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Results for “Compressive Strength”

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PubMed1994

Experimental studies on a new bioactive bone cement: hydroxyapatite composite resin.

We developed hydroxyapatite composite resin (CAP) as a new type of bioactive bone cement. CAP is composed of 80% w/w hydroxyapatite granules (mean particle size: 2 microns) and bis-phenol-A glycidyl methacrylate-based resin. The setting time is 5 min and the peak curing temperature during polymerization is 46 degrees C. In this study, the mechanical strength of CAP and the biological behaviour of the CAP-bone interface were examined. The compressive strength of CAP was 260 MPa and this was about three times greater than that of commercial polymethylmethacrylate (PMMA) bone cement. The tensile strength and fracture toughness of CAP also exceeded those of PMMA cement. CAP was implanted into the femoral condyles of rabbits. Two weeks later, new bone formation was already seen on the surface of the CAP implants. At 8 wk, bone was growing directly onto the surface of the CAP implants and no intervening fibrous tissue could be observed at the CAP-bone interface. These results show that CAP is a promising material which possesses superior mechanical strength and the biological property of achieving direct contact with bone.

Animals↗

PubMed1993

Relationships between bone structure in the iliac crest and bone structure and strength in the lumbar spine.

The purpose of this study was to examine the relationship between histomorphometric variables of cancellous bone structure and ultimate compressive strength (UCS) in the second lumbar vertebra (L2) and to determine whether structural variables in the iliac crest are predictive of the same variables and of UCS in L2. At autopsy, 7.5 mm diameter cores were removed from the iliac crest and from L2 of 29 subjects who had died suddenly without bone disease. Cancellous bone volume (BV/TV, %) was significantly lower in L2 than in iliac crest due to lower trabecular number (Tb.N, per mm) and thickness (Tb.Th, microns). There were significant correlations between iliac crest and L2 for BV/TV, Tb.N and trabecular separation (Tb.Sp, microns), but not for Tb.Th. BV/TV was negatively correlated, and Tb.Sp was positively correlated with age at both sites. Tb.Th was not significantly correlated with age in the iliac crest, but a significant negative correlation was observed in L2. The UCS of vertebral cores was negatively correlated with age. BV/TV and Tb.Th in L2 were positively correlated with UCS in L2.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

PubMed1993

Mechanical performance of a dental composite: probabilistic failure prediction.

In clinical situations, the mechanical performances of dental structures--for example, composite restorations--depend on many factors. Most of them have a probabilistic character. Because composites are brittle materials, their strength should also be considered as a probabilistic quantity. For successful prediction of mechanical failure of structures consisting of these materials, a probabilistic approach is indispensable, and a suitable definition of equivalent stress must be introduced. An equivalent stress facilitates the transfer of strength data of laboratory specimens to situations where the stress state is much more complicated. The tensile and compressive strengths of composites differ considerably. Of two equivalent stress definitions that potentially describe this experimental fact (the Drücker-Prager and the Modified von Mises equivalent stress), the predictive capacity was investigated for a microfine composite. In a probabilistic approach to failure, use of the Drücker-Prager equivalent stress appeared to be superior, because the average failure load of notched beams was predicted with an error smaller than 8%.

Bisphenol A-Glycidyl Methacrylate↗

PubMed1990

Use of high-energy shock waves for bone cement removal.

The revision rate of total hip arthroplasty has increased dramatically over recent years, leading to different methods of extraction of the femoral cement mantle to reduce operative time and surgical risks. The use of high-energy shock waves produced by the Dornier HM.3 Lithotripter to interrupt the cement-bone interface and to reduce the material properties of the cement is investigated. Tests were conducted to measure the pull-out strength of cemented treated rods versus untreated rods, from the medullary canal of canine femurs. The treated femurs showed an average reduction in pull-out strength of 43%. An investigation involving the material properties of acrylic bone cement was also conducted. The properties tested were the compressive modulus of elasticity, the ultimate compressive strength, the ultimate tensile strength, and fracture toughness. The scanning electron microscope aided in determining whether microfractures in the cement resulted from the shock wave treatment. A theoretical study utilizing the finite element method was used to investigate areas of select shock wave treatment about the femoral prosthesis. Analysis of the results showed that the lithotripter treatment had no significant effect on the compressive properties but reduced the tensile properties and fracture toughness significantly. Scanning electron microscopy uncovered definite areas of induced microfractures not present in the control specimens. This study supports the concept of clinically noninvasive, preoperative shock wave treatment prior to total hip revision.

