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Latency shifts in the N2b component track phonological deviations in spoken words.

OBJECTIVE: We investigated event-related brain potentials (ERPs) elicited by a novel speech comprehension paradigm modelled after the neuropsychological Token Test. The objective of the study was to determine whether the ERPs were sensitive to differences in the initial phonemes of the speech stimuli. METHODS: Twenty-seven healthy subjects identified incorrect spoken sentences on the computerised Token Test (CTT). The incorrect spoken sentences contained one word that did not match the previously studied animations. The initial phonemes of these words were either different than or similar to the initial phonemes of their correct counterparts. RESULTS: Different initial phonemes were associated with an early N2b, while words having similar initial phonemes resulted in a substantially delayed N2b. CONCLUSION: The delayed latency effect was due to whether the incorrect word's initial phoneme matched or mismatched that of the expected word. In both cases, this component reflected a mismatch with an existing cognitive template maintained in phonological working memory. The results indicate that this mismatching effect reflected primarily attentional detection rather than language processing.

Adult↗

Relationship between lifetime smoking, smoking status at older age and human cognitive function.

Cigarette smoking is a major risk factor for clinical cardiovascular disease and may also be associated with poorer cognitive functioning in older age. We measured lifetime cigarette smoking, smoking status and cognitive function in over 2,000 men and women from the general population aged over 50 years with subclinical atherosclerosis (ankle brachial pressure index<or=0.95 but no history of clinical cardiovascular disease). In this population, an association was found between greater lifetime smoking and poorer cognitive function in men and between smoking cessation and better cognitive function in women. The former relationship appeared to reflect an association between smoking habit and prior cognitive function (in early life), whereas the latter remained significant after adjustment for tests of crystallised cognitive function, suggesting a relationship between continuing to smoke (as opposed to quitting) and age-related cognitive decline. Both relationships were independent of the degree of atherosclerosis (as measured using the ankle brachial pressure index), suggesting alternative underlying mechanisms for the association between smoking and human adult cognitive function.

Aged↗

Stress, verbal cognitive activity and bilateral electrodermal responses.

The simultaneous recording of bilateral electrodermal activity (skin potential responses) on both right and left hands (the reference electrode being located on the forearm under the skin) on 30 right-handed subjects during the reflection phase of a verbal cognitive task and a stressful situation showed that, contrary to the expectations related to the hypothesis of lateralization, the percentage of equal amplitude (right and left) SPRs is very high in both situations, and SPRs are significantly less lateralized in the stressful stiuation than in the verbal task.

Action Potentials↗

Behavioral and cognitive treatment methods: a critical comparative review.

Forty clinical outcome studies were selected using strict criteria in which standard behavior therapy (BT) procedures were compared with procedures considered cognitive. The question asked was whether the addition of cognitive therapy (CT) methods yielded more beneficial treatment outcomes. Most studies reflected an equivalence in outcome between cognitive-behavioral therapy (CBT) procedures and behavioral procedures alone. Behavior therapy was superior in two studies to treatments with a cognitive component. One finding was that cognitive therapy has shown promise in the areas of social anxiety. The behavioral aspect of CBT seemed central to its effectiveness, while the same cannot be said for the cognitive components. Given that only a modicum of clinical benefit has been added in twenty years of the cognitive therapy movement, it is suggested that the wholesale adoption of cognitive procedures is unmerited.

Behavior Therapy↗

Concurrent counting and typing: lateralized interference depends on a difference between the hands in motor skill.

