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At least 811 records · Page 45Linked to original sources
PubMed2003

[Acute posterior multifocal epitheliopathy: case report].

PURPOSE: To present an atypical course of acute posterior multifocal placoid epitheliopathy. MATERIALS AND METHODS: 59 years-old diabetic man was seen at emergency because of a few days history of blurred vision in his right eye. Ophthalmologic examination revealed patches of blurred margine, multiple, yellowish lesions 1-2 dd in the fundus in both eyes. There were also lesions typical for non proliferative diabetic retinopathy like microaneurysms, dot and blot intraretinal hemorrhages and hard exudates. Optic discs and blood vessels were normal. We found peripheral drusen extending from the equator to the ora serata in both eyes. During 8 months of observation, we performed three times ophthalmologic examination, fluorescein and indocyanine green angiographies, USG A and B. No treatment was given. CONCLUSIONS: There is disagreement about the site of origin of placoid lesions, etiology and pathogenesis in acute posterior multifocal placoid epitheliopathy. In our report we agree with thesis, that the choriocapillaris are the primary site of the break. We propose, that different duration of the APMPPE and recurrences are directly proportional to the state and quality of the blood vessels. The possible explanation for longstanding lesions in our patient is diabetic damage of the capillaries in the retina and choroid.

Acute Disease↗
PubMed2003

[Treatment of retinal detachment of the course of retinopathy of prematurity].

Cryo- and laser therapy of stage 3 have reduced, but not eliminated the occurrence of retinal detachment in stages 4a, 4b and 5 of ROP. In this disease the treatment of these stages is still the greatest challenge to the ophthalmologist. Therefore, the aim of this paper is to present our up-to-date possibilities of treatment of different kinds of retinal detachments in ROP, including segmental scleral buckling, encircling scleral buckling, scleral resection, vitrectomy and its modifications in ROP. Guidelines of surgery of retinal detachment in active stage 4 and 5 of retinopathy of prematurity have been described.

Cryosurgery↗
PubMed1992

[Malondialdehyde production and erythrocyte membrane resistance to free radicals, in function of adequate or inadequate protein intake, associated with different oils (sunflower, soybean, coconut, salmon)].

Requirements in polyunsaturated fatty acids (PUFA) of series n-3 and n-6 may be amplified and their metabolism, transport, and utilization may be impaired in the long term, by protein depletion. The aim of this study was to evaluate, in young rats, malondialdehyde (MDA) production and erythrocyte membrane antioxidative defense, when they were fed balanced (20% casein) or depleted (2% casein) protein diet associated with various oils (sunflower, soybean, coconut or salmon). Over a short period (28 days), eight groups of 10 male Wistar rats were fed eight different diets: TOC (20% casein + 5% sunflower oil), TOd (2% casein + 5% soybean oil), SOC (20% casein + 5% soybean oil), SOd (2% casein + 5% soybean oil), COC (20% casein + 5% coconut oil), COd (2% casein + 5% coconut oil), SAC (20% casein + 5% salmon oil), SAd (2% casein + 5% salmon oil). Blood was removed, MDA was assessed in plasma (reaction with thiobarbituric acid). Washed erythrocytes were subjected to organic free radical generator (Kit KGRL 400 Spiral R.D., Couternon, 21560 France). The haemoglobin released was analysed by spectrophotometry. The total anti-radical defense status was expressed as the length of time to reach 50% hemolysis (T 50% in min). Plasma of deficient groups (2% casein) exhibited low concentrations of protein, particularly with coconut and salmon oils; phospholipid and total cholesterol, excepted with diet containing coconut oil; triacylglycerol; and VLDL. Malondialdehyde. In groups fed balanced protein diets, the lowest values were obtained with salmon and coconut oils. MDA contents of groups TOd, COd and SAd were higher than those of their respective control groups, but significantly only in group COd. Antiradical defense status. Total anti-radical defence status in erythrocytes was not modified in the short term by balanced or depleted protein diets which ever oil was used, despite deep changes in fatty acid composition of membrane phospholipids. In particular, phospholipid contents in eicosapentaenoic, docosahexaenoic acids were greatly enhanced by the consumption of salmon oil compared to the values obtained with coconut oil.

Animals↗
PubMed1992

[Systematized cavernous angiomatosis with multiple cerebral and cutaneous localizations].