Animals↗

PubMed2001

[Comprehensive assessment of the ovariectomized rat model of postmenopausal osteoporosis].

Dual-energy X-ray absorptiometry(DEXA), scanning electron microscopy, and bone biomechanical test were used to assess comprehensively bone quantity and quality of ovariectomized rats. In OVX rats, not only bone mineral density (BMD) of lumbar vertebrae in vivo and vitro, but also BMD of femora (except for R3 region) and proximal metaphysis(R1 region) in vitro decreased obviously (P < 0.01), whose bone loss rates of L5 and L6 were the highest and achieved 13%; the trabeculae of OVX rats were few, fine, and discontinued and there were lacunae on the surface; in OVX rats, both compressive strength of vertebral bodies and the mechanical properties of femora decreased; the falling degree of the former was greater; the maximal compressive power of lumbar vertebrae decreased with 33.32%. We conclude that after 4-month post-ovariectomy, the bone quantity and quality of six-month-old rats decreased, especially in the area of abundant cancellous bone such as vertebral bodies, distal femora; the assessment of the efficiency of new drugs to prevent and treat postmenopausal osteoporosis using rat models should include these drugs' effects to the bone mass, the bone structure, and the bone strength.

Absorptiometry, Photon↗

PubMed2000

Anterior cervical fusion: a finite element model study on motion segment stability including the effect of osteoporosis.

STUDY DESIGN: Three-dimensional, nonlinear finite element models were used to evaluate the stability of the mid cervical spine after anterior fusion in patients with and without osteoporosis. OBJECTIVES: The objective of this study was to compare the change in flexibility of C5-C6 after anterior discectomy with both loose-fitting and tight-fitting fusion graft. SUMMARY OF BACKGROUND DATA: Many factors such as surgical technique, osteoporosis, and excess neck motion during the postoperative period may contribute to fusion failure. Knowledge about changes in biomechanical properties after the surgical procedure is important for selection of grafts with appropriate strength and for guiding patients in postoperative care and rehabilitation. METHODS: Analyses with anterior fusion models with both loose-fitting and tight-fitting graft were performed in a normal and an osteoporotic spine. The motion of the C5 vertebra in relation to the C6 vertebra were calculated, after multidirectional moment loads of 0.5 Nm combined with a compressive preload of 105 N. RESULTS: Loose-fitting graft produced both an increase and a decrease in motion under various external moment loads, with graft compressive stress below the compressive strength of the graft material. A reduction in motion was observed under all moment loads when a tight-fitting graft was used. The compressive stress in the tight-fitting graft was higher than the strength of the graft material. Osteoporosis increased the principal motions with both the loose-fitting graft and tight-fitting graft. Maximum increase in motion with a loose-fitting graft construct was observed under extension and axial torsion moment loads. CONCLUSIONS: Anterior discectomy and insertion of the loose graft resulted in increased motion. A tight-fitting graft is beneficial in reducing motion, but the stress within the graftincreases beyond the graft strength. The presence of osteoporosis was nominally significant when the graft was tight fitting.

Adult↗

PubMed1997

Strength and stability of posterior lumbar interbody fusion. Comparison of titanium fiber mesh implant and tricortical bone graft.