In previous demonstrations of differences between left- and right-handers in dual-task performance, participants' hand preference has been confounded with asymmetry of manual skill. The present study was designed to disentangle those two factors as sources of lateralized interference in the concurrent-task paradigm. Forty-eight normal adults (24 females and 24 males) counted backward by ones or by twos while typing an easy or difficult sequence of letters with either hand. When participants were grouped according to self-reported hand preference, both groups showed bilaterally symmetric slowing, relative to single-task conditions. However, when the same participants were grouped according to manual asymmetry in the baseline condition, the cognitive task interfered significantly more with the faster hand than with the slower hand. Baseline typing rate, averaged across hands, did not influence dual-task interference. Both self-reported left-hand preference and left-hand superiority in baseline typing were associated with reduced interference on the cognitive task, and the reduced interference in those groups seemed to reflect relatively loose coupling between manual and cognitive tasks. The results support and extend Caroselli et al.'s (1997) findings regarding the effect of baseline manual asymmetry on the pattern of dual-task interference. Irrespective of the participant's hand preference, the presence or absence of baseline asymmetry may be sufficient to determine whether dual-task interference is lateralized.

Adolescent↗

Hyperactive children treated with stimulants. Is cognitive training a useful adjunct?

We evaluated whether, among hyperactive children who required maintenance stimulant treatment, cognitive training enhanced academic performance; improved the functioning of youngsters who had only a partial behavioral response to medication; facilitated withdrawal of stimulant treatment; and enhanced maintenance effects of academic gains following termination of stimulants. A 16-week cognitive training program that emphasized reflective problem-solving strategies and social problem-solving skills was compared with an attention control treatment and with no training. There was virtually no evidence of efficacy of cognitive training. No significant treatment effects were obtained on academic, behavioral, and cognitive measures. Cognitive training did not improve behavior among children with residual problems, nor did it facilitate the withdrawal of medication. With placebo substitution, the overwhelming majority of children required remedication, regardless of previous exposure to cognitive training.

Achievement↗

Objective assessment of motor slowness in Huntington's disease: clinical correlates and 2-year follow-up.

Functional disability of patients with Huntington's disease (HD) is determined by impairment of voluntary motor function rather than the presence of chorea. However, only few attempts have been made to quantify this motor impairment. By using a simple reaction time paradigm, we measured the time needed for movement initiation (akinesia) and execution (bradykinesia) in 76 HD patients and 127 controls. Akinesia and bradykinesia were already evident in early stages and increased linearly with increasing disease stage. Quantified motor slowness correlated with clinical impairment of voluntary movements but also with cognitive impairment and medication use. In patients without severe cognitive impairment, quantified motor slowness reflected clinical motor impairment more purely. During 1.9 years follow-up (range, 0.8-3.8 years), quantified akinesia and bradykinesia progressed concomitantly with progression of clinical impairment of voluntary movements, cognition, and functional capacity. However, rate of change in motor slowness did not discriminate between patients whose disease stage remained stable and those whose disease stage progressed. We conclude that the reaction time paradigm may be used to quantify akinesia and bradykinesia in HD, at least in patients without severe cognitive impairment. Although reaction and movement times increased in time, these measures failed to detect functionally important changes during our follow-up period.

Adult↗

[Subjective memory loss--a sign of cognitive impairment in the elderly? An overview of the status of research].

According to the growing clinical interest in early indicators of dementia, numerous studies have examined the association between subjective memory complaints and cognitive performance in old age. Their results are contradictory. In this paper, studies carried out over the last 10 years are compared with regard to the study design and the assessment instruments used. The results are discussed with particular reference to the diagnostic validity of subjective memory complaints. The majority of case-control studies and cross-sectional studies of non-representative samples could not demonstrate an association between subjective memory complaints and cognitive performance. Most field studies of larger representative population samples, however, have come to the opposite conclusion. A consistent assessment of these statistically significant associations against the background of diagnostic validity showed that memory complaints cannot be taken as a clear clinical indicator for cognitive impairment. Subjective memory complaints may reflect depressive disorders and a multitude of other processes, of which an objective impairment of cognitive performance is just one aspect. As a consequence, an inclusion of subjective memory complaints as a diagnostic criterion for the diagnosis of "mild cognitive disorder" according to ICD-10 is not justified.

Aged↗

Visual information-processing speed in reflective and impulsive children.

