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Clinical variations of border disease in sheep according to the source of the inoculum.

Non-cytopathogenic pestivirus obtained from lambs with border disease, with or without nervous signs, was inoculated into pregnant ewes at 57 to 65 days of gestation. Live lambs born to inoculated ewes were clinically identical to the lambs from which virus was obtained, ie, either a hairy birth coat with central nervous system disturbance or a hairy birth coat without central nervous system disturbance.

Abortion, Veterinary↗

Experimental infection of pregnant gilts with Leptospira interrogans serovar mozdok.

Three pregnant gilts were experimentally infected with leptospires of the serovar mozdok, isolated from an aborted pig fetus from a Portuguese pig farm with abortion problems. All the gilts aborted dead or dying piglets on days 105 or 106 of pregnancy. Serovar mozdok was isolated from 12 of the 22 piglets in the three litters. Histological examination of the livers and kidneys of the gilts at the end of the experiment revealed evidence of disease, and leptospires were isolated from their kidneys. Their serological responses up to 42 days after inoculation were monitored by means of a microscopic agglutination test, using 21 antigens from 18 serogroups. Cross reactions to heterologous antigens belonging to the Grippotyphosa, Australis, Icterohaemorrhagiae and Cynopteri groups were observed in all of them.

Abortion, Veterinary↗

Maternal morbidity following routine second trimester genetic amniocentesis.

Two cases of septic complications of routine second trimester amniocentesis are presented. The first case is a 37-year-old gravida suffering from ulcerative colitis who was admitted for amniocentesis in the 18th week of her third pregnancy. An uncomplicated transabdominal amniocentesis was performed using a sterile technique and ultrasound guidance. Twenty-eight hours later the patient had a septic abortion and sepsis. The second case is a 34-year-old gravida in the 24th week of her pregnancy who was admitted with amnionitis 10 h after an uncomplicated amniocentesis, and subsequently had a septic abortion. A high index of suspicion and rapid intervention were crucial in both cases.

Abortion, Septic↗

Treatment and results of chronic toxoplasmosis. Analysis of 33 cases.

Women who grew up in Turkey, where undercooked meat is part of the usual diet, have an increased risk of toxoplasmosis. This study covers treatment and prognosis of 33 cases with chronic toxoplasmosis. The study group was selected among the patients with a history of repeated abortions, recurrent preterm labor, stillbirths and babies with congenital anomaly after all other causative reasons were ruled out. IgG and IgM antibody titers were detected by Sabin-Feldman's dye test and indirect fluorescence antibody test. 33 patients, who had negative IgM and IgG antibody titers above 1/64, were accepted as having chronic toxoplasmosis and were included in our study group. These patients were treated with our pyrimethamine treatment protocol (Dinçer Formula) for 36 days before their pregnancies. IgG antibody titers were repeated in the 8th and the 20th week of pregnancy. With the exception of 7 cases, 24 patients (72.7%) still had IgG antibody titers of more than 1/64 and were given the same treatment protocol in the 8th week of pregnancy. Very early abortions occurred in 2 cases. Of 24 patients, 8 had antibody titers still above 1/64 and were treated with spiramycine. While 28 cases (84.8%) had healthy and living infants, pregnancies of 3 cases are still continuing. No teratogenic effects of pyrimethamine on the fetuses were seen. As a result, we can say that a patient who presents with complaints of repeated abortions, recurrent preterm labor or stillbirth should be investigated for toxoplasmosis during pregnancy; even if the IgG antibody test is normal before pregnancy, she should be treated with the protocol mentioned above before pregnancy and in the 8th week of pregnancy when chronic toxoplasmosis is diagnosed.

Abortion, Spontaneous↗

Ovine abortion and stillbirth due to purulent placentitis caused by Yersinia pseudotuberculosis.

Yersinia pseudotuberculosis was isolated from an aborted placenta and stillborn lamb from a sheep flock having multiple abortions. Given intravenously, it caused elevated body temperatures and purulent placentitis in eight of nine ewes. Two ewes died following infection at 2.5 months of gestation. Two ewes infected at 3.5 months gestation aborted; three infected at four months gave birth to weak, premature, or moribund lambs. One ewe infected at 4.5 months gave birth to a healthy lamb. One lamb which died minutes after birth had focal necrotizing hepatitis, a lesion observed in a stillborn lamb during the original disease outbreak. Y. pseudotuberculosis was reisolated from endometrial, placental, and fetal lesions of experimentally infected animals.

Abortion, Veterinary↗

[Decreased serum prolactin levels associated with infections in female patients with symptoms of spontaneous abortion].