A 45 year-old woman with no history of familial disease presented with multiple cutaneous and cerebral cavernous angiomas. The diagnosis rested on biopsy for cutaneous angiomas and on MRI for cerebral angiomas. The clinical manifestations of cerebral angiomas were headaches and a cerebellar syndrome, the latter most probably due to progressive growth of cerebellar angiomas. Systematized cavernous angiomatosis is characterized by multiple angiomas of the brain and other viscera and is considered to be a phacomatosis.

Angiomatosis↗
PubMed2003

[Results of treatment of retinal detachment in active stage-5 retinopathy of prematurity].

PURPOSE: To evaluate the surgical and functional results of encircling scleral buckling in treatment of active stage 5 retinopathy of prematurity. MATERIAL AND METHODS: 68 premature infants (121 eyes) with active stage 5 ROP operated with the use of the modified encircling buckling technique. The surgical and functional results were compared with the results observed in 91 unoperated children with active stage 5 ROP. RESULTS: In the operated group total retinal reattachment was observed in 52% and partial reattachment in 24.5% of premature infants. The surgery failed to reattach the retina in 23.5%. Visual acuity was: no light perception in 56.1%, light perception to 0.02 in 24.5% and 0.02 to 0.2 in 19.4% of children. In unoperated group spontaneous reattachment was observed in 6% of infants and visual acuity was: no light perception in 76%, light perception in 20% and finger counting in 4% of them. CONCLUSION: The obtained results indicate, that modified encircling buckling can be an effective treatment in reattaching the retina in stage 5 ROP although useful vision can be obtained in only 20% of operated children.

Female↗
PubMed2004

[Botulinum toxin A in the treatment of concomitant strabismus in children].

PURPOSE: To evaluate the results of treatment of esotropia, exotropia and hypertropia with botulinum toxin A. MATERIAL AND METHODS: 72 children with esotropia, exotropia and hypertropia treated with intramuscular injection of botulinum toxin A. RESULTS: Squint angle decreased 76% in children with alternant esotropia, 70% in children with monocular esotropia, 64% in alternant exotropia and 54% in monocular exotropia after treatment with botulinum toxin A. In hypertropia squint angle reduced in 50%. CONCLUSIONS: The use of injections of botulinum toxin A in treatment of concomitant strabismus improves position of eyes, which creates better conditions for development of localization with normal retinal correspondence.

Botulinum Toxins, Type A↗
PubMedDate not supplied

[Effect of fish protein on blood pressure, glycemia and plasma and urinary parameters in spontaneously hypertensive rats (SHR) and diabetic SHR].

Fish protein (FP) effect compared to casein (CAS) was studied on blood pressure (BP) evolution and glycemia in part, and on plasma lipid, angiotensine II and aldosterone concentrations and urinary aldosterone on the other hand, in SHR and in SHR with streptozotocin-induced diabetes (SHR-STZ). Two groups of rats (6 SHR and 6 SHR-STZ) were fed for 2 months diet containing 20% CAS or 20% FP. One month before sacrifice, diabetes was induced into one group of rats by a single intraperitonealy injection of streptozotocin (STZ). The results showed that FP diminished blood pressure (-9%) in SHR, compared with CAS. In contrast, FP enhanced significantly blood pressure in SHR-STZ vs SHR (p<0.01). There was no effect on glycemia with fish protein. FP compared to CAS involved a diminution (-41%) and (-17%) of total cholesterol and (-26%) and (-9%) of phospholipids in SHR and SHR-STZ, respectively. Moreover, a decrease of triacylglycerols (-21%) was noted in SHR-STZ with FP vs CAS. In SHR, plasma aldosterone and angiotensine II concentrations were reduced (-62%) and (-64%) and urinary aldosterone amounts were enhanced with FP compared to CAS (p<0.05). In SHR-STZ group, aldosterone value was fivefold lower in plasma and twofold higher in urine with FP compared to CAS. A significant enhancement of urinary aldosterone was noted in SHR-STZ vs SHR whatever diet-consumed. In conclusion, FP has a beneficial effect on blood pressure by modulating the hypertension markers i.e. plasma total cholesterol, angiotensine II and aldosterone, in SHR group, and on total cholesterol and triglycerids in SHR-STZ. FP reduces plasma aldosterone by its enhanced urinary excretion. It is necessary to specify the action mode of FP in order to propose it as nutritional complement in the degenerative diseases such as hypertension and diabetes.

Aldosterone↗