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Results for “Retinal Detachment”

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At least 829 records · Page 46Linked to original sources

PubMed2005

Retinal detachment with macular holes in infants with retinopathy of prematurity.

OBJECTIVE: To describe retinal detachment with macular holes in infants with retinopathy of prematurity and the methods of surgical repair with their outcomes. METHODS: A retrospective review of 4 cases of retinopathy of prematurity and 1 case of retinopathy in a full-term infant that resembled retinopathy of prematurity, in which a macular hole and associated retinal detachment developed and surgical repair was attempted. RESULTS: The average gestational age of the 4 infants with retinopathy of prematurity was 26 weeks. All 5 patients had a history of vitreoretinal surgery prior to discovery of the macular hole. All 4 who underwent further surgical correction have partially or completely attached retinas and ambulatory vision. CONCLUSIONS: Vitrectomy combined with fluid-air exchange failed to close a macular hole associated with retinal detachment in infants with retinopathy of prematurity. Athermal scleral buckling of the macula can close macular holes and reattach the retina. Scleral buckling appears to be the method of choice for repair.

Child, Preschool↗

PubMed1981

Primary scleral atrophy and retinal detachment.

In a retrospective study 27 patients with retinal detachment had an advanced primary scleral atrophy, needing treatment with a scleral graft. Among these 27 patients none was younger than 47. There was s good correlation between the location of the atrophic sclera and the retinal tears. Many of these eyes had an oblique astigmatism. Lattice degeneration was found to be rare. A history of retinal detachment was common in the fellow eye. The scleral grafts were well accepted by the eyes.

Aged↗

PubMed2004

FAS-mediated apoptosis and its relation to intrinsic pathway activation in an experimental model of retinal detachment.

PURPOSE: To determine whether the FAS-mediated apoptosis pathway becomes activated in the retina after retinal detachment and to investigate the temporal relationship between the activation of the FAS-pathway and the intrinsic apoptosis pathway involving caspase-9 and cytochrome c. METHODS: Experimental retinal detachments were created in Brown-Norway rats by injecting 10% hyaluronic acid into the subretinal space. Retinal tissue was harvested at 2, 4, 8, 24, 72, and 168 hours after creation of the detachment. Immunoprecipitation was performed to assess for FAS-receptor/FAS-ligand complex formation, and activation of caspase-8 and BID (a member of the Bcl-2 family of proteins) was assessed by Western blot analysis. A caspase-9 activity assay and immunoprecipitation of the caspase-9/cytochrome c complex were performed at these same time points. Specific pathway inhibition was performed with the caspase-9 inhibitor zLEHD.fmk or neutralizing antibodies against either the FAS-receptor or FAS-ligand. Transcription levels of FAS and intrinsic pathway intermediates were assessed as a function of time after retinal detachment by using quantitative real-time polymerase chain reaction. RESULTS: Retinal detachment resulted in the time-dependent formation of the FAS-receptor/FAS-ligand complex that preceded the peak of caspase-9 activity and caspase-9/cytochrome c complex formation. Cleavage of caspase-8 and truncation of BID were also observed. Injection of zLEHD.fmk into the subretinal space of a detached retina resulted in decreased caspase-9 activity, as did injection of anti-FAS-receptor antibody into either the subretinal space or the vitreous. Retinal detachment resulted in the transcriptional upregulation of the FAS-receptor, FAS-ligand, caspase-8 and BID, but not caspase-9 and cytochrome c. CONCLUSIONS: The FAS-mediated apoptosis pathway becomes activated and transcriptionally upregulated after retinal detachment. The peak of FAS activation precedes that of the intrinsic pathway, and inhibition of FAS activation can decrease caspase-9 activity.

Animals↗

PubMedDate not supplied

Surgical outcomes in juvenile retinal detachment.

