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At least 829 records · Page 46Linked to original sources
PubMed2004

Fish protein improves the total antioxidant status of streptozotocin-induced diabetes in spontaneously hypertensive rat.

BACKGROUND: We measured the effects of fish protein (FP) on blood pressure, glycemia and antioxidant status in spontaneously hypertensive (SH) rats with streptozotocin-induced diabetes (STZ). MATERIAL/METHODS: Two groups of 12 rats each were fed 20% casein (C) or FP for 2 months. The total antioxidant status of blood and organs (liver, kidney and heart) was measured by the KRL test. Antioxidant enzyme activities (G-Px, G-Red, and SOD) and antioxidant substances (GSH, NO) were determined in organs, and vitamin C in plasma. RESULTS: FP lowered blood pressure in SH rats, but not in SH-STZ. Blood and plasma antioxidant status increased 35% and 9%, respectively, with FP in SH-STZ compared to SH rats; when compared to C, these values were more enhanced. SOD activity values were elevated with FP in SH-STZ rats, compared to the C diet, regardless of organ. Higher kidney NO and heart GSH values were noted in SH-STZ rats than SH. In SH rats fed FP, the GSH value was 2.26 times higher in liver, and NO was 3 times higher in heart. Higher NO was noted in kidney (1.84 times) and heart (1.91 times), GSH in heart (1.79 times), and vitamin C in plasma (+46%) in SH-STZ rats with FP than with C. CONCLUSIONS: Fish protein has a beneficial effect on blood pressure in SH rats but not in SH-STZ, and plays an important role in antioxidative defense. This protein may be useful in future treatments of such diseases as diabetes and hypertension.

Animal Feed↗
PubMed2004

New gas chromatography-olfactometric investigative method, and its application to cooked Silurus glanis (European catfish) odor characterization.

A new gas chromatography-olfactometric method, gas chromatography-global olfactometry omission detection (GC-GOOD), was applied to dynamic headspace odor extracts of Silurus glanis (European catfish). The GC-GOOD method is based on the omission test theory and uses a gas chromatograph coupled with a three-way valve and an a flame ionization detector. The GC-GOOD method enabled the identification of key families of volatile compounds in the S. glanis global odor and the elucidation of the interactions occurring between these families. Significant main effects were observed for the families of volatile compounds exhibiting cooked odor, grassy odor and alcohol, solvent and plastic odors. Omission of these families involved a loss of odor similarity.

Animals↗
PubMed2004

[Arrhythmogenic right ventricular dysplasia].

Congestive cardiac failure could be as important as cardiac arrhythmias in the natural history of arrhythmogenic right ventricular dysplasia. This can be related to the progressive replacement of myocardium by fat and fibrosis of the right ventricle. The left ventricle may also be involved by the same disease process. Moreover, inflammation can be superimposed on ARVD, resulting in a wide spectrum of clinical presentation which can mimick idiopathic dilated cardiomyopathy. Right ventricular cardiac failure has been controlled by anterior dynamic cardiomyoplasty.

Arrhythmogenic Right Ventricular Dysplasia↗
PubMed1992

[Does bullous pemphigoid with negative direct immunofluorescence exist? Apropos of 3 cases].

Subepidermal autoimmune bullous dermatoses are defined by clinical, histological and immunological criteria, notably the presence of anti-basement membrane antibodies detectable in vivo by direct immunofluorescence. We report three cases where anti-basement membrane antibodies were not detectable in vivo by direct immunofluorescence but were detected in high titres by indirect immunofluorescence. This situation is extremely rare in the literature. The first case concerns a 69-year old woman seen for bullous and pruriginous lesions of the lower limbs of 2 months' duration. Histological examination found dermoepidermal bullae with, in their lumen, a serous fluid spotted with numerous polymorphonuclears. A search for anti-basement membrane antibodies was positive in significant titres (1,280; 320; 480) at indirect immunofluorescence on rabbit lip whereas five successive direct immunofluorescence test in perilesional skin and on the thigh medial surface remained negative. The second case is that of a 91-year old woman suffering from generalized pruritus associated with erythematous lesions predominant on the extension surfaces of the forearms and thighs, without any bullous lesion. Pathological examination only showed a superficial dermal lymphocytic infiltrate. Four direct immunofluorescence tests were negative, whereas a search for anti-basement membrane antibodies on rat oesophagus was positive at 1/1,280. The third case resembles the second one. It concerns a 72-year old woman who consulted for generalized pruritus of several months' duration which interfered with sleep and was incompletely relieved by emollients. There was no specific skin lesion. Pathological examination revealed nothing more than a discrete perivascular mononucleate infiltrate. Direct immunofluorescence tests performed on two occasions on the skin of the abdomen and of the medial thigh surface were negative.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed2004

[The analysis of refractive error in children and adolescents from 6-15 years of age based on 1000 examinations in two major Polish regions].

