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At least 829 records · Page 46Linked to original sources
PubMed2007

Maternal human platelet antigen-1a antibody level correlates with the platelet count in the newborns: a retrospective study.

BACKGROUND: Maternal plasma and/or serum levels of anti-HPA-1a at delivery were compared to neonatal platelet (PLT) counts. STUDY DESIGN AND METHODS: Samples from HPA-1bb women who gave birth to children with thrombocytopenia or had anamnestic information about a previous child with neonatal alloimmune thrombocytopenia (NAIT) were collected at delivery. A modified monoclonal antibody immobilization of PLT antigen method was used for quantification of anti-HPA-1a. RESULTS: The anti-HPA-1a level in women with severely thrombocytopenic children was higher than the corresponding level in mothers of children born with moderate thrombocytopenia or normal PLT counts. CONCLUSION: Our data show a significant correlation between maternal anti-HPA-1a level and the neonatal PLT count and indicate strongly that this may be a reliable predictive measure for NAIT. Suitable test systems for quantitative measurements of anti-HPA-1a must be developed and evaluated for this particular purpose.

Antigens, Human Platelet↗
PubMed1980

The Ultra-Flo 100 platelet counter: a new approach to platelet counting.

The Clay Adams Ultra-Flo 100 whole blood platelet counter is a semiautomated instrument. The count is made on dilute whole blood by the detection of comparatively small current changes induced by the cells suspended in a conducting diluent as they flow thrugh an orifice. Alarm systems are incorporated in the instrument to detect sample irregularities due to microcytosis, and large and small platelets. The results of this evaluation are given, and confirm that the results using the Ultra-Flo 100 compare very favourably with those obtained using phase contrast microscopy.

Blood Platelets↗
PubMed1990

[Effects of granulocyte colony-stimulating factor on peripheral white blood cell and platelet counts in mice pretreated with anticancer drugs].

Effects of human recombinant granulocyte colony-stimulating factor (G-CSF) on peripheral white blood cell (WBC) and platelet (PLT) counts were examined in BALB/c mice pretreated with various kinds of anticancer drugs. Significant increase of WBC and significant decrease or tendency to decrease of PLT count were observed in mice treated with ACNU (40 mg/kg), CY (150 mg/kg), MMC (8 mg/kg) or VDS (3 mg/kg) followed by G-CSF treatment. These results indicate that we should study more about a possibility that treatment with G-CSF and anticancer drugs may cause in man a more severe thrombocytopenia than is observed with only chemotherapy treatment.

Animals↗
PubMed2005

Prognostic relevance of large-platelet counts in patients with immune thrombocytopenic purpura.

In this preliminary study, the value of different platelet parameters, measured by the ADVIA120 Analyzer, in predicting the immediate response to intravenous immunoglobulin or intravenous anti-RhoD was assessed in 31 patients with immune thrombocytopenic purpura. The number of large platelets pre-treatment was the only independent predictor of the 24 hour-platelet increase.

Adolescent↗