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Isometric performance following total hip arthroplasty and rehabilitation.

We compared differences in isometric strength between older adults who have undergone elective unilateral total hip arthroplasty (THA) and completed rehabilitation with a population of community-dwelling older adults who have not had THA. The study was a cross-sectional design, and 22 unilateral THA subjects and 38 community-dwelling older adults participated. THA subjects received on average 13 outpatient or home-based physical therapy sessions before evaluation. THA subjects were evaluated 4 to 5 months postsurgery. We assessed isometric muscle strength by measuring peak hip torque per body weight with a robotic dynamometer during abduction, flexion, and extension. No significant performance differences were observed between operated and nonoperated hips of THA subjects. THA subject operated and nonoperated hips generated significantly less peak torque per body weight during flexion (p = 0.03) compared with community-dwelling older adult hips (THA subject operated hips = 6.96 ft-lb/lb, THA subject nonoperated hips = 8.26 ft-lb/lb, community-dwelling older adult hips = 11.56 ft-lb/lb). No significant differences were observed between THA subjects and community-dwelling older adults during hip extension (p = 0.55) or abduction (p = 0.17). At 4 to 5 months postsurgery, THA subjects were not at the same level of biomechanical performance as community-dwelling older adults. Significant strength deficits were found in THA subject operated versus nonoperated hips during isometric flexion. Additional or modified physical therapy that targets the hip flexors is recommended after THA.

Aged↗

Hybrid logistic characterization of isometric twitch force curve of isolated ferret right ventricular papillary muscle.

We previously found that the isovolumic pressure curve of the left ventricle and the isometric twitch force curve of the right ventricular in situ papillary muscle, both of the blood-perfused canine heart, were precisely fitted by our newly proposed hybrid logistic function. This function describes the difference between the two S-shaped logistic functions for the rising and falling components: A/[1+exp{-(4B/A)(t-C)}]-D/[1+exp{-(4E/D)(t-F)}]+G. This function characterizes comprehensively both ventricular and in situ papillary muscle contraction and relaxation. In the present study, we hypothesized that this function could also characterize the force curve of the most popular, standard-type, isolated and Tyrode-superfused papillary muscle preparation. To test this hypothesis, we investigated how precisely the hybrid logistic function could fit 112 isometric twitch force curves observed in eight isolated and Tyrode-superfused ferret right ventricular papillary muscles at different muscle lengths and extracellular Ca2+ concentrations. We always obtained a precise curve fitting with a correlation coefficient above 0.9987. This fitting was much more precise than sinusoidal and polynomial exponential function curve fittings. These results supported the present hypothesis. We conclude that our hybrid logistic function reasonably characterizes the force curve of the isolated myocardial preparation. This result broadens the generality of the hybrid logistic characterization of ventricular isovolumic pressure and myocardial isometric twitch force generation. The hybrid logistic characterization seems to be an integrative expression of contractile processes in myocardial twitch contraction.

Animals↗

Isometric squeeze relaxation (progressive relaxation) vs meditation: absorption and focusing as predictors of state effects.

We taught isometric squeeze relaxation (a variant of progressive relaxation) or meditation to 52 anxious subjects (16 men, 36 women). For meditation, pretreatment high absorption correlated with reductions in state cognitive and somatic anxiety as well as increments in state focusing. For isometric squeeze relaxation, pretreatment low state focusing correlated with reductions in somatic anxiety and increments in focusing. Results suggest that isometric squeeze relaxation (and progressive relaxation) may be more appropriate for individuals who have difficulty focusing, and meditation for those who already possess well-developed relaxation skills at a trait level. The results appear more consistent with Smith's cognitive-behavioral model of relaxation than with Benson's relaxation response or Davidson and Schwartz's specific effects models.

Adult↗

Assessment of quadriceps muscle performance by hand-held, isometric, and isokinetic dynamometry in patients with knee dysfunction.

