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PubMed1977

[Nonsteroid antirheumatic agents].

It is given a short, oriented to practice survey on the at present internationally most usual non-steroidal antirheumatic drugs. Picture of effect and efficiency, side-effects, indications and contraindications of these remedies are described and compared. The description comprises salicylates, phenylbutazone, indomethacin, flufenamine acid and mefenamine acid, ibuprofene as well as new substances (benorylate, clofezone, nuflumine acid, azapropazone, bumadizone calcium, naproxene and others). In their qualitities of effect the new drugs do not essentially differ from the classical antirheumatic drugs. However, they partly reveal a more favourable relation between desirable and undesirable effects.

Anti-Inflammatory Agents↗
PubMed1968

The assay of anti-pyretic drugs in mice, using intracerebral injection of pyretogenins.

1. A simple, cheap, and reliable method is described for the screening of new compounds for anti-pyretic activity. It involves the intracerebral injection of a suitable pyretogenin in conscious mice.2. The pyretic response is related to the logarithm of the dose in a substantially linear manner when "E" Pyrogen is used.3. A selection of established anti-pyretic drugs were effective in oral doses approaching those used clinically, which shows that the method is unusually sensitive.4. The response to intracerebral pyretogenin is not unduly influenced by drugs known to cause hypothermia.5. It is suggested that "E" Pyrogen injected intracerebrally has a direct effect on the central nervous system, rather than an indirect action through release of endogenous pyrogen.

Acetaminophen↗
PubMed1981

Tolfenamic acid. Detection and structure of urinary metabolites.

N-(2-Methyl-3-chlorophenyl)anthranilic acid (tolfenamic acid) and its metabolites in serum and urine were analyzed by a reversed-phase ion-pair HPLC method. The major metabolites were N-(2-methyl-3-chloro-4-hydroxyphenyl)anthranilic acid, and one of the minor metabolites was N-(2-formyl-3-chlorophenyl)anthranilic acid, i.e., products resulting from hydroxylation in either the methyl group or the methylchlorophenyl group of tolfenamic acid, and further oxidation of the hydroxymethyl group to a formyl group.

Adult↗
PubMed1999

Role of endothelial factors in the specific response of mouse tumour-feeding arterioles to stimulation of 5-HT1 receptors.

PURPOSE: To investigate the possible role of endothelial mediators on the increased vasoconstriction to 5-HT1 receptor stimulation by the host-modified arterioles feeding a Meth-A tumour implanted in the flank of female Balb/c mice. MATERIALS AND METHODS: Using intravital microscopy, the response to the topical administration of the general 5-HT1 agonist 5-carboxamidotryptamine maleate (5-CT; 10(-6) M to 10(-4) M) by the tumour-feeding arterioles with the responses of tumour-independent arterioles and those of control arterioles from mice without tumour after antagonization or inhibition of the synthesis of endothelial mediators was compared. RESULTS: The dramatically higher vasoconstriction to 5-CT observed in tumour-feeding arterioles than in tumour-independent or control arterioles still persisted when either nitric oxide synthase, cyclooxygenase, lipoxygenase, or phospholipase A2 were inhibited or when thromboxane A2 or endothelin were antagonized. CONCLUSIONS: It was concluded that the higher reactivity to 5-HT1 stimulation by tumour-feeding arterioles is not due to changes in endothelial mediator release but probably due to changes affecting arteriolar smooth muscle.

Animals↗