INTRODUCTION: Previous research indicates that intraocular infections result in dramatic decrease of prolactin serum levels during pregnancy. The aim of this study was to assess biochemical aspects of pregnancy, including determination of serum prolactin levels in patients with infection. MATERIAL AND METHODS: The evaluation included patients with symptoms of imminent miscarriage and present, or absent signs of vaginal infection, as well as patients with uncompromised pregnancies, as controls. RESULTS: Serum estradiol levels, progesterone and prolactin were decreased in patients with bacterial infections. DISCUSSION: The role of prolactin in regulation of pregnancy was discussed, as well as its interactions with other regulatory hormones of pregnancy. CONCLUSION: Serum prolactin levels were decreased (17.68%) in patients with symptoms of imminent miscariage and current lower genital infection.

Abortion, Threatened↗

Rate and various aspects of eye infection resulting from congenital rubella.

A study on the eyes of 39 embryos, which were removed from women who had contracted clinical or subclinical rubella during the first and beginning of the second trimester of gestation is presented. A virological and histological study was performed on the eyes. In four cases rubella virus was isolated from the eye tissues (10.3%) and in nine cases, histological evidence of rubella cataract was found (27.3%). These results suggest that the rubella infection, even in cases of subclinical infections in pregnant women in the first trimester, are highly dangerous (in our study--37.6%) to the eye of the fetus, and, therefore, early diagnosis is necessary in order to avoid the risk of the consequences of congenital rubella infections in the newborn.

Abortion, Therapeutic↗

Tumor necrosis factor in malaria-induced abortion.

The cause of fetal loss in malaria is not known. We report that a small (1.5-5.0 micrograms) intravenous dose of recombinant human tumor necrosis factor (TNF) caused fetal death and abortion in 16 day pregnant mice that were carrying low densities of Plasmodium vinckei. In contrast, 50 micrograms human TNF did not cause fetal death or abortion in uninfected 16 day pregnant mice. Endogenous TNF, which was not detectable in plasma of low parasitemia animals, pregnant or not, was present (1.6 +/- 0.9 ng/ml) in samples from malarial pregnant mice when, on day 17, parasitemia was high and the first signs of impending abortion were evident. No TNF was detectable in the plasma of uninfected mice at day 17 of pregnancy. A small dose of TNF also caused fetal death in 16 day pregnant mice that had received an intravenous injection of Coxiella burneti extract 9-10 days earlier. Thus, TNF-induced abortion may occur in a range of infections in which systemic macrophage activation occurs and a trigger for TNF release is present.

Abortion, Spontaneous↗

[The effect of chlamydia trachomatis infection in pregnant women on pregnant outcome and neonates].

OBJECTIVE: To determine the prevalence of chlamydia trachomatis (CT) in pregnant women and its effect on pregnant outcome and neonate. METHODS: Specimen of cervical swab were collected and detected for CT by polymerase chain reaction (PCR) method meanwhile relevant factors were investigated. Pregnant outcome and neonatal situation were also followed up. RESULTS: The infection rates of CT in pregnant women were 35.90%. The Incidence of abnormal pregnant outcome (premature delivery and abortion) was significantly higher in CT positive groups (24.72%) than that in negative groups (12.20%) (P < 0.05). Incidence of neonatal conjunctivitis and pneumonia were significantly higher in CT positive groups (17.98%) than that of negative groups (0.61%) (P < 0.01). There was statistically significant difference in the prevalence of low birth weight (< 2,500 g) between the two groups (13.48% versus 4.88%) (P < 0.05), and mode of delivery also had influence on neonatal morbidity. CONCLUSION: Prevalence of CT infection in pregnant women is rather common, and it may cause adverse pregnancy outcome.

Abortion, Spontaneous↗

Congenital cytomegalovirus infection. Is there a breakthrough?

QUESTION: My 26-year-old patient is planning her first pregnancy in the coming month. She works in a day-care centre. Recently, two cases of cytomegalovirus (CMV) infection were diagnosed in her class. What tests should she have before and during the pregnancy, and how should I care for her? ANSWER: Cytomegalovirus infection, the most common congenital viral infection in humans, carries high risk of long-term morbidity and mortality. Seronegative mothers of children in day-care centres are at as high risk of acquiring the infection as day-care workers themselves. The immune status of at-risk patients should be evaluated as pregnancy progresses. Evidence of fetal infection does not necessarily mean fetal disease or damage. With a primary-infected fetus, termination of pregnancy might be discussed with the parents.

Abortion, Induced↗