A backward-masking procedure was used to measure the rate of visual information processing in 8- and 10-year-old reflective and impulsive children. The test stimulus (TS) and the masking stimulus (MS) which followed it were presented tachistoscopially. The subject's information-processing threshold was defined as the next highest TS-MS interval above the interval where at least 3 of the 4 TSs were incorrectly identified. Reflective children were significantly faster than impulsive children at processing information. This finding was related to research indicating that reflective and impulsive children employ similar cognitive strategies; it was suggested that performance differences between these children might be related to reflective children employing their strategies with more adequate information.

Age Factors↗

Cognitive function in diabetes mellitus: the effects of duration of illness and glycaemic control.

Post-mortem studies suggest that chronic, poorly controlled diabetes mellitus might be associated with degenerative changes in the central nervous system. However, the evidence that these changes are reflected in any impairment of cognitive performance is equivocal. The study reported here evaluated the effects of duration of illness and glycaemic control upon memory function in 40 cases of insulin-dependent diabetes mellitus (IDDM). Duration of illness was inversely related to performance, but degree of glycaemic control had no effect at all. This suggests that any impairment of cognitive function associated with IDDM is more likely to be attributable to the impact of suffering from a life-threatening disease rather than to organic neurological damage. The effect of chronicity was somewhat more pronounced in the case of concrete material than in the case of abstract material, and it is suggested that chronic IDDM might be associated with a specific impairment in elaborative encoding.

Adult↗

A voxel-based investigation of brain structure in male adolescents with autistic spectrum disorder.

Autistic spectrum disorder (ASD) has been associated with abnormal neuroanatomy in many imaging and neuropathological studies. Both global brain volume differences and differences in the size of specific neural structures have been reported. Here, we report a voxel-based morphometric whole brain analysis, using a group specific template, on 16 individuals of normal intelligence with autistic spectrum disorder (ASD), and a group of 16 age-, sex- and IQ-matched controls. Total grey matter volume was increased in the ASD group relative to the control group, with local volume increases in the right fusiform gyrus, the right temporo-occipital region and the left frontal pole extending to the medial frontal cortex. A local decrease in grey matter volume was found in the right thalamus. A decrease in global white matter volume in the ASD group did not reach significance. We found the increase in grey matter volume in ASD subjects was greatest in those areas recognised for their role in social cognition, particularly face recognition (right fusiform gyrus), mental state attribution: 'theory of mind' (anterior cingulate and superior temporal sulcus) and perception of eye gaze (superior temporal gyrus). The picture as a whole may reflect an abnormally functioning social cognitive neural network. We suggest that increased grey matter volume may play a pivotal role in the aetiology of the autistic syndrome.

Adolescent↗

Cognitive behavior therapy, relaxation training, and tricyclic antidepressant medication in the treatment of depression.

Outcomes of seven treatment trials comparing cognitive behavioral therapy to treatment with tricyclic antidepressant medication in major depressive disorder have been quite similar to one another. This led us to question whether treatment outcome in time-limited studies reflected a unique effect of cognitive behavioral therapy. To test the uniqueness hypothesis, relaxation training, a nonpharmacologic, noncognitive treatment, was chosen as a comparison for cognitive behavioral therapy as well as drug therapy. Treatment duration was 16 weeks. The sample of 37 patients treated for major depressive disorder was less depressed than those previously studied. For both cognitive behavioral therapy and relaxation training, outcome of depression was superior to that of tricyclic antidepressant medication by endpoint analysis. The posttreatment scores on the Beck Depression Inventory of 82% of the group receiving cognitive behavioral therapy improved to a Beck Depression Inventory score < or = 9 which was not significantly greater than that for the group receiving relaxation training (73%), so a unique effect was not demonstrated for cognitive behavioral therapy. The outcome for tricyclic antidepressant medication (29% improved to criteria) was significantly worse than that for cognitive behavioral therapy. The patient's pretreatment initial expectancy was not predictive.