One component of patient evaluation is muscle performance assessment. The purpose of this study was: 1) to determine the difference and correlation between hand-held, isometric, and isokinetic dynamometry test results in patients with knee dysfunction and 2) to determine the effect of pain during such testing. Bilateral quadriceps strength in 23 subjects with unilateral knee dysfunction was tested using concentric and eccentric isokinetic dynamometry at 60 degrees/sec, isometric dynamometry, and hand-held dynamometry, both at 60 degrees of knee flexion. Pain ratings were obtained before, during, and after each test. Statistical analysis revealed a significant difference between involved and uninvolved limbs for eccentric isokinetic dynamometry (p = 0.002) and hand-held dynamometry (p = 0.005); no difference was found between limbs for the concentric isokinetic and isometric dynamometry (p > 0.05). Mean percent deficits in quadriceps strength ranged from 11 to 18%, with no significant difference found between testing modes. Pearson product moment correlations ranged from 0.34 to 0.76 when comparing testing modes. No significant difference existed in pain scores before, during, and after each mode of testing. It was concluded that large variation existed between different testing modes, which results in different conclusions regarding the strength of the quadriceps in patients with knee dysfunction.

Adolescent↗

Isometric muscle strength and endurance after knee arthroplasty with the modular knee in patients with osteoarthrosis and rheumatoid arthritis.

Maximum isometric muscle strength and endurance were used in an investigation of knee extension and knee flexion in patients with rheumatoid arthritis (RA) and osteoarthrosis (OA) with such severe changes of the joint that arthroplasty with the Modular prosthesis was performed. The measurements were done preoperatively and 3, 12, 24 and 36 months postoperatively. Muscle strength preoperatively was very weak compared with that of a group of healthy persons. The muscle strength 3 months postoperatively remained unchanged, which could mean a very slight trauma from the operation, very good pain relief and efficient physiotherapy. During the first 2 years the maximum isometric muscle strength was significantly increased both in patients with RA and in those with OA. Thereafter there was no increase in the RA patients, whereas in women with OA there was an improvement up to 3 years postoperatively. The improvement in the flexion strength was greater than that of the extension strength, thus indicating the importance of postoperative training of extension strength. Isometric muscle strength measurements show that there is an equalization between the non-diseased knee and the one operated with the Modular knee.

Aged↗

+Gz tolerance in man after 14-day bedrest periods with isometric and isotonic exercise conditioning.

The purpose of this study was to determine the effects of isometric or isotonic exercise training on post-bedrest +Gz tolerance. Seven male volunteers, 19-22 years, underwent accelerations of +2.1 Gz (740 s), +3.2 Gz (327 s), and +3.8 Gz (312 s) in a selected, randomized order; the ramp to peak acceleration was 1.8 G/min. The centrifugation runs were terminated by loss of central vision (blackout) to a white light with a luminance of 3.15 times 10-5 log candle/cm-2 (0.092 ft-lambert). The study began with a 14-d ambulatory control period, followed by three 14-d bedrest periods (each separated by a 21-d recovery period) and then a final week of recovery. During the ambulatory periods, the subjects exercised on a bicycle ergometer at 50% of their maximal oxygen uptake (max VO2) for 1 h/d. During two of the three bedrest periods, the subjects performed in the supine position one of two routines, either isometric exercise (21% of max leg extension force for 1 min followed by 1-min rest) or isotonic exercise (68% of max VO2) for 0.5 in the morning and afternoon. During the third bedrest period, no exercise was performed. In general +Gz tolerance was reduced by 24% to 35% (p less than or equal to 0.05) after bedrest. Compared with control values, there were significant reductions in average tolerance times after bedrest with no exercise and isotonic exercise at all G levels. With isometric exercise, there was a significant decrease in tolerance at 2.1 Gz but not at 3.2 Gz or 3.8 Gz, even though the latter tolerances were reduced 15.6% and 10.0%, respectively. Both exercise regimens maintained tolerance at levels equal to or above that obtained with no exercise. Compared with control values, average tolerances were lower (p less than or equal to 0.05) after the two recovery periods between the bedrest periods (minus 24% to minus 26% at 3.2 Gz and 3.8 Gz), indicating that 3 weeks of ambulation was not sufficient time for full recovery from the deconditioning induced in this study. A prediction equation was constructed with data from all comparable studies utilizing deconditioned men riding relaxed without protective garments: Tolerance (in seconds) equals minus 334 + (1715/+Gz level). From this equation, the calculated tolerance after bedrest is 13.5 min at 1.5 G, and the point of zero tolerance is 5.1 Gz.

Acceleration↗

[Behaviour of left ventricular systolic time intervals after isometric exercise in patients with ischemic heart disease (author's transl)].

