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At least 847 records · Page 47Linked to original sources
PubMedDate not supplied

Dacryoadenitis as the earliest presenting manifestation of systemic Wegener's granulomatosis.

PURPOSE: To report a case presenting with dacryoadenitis as the earliest manifestation of systemic Wegener's granulomatosis (WG). DESIGN: Observational case report. METHODS: A 41-year-old woman initially presented symptoms of bilateral dacryoadenitis. She subsequently developed upper and lower respiratory tract involvement, scleritis and keratitis. RESULTS: Cytoplasmic antineutrophil antibody (c-ANCA) titer was positive. The lacrimal gland and lung biopsies were consistent with WG. The patient responded well to cyclophosphamide and prednisolone. CONCLUSIONS: Dacryoadenitis maybe the earliestpresenting manifestation of WG andprompt immunosuppressive chemotherapy may control it preventing the limited disease from progressing to a complete form and reducing its morbidity and mortality.

Adult↗
PubMedDate not supplied

Lacrimal sac dacryolith: a study wit atomic absorption spectrophotometry and scanning electron microscopy.

Dacryoliths are uncommon causes of partial or complete obstruction of the nasolacrimal drainage apparatus. We report our findings of a dacryolith that we studied by culture, light microscopy, atomic absorption spectrophotometry, and scanning electron microscopy. Although no fungi were recovered by culturing, hyphae-like structures were observed. No inorganic material was detected by atomic absorption spectrophotometry. Scanning electron microscopy of ultrastructure showed the stone was composed of lobes and lobules built on an amorphous core material.

Calculi↗
PubMed2005

Physiologic self antigens rapidly capacitate autoimmune disease-specific polyclonal CD4+ CD25+ regulatory T cells.

Studies on CD4+ CD25+ regulatory T cells (Tregs) with transgenic T-cell receptors indicate that Tregs may receive continuous antigen (Ag) stimulation in the periphery. However, the consequence of this Ag encounter and its relevance to physiologic polyclonal Treg function are not established. In autoimmune prostatitis (EAP) of the day-3 thymectomized (d3tx) mice, male Tregs suppressed EAP 3 times better than Tregs from female mice or male mice without prostates. Importantly, the superior EAP-suppressing function was acquired after a 6-day exposure to prostate Ag in the periphery, unaffected by sex hormones. Thus, a brief exposure of physiologic prostate Ag capacitates peripheral polyclonal Tregs to suppress EAP. In striking contrast, autoimmune ovarian disease (AOD) was suppressed equally by male and female Tregs. We now provide evidence that the ovarian Ag develops at birth, 14 days earlier than prostate Ag, and that male Tregs respond to neonatal ovarian Ag in the Treg recipients to gain AOD-suppressing capacity. When d3tx female recipients were deprived of ovarian Ag in the neonatal period, AOD was suppressed by female but not by male Tregs, whereas dacryoadenitis was suppressed by both. We conclude that the physiologic autoAg quickly and continuously enhances disease-specific polyclonal Treg function to maintain self-tolerance.

Animals↗
PubMed2003

Role of endoscopic dacryocystorhinostomy in treating acquired lacrimal fistulae.

Acquired lacrimal fistula occurs in an improperly and inadequately treated lacrimal sac abscess. This study was done to evaluate the success of endoscopic dacryocystorhinostomy (EDCR) in treating such lacrimal fistula. A retrospective analysis of nine