PURPOSE: To evaluate retrospectively clinical features and surgical outcomes of rhegmatogenous retinal detachment in juvenile patients. METHODS: Between 1991 and 1996, 28 patients younger than 15 years of age with rhegmatogenous retinal detachment (32 eyes) underwent the first surgical procedure, scleral buckling and/or pars plana vitrectomy, at our hospital. RESULTS: The major types of juvenile detachment, in order of frequency, were idiopathic, familial exudative vitreoretinopathy, trauma, and high myopia. Proliferative vitreoretinopathy (PVR) of grade C or D was involved in 12 cases (37.5%). Among the 12 eyes with PVR, 7 attained retinal reattachment after the first surgery with scleral buckling. The overall reattachment rate was 28/32 (87.5%) after the first operation and 30/32 (93.8%) after the second operation. CONCLUSION: These findings indicate that the reattachment rate and visual prognosis can be as good in juvenile retinal detachment as in adult cases, when appropriate surgical procedures are used.

Adolescent↗

PubMed1993

Retinal detachment as a potential hazard in surgical correction of severe myopia with phakic anterior chamber lenses.

Phakic anterior chamber lenses have been proposed as an effective refractive surgical procedure for the correction of severe myopias. We managed three cases of retinal detachment that complicated this operation. Two patients had retinal detachment in the immediate postoperative period at the fourth and sixth weeks, respectively. Both patients had preoperative equatorial lattice degeneration, which was prophylactically managed with argon laser in one case. The third patient developed retinal detachment at the eighth postoperative month and was associated with a severe fibrinoid uveitis and a combined exudative and rhegmatogenous retinal detachment. This third patient did not have any previous retinal degenerative lesion. Scleral buckling was successful in two of the patients, whereas the patient with preoperative inflammation required vitreous surgery because of proliferative vitreoretinopathy. The retinas were reattached in all three patients without explanting the phakic anterior chamber lens, but severe loss of visual acuity occurred in one patient. Retinal detachment should be regarded as a potentially important hazard in this type of refractive surgery.

Adult↗

PubMed1981

Relationship of cystic retinal tufts to retinal detachment.

The histologic and gross pathologic features of cystic retinal tufts are reviewed, and the clinical characteristics of this lesion described. A survey of 200 retinal detachments revealed that cystic retinal tuft was the precipitating lesion for the detachment in from 6.5 to 10% of cases. Since the prevalence of cystic retinal tuft is 5%, the risk of such a lesion leading to retinal detachment was computed to be from 0.18 to 0.28%, and for this reason prophylactic treatment of cystic retinal tufts is not advised.

Adult↗

PubMed2000

[Complications after external retinal surgery in pseudophakic retinal detachment--are scleral buckling operations still current?].

BACKGROUND: After conventional buckling procedures for pseudophakic retinal detachment the primary reattachment rate is 60 to 90% according to literature. Primary vitrectomy may be advantageous in these cases. The purpose of this study was to investigate the spectrum and role of potential side effects like anisometropia and diplopia, to find arguments for or against primary vitrectomy. Also risk factors for pseudophakic retinal detachment were analyzed in our study group, because they may be different from former studies, which were mostly undertake at the time of ec cataract extraction. PATIENTS AND METHODS: The data from 115 patients (120 eyes) with pseudophakic retinal detachment, who undergone buckling procedure between 1991 and 1996 were retrospectively reviewed. We analyzed the retinal reattachment rate, choroidal detachment, postoperative visual acuity, refraction, occurrence of diplopia, anisometropia and metamorphopsia. RESULTS: The primary retinal reattachment rate was 83.3%. There was a retinal redetachment rate of 16.7%. The primary PVR-rate was 4.2%. After the first reoperation an reattachment rate of 91.6% could be achieved, after the second one an overall rate of 95%. A choroidal detachment occurred in 29.2%. Postoperatively (26.5 months +/- 17.2) we found a cellophane maculopathy in 26.5% with consecutive metamorphopsia in 12.1%. 13 patients (15.9%) complained about diplopia, which had to be corrected by operation in 2 cases and prismatic glasses in 4 cases. Anisometropia could be deserved in 16.4%. The buckling procedures caused refractive changes of -1.80 dpt +/- 1.78 after an encircling band and +0.38 dpt +/- 1.01 after a plombage (average -1.05 +/- 1.86). 20% of patients treated with an encircling band developed anisometropia and only 8.3% of patients with a plombage. Postoperatively the visual acuity raised significantly from 0.3 to 0.6 (median). Best visual recovery could be observed in patients, who underwent only one operation. CONCLUSIONS: The primary retinal reattachment rate in pseudophakic retinal redetachment after conventional buckling procedures in our patients are comparable to those in the literature. In spite of phacoemulsification the risk-factors for pseudophakic retinal detachment has not changed. A considerable number of patients complained about postoperative complications like anisometropia and diplopia, which could be avoided by primary vitrectomy. To compare anatomic and functional results of both procedures a randomized prospective study should be undertaken.