STUDY DESIGN: A paired comparison was done of the bending flexibility and compression strength of tricortical bone graft and titanium fiber mesh implants in a human cadaver model of posterior lumbar interbody fusion. OBJECTIVES: To test the hypothesis that a titanium fiber mesh implant and a tricortical bone graft provide adequate and equal mechanical strength and stability in posterior lumbar interbody fusion constructs. SUMMARY OF BACKGROUND DATA: Although studies of posterior lumbar interbody fusion constructs have been performed, the authors are unaware of any study in which the strength and stability of a titanium fiber mesh implant are compared with those of tricortical bone graft for posterior lumbar interbody fusion in the human cadaver lumbar spine. METHODS: Changes in neutral zone and range of motion were measured in a bending flexibility test before and after placement of posterior lumbar interbody fusion constructs. Tricortical bone graft and titanium fiber mesh implant construct stability than were compared in a paired analysis. The constructs than were loaded to failure to evaluate construct strength as a function of graft material and bone mineral density. RESULTS: The posterior lumbar interbody fusion procedure produced statistically significant decreases in neutral zone when compared with the intact spine. No statistically significant differences in neutral zone, range of motion, or strength were detected between the two implants. Construct strength correlated strongly with bone mineral density. CONCLUSIONS: Posterior lumbar interbody fusion procedures result in equal or improved acute stability for titanium fiber mesh implants and tricortical bone graft implants when used without additional posterior stabilization.

Aged↗

PubMed1989

Physical activity and the strength of the lumbar spine.

The cadaveric lumbar spines of nine young men killed in road accidents were subjected to a range of mechanical tests, and the results compared with the men's occupational and recreational histories. It was found that the compressive strength of the spines tended to increase with the level of physical activity in life, but the increase was significant only in the eight spines aged 18 or over. Compressive failure usually occurred in the vertebral body, but in three cases, the disc prolapsed into the vertebral canal; these discs came from three of the four most physically active individuals. It is concluded that physical activity strengthens both the vertebrae and the discs. A high level of activity can cause vertebral strength to exceed that of the discs.

Adolescent↗

PubMed1989

Effects of bone ingrowth on the strength and non-invasive assessment of a coralline hydroxyapatite material.

The dependence of strength on the amount of bone growth into a hydroxyapatite material made from coral was investigated. Block and granular forms of the material were implanted into cortical and trabecular regions of the skeletons of 16 dogs. The results were examined after 4, 8, 12 and 16 wk, with four dogs in each experimental group. When implanted into cortical bone, the bending strength of the implant material was found to be highly correlated with the amount of pore space which had become occupied by bone (r = 0.92, P less than 0.005 for the block form; r = 0.84, P less than 0.005 for the granular form). Multiple regression analysis showed that six histomorphometric measures of ingrowth accounted for 96% of the variability in bending strength of the block material, and there were no significant differences between block and granular forms of the material. On the other hand, when implanted into trabecular bone, the block form of the material achieved greater compressive strength than the granular form. While both strength and ingrowth increased with time, there were poor correlations between these two variables. Finally, when the material is implanted into trabecular bone, it becomes stronger in compression than the surrounding bone; when implanted in cortical bone, linear modelling suggests that resorption and replacement of the implant would be required to approximate the bending strength of the surrounding bone.

Animals↗

PubMed1997

Ex vivo degradation of a poly(propylene glycol-fumarate) biodegradable particulate composite bone cement.