The authors describe differences in behaviour of left ventricular systolic time intervals after isometric exercise between patients with ischemic heart disease and normal control. Isometric exercise consists of tonic hand-grip, which is to be gauged by hand-grip dynamometer for 5 minutes at 30% of the patient's maximum voluntary contraction or for 2-3 minutes at 50%. The parameters referred to are pre-ejection period and left ventricular ejection time index (PEPI, TETI), the PEP/TET ration, heart rate and arterial pressure. The authors conclude that from isometric exercise it is possible to point out the heart failure degree in patients with ischemic heart disease.

Blood Pressure↗

Force control of isometric elbow flexion with visual feedback in cold with and without shivering.

BACKGROUND: Exposure to cold impairs manual performance through effects on muscle tissue and control mechanisms. The purpose of this study was to assess the influence of increased muscle tone and shivering on ability to maintain required force during isometric flexion over a wide range of effort levels. METHODS: Lightly clad male subjects (n = 6) were exposed to thermoneutral air (TN, 27 degrees C) for 30 min, or to cold air (CA, 10 degrees C) for 30 min followed by a cold drink (1 L, 8 degrees C) to cause vigorous shivering (SH). At the end of each condition, subjects performed isometric elbow flexion at 10, 20, 40, and 80% of individual maximal voluntary contraction (MVC) for 10 s each, using digital visual feedback to control the force. We analyzed mean force output (F), the coefficient of force variation (FCv), information transmission (F/SD), and the coefficient of force auto-correlation (Ra), and the averaged electromyogram (aEMG) from elbow flexors, elbow extensor, and pectoral girdle muscles. RESULTS: Compared with TN, CA with increased muscle tone raised the aEMG by 5-30% but did not impair any of the force characteristics. In SH, F was not affected, while FCv and Ra were significantly increased at 10% MVC, while aEMG increased by 30-400% depending on the specific muscle and MVC level. CONCLUSION: Neither thermoregulatory muscle tone nor shivering influenced the control of force output during isometric elbow flexion, except that at the lowest MVC (10%) the force output was more variable during shivering.

Adult↗

[Muscle synergy in isometric flexion of the elbow].

A technique was developed for calculating the torque generated by two individual muscles (biceps brachii and brachioradialis) that contribute to the isometric flexion of the elbow. The external torque is the sum of individual torques which are unknown. Each individual torque (CB or CBR) can be related to the corresponding integrated surface EMG (QB or QBR) by means of coefficients (pB or PBR). A block of several equations C = pB QB + pBR QBR is obtained by exploring several experimental conditions. In these conditions, isometric flexion efforts of the elbow were associated to isometric efforts of supination or pronation so as to vary integrated EMG by reciprocal inhibition. By means of a least square method it was possible to know the coefficients PB and PBR. With these coefficients, it was possible to calculate the individual torques generated by the biceps brachii and brachioradialis muscles in each experimental condition.

Arm↗

Flight-training effect on the cervical muscle isometric strength of trainee pilots.

External stimulus/loading initiates adaptations within skeletal muscle. It has been previously found that the cervical area has the highest loading while performing flying maneuvers under +Gz. The first purpose of this study was to examine the neck muscle response to the physical environment associated with flight training, incorporating limited exposure to +Gz force, in a Pilatus PC-9 aircraft. The second purpose was to examine the short-term range of movement (ROM) response to flight training. Isometric cervical muscle strength and ROM was monitored in 9 RAAF pilots completing an 8-mo flight-training course at Pearce Airbase in Western Australia, and in 10 controls matched for gender, age, height, and weight. Isometric cervical muscle strength and ROM were measured at baseline and at 8 mo using the multi-cervical rehabilitation unit (Hanoun Medical, Downsview, Ontario, Canada). Results indicated that an increase in pilot neck strength was limited to flexion while in a neutral position. No strength changes were recorded in any other site in the pilots or for the controls. These findings suggest that short-term exposure to the physical environment associated with flight training had a limited significant effect on increasing isometric cervical muscle strength. No significant changes were observed in pilot ROM, indicating that short-term exposure to flight does not effect ROM.

Adult↗

Cardiovascular responses and endurance during isometric exercise in patients with Type 2 diabetes compared to control subjects.

