tumour surface were used. The resection of the tumour begins from its centre. In the first phase 1980-1982 bipolar coagulation, micro-sucker and pincer were used, since 1983 tumour resections have been performed with the CO2 and Nd-Yag laser and CUSA. Tumours located in functionally important regions such as the speech area, thalamus, brain stem, etc. could be removed without additional morbidity and there was a rapid improvement in neurological deficits. The early prognosis of patients harbouring these tumours is improved thanks to minimized operative trauma. The quality of life during the recurrence free period is improved and surgery of recurrence is indicated more frequently than in the past. There is no evidence that these techniques influence the length of the total survival. The use of CT and MRI improved the early diagnosis of small tumours and intraparenchymal lesions. This requires exact intraoperative localization and identification of the lesion. The technical aspects of these procedures are described. Thanks to the improvement in operative technique some limitations of surgery such as location, nature of the tumour and the age of the patient have lost much of their importance.

Astrocytoma↗

Anterior decompressive microsurgery and osteosynthesis for the treatment of multi-segmental cervical spondylosis. Pathophysiological considerations, surgical indication, results and complications: a survey.

Surgical treatment of cervical myelopathy due to multi-segmental cervical spondylosis (MSCS) is currently performed by either anterior or posterior approaches. Considering the complex nature of the underlying disease involving more than one cervical segment, as well as the patho-biomechanical features of the spondylotic cervical spine, adequate decompression of the spinal cord and correction of hypermobility should be achieved by surgery in one stage, in order to achieve positive immediate and long-term benefit for the patient suffering from progressive myelopathy. Recently, anterior decompressive surgery, consisting of single or multi-level vertebrectomy, microsurgical epidural decompression and osteo-synthesis has emerged as an aggressive therapeutic approach for the treatment of MSCS. Based on the experience of a series of 92 patients with progressive cervical myelopathy due to MSCS operated on using the above described combined techniques, as well as the results from a limited number of clinical studies of anterior decompressive surgery in MSCS patients from the literature, the pathophysiological considerations, surgical indications, surgical technique as well as clinical results and complications of anterior surgery in patients with MSCS are reviewed and discussed.

Cervical Vertebrae↗

[Transplantation of nervus peroneus by microsurgery (author's transl)].

From 1969-1977 at the Erlangen University Surgical Clinic 15 transplantations of the nervus peroneus were performed. 10 patients could be followed up within a time of 2-5 years after operation. As to the sensibility in most cases only protective sensibility could be achieved; as to the motor function the results were likewise poorer than in the upper limb. Beside our own results those of other authors were reported. Possible causes of the relatively bad prognosis of the Nervus peroneus were shown.

Accidents↗