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Half-scan fan-beam computed tomography with improved noise and resolution properties.

Half-scan strategy can be used for reducing scanning time and radiation dose delivered to the patient in fan-beam computed tomography (CT). In helical CT, the data weighting/interpolation functions are often devised based upon half-scan configurations. The half-scan fan-beam filtered backprojection (FFBP) algorithm is generally used for image reconstruction from half-scan data. It can, however, be susceptible to sample aliasing and data noise for configurations with short focal lengths and/or large fan-angles, leading to nonuniform resolution and noise properties in reconstructed images. Uniform resolution and noise properties are generally desired because they may lead to an increased utility of reconstructed images in estimation and/or detection/classification tasks. In this work, we propose an algorithm for reconstruction of images with uniform noise and resolution properties in half-scan CT. In an attempt to evaluate the image-noise properties, we derive analytic expressions for image variances obtained by use of the half-scan algorithms. We also perform numerical studies to assess quantitatively the resolution and noise properties of the algorithms. The results in these studies confirm that the proposed algorithm yields images with more uniform spatial resolution and with lower and more uniform noise levels than does the half-scan FFBP algorithm. Empirical results obtained in noise studies also verify the validity of the derived expressions for image variances. The proposed algorithm would be particularly useful for image reconstruction from data acquired by use of configurations with short focal lengths and large field of measurement, which may be encountered in compact micro-CT and radiation therapeutic CT applications. The analytic results of the image-noise properties can be used for image-quality assessment in detection/classification tasks by use of model-observers.

Algorithms↗

Improving the resolution of dynamic intensity modulated radiation therapy delivery by reducing the multileaf collimator sampling distance.

The conformality of a dose distribution delivered by a multileaf collimator (MLC) for intensity modulated radiation therapy (IMRT) is limited in the direction perpendicular to leaf motion by the finite leaf width. Two methods of improving the resolution of IMRT intensity maps in this direction were investigated. In the first, the desired fluence distribution is considered to be sampled by the MLC, with the sampling distance being the center-to-center distance between the MLC leaves. The sampling distance is reduced below the leaf width by combining separate irradiations with a couch shift between them. This has been applied to static field therapy [Galvin et al., Int. J. Radiat. Oncol., Biol., Phys. 35, 89-94 (1996)], and was proposed for IMRT by Bortfeld et al. [Med. Phys. 27, 2494-2502 (2000)]. In the second method, two MLC component fluences, with leaf width L = 2deltay and offset by deltay, are combined to reproduce desired intensity bins with deltay width. The effect of MLC leaf sampling distance on dose resolution was quantified for both 1.0 and 0.5 cm MLC leaf widths, utilizing a high resolution bar-pattern fluence, an annular shaped fluence, and an intensity step-edge. Improvement in resolution was found for the 1.0 cm leaf width at a sampling distance of 0.5 cm, with only a small benefit for further reduction. For the 0.5 cm leaf width, a sampling distance of 0.25 cm resulted in a dose resolution that was nearly independent of direction.

Algorithms↗

Theoretical signal-to-noise ratio and spatial resolution dependence on the magnetic field strength for hyperpolarized noble gas magnetic resonance imaging of human lungs.

In hyperpolarized noble gas (HNG) magnetic resonance (MR) imaging, the available polarization is independent of magnetic field strength and for large radiofrequency (rf) coils, such as those used for chest imaging, the body noise becomes the primary noise source making signal-to-noise ratio (SNR) largely frequency independent at intermediate field strengths (0.1-0.5 T). Furthermore, the reduction in the transverse relaxation time, T2, of HNG in lungs with increasing field strength, results in a decrease in the achievable SNR at higher fields. In this work, the optimum field strength for HNG MR imaging was theoretically calculated in terms of both SNR and spatial resolution. SNR calculations used the principle of reciprocity and included contributions to the noise arising from both coil and sample losses in a chest-sized coil for lung imaging. The effects of susceptibility differences, transverse relaxation time, and diffusion were considered in the resolution calculations. The calculations show that the optimum field strength for HNG MR imaging of human lungs is between 0.1 and 0.6 T depending on gas type (helium or xenon) and sample size. At the field strengths currently used by conventional clinical proton MR imaging systems (1-3 T), the predicted SNR are 10%-50% lower than at the optimum field with only slightly worse spatial resolution (10%-20%). At higher fields (>3 T), however, the SNR degrades considerably reducing the achievable spatial resolution. Although HNG of the lung is still feasible at very low field strengths (<50 mT), the available SNR is much lower than at optimum fields and this reduces the achievable spatial resolution. These findings suggest that HNG imaging may be optimally performed at much lower field strengths (0.1-0.6 T) than conventional clinical proton MR imaging systems. This could considerably decrease cost, improve patient access, and reduce chemical shift and susceptibility artifacts and rf heating.