BACKGROUND: While it is well documented that diabetes impairs the microcirculation, its effect on isometric exercise has not been determined. MATERIAL/METHODS: Isometric strength and endurance of the handgrip muscles for a series of 2 fatiguing isometric contractions at a tension of 40% of the maximum strength were assessed in 10 subjects with Type 2 diabetes compared to 10 control subjects; 5 minutes were allowed between the contractions. Blood pressure (BP), heart rate (HR), blood flow (BF) of the whole arm and of the skin on the chest and foot were measured. RESULTS: Strength and endurance for the first contraction was the same in control subjects compared to subjects with Type 2 diabetes (p>0.05), but endurance of the second contraction was significantly less in subjects with diabetes (p<0.01). HR increased significantly (p<0.01) by over three fold during exercise in control subjects compared to subjects with diabetes. Resting and peak blood pressures were greater in subjects with type 2 diabetes compared to control subjects (p<0.01). Forearm blood flow was significantly lower at rest, during exercise and post exercise in subjects with diabetes compared to control subjects (p<0.01). CONCLUSIONS: The results are probably explained by the damage to the microcirculation seen in subjects with diabetes.

Adult↗

[Isometric muscle strength measurements and assessment: a pilot study].

OBJECTIVE: To determine the anthropometric parameters and the isometric muscle strength in a working population sample in China, and to investigate the relationship between muscle strength and individual attributes, such as age, gender, height and weight. METHODS: The study population consisted of 146 male and 47 female people including workers, administrators and college students. Four types of muscle strength, i.e., handgrip, arm lift, shoulder lift, and torso pull, were measured. RESULTS: Left handgrip, right handgrip, arm lift, shoulder lift and torso pull of male workers were (42.07 +/- 7.20), (43.92 +/- 7.14), (26.79 +/- 4.64), (33.79 +/- 6.88), (88.56 +/- 17.98) kg, respectively while those of female workers were (21.29 +/- 5.09), (23.26 +/- 5.47), (13.29 +/- 3.37), (18.52 +/- 4.01), (41.06 +/- 12.04) kg, respectively. The female's strength was about 50% lower than the male's. The strength in the 40 approximately years old group was higher than that in other age groups. There were significant positive correlation between the gender and the isometric strength as well as between the body weight and the isometric strength. If the body weight served as the corrected parameter, there was no significant difference in the handgrip among the groups (P < 0.05), but the torso pull of male workers > college students > administrators. All relative muscle strengths except the torso pull were similar for all age groups. CONCLUSION: The body weight as the independent variable can be used for establishing the predictive equation of the muscle strength. Calculation of the relative muscle strength can relieve the interference of the body weight for the muscle strength.

Adolescent↗

[The efficacy of isometric training during hospitalized rehabilitation in patients with myocardial infarction].

The study included 57 patients with myocardial infarction who underwent isometric exercise tests on days 10 and 30 of hospitalization. The patients of the main group had isometric exercise tests by using a key expander for 20 days between the first and second exercise tests. The tests were performed in 4 stages, each lasting 5 days. The patients from the control group had no tests. The study had indicated that isometric exercise tests performed in the hospital treatment period enhance the patients' tolerance to static exercise and they are sufficiently effective despite its short duration.

Exercise Test↗

[Value of isometric and dynamic exercise tests with standard drug doses for selecting long-term antihypertensive treatment with vasodilators, adrenergic beta blockaders and diuretics].

The paper presents the results of the study into the efficacy of single routine doses of essential antihypertensive agents (nifedipine, propranolol, and hydrochlorothiazide) versus its course treatment at rest and during isometric and dynamic exercise tests. The efficacy was assessed by using the Dixon criterion. The routine drug dose tests performed at rest and during isometric and dynamic exercise were shown to have a varying informative value in the prediction of long-term treatment with the above drugs. The isometric and dynamic exercise tests are of the greatest significance in the evaluation of the antihypertensive routine dose of nifedipine, whereas the dynamic exercise test alone is of value for propranolol and the rest exercise test, the both exercise tests for hydrochlorothiazide. Thus, the results of the corresponding routine drug dose tests are of varying predictive informative value, which is essential both for choosing an effective drug and for making an objective assessment of the outcomes of the course therapy.

Adult↗

[Effects of sevoflurane and enflurane on isometric tension and maximum velocity of shortening in glycerinated guinea pig masseter muscles].