Adult↗

PubMed1992

Rhegmatogenous retinal detachment in Royal Naval personnel: a retrospective study.

A retrospective study was conducted to assess the various factors thought to influence the outcome of retinal detachment in RN personnel. A description of retinal detachment and its management, aimed at non-specialists, is given in the introduction. In the study period eight Servicemen had rhegmatogenous retinal detachments. All underwent conventional detachment surgery, but two required two further operations including vitrectomy. Important features of each patient's detachment are discussed, as is post-operative progress. All patients spent a considerable time away from duty and three were discharged from the Service on medical grounds. Poor outcome could be related to myopia, trauma, delay in presentation to primary care, the number of operations performed and to post-operative complications. Advice is given regarding assessment and management of suspected cases by non-specialists. It is hoped that reporting this study will increase awareness within the RN of retinal detachment as a sight-threatening condition.

Adolescent↗

PubMed1983

Intraocular SF6 gas applications: treatment of retinal detachments caused by holes at the posterior pole.

Retinal detachments caused by holes in the posterior pole are rare among rhegmatogenous detachments, but the central position of the holes causes considerable difficulties on surgery. The use of intraocular gas bubbles affords new possibilities for the treatment of these cases. Among 1,800 consecutively treated retinal detachments, we found only 21 which were due exclusively to one or more holes at the posterior pole; of these, only 7 exhibited a hole directly in the macula. The operative treatment of these 21 detachments consisted of an intraocular gas tamponade effected through injection of SF6 combined with cryo- and laser coagulation of the periphery of the holes. Reattachment of the macula and improved visual acuity were achieved in 19 cases. The postoperative follow-up ranges from 4 to 60 months, with a mean of 29 months.

Adolescent↗

PubMed1983

[Retinal detachment in the 2d eye. Risk factors].

1148 patients underwent retinal detachment (RD) surgery between october 1st 1969 and december 31st 1979 with follow up assured until june 30th 1983 non idiopathic retinal detachments were excluded from this study which was focused on the risk factors concerning detachment of the second eye. With this time criteria the present rate of RD on the second eye is 4,03% : 39 eyes in 970 patients for whom the second eye was present examinable and free of any RD at the time of the first examination. A statistical analysis with the X2 test shows that male patients (p less than 0,025) and heavily myopic eyes (p less than 0,025) are at greater risk; giant tears (70 degrees and more) in the first eye are also an important risk factor. When it comes to preexisting peripheral lesions, the data are more confusing. While the absence of such lesions is not protective against detachment, the contralateral eyes of patients with so-called dangerous lesions may remain detachment-free for a very long time without any treatment. We think that the best prophylactic treatment consists of an equatorial 360 degrees argon laser photocoagulation, with the following indications: giant tear, any break, and peripheral degenerations that lead to a progressive thinning of the inner retina. Care must be taken not to perform heavy photocoagulation therapy on eyes harboring a cellular, densified vitreous.

Female↗

PubMed1979

Bullous retinal detachment associated with renal failure: case report.

A case of bilateral bullous retinal detachment in a patient with long-standing disseminated lupus erythematosus is presented. Although several authors have reported the presence of bullous retinal detachment in association with chronic renal disease, in no other case have the ocular findings preceded the onset of frank renal failure. The etiology of nonrhegmatogenous detachment and uveal effusion in association with chronic renal disease was discussed and the possible contributory role of hypertension, electrolyte imbalance, and renal glomerular malfunction was investigated. The additional finding of late onset bilateral keratoconus is, in all probability, unrelated to the patient's retinal findings, though it is a major factor in her present visual morbidity. The purpose of this paper is twofold. First-ly, to alert the ophthalmologist to the possible development of bullous retinal detachment in patients with chronic renal disease, and secondly, to alert the internist to the possibility of impending renal failure in patients with such bilateral nonrhegmatogenous detachments.