Artifacts↗

Energy resolution in a high-pressure gas scintillation proportional chamber.

A high-pressure gas scintillation proportional chamber has been designed and constructed to image x and gamma rays for medical applications. The chamber contains 4 atm of pure xenon. Ultraviolet light emitted from excited xenon atoms within the detector is collected by a hexagonal array of seven UV-sensitive photomultiplier tubes, which in turn are separated from the pressurized gas by 1-cm-thick fused-silica windows. A model was used to predict the energy resolution of the device as a function of fill-gas pressure, voltage within the detector, and light-collection efficiency. The energy resolution improved with increasing scintillation region voltage from 17% full width at half maximum (FWHM) at 1.9 kV to 10% FWHM at 3.0 kV for 59.5-keV photons; once above 1.5 kV, there was no improvement with increasing drift voltage. The addition of the signals from the peripheral phototubes to that of the center phototube did not substantially improve the energy resolution of the device. This was because the noise that was present yielded a high correlation between the phototubes; when this noise was incorporated into the model, the energy resolution of the multiphototube system was accurately estimated. The energy resolution of the gas scintillation proportional chamber was found to be superior to the sodium iodide Anger camera at 59.5 keV by a factor of 2. Further improvement can be obtained by increasing the scintillation region voltage and by increasing the light-collection efficiency by moving the scintillation region closer to the phototubes.

Gamma Rays↗

Nuclear magnetic resonance microscopy with 4-microns resolution: theoretical study and experimental results.

Nuclear magnetic resonance (NMR) microscopy with 4-microns resolution, a step closer to the 1-micron resolution with which in vivo cellular imaging would be possible is described. An analysis of the ultimate resolution and voxel size dependent signal-to-noise ratio (SNR) in NMR microscopy is presented and experimentally verified. For microscopic scale objects (less than 1-mm diameter), the SNR based on the geometrical scale factor(s) is found to be proportional to sn where n less than 2, rather than n = 3 as previously supposed. This comes about because of a drastic reduction in sample noise coupled with a significant sensitivity gain realized in small diameter radiofrequency coils. A new pulse sequence which reduces both diffusion dependent resolution degradation and signal attenuation is presented. The selection of optimal bandwidth and acquisition time for maximal SNR is discussed. Experimental results obtained on both a 2.0-T whole-body system and a 7.0-T small bore system adapted for microscopy indicate the potentials of 4-microns resolution microscopy with the existing magnets.

Animals↗

Assessing fluoroscopic contrast resolution: a practical and quantitative test tool.

Fluoroscopic contrast resolution is commonly determined at a specified kVp by imaging a test object comprised of targets where contrast decreases gradually and sequentially. Threshold contrast or contrast resolution is the contrast of the lowest contrast target that can be perceived. This approach suffers from two problems. First, test object contrast is specified at a x-ray tube voltage that is not always obtainable in practice. Second, the small change in contrast between adjacent targets contributes to observer variability making consistent and reproducible contrast threshold determinations difficult. Described is a contrast resolution test tool that eliminates or reduces these problems. The novel target arrangement allows one to quickly and easily specify the contrast resolution of a fluoroscopic imaging chain to a precision approximately equal to 0.5%. Tables of target contrast versus x-ray tube potential are developed that permit one to employ the test object for contrast resolution determination over the normal range of tube potentials encountered on clinical units.

Fluoroscopy↗

Longitudinal resolution in volumetric x-ray computerized tomography--analytical comparison between conventional and helical computerized tomography.

The primary advantage of helical computerized tomography (CT) is the capability of scanning a complete anatomical volume in a single breath hold. Due to the table motion and subsequent interpolation process, the slice sensitivity profile (SSP) in helical CT is worse than the response function of the detector array. In this paper, image longitudinal resolution in volumetric x-ray CT is analytically characterized, and a comparison made between conventional and helical CT. First, the SSPs are derived for both conventional and helical CT with the half-scan interpolation method under the condition that the table increment and detector collimation are the same. Then, the corresponding transfer functions are obtained for bandwidth determination, which directly describe the spatial resolution. Both one-tenth-cutoff and mean-square-root measures are used to quantify the bandwidth. Although it appears that broadening the SSP in helical CT could adversely affect longitudinal resolution, it is proved that for a given x-ray dose, helical CT allows substantially better longitudinal resolution than conventional CT due to its inherent retrospective reconstruction capability. To make full use of the potential of helical CT scan data, it is recommended that about five slices be reconstructed per table increment. Helical CT is superior in applications requiring a high longitudinal resolution.

