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At least 811 records · Page 45Linked to original sources
PubMed1986

[Isolation and study of the biological properties of substances stimulating levorin biosynthesis in a mixed actinomycete and yeast culture].

Active components responsible for increased synthesis levels of levorin, a polyenic antibiotic in mixed cultures of an actinomycete and a yeast-like fungus C. tropicalis were isolated from the fermentation broth. Component I identified as succinic acid increased the levels of the antibiotic production by 40-50 per cent. Component II found to be lactic acid increased the antibiotic production levels by 20 per cent. Component III, a mixture of nonidentified substances of the amine nature stimulated biosynthesis of levorin by 20-25 per cent. Addition of a mixture of succinic acid and N-methyl glucosamine to the nutrient medium provided increase of the antibiotic activity of the fermentation broth up to 175-185 per cent as compared to the control.

Antifungal Agents↗
PubMed1987

Bioequivalence studies of five brands of ampicillin trihydrate capsules.

Using the microbiological assay method, the bioavailability of ampicillin in healthy human volunteers has been examined. The plasma levels were used to determine the extent and rate of bioavailability following oral administration of 250 mg capsules produced by 5 different manufacturers. Balanced incomplete block design was employed and standard statistical techniques were used to detect any significant difference between multivariate and univariate characteristics. The results indicate that the different brands are almost bioequivalent with respect to the rate of bioavailability but that they are bioinequivalent with respect to the extent of bioavailability.

Adult↗
PubMed1985

Cefoxitin and cefamandole levels in the human bile.

The bile levels of cefoxitin and cefamandole were studied in 75 patients. The two antibiotics were shown to be present at high concentration and to undergo a rapid metabolization. It is concluded that they represent the antibiotics of choice in the prophylactic and therapeutic treatment of biliary tract infections.

Bile↗
PubMed1978

Tissue distribution and residues of oxytetracycline in normal and emergency-slaughtered ruminants.

The concentration of oxytetracycline (OCT) in the blood, kidneys urine and meat was determined in a group of clinically normal dairy cows slaughtered at different times after treatment. Drug concentrations were similarly determined in a group of emergency-slaughtered dairy cows and calves. Distribution pattern of the drug in the body, expressed as muscle-drip-to-serum and kidney-cortex-to-serum ratios of the drug concentrations were determined in clinically normal cows and these ratios were compared with the corresponding ratios found in the emergency-slaughtered cows. Attempts were also made to relate changes in the expected ratios to the clinical and pathological findings in the emergency-slaughtered cows. High and persistent levels of the drug in the serum and a slower drug elimination from the body were the main characteristic findings in the sick cows. Drug persistence could not be related to specific tissue uptake or to better drug distribution, although the actual drug concentration in the muscle and the kidney of cows with different clinical pathological findings varied widely and was quite unpredictable. It is concluded that the kinetics of the oxytetracycline residues follow the same pattern as the drug residues in the serum, and these principles seem to apply in normal and in emergency-slaughtered dairy cows.

Animals↗