We have developed a biodegradable particulate composite bone cement consisting of a poly(propylene glycolfumarate)-(methylmethacrylate) matrix mixed with calcium carbonate and tricalcium phosphate particulates. Previous ex vivo studies suggest that this system provides sufficient strength for a number of potential clinical applications including structural reinforcement of osseous defects, internal fixation devices for age-related fractures, and delivery of antibiotics to treat osteomyelitis. As a first step toward investigating in vivo responses to this material, we studied the influence of varied concentrations of crosslinker, accelerator, and free radical on the mechanical properties of the cement. We then developed an ex vivo degradation assay and correlated the mechanical properties of degrading cement with the temporal changes in chemical properties of both the cement and the bathing medium. The optimal cement formulation was composed of one-third poly(propylene glycolfumarate)-(methylmethacrylate), one-third calcium carbonate, and one-third tricalcium phosphate, and provided initial compressive strengths of up to 30 MPa and compressive moduli of up to 300 MPa. Degradation rates, measured by a decline in mechanical properties, dissolution of calcium from the cement, and change in pH of the bathing medium, could be controlled by changing the concentration of reactants in the matrix. Specifically, an increase in methylmeth-acrylate or increase in both methylmethacrylate and benzoyl peroxide was inversely proportional to the rate of degradation and directly proportional to the initial mechanical properties. The degradation products and environmental changes appear to be compatible with physiologic remodeling and therefore justify examination of the in vivo response to implantation of this material.

Analysis of Variance↗

PubMed2002

[Development of artificial bone made from nacre and polylactic acid and property assessment].

OBJECTIVE: To explore a new bone substitute for bone grafting and evaluate its properties. METHODS: Pressurized molding of nacre, polylactic acid and NaCl that were proportionally mixed was performed to obtain the bone grafting material, and its properties as porosity, pore size and mechanical strength were compared with those of the material prepared by solvent casting. RESULTS: Compared with that of the material made by solvent casting, the mechanical strength of the new artificial bone material was 10-fold stronger with an average porosity rate of 47.65%, pore size of 218.83 micrometer compressive strength of 16.10 MPa and flexural strength of 60.18 MPa. CONCLUSION: The new technique adopted in this study can effectively enhance the biomechanics of the artificial bone material, which can be suitable for repairing bone defect.

Biocompatible Materials↗

PubMed2003

The fabrication and biochemical evaluation of alumina reinforced calcium phosphate porous implants.

Alumina reinforced calcium phosphate porous implants were manufactured to improve the mechanical strength while maintaining the bioactivity of calcium phosphate ceramics. The alumina porous bodies, which provided the mechanical strength, were fabricated by a polyurethane sponge method and multiple coating techniques resulted in the porous bodies with a 90-75% porosity and a compressive strength of up to approximately 6MPa. The coating of hydroxyapatite (HAp) or tricalcium phosphate (beta-TCP) was performed by dipping the alumina porous bodies into calcium phosphate ceramic slurries and sintering the specimens. The fairly strong bonding between the HAp or TCP coating layer and the alumina substrate was obtained by repeating the coating and sintering processes. The biochemical evaluations of the porous implants were conducted by in vitro and in vivo tests. For in vitro test, the implants were immersed in Ringer's solution and the release of Ca and P ions were detected and compared with those of calcium phosphate powders. For in vivo test, the porous bodies were implanted into mixed breed dogs and bone mineral density measurements and histological studies were conducted. The alumina reinforced HAp porous implants had a higher strength than the HAp porous implants and exhibited a similar bioactivity and osteoconduction property to the HAp porous implants.

Aluminum Oxide↗

PubMed1997

Texture analysis of direct magnification radiographs of vertebral specimens: correlation with bone mineral density and biomechanical properties.

RATIONALE AND OBJECTIVES: The authors used direct magnification radiographs, combines with texture analysis, to investigate the trabecular structure of human vertebral specimens and compared these techniques with measurement of bone mineral density (BMD) by using quantitative computed tomography to predict bone strength. METHODS: Direct magnification radiographs and BMD measurements were obtained from 38 motion segments from the thoracolumbar spines of 11 female human cadavers. Maximum compressive strength (MCS) was determined with a materials testing machine. Morphologic parameters, digital skeletons, and fractal dimension were obtained from the radiographs in three different regions of interest. RESULTS: Correlations between BMD and MCS were statistically significant (r = .81, P < .01). With morphologic parameters, correlation coefficients of up to .64 (P < .01) were obtained. Use of multivariate regression analysis with one morphologic parameter (the width of the black pixels, or thicknessB) in addition to BMD improved correlations versus MCS (P < .01). CONCLUSION: In an experimental setting, BMD showed statistically significant correlation with bone strength, whereas the structural parameters demonstrated only modest correlations. BMD together with one of these measures (thicknessB), however, showed the highest correlation.