Adult↗

PubMed1998

Retinal detachments due to traumatic tears in the pars plana ciliaris.

PURPOSE: To describe the clinical features of retinal detachments caused by traumatic tears in the pars plana ciliaris. METHODS: This study is a retrospective review of five cases of retinal detachments secondary to traumatic breaks limited to the nonpigmented epithelium of the pars plana ciliaris. Four patients had a history of recent closed-globe trauma due to a fist blow and the remaining patient had a history of remote closed-globe trauma. RESULTS: In all cases, the tearing of the pars plana developed in the superonasal quadrant. The low-lying configuration of the detachment and the absence of a retinal break, oral tear, or avulsed vitreous base challenged the ability of the initial examiners to establish the correct diagnosis. Each patient underwent successful surgical reattachment of the retina. CONCLUSIONS: Retinal detachments may result from traumatic tears in the nonpigmented epithelium of the pars plana ciliaris. These detachments often do not become clinically manifest for several months or longer following ocular contusion. They tend to be shallow with a smooth and flat surface, which makes diagnosis difficult during routine ophthalmoscopy. Scleral depression is almost always necessary to identify the pars plana tear(s).

Adult↗

PubMed1985

Experimental retinal detachment. IX. Aqueous, vitreous, and subretinal protein concentrations.

Unilateral rhegmatogenous retinal detachments were created in seven cynomolgus monkeys. Six months later, aqueous, vitreous, and subretinal fluid protein concentrations were measured. In fellow eyes with vitrectomy alone, mean aqueous and vitreous protein concentrations were 0.28 and 0.23 mg/mL, respectively. In eyes with retinal detachments, mean aqueous, vitreous, and subretinal protein levels were 1.46, 2.66, and 4.74 mg/mL, respectively. Eyes with a large retinal hole (greater than or equal to 1 disc diameter) had a subretinal fluid-vitreous protein concentration ratio of 1.1, indicating free diffusional exchange between the vitreous and subretinal space. In eyes with a small retinal hole (less than or equal to 1/4 disc diameter), the corresponding ratio was 4.0. These findings are consistent with the hypothesis that fluid moves from the vitreous cavity through the retinal hole into the subretinal space, preventing back diffusion of protein from the subretinal space into the vitreous, and allowing accumulation of protein in the subretinal space.

Animals↗

PubMed1998

Silicone oil in the repair of complex retinal detachments. A prospective observational multicenter study.