PURPOSE: The aim of this study is to present the results of screening examinations of refractive errors, taken on 1002 of school children ranging from 6 to 15 years of age. MATERIAL AND METHODS: As the result of Internet screening visual acuity and color perception tests named "I can see..." in 10,021 children from randomly chosen schools in Poland in the year 2002, the group of 1002 children was chosen. In this group, the subjective and objective refractive error examination was taken as well as the visual acuity test, color perception with the use of Ishihara tables and full ophthalmologic examination. RESULTS: Average visual acuity was RE: 0.72 (SD +/- 0.31) and LE: 0.72 (SD +/- 0.31). The prevalence of emmetropia was 34%. In the examined group myopia in 17%, hyperopia in 20%, astigmatism in 5.5% of children was found, and in 24.5% of patients complex errors occur such as myopic and hyperopic astigmatism.

Adolescent↗
PubMed2004

[Botulinum toxin A in the treatment of congenital nystagmus in children].

PURPOSE: To evaluate the use of, botulinum toxin A in the treatment of congenital nystagmus in children. MATERIAL AND METHODS: 32 children with nystagmus and esotropia (group I), nystagmus and exotropia (group II) and horizontal and vertical nystagmus (group III). Intramuscular injections of botulinum toxin A was performed in all treated children. RESULTS: In group I the amplitude of nystagmus diminished of 50%, in group II of 42.9% and in group III of 28,6%. Near and distant visual acuity improved in all treated children. CONCLUSIONS: Treatment of congenital nystagmus with botulinum toxin A causes reduction of the amplitude of nystagmus, partial improvement of visual acuity and improvement of anomalous head posture.

Botulinum Toxins, Type A↗
PubMed2004

[IOL calculations in cataract operations in children].

The rapid growth of the eye must be accounted for, when calculating the dioptric power of the IOL before cataract surgery in children. Therefore in the paper, changes in axial length of the eye, refractive power of the cornea and dioptric power of IOL for correction of aphakia in children aged 0-14 years were measured. Basing on the obtained data, the guidelines for the choice of IOL in different age of children were worked up. Between 1 and 2 years the power of the IOL should be undercorrected by 20%, at 2 to 4 years by 15% and at 4 to 8 years by 10%.

Adolescent↗
PubMedDate not supplied

Relational systems change: implementing a model of change in integrating services for women with substance abuse and mental health disorders and histories of trauma.

This article describes the "relational systems change" model developed by the Institute for Health and Recovery, and the implementation of the model in Massachusetts from 1998-2002 to facilitate systems change to support the delivery of integrated and trauma-informed services for women with co-occurring substance abuse and mental health disorders and histories of violence and empirical evidence of resulting systems changes. The federally funded Women Embracing Life and Living (WELL) Project utilized relational strategies to facilitate systems change within and across 3 systems levels: local treatment providers, community (or region), and state. The WELL Project demonstrates that a highly collaborative, inclusive, and facilitated change process can effect services integration within agencies (intra-agency), strengthen integration within a regional network of agencies (interagency), and foster state support for services integration.

Adult↗
PubMed2005

[The value of topical immunosuppressors in the treatment of atopic dermatitis in children].

The use of topical immunosuppressors during treatment of atopic dermatitis is an important innovation that reinforces the therapeutic arsenal in this chronic disease in children. Two products have been studied in depth: tacrolimus, which exists in pomade form at a concentration of 0.1 and 0.03% under the trademark Protopic. It is the 0.03% concentration that has been studied in children and obtained official indication in children aged over 2. Pimecrolimus marketed under the trademark Elidel in the form of a 1% cream has also been studied in depth and obtained European marketing authorisation for prescription in children aged over 2. Unfortunately it is not yet available in France, although it is marketed in nearly all countries worldwide. These products decrease the production of cytokines by the T-cell lymphocytes when stimulated by the antigen. This effect is produced by the inhibition of calcineurine. The clinical efficacy of these two products has been demonstrated in many studies in the United States and in Europe. Short term efficacy has been demonstrated in comparisons versus a placebo or versus grade 2 or 3 corticosteroids. Longer term studies (6 months to one year) have confirmed the efficacy. Short-term tolerance to these new treatments has been shown, although, as with any new product, the long-term results are unknown. Nevertheless, tolerance studies after more than 4 years' use exist. The side effects most often reported are local, erythema-like at the start of treatment with burning and pruritus. There has been no significant increase in the number of bacterial and viral infections compared with control groups. Doubt remains regarding viral infections of herpetic origin, notably Kaposi-Juliusberg's disease, although no significant difference has been observed compared with the placebo-treated. No systemic impact has been reported with these two products or inhibition of the effect of vaccinations made in infants or children. However, care should be taken: not to use the products in patients with a history of Kaposi-Juliusberg's disease and any contact with a patient exhibiting herpes should be avoided; the photoprotection measures should be respected as instructed in the patient insert for the use of tacrolimus.