To study the effects of inhalation anesthetics on the contractile system of masseter muscles, the Ca2+ concentration-isometric tension relationship and the maximum velocity of shortening were investigated in glycerinated guinea pig masseter muscles under the presence and absence of sevoflurane (10 mg% and 100 mg%) or enflurane (10 mg% and 100 mg%). Relative isometric tensions increased sigmoidally with an increase in Ca2+ concentration in all groups. K1/2 (pCa at the half maximum activated tension) was 6.53 in the control (absence of the anesthetics) and about 6.70 in the experimental groups under anesthetics regardless of the concentrations of anesthetics. The isometric tensions at higher Ca2+ concentrations were reduced by enflurane dose-dependently. They were also reduced by the low concentration of sevoflurane but increased by its high concentration. The maximum velocity of shortening was not influenced by these anesthetics (100 mg%) as far as the Ca2+ concentration was constant (pCa 6.36 or 5.94). These results suggest that in the masseter muscle, sevoflurane and enflurane alter the Ca2+ affinity in troponin C for actin filaments without changing the cross-bridge turnover rate.

Anesthetics↗

The isometric twitch of rabbit papillary muscle: reflection of the cellular calcium movements?

The cycling of the activator-Ca of the myocardium is mediated by the sarcolemma (SL) and the sarcoplasmic reticulum (SR). Both the extent and the time course of the release as well as of the removal of the activator-Ca by the SL differ from that by the SR. The visualization of these differences in the isometric myograms of isolated myocardium (Bogdanov et al. 1979; Günther et al. 1986; King and Bose 1983; Malecot et al. 1986) prompted the conclusion that distinct cellular Ca movements determine distinct parts of the isometric contraction-relaxation cycle. To test this hypothesis the effects of Ca, isoprenaline and ouabain on the isometric contraction-relaxation cycle of rabbit papillary muscles were re-evaluated. The similarities and differences in the effects of the interventions on the twitch measures could be explained by their effects on the cellular Ca movements.

Animals↗

Age as a factor in the hemodynamic responses to isometric exercise.

This study was designed to determine the effect of isometric contractions of the finger flexors and leg extensor muscle groups on the cardiovascular responses of men 18-31 and 50-71 years of age. A 2X2X4 split-plot design was carried out with men representing two age groups, using two muscle groups and performing isometric contractions at four different intensities. Analysis of variance indicated significant differences for all main effects. The systolic and diastolic blood pressures were found to be (1) higher for the leg extension contractions compared to the finger flexion contractions, (2) higher for each increment in %MVC workload, and (3) higher for the older individuals. Heart rate responses were found to be (1) higher for the leg extension exercises, (2) higher with each increase in %MVC, and (3) higher for the younger subjects. Stroke volumes demonstrated (1) higher values for the young men at each workload, (2) lower values for leg extension exercises, and (3) a greater decline with longer contraction times. The older individuals had higher pressor responses than did the younger subjects, higher pressor and heart rate responses were observed with isometric leg extension exercises and increasing %MVC levels, and the older subjects had lower stroke volume responses compared to the younger subjects.

Adolescent↗

Divergent pharmacological effects of three calmodulin antagonists, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), chlorpromazine and calmidazolium, on isometric tension development and myosin light chain phosphorylation in intact bovine tracheal smooth muscle.

To investigate the usefulness of calmodulin antagonists in intact cell systems, effects of three calmodulin antagonists, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), chlorpromazine (CPZ) and calmidazolium on isometric tension development and myosin light chain (P-LC) phosphorylation in bovine tracheal smooth muscle strips were compared to inhibition of purified myosin light chain kinase activity. These antagonists inhibited the Ca++-calmodulin-induced activation of myosin light chain kinase in a concentration-dependent manner, with IC50 values of 1.0 (calmidazolium), 25 (W-7) and 65 microM (CPZ), respectively. Inhibitory effects of these antagonists were abolished with increasing concentrations of calmodulin. However, when these antagonists were used in intact smooth muscle strips, the gradation of potencies did not parallel the anticalmodulin activities. W-7 (100 microM) exhibited a similar extent of antagonism between the contractile responses to carbachol and KCl. The increase in P-LC phosphate content in response to 1-min stimulation with 10(-5) M carbachol was inhibited by W-7. CPZ exhibited an unexpectedly potent antagonism on carbachol-induced isometric tension development and P-LC phosphorylation. Atropine showed an antagonism similar to CPZ. CPZ and verapamil had similar antagonistic effects on KCI-induced contractions. Calmidazolium (50 microM) produced no significant inhibition on carbachol-induced isometric tension development and P-LC phosphorylation in intact smooth muscle strips. It may be concluded that 1) W-7 antagonizes the smooth muscle contraction through the inhibition of the initial increase in the P-LC phosphorylation; 2) CPZ produces effects other than calmodulin antagonism; and 3) calmidazolium is not effective in intact smooth muscle strips.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