Algorithms↗

A bound on the energy resolution required for quantitative SPECT.

Scattered radiation is one of several physical perturbations that limit the accuracy of quantitative measurements in single-photon emission computed tomography (SPECT). Improvement in detector energy resolution leads to a reduction of scatter counts and a corresponding improvement in the quantitative accuracy of the SPECT measurement. In this study, simulated SPECT projections of a simple myocardial perfusion phantom were used to investigate the effect of detector energy resolution on the data. The phantom consists of a spherical shell of radionuclide within a 15 cm radius water-filled cylinder. Each projection contains on the order of 3 x 10(5) counts. The results demonstrate that a full-width, half-maximum energy resolution of 3-4 keV is sufficient to render the error due to scatter insignificant compared to the uncertainty due to photon statistics in this case. Further simulations verify that because smaller objects produce less scatter, they can be imaged accurately with degraded energy resolution. These results are useful when designing prototype systems that utilize solid-state detectors and low-noise electronics to achieve improved energy resolution.

Biometry↗

New low-contrast resolution phantoms for computed tomography.

Computed tomography (CT) has been established as a major imaging modality in diagnostic radiology. Accordingly, acceptance testing and quality control of CT scanners is of great importance. While most procedures and phantoms for testing are widely accepted, there is still discussion and uncertainty about low-contrast (LC) sensitivity. In our opinion this unsatisfactory situation is caused at least in part by the lack of suitable phantoms for LC resolution measurements. We investigated the commonly used phantoms for LC detectability, the Catphan, and for LC resolution, the ATS phantom. While the Catphan showed stable object contrasts, the ATS phantom's measured contrast exhibited a strong dependence on temperature and x-ray quality. Based on newly developed polyurethane resin materials, we designed and tested a LC resolution phantom with several different contrast steps. The object contrasts showed no dependence on temperature and beam quality. The new LC resolution phantom proved to be very suitable for measuring a scanner's low-contrast sensitivity in the image plane, one of the most important image quality parameters. To assess LC resolution in three dimensions we designed an additional phantom with rows of spherical objects. A first prototype was evaluated in a multicenter study. The setup proved to be very helpful to quantify the in-plane and axial LC sensitivity of spiral CT scan modes.

Image Enhancement↗

The resolution of complex spectral patterns by cochlear implant and normal-hearing listeners.

The differences in spectral shape resolution abilities among cochlear implant (CI) listeners, and between CI and normal-hearing (NH) listeners, when listening with the same number of channels (12), was investigated. In addition, the effect of the number of channels on spectral shape resolution was examined. The stimuli were rippled noise signals with various ripple frequency-spacings. An adaptive 41FC procedure was used to determine the threshold for resolvable ripple spacing, which was the spacing at which an interchange in peak and valley positions could be discriminated. The results showed poorer spectral shape resolution in CI compared to NH listeners (average thresholds of approximately 3000 and 400 Hz, respectively), and wide variability among CI listeners (range of approximately 800 to 8000 Hz). There was a significant relationship between spectral shape resolution and vowel recognition. The spectral shape resolution thresholds of NH listeners increased as the number of channels increased from 1 to 16, while the CI listeners showed a performance plateau at 4-6 channels, which is consistent with previous results using speech recognition measures. These results indicate that this test may provide a measure of CI performance which is time efficient and non-linguistic, and therefore, if verified, may provide a useful contribution to the prediction of speech perception in adults and children who use CIs.

Adult↗

Transmission mode time-reversal super-resolution imaging.