Adult↗

PubMed1998

Optimal selection and preparation of fresh frozen corticocancellous allografts for cervical interbody spinal fusion.

STUDY DESIGN: Iliac crest corticocancellous allografts for anterior interbody fusion were harvested from six cadavers. The grafts were cut sequentially from left and right crests and randomly assigned to tricortical or bicortical preparations. Their compression strengths then were determined and compared by matched pair analysis. OBJECTIVES: To quantify the failure strength of the grafts from different iliac locations and determine the optimal type of preparation of the grafts for anterior interbody fusion. SUMMARY OF BACKGROUND DATA: Iliac crest corticocancellous autografts and allografts commonly are used for interbody cervical fusions. However, graft strengths for specific sites have not been determined fully. METHODS: Six paired, fresh frozen, iliac crests were sectioned using a customized miter box into multiple 1-cm-thick grafts 1.5 cm in depth to simulate cervical interbody grafts. The left and right sides of each pair were randomly assigned to tricortical and bicortical preparations. The samples were tested by applying a compressive load to failure using a specialized fixture to simulate vertebral body loading. RESULTS: The grafts closer to the anterosuperior iliac spine had significantly higher failure loads and failure strengths than those closer to the posterosuperior iliac spine. The strengths of the bicortical grafts were 72 +/- 14% of the strengths of the tricortical grafts (P < 0.001). CONCLUSIONS: Anterior iliac crest grafts were stronger in compression, even after removal of one cortical surface, than posterior iliac crest grafts.

Adult↗

PubMed1987

Bone ingrowth into polymer coated porous synthetic coralline hydroxyapatite.

Porous hydroxyapatite, converted hydrothermally from the calcium carbon exoskeleton of the coral genus Goniopora (CHAG), has been shown to be effective as a scaffold for bone ingrowth (2,3,5-7,9). However, the large pores in the material resulted in low compressive strengths. In a previous study, we found that microcoating the internal surfaces of CHAG with dilactic-polyactic acid (DL-PLA) improved significantly its compressive properties. The objective of this study was to determine the effect of PLA microcoating on bone ingrowth into CHAG plugs. Plugs of thick- (3:1 chloroform to DL-PLA by weight), medium- (10:1), and thin- (30:1) coated as well as uncoated CHAG were implanted transcortically in the proximal third of the diaphysis of the rabbit tibia. Specimens were harvested at 3, 12, and 24 weeks for mechanical testing and contralaterally for histological and histomorphometric assessment. At 12 weeks, uncoated CHAG plugs developed an average ultimate interface shear stress of 26.7 MPa, compared with 17 MPa for 30:1 and 8 MPa for 10:1 and 3:1 coated specimens. At 24 weeks, there were no significant differences in shear stress among any of the specimens. Histomorphometric assessments showed that the ratio of area fractions of new bone to area fractions of new bone and void space increased from 68-70% for 3:1 and 10:1 coated specimens at 3 weeks, and to 85.5-89.5% at 24 weeks. In comparison, uncoated and 30:1 specimens had area fraction ratios of about 82% at 3 weeks and 93% at 24 weeks. Histologic sections demonstrated direct apposition of new bone to both the coating and the hydroxyapatite as well as degradation of the coating.

Animals↗

PubMed2005

Properties of acrylic bone cements formulated with Bis-GMA.

