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At least 829 records · Page 46Linked to original sources
PubMed1991

[Ultrasound as a diagnostic aid in maxillofacial surgery].

Ultrasonography is a relatively new diagnostic aid in maxillofacial surgery. It can be used in maxillofacial surgery in three modifications: Doppler sonography, A-scan sonography, B-scan sonography. As clinicians we wanted to determine what contribution ultrasound examination has made to the diagnosis of superficial maxillofacial masses, when compared with clinical examination, intraoperative findings and with other methods of investigations. Since 1985 B-scan sonography has been performed in the examination of congenital, inflammatory and neoplastic masses of the head and neck on more than 1500 patients. The ultrasound examination was performed in the Department of Radiology by radiologists. The value of the ultrasound findings varied depending on the soft tissue lesions which were examined and the experience of the radiologists who performed the examination. The advantages of the diagnostic ultrasound are in being noninvasive, without any known deleterious biological effect, rapid, painless, inexpensive and easily reproducible. Ultrasonography is a procedure which nowadays is routinely performed in our department for the preoperative evaluation of our cancer patients and postoperative follow-up as well as for the patients with inflammations, diseases of the salivary glands and soft tissue swellings.

Head and Neck Neoplasms↗
PubMed1981

[Results of sialography (author's transl)].

A randomly selected group of patients which had been subjected to sialography during 1975/76, was analysed retrospectively. In a total of 386 patients, 395 contrast radiographs had been performed; of these, 243 sialographs were evaluated retrospectively, the definite diagnosis having been established by surgery, biopsy or clinical course of the disease. The accuracy of diagnosis was 95% when employing diagnosis by exclusion (sialographic diagnosis having yielded "normal findings"), the correct diagnosis being the presence of concrements and inflammatory diseases of the salivary gland. However, the rate of error amounting to 5% must be considered a cause for concern insofar as of the total of 8 wrong diagnoses (against a total of 154 correct diagnoses), 7 patients had tumours which had not been recognized, four of these tumours being of a malignant nature. The presence of a space-occupying process was diagnosed with an accuracy of 88%. Space-requiring growths, provided they were properly diagnosed, were correctly localised in 83% of the cases. Statements on the degree of malignancy of a tumour--which were made in about one-third of the tumour diagnoses only--were found to be correct in 83% of the cases. False positive findings were obtained in 12% of the patients.

Adolescent↗
PubMed1978

Salivary immunoglobulins in diseases affecting salivary glands.

Inflammatory disorders of the salivary glands cause marked abnormalities in secretion of immunoglobulins. The changes are reversible, however, in a relatively short period of time. More subtle changes in immunoglobulin transport are present in such diseases as Sjogren's syndrome and diabetes. No changes are discernable in alcoholic cirrhosis. Apparently salivary gland basement membranes are much more resistant to derangement than plasma membranes and the secretory IgA system can continue to operate in the face of numerous affronts. If nothing else these findings suggest that vaccination procedures in the region of the salivary glands may produce an inflammatory response, but it would be readily reversible. In addition, one could anticipate a functioning s-IgA system even in salivary glands with alterations in electrolyte transport. It is difficult to anticipate the situation in immunologically compromised patients, such as those on hemodialysis. Fortunately these patients represent a small population and for them at least, caries is a relatively minor concern.

Albumins↗
PubMed1998

Studying development of disease through temporally controlled gene expression in the salivary gland.

Multistep tumorigenesis proceeds through activation of oncogenes and inactivation of tumor suppressor genes. Initiating oncoproteins induce secondary changes that maintain transformation in the absence of original stimuli. Time-dependent reversal of SV40 T antigen (TAg)-induced hyperplasia was studied using temporally controlled gene expression. Targeting TAg expression to the submandibular salivary gland of transgenic mice produces focal hyperplasias at age two weeks, which extend through large areas of the gland by four months. At twelve months, fibrosis and tumor foci accompany hyperplasia. Hyperplasia reverses when TAg expression in discontinued at four months but not at seven months. Secondary changes that maintain transformation appear to be time dependent. The system can be used to identify genetic events resulting in phenotypic reversal at four months and to expose factors preventing its occurrence at seven months. Expression of other proteins can be targeted to the salivary gland, and temporally controlled gene deletions can also be made using this system.

Animals↗
PubMed2005

Histological and histochemical observations on salivary microliths in ferret.

The fortuitous observation of salivary microliths in ferret was pursued in the present investigation. Major salivary glands obtained post-mortem from mature ferrets of either sex were examined with the use of histology and light microscopical histochemistry for calcium, protein, amino acids, mucosubstances and hydrolytic enzymes. Microliths were detected in most parotids, but were absent from submandibular and sublingual glands. The microliths were usually seen in lumens, and occasionally in parenchyma and interstices. They were variably stained for calcium, tryptophan, and neutral and acidic mucosubstances, similarly to acinar or ductal secretory granules. Unlike secretory granules, microliths showed autofluorescence, high levels of tyrosine and a low concentration of -SS- groups. Acid phosphatase and beta-glucuronidase reaction surrounded non-luminal microliths. The present data establish ferret as a new model for the investigation of salivary microliths and do not support the notion of microliths being almost absent from the parotid. Probably there is secretory inactivity in ferret parotid and this fosters the formation and accumulation of microliths containing calcium and disintegrated secretory material.

Acid Phosphatase↗
PubMedDate not supplied

Necrotizing sialometaplasia of the nasopharynx.

Necrotizing sialometaplasia is an uncommon salivary gland disease originally described by Abrams et al in 1973. The disease may occur wherever salivary gland tissue is found. Theories on the etiology of this disorder have been advanced, but never definitely determined. Treatment consists of adequate biopsy and observation until healing occurs at six to eight weeks. While the disease is considered benign, its similarity to more aggressive neoplasms can be both disturbing and misleading to the patient and the clinician. Such a case of necrotizing sialometaplasia of the nasopharynx is presented to demonstrate the clinical and histological similarity of this disease to carcinoma. In this case, the patient first presented with a neck mass which could easily have been mistaken for a regional metastasis. The current literature is reviewed.

Diagnosis, Differential↗
PubMed1989

[Salivary secretion and taste alterations in elderly subjects].

Morphologically the relative volume of the secretory acini in all types of salivary glands decreases with the age, whereas that of connective and adipose tissue increase. In addition, the rate of protein synthesis diminishes in older salivary glands. Nevertheless, the function of the secretory process is maintained throughout life. Stimulation of the salivary secretion by citric acid is unchanged in older people. On the other hand, the composition of saliva undergoes alterations with age. Taste alterations are in general not dramatical: the least for acid and the most for the salt acuity. From these data it can be concluded that xerostomia and salivary complaints of elderly are not caused primarily by decrements in the function of the salivary glands, but rather in many cases a secondary consequence of a salivary gland disease, or of a chronic medication e.g. by antihypertensive, sedative, antidepressive, narcotics etc.

Aged↗
PubMed1981

Etiology and pathogenesis of the inflammatory diseases of the cephalic salivary glands.

The complexity of the inflammatory pathological processes in the salivary glands, especially in the parotid gland, requires subtle diagnostic techniques. A multitude of clinical, pathological and anatomical as well as laboratory investigation methods are now available. This permits to make a safe diagnosis in most cases. However, many questions concerning etiology and pathogenesis of the inflammatory diseases of the cephalic salivary glands remain unanswered. This impedes a specifically directed therapy with will have to be the aim of further clinical and theoretical research.

Humans↗
PubMed2003

[Bilateral swelling of the parotid glands as part of a systemic disease].

In four patients, a man aged 34 years and three women aged 35, 32 and 55 years respectively bilateral swelling of the parotid glands was caused by systemic disease i.e. HIV-salivary gland disease, mucosa-associated lymphoid-tissue (MALT) lymphoma, sarcoidosis with coexisting Sjögren's syndrome, and sialosis and hypothyroidism, respectively. The HIV patient was treated with antiretroviral therapy, the first two women were treated expectantly and the third woman was given a thyroid hormone supplement which resulted in regression of the bilateral parotid enlargement. Bilateral enlargement of the parotid glands is not necessarily caused by infection, it can also be of systemic origin. Minimal invasive investigations of the salivary glands, such as sialography, measurement of salivary secretion rate (sialometry) and analysis of salivary composition (sialochemistry) can offer valuable information about the origin of the parotid gland swelling. Histopathological investigation of an incision biopsy of the parotid gland is an easy way to confirm the diagnosis. The morbidity associated with parotid biopsy is negligible.

Adult↗
PubMed2002

Interleukin 10 (IL-10) influences autoimmune response in primary Sjögren's syndrome and is linked to IL-10 gene polymorphism.

OBJECTIVE: To investigate the association between serum levels of interleukin 10 (IL-10), the synthesis of autoantibodies, salivary gland disease activity, clinical manifestations, and IL-10 microsatellite polymorphism in patients with primary Sjögren's syndrome (pSS). METHODS: Serum IL-10 and autoantibody levels [IgG anti-Ro and anti-La, total and IgA rheumatoid factor (RF)] were measured by ELISA. A minor salivary gland (MSG) biopsy was performed in all patients and the focus score was determined as a measure of salivary gland disease activity. In addition, IL-10 microsatellite typing was performed by polymerase chain reaction technique. RESULTS: IL-10 concentration was higher in patients (n = 39) than in controls (n = 15) (21.4 +/- 6.7 vs 2.5 +/- 3.5 pg/ml; p = 0.001). We found a significant positive correlation between IL-10 levels and titers of IgA RF, anti-Ro, and anti-La antibodies, as well as focus score. In comparison with patients with low IL-10 production (< 9.5 pg/ml), patients producing high IL-10 had significantly more episodes of cutaneous vasculitis and a higher proportion of them carried the IL-10.G9 allele. CONCLUSION: Autoimmune response in pSS patients as well as salivary gland disease activity and cutaneous involvement appears to be mediated by IL-10 levels; in turn, there is a linkage with IL-10 gene polymorphism.

Adult↗