The theory of time-reversal super-resolution imaging of point targets embedded in a reciprocal background medium [A. J. Devaney, "Super-resolution imaging using time-reversal and MUSIC," J. Acoust. Soc. Am. (to be published)] is generalized to the case where the transmitter and receiver sensor arrays need not be coincident and for cases where the background medium can be nonreciprocal. The new theory developed herein is based on the singular value decomposition of the generalized multistatic data matrix of the sensor system rather than the standard eigenvector/eigenvalue decomposition of the time-reversal matrix as was employed in the above-mentioned work and other treatments of time-reversal imaging [Prada, Thomas, and Fink, "The iterative time reversal process: Analysis of the convergence," J. Acoust. Soc. Am. 97, 62 (1995); Prada et al., "Decomposition of the time reversal operator: Detection and selective focusing on two scatterers," J. Acoust. Soc. Am. 99, 2067 (1996)]. A generalized multiple signal classification (MUSIC) algorithm is derived that allows super-resolution imaging of both well-resolved and non-well-resolved point targets from arbitrary sensor array geometries. MUSIC exploits the orthogonal nature of the scatterer and noise subspaces defined by the singular vectors of the multistatic data matrix to form scatterer images. The time-reversal/MUSIC algorithm is tested and validated in two computer simulations of offset vertical seismic profiling where the sensor sources are aligned along the earth's surface and the receiver array is aligned along a subsurface borehole. All results demonstrate the high contrast, high resolution imaging capabilities of this new algorithm combination when compared with "classical" backpropagation or field focusing. Above and beyond the application of seismo-acoustic imaging, the time-reversal super-resolution theory has applications in ocean acoustics for target location, and ultrasonic nondestructive evaluation of parts.

Acoustics↗

Temporal integration, frequency resolution, and off-frequency listening in normal-hearing and cochlear-impaired listeners.

Temporal integration for a 1000-Hz signal was determined for normal-hearing and cochlear hearing-impaired listeners in quiet and in masking noise of variable bandwidth. Critical ratio and 3-dB critical band measures of frequency resolution were derived from the masking data. Temporal integration for the normal-hearing listeners was markedly reduced in narrow-band noise, when contrasted with temporal integration in quiet or in wideband noise. The effect of noise bandwidth on temporal integration was smaller for the hearing-impaired group. Hearing-impaired subjects showed both reduced temporal integration and reduced frequency resolution for the 200-ms signal. However, a direct relation between temporal integration and frequency resolution was not indicated. Frequency resolution for the normal-hearing listeners did not differ from that of the hearing-impaired listeners for the 20-ms signal. It was suggested that some of the frequency resolution and temporal integration differences between normal-hearing and hearing-impaired listeners could be accounted for by off-frequency listening.

Adult↗

Frequency resolution and discrimination of constant and dynamic tones in normal and hearing-impaired listeners.

Frequency resolution and three tasks of frequency discrimination were measured at 500 and 4000 Hz in 12 normal and 12 hearing-impaired listeners. A three-interval, two-alternative forced-choice procedure was used. Frequency resolution was measured with an abbreviated psychoacoustical tuning curve. Frequency discrimination was measured for (1) a fixed-frequency standard and target, (2) a fixed-frequency standard and a frequency-transition target, and (3) frequency-transition standard and a frequency-transition target. The 50-ms frequency transitions had the same final frequency as the standards, but the initial frequency was lowered to obtain about 79% discrimination performance. There was a strong relationship between poor frequency resolution and elevated pure-tone thresholds, but only a very weak relationship between poor frequency discrimination and elevated pure-tone thresholds. Several hearing-impaired listeners had normal discrimination performance together with pure-tone thresholds of 80-90 dB HL. A slight correlation was found between word recognition and frequency discrimination, but a detailed comparison of the phonetic errors and either the frequency-discrimination or frequency-resolution tasks failed to suggest any consistent interdependencies. These results are consistent with previous work that has suggested that frequency resolution and frequency discrimination are independent processes.

Acoustic Stimulation↗

Frequency resolution as a function of hearing threshold level and age.

Frequency resolution ability was measured using a psychoacoustical tuning curve (PTC) or a notch-noise technique in two population samples. The first sample incorporated 1764 subjects with various degrees of sensorineural hearing impairment and ranging in age from 17-80 years. The second sample included 240 subjects aged between 50 and 75 years, carefully balanced in terms of impairment and age to avoid confounding between these two variables. In both samples, frequency resolution ability declined with increasing hearing threshold level (HTL), as measured by either method. In a subsample tested with both methods, the correlation between the two was only modest. After accounting for HTL, there was a minor dependence of frequency resolution on age, older subjects having poorer frequency resolution once HTL had been accounted for. No addition to the explained variance was achieved by taking sex, occupational group, or audiogram slope into account. Despite the documented reproducibility of the measures, much of the variance in the frequency resolution measurements remained unrelated to HTL or age.

Adolescent↗

Intensity resolution and loudness in high-pass noise.