Adolescent↗

[Early clinical signs of dementia in the elderly].

Clinical signs and symptoms preceding the onset of dementia are sometimes acute, such as mood disorders often associated with hypochondriacal traits and cognitive slowing, sudden and serious suicide attempts, character and conduct disorders contrasting with the previous state, and psychotic disorders presenting as pathological mistrust, or ill-structured prejudice or persecution. Most forerunning symptoms reflect a progressive deterioration of cognitive functions over a long period, that have been masked by various coping strategies used by the patient with the spouse's help. Progressive cognitive deficits may develop over years before dementia can be diagnosed with confidence. Quantitative tools can help to detect dementia incipiens, such as the Folstein Mini Mental Test, the Mattis Dementia Scale, the five-word learning test, the clock drawing test, and the brief cognitive battery. The profile of early cognitive deterioration varies according to the type of dementia (Alzheimer's disease, fronto-temporal dementia, Lewy body dementia, and vascular dementia). The symptoms of dementia may be interlinked with symptoms of other disorders. Neuropsychological tests and brain imaging are needed to validate the diagnosis.

Aged↗

Taste-related activity in the human dorsolateral prefrontal cortex.

Taste remains one of the least-explored human senses. Cortical taste responses were investigated using neuroimaging in 40 subjects tasting a range of different taste stimuli compared to a neutral tasteless control. Activation was found in the anterior insula/frontal opercular taste cortex and caudal orbitofrontal cortex, both areas established as taste cortical areas by neuronal recordings in primates. A novel finding in this study was a highly significant response to taste in the dorsolateral prefrontal cortex. This may reflect an effect of taste on cognitive processing to help optimise or modify behavioural strategies involved in executive control; or it could reflect the engagement of this region in attentional processing by a taste input.

Adult↗

An investigation of the relationship between cognitive tempo and creativity in preschool-age children.

70 preschool-age children were administered a modified version of the Matching Familiar Figures test as well as a modified version of the picture completion task from the Torrance Tests of Creative Thinking. Sex of subject and cognitive tempo were combined factorially with type of creativity measure in a 2 times 2 times 4 repeated-measures design. A significant effect for cognitive tempo was found showing reflective subjects scoring higher than impulsive subjects on each measure of creativity.

Child, Preschool↗

Contribution of changes in ubiquitin and myelin basic protein to age-related cognitive decline.

The structural substrates for age-associated cognitive and motor slowing are not known, but age-related white matter changes, such as ubiquitin (UBQ)-immunoreactive granular degeneration of myelin, might contribute to this slowing. To address this hypothesis we measured immunoreactivity for UBQ and myelin basic protein (MBP) in frontal white matter of age-, sex- and postmortem interval-matched cases with no cognitive impairment (NCI; N=12), mild cognitive impairment (MCI; N=14) and Alzheimer disease (AD; N=12). There were no significant correlations between UBQ in white matter and cognitive measures, but MBP was significantly lower in AD compared with NCI and MCI. MBP correlated with overall cognition as assessed by neuropsychological summary scores, as well as with timed cognitive tests and those that reflect frontal functions. An age-related decrease in MBP immunoreactivity was detected in NCI cases (r=0.71). These results support the hypothesis that white matter pathology may contribute to age-associated decline in cognition.

Aged↗

An extended epistemology for fostering transformative learning in holistic nursing education and practice.

The transformation from traditional nursing practice to holistic nursing is one that requires recognition of multiple ways of knowing. Transformative learning theory reflects a strong bias toward cognitive epistemology and propositional knowing. This epistemology, labeled here as truncated, rests on an understanding of experience derived from pragmatism. This article describes an extended epistemology derived from the work of John Heron that better reflects the full range of knowing utilized by holistic nurses. This epistemology provides a foundation for innovative approaches for the development of holistic awareness in the training and continuing professional development of nurses. One such approach, collaborative inquiry, is described.

Clinical Competence↗