Experimental cement formulations were prepared by replacing part of the methylmethacrylate (MMA) liquid phase of a conventional surgical cement with an equivalent weight of 2,2-bis [4(2-hydroxy-3-methacryloxypropoxy) phenyl] propane (Bis-GMA), which is the reaction product of diglycidyl ether of bisphenol A and methacrylic acid. It was found that up to 50 wt % of the MMA could be replaced by Bis-GMA without reductions in flow characteristics of the precured polymers. Cements containing 20, 30, 40, and 50 wt % of Bis-GMA in the liquid component were prepared. Over this range of Bis-GMA wt %, it was found that, relative to the unmodified cement, the volumetric shrinkage (DV), the peak temperature reached during the polymerization reaction (Tp), and the flexural strength (obtained in three-point bend tests) were each significantly reduced, the flexural modulus (obtained in three-point bend tests) increased significantly, the compressive strength increased slightly, while there were no significant effects on any of the other properties determined, namely, degree of conversion of the monomer during the polymerization reaction and the glass transition temperature. The drops in D(V) and Tp indicate that cements whose liquid monomers are modified using Bis-GMA hold promise for use in anchoring total joint replacements. The increase in the crosslinking density with increasing amount of Bis-GMA renders the polymer matrix more brittle. This feature was considered responsible for the reduced flexural strength.

Bisphenol A-Glycidyl Methacrylate↗

PubMed1995

The effect of potential investment expansion and hot strength on the fit of full-crown castings made with a gypsum-bonded investment.

OBJECTIVES: It has been claimed that the strength of the investment mold at the casting temperature affects the dimensional accuracy of castings (e.g., Markley, 1953; Earnshaw, 1957; Asgar, 1972), but the relationship has not been studied quantitatively. In this investigation, the effects of both mold expansion and hot strength on the relative inaccuracy of full-crown castings have been measured and analyzed. The likelihood that a strong investment could cause distortion of the casting by non-uniform restriction of casting shrinkage (Earnshaw, 1969b) was also considered. METHODS: Castings were made with a commercial gypsum-bonded inlay investment, used both as supplied and with modifications that increased its expansion and reduced its hot strength. In both series of tests, the investments were used over a wide range of liquid/powder (L/P) ratios in casting rings fitted with dry ceramic liners, and set under dry conditions. RESULTS: Casting inaccuracy showed a significant linear correlation with total expansion and a highly significant linear correlation with the combination of total expansion and hot strength. The modified investment, with its low hot strength, gave less distortion of casting shape than did the much stronger unmodified material. However, it was found that to ensure sound castings, the hot compressive strength should not be less than 1.8MPa. SIGNIFICANCE: This investigation showed that while investment expansion is the major variable affecting casting inaccuracy, hot strength is an important modifying factor which also has to be considered when predicting casting inaccuracy from measured properties of the investment.

Calcium Sulfate↗

PubMed2003

Ex vivo gene therapy in autologous bone marrow stromal stem cells for tissue-engineered maxillofacial bone regeneration.

This study examines the clinical relevance of tissue engineering integrating gene therapy and polymer science to bone regeneration. Bilateral maxillary defects (3 x 1.2 cm(2)) in 20 miniature swine were bridged with a bioresorbable internal splint. Constructs were created using ex vivo adenovirus bone morphogenetic protein (BMP)-2-mediated gene transfer to the expanded bone marrow mesenchymal stem cells (MSCs) 7 days before implantation. Controls were performed using adenovirus beta-galactosidase. The BMP-2 cell/construct displayed white solid bone formation after 3 months. Meanwhile, the hematoxylin and eosin and Von Kossa stains demonstrated exhibited mature woven bone with good mineralization. Additionally, three-dimensional computer tomography imaging revealed a nearly complete infraorbital rim repair. Quantitative analysis demonstrated a significant difference (P<0.001) in bone formation. Finally, biomechanical testing revealed no statistically significant difference in the maximal compressive strength of new bone formed by BMP-2 cell constructs and the normal maxilla. The data evidenced de novo bone formation capable of sustaining axial compressive loads. The measurement results showed that ex vivo replication defective adenovirus-mediated human BMP-2 gene transfer to MSCs enhances autologous bone formation in the repair of maxillary defects.

Adenoviridae↗