Intensity resolution and loudness growth for a 1000-Hz tone were studied in the presence of high-pass noise (cutoff: 1800 Hz). Intensity resolution was measured for gated and continuous standards using a three-interval forced-choice (3-IFC) adaptive procedure. Loudness matches were obtained using an adaptive, alternate binaural loudness balance procedure. Three subjects listened in three conditions (1) quiet; (2) high-pass noise with a spectrum level of 32 dB SPL; and (3) high-pass noise with a spectrum level of 42 dB SPL. Noise levels were selected so that detection thresholds were minimally affected at the test frequency; however, for frequencies in the noise passband, thresholds were shifted to either 50 or 60 dB SPL, depending on the spectrum level of the noise. On average, loudness growth and intensity resolution were unaltered by the presence of the noise for tonal levels below 40 dB SPL; above 40 dB SPL the following was generally true: (1) intensity resolution for gated standards was well described by Weber's law except at the highest levels where the Weber fraction decreased; (2) intensity resolution for continuous standards showed a "near-miss" to Weber's law, but just-noticeable differences (jnd's) were slightly larger than those in quiet for the same SPL; (3) loudness was reduced. A comparison of jnd's for equally loud tones showed that loudness is less dependent on excitation spread than the jnd. That is, jnd's in the threshold-shifted ear were larger than the ones in quiet when the comparison was made for tones judged to be equally loud.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

Ripple density resolution for various rippled-noise patterns.

Ripple-density resolution was measured in normal humans using rippled noise with a phase-reversal test. The principle of the test was to find the highest ripple density at which an interchange of spectral peak and trough positions (the phase reversal) is detectable. Different rippled noise patterns were used: (i) either frequency-proportional or constant ripple spacing; (ii) various bandwidth; and (iii) either steep or shallow slopes of the spectrum envelope. When tested with frequency-proportional rippled noise, ripple-density resolution as expressed in relative units (the center frequency to ripple spacing ratio) little depended on frequency within a range of 1 to 8 kHz: from 11.4 at 1 kHz to 14.9 at 8 kHz, mean 13.1. These values were virtually independent on noise bandwidth. When tested with constant ripple spacing, the resolution was of similar values taking the relative ripple density at the lower part of the passband. Being measured by noise with steep spectral edges, the resolution was five units higher than it was for shallow-enveloped spectra, thus suggesting some edge effects at the spectrum boundaries. The resolution values obtained were about twice higher than those predicted by peripheral auditory filter tuning.

Adult↗

Auditory perception following hair cell regeneration in European starling (Sturnus vulgaris): frequency and temporal resolution.

Behavioral detection thresholds, auditory filter widths, and temporal modulation transfer functions were obtained from four starlings before, during and after 11 days of subcutaneous injections of kanamycin, an aminoglycoside antibiotic. Birds were operantly conditioned to respond to pure tones and amplitude modulated noises ranging in frequency from 0.25 to 7 kHz using adaptive staircase procedures and were tested daily for 92 days after the first injection of aminoglycoside. All birds had threshold shifts of at least -60 dB at frequencies above 4 kHz. Lower frequencies were affected in some birds, although none of the birds had hearing loss below 3 kHz. All four birds had wider auditory filters at 5 kHz immediately after the aminoglycoside series. Any changes in frequency resolution at frequencies below 5 kHz were slight, transitory, and rarely observed. Two of the four birds had permanently wider auditory filters at 5 kHz. Temporal modulation transfer functions were briefly affected in two birds during the time of greatest threshold shift. Recovery of detection thresholds began soon after the injections ceased and continued for approximately 60 days. Recovery in frequency resolution lagged behind auditory threshold by about 10 days. Normal temporal resolution was observed in the context of impaired intensity and frequency resolution. Changes in auditory threshold and frequency resolution were closely associated for all birds at 5 kHz, but were correlated with statistical significance in only two birds. Scanning electron microscopy was performed on all four birds after 90 days of recovery and confirmed that the extent of initial damage was consistent with the pattern of observed hearing loss.

Animals↗

High-resolution scanning electron microscopy of bacteriophages 3C and T4.

An account is presented of the design and operation of a new scanning electron microscopic, and its first application to the study of biological samples. Bacteriophages were chosen because much of their ultrastructure is beyond the resolution of the conventional scanning electron microscope. The new instrument permits examination of bulk samples with a resolution that exceeds, by at least a factor of 2.5, the resolution obtained in the best secondary electron scanning electron microscopes using high brightness guns, and exceeds by an order of magnitude the resolution of standard scanning electron microscopes using tungsten filament guns. It also permits examination of biological samples in scanning transmission mode at resolutions similar to conventional transmission electron microscopes.

Coliphages↗