Administration, Topical↗
PubMed1992

[Value of different serological tests in the diagnosis of various forms of active ocular toxoplasmosis].

The analysis of results of indirect immunofluorescence and direct agglutination reaction in patients with various forms of ocular toxoplasmosis showed that these reactions have a limited value in diagnostics of this condition. One can define a sure diagnosis of active ocular toxoplasmosis when the titre of these reactions are higher than 512. The ELISA IgM reaction is specific for the active form of this disease. The sensitivity of this reaction amounts 43-50%. In cases of iridocyclitis the results of the serological tests were similar to those of the control group; this confirms the hypothesis that the inflammation is evoked by an allergic reaction.

Adult↗
PubMed2005

Antioxidant status in alcohol-related diabetes mellitus in Beninese subjects.

In the present study, we investigated the antioxidant status in diabetes mellitus, related or not to alcohol consumption. A total of 38 type 1, 48 type 2 and 42 alcohol-related diabetic patients were selected. Total antioxidant status was assessed through the oxygen radical absorbance capacity of the plasma and the determination of enzymatic and non-enzymatic antioxidant molecules. Serum triglycerides, total cholesterol and HDL-cholesterol concentrations were determined and the lipid peroxydation was evaluated by measuring thiobarbituric acid reactive substances (TBARS) assay. Plasma total antioxidant capacity was more decreased in alcohol-related diabetes than that in type 1 and type 2 diabetes, regardless of the complications (retinopathy and renal failure). Plasma vitamin E concentrations were significantly decreased whereas those of vitamin C increased in all of the diabetic patients compared to the controls, irrespective to the complications. In addition, superoxide dismutase and glutathione peroxidase activities were reduced in all the patients (type 1, type 2 and alcohol-related), irrespective to the complications. Glutathione reductase activity was diminished in type 1 and alcohol-related, but not in type 2, diabetic patients. Glutathione (GSH) concentrations significantly decreased in all diabetic patients with a significant decrease in alcohol-related diabetic patients. Excessive alcohol consumption appears as an oxidative aggravating factor in diabetes mellitus. Besides, alcohol-related diabetes highly resembles to type 1 diabetes as far as the antioxidant parameters are concerned.

Adult↗
PubMed2005

[Antibiotic resistance of conjunctival bacterial flora in children].

PURPOSE: To evaluate conjunctival bacterial flora in children and its resistance to the most frequently antibiotics used by the ophthalmologists in Poland. MATERIAL AND METHODS: Bacterial conjuntival cultures obtained in 593 children without ocular infections. RESULTS AND CONCLUSIONS: Pathogenic bacterial isolates were identified in 26.3% children. Most frequently isolated were Gram-positive cocci (70.5%). Significant resistance of Gram-positive cocci to aminoglicosides (5% to 65%) was observed. Emerging resistance to fluoroquinolones, especially of coagulase-negative staphylococci (in 21%), was also observed.

Anti-Bacterial Agents↗
PubMed2006

Presurgical and intraoperative mapping of the motor system in congenital truncation of the precentral gyrus.

A 43-year-old man presented with a grade II astrocytoma in the left postcentral gyrus and superior parietal lobule. Preoperative functional MR imaging and diffusion tensor imaging mapped distal upper-extremity primary motor cortex and white matter, respectively, adjacent to the tumor, within a congenitally truncated precentral gyrus. Because of the congenital anomaly, this region of primary motor cortex was inaccessible to direct visualization or intraoperative electrocortical stimulation. The integration of preoperative and intraoperative mapping data facilitated resection of the tumor while avoiding a postoperative motor deficit.

Adult↗
PubMed2006

[Atopic dermatitis in children].

Atopic dermatitis is a chronic inflammatory and recurrent dermatosis, the frequency of which increases regularly in industrialised countries. It begins in the first months of life and the clinical presentation changes with the age of the child. The diagnostic is clinical in the majority of cases. Sometimes allergological explorations are necessary. The treatment has two objectives: treatment of the flares (mainly topical corticosteroids) and preventive adjuvant measures. The use of topical immunosuppressors reinforces the therapeutic management, after failure of topical corticosteroids.

Child, Preschool↗