OBJECTIVE: This study aimed to report anatomic and visual acuity outcomes and complications after 1000-centistoke silicone oil was used as a retinal tamponade for the treatment of complex retinal detachments. DESIGN: Prospective observational multicenter study conducted at community and university-based ophthalmology clinics. PARTICIPANTS: The study cohort consisted of 2439 patients (2573 eyes) treated for complex retinal detachments associated with cytomegalovirus (CMV) necrotizing retinitis or a non-CMV etiology, including proliferative diabetic retinopathy, giant retinal tears, proliferative vitreoretinopathy, or ocular trauma. INTERVENTION: Vitrectomy surgery was performed for complex retinal detachment with 1000-centistoke silicone oil as the retinal tamponade. MAIN OUTCOME MEASURES: Anatomic outcomes were complete retinal attachment and macular attachment. Visual acuity outcomes were ambulatory vision (> or = 4/200) and preservation of preoperative visual acuity. Complications were rates of secondary intraocular pressure elevation (> or = 30 mmHg), hypotony (< or = 5 mmHg), corneal opacification (including band keratopathy, corneal edema, and corneal abrasions), oil emulsification, and cataract. Outcomes were assessed 6, 12, and 24 months after surgery. RESULTS: At the 6-month examination, the retina was completely attached in 178 (78%) of 228 CMV eyes and in 855 (70%) of 1219 non-CMV eyes. The macula was attached in 216 (95%) of 228 and 1062 (89%) of 1189 CMV and non-CMV eyes, respectively. Ambulatory vision was noted in 151 (65%) of 234 CMV eyes and in 480 (38%) of 1251 non-CMV eyes. Visual acuity was preserved in 106 (46%) of 230 and 1035 (84%) of 1229 CMV and non-CMV eyes, respectively. The corresponding rates of complications for CMV and non-CMV eyes were: elevated intraocular pressure, 0 (0%) of 196 and 35 (3%) of 1196; hypotony, 11 (6%) of 196 and 228 (19%) of 1196; corneal opacity, 13 (6%) of 229 and 326 (26%) of 1248; emulsification, 3 (1%) of 211 and 29 (3%) of 959; and cataract in phakic eyes, 118 (64%) of 185 and 50 (63%) of 80. CONCLUSIONS: Retinal reattachment was achieved in the majority of eyes using vitrectomy and silicone oil retinal tamponade. Complication rates generally were less frequent in CMV eyes, but follow-up was shorter in this group of patients, largely because of reduced life expectancy. Cataract frequently developed in phakic eyes of study patients. Use of 1000-centistoke silicone oil can be considered in the management of complex retinal detachments associated with multiple etiologies.

Adult↗

PubMed1996

Bilateral exudative retinal detachment complicating systemic corticosteroid therapy in the presence of renal failure.

PURPOSE: We describe an elderly patient with chronic renal failure who developed bilateral exudative retinal detachments after initiation of systemic corticosteroid therapy, followed by prompt resolution of the retinal detachments after the corticosteroids were discontinued. METHODS: The medical record was examined and reviewed to document the clinical course, treatment, and therapeutic response. RESULTS: Two weeks after receiving systemic corticosteroids for deteriorating renal failure, the patient had painless bilateral visual loss. Rapid tapering of the corticosteroids concurrent with hemodialysis and subsequent improvement of renal failure resulted in resolution of the exudative retinal detachments. The right eye developed a 360-degree retinal pigment epithelial tear in the macula. CONCLUSIONS: Exudative retinal detachments may complicate systemic corticosteroid therapy.

Aged↗

PubMed1995

[Retinal detachment with vitreous hemorrhage].

PURPOSE: To have the knowledge of the diagnosis in time and the choice of operations of retinal detachment with vitreous hemorrhage. METHODS: Sixty eight eyes in 68 cases of retinal detachment with vitreous hemorrhage were reviewed and the main factors affect the operative effect were analysed. RESULTS: Retinal detachment with vitreous hemorrhage usually causes PVR. The successful rate of the operation is low by scleral blucking procedure only, but it can be raised when the operation is combined with vitrectomy. CONCLUSIONS: Owing to the vitreous hemorrhage which has influence on the examination of fundus, it is difficult to make the diagnosis and treatment of retinal detachment. Furthermore, vitreous hemorrhage is easy to cause intraocular inflammatory reaction and PVR. Once the diagnosis is definite, the operation should be taken as soon as possible.

Adolescent↗

PubMed1986

Surgical repair of rhegmatogenous retinal detachments in dogs.

One to five weeks after cataract removal, retinal detachments due to retinal breaks (rhegmatogenous detachments) were detected in 4 dogs. Surgical repair of the detachments, using a scleral buckling procedure, was successful in 3 of the 4 dogs.

Animals↗

PubMed1977

Retinal detachment in aphakia.

In a prospective study five hundred consecutive cases of cataract operations were followed during ten years. Nine cases of retinal detachment were observed. In a retrospective study 77 cases with aphakic retinal detachment were studied according to type of cataract operation, interval between this operation and the onset of retinal detachment, refraction, area of detachment and results of treatment. About fifty percent of the cases of retinal detachment are observed during the first year after the cataract operation. At the first examination the detached area is usually larger in aphakic eyes than in phakic eyes. The anatomical and functional cure after detachment operation is probably less in aphakic than phakic eyes.

Cataract Extraction↗