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At least 847 records · Page 47Linked to original sources
PubMed1963

Total replacement of the mitral valve: results of insertion of a Starr-Edwards valve in five patients.

In five patients the mitral valve was resected and total valve replacement undertaken. The Starr-Edwards prosthesis was inserted. The first patient died, two and one-half months after operation, of a wide massive left-atrial clot and peripheral embolization. The second and third patients are well and back at work at eight months after operation, and the fourth patient is well at two and one-half months after operation. The fifth patient died suddenly at three weeks from massive peripheral embolization originating from the left side of the heart. The technical details of the insertion of the valves are described and the importance of careful postoperative anticoagulant management is stressed.

Anticoagulants↗
PubMed1964

TOTAL PROSTHETIC REPLACEMENT FOR AORTIC VALVULAR DISEASE.

At the hospital of the University of California, Los Angeles, patients with acquired aortic valvular disease have been treated in the past by debridement of the obstructing calcifications or partial replacement of the valve with prosthetic cusps or a combination of these techniques. In a long-term evaluation of these patients, such methods were shown to be inadequate in most instances. We now recommend total valve replacement with the Starr-Edwards prosthetic valve in all patients with calcific aortic stenosis and for those with aortic insufficiency due to irreparable valvular lesions. The selection of patients, the operative technique, and the results thus far in nine patients are presented.

Aortic Valve↗
PubMed1963

HEPARIN BONDING ON COLLOIDAL GRAPHITE SURFACES.

Experiments on clotting, both in vitro and in vivo, showed that a colloidal graphite surface, when rinsed with a cationic, surface-active agent, was capable of bonding heparin. The resistance of this graphite-heparin surface to the formation of clots was far greater than plastic or silicone surfaces in comparable studies.

Ammonium Compounds↗
PubMed2003

Current state of and outlook for organogenesis from undifferentiated cells.

PURPOSE: The aims of regenerative medicine and artificial internal organ development are, respectively, to regenerate and provide for transplant tissue or organs. METHODS: We summarize recent research on tissue differentiation and organogenesis using stem cells and report our laboratory's research using amphibian undifferentiated cells. RESULTS: We have successfully induced differentiation in cells from Xenopus laevis and generated structures in vitro that function in a similar way to organs when transplanted to Xenopus and newt embryos. We are attempting to establish a system to induce sensory organs, including eyes. CONCLUSION: Our experimental systems in amphibians are useful for organogenetic research, and it is hoped that our techniques can, in the future, be applied to mammals.

Amphibians↗
PubMed2003

[Effects of centrifugation-related artificial gravity on the human organism. Positive and negative effects].

Data of investigations of the artificial gravity issues in centrifuge experiments in Russian, USA and Japan over the past 40 years were analyzed. Periodic +Gz centrifugation was used to prevent or eliminate body deconditioning after 3- to 56-d simulated microgravity, and to increase the body functional reserve (orthostatic stability) in ordinary life. Positive effects included prevention of a decline of gravitational stability and reduction or averting the negative effects of simulated microgravity on various physiological systems. Better results can be achieved by combining artificial g-loads with the well-proven methods of combating deconditioning, i.e. physical training on bicycle ergometer and induced hydration. Human tolerance of g-loads on a short-arm centrifuge with a high (100%) gravitational gradient was found no worse than on a mid-arm centrifuge with a lower (20%) gravitational gradient. Negative effects of +Gz on a short-arm centrifuge were revealed and counteracting measures were determined.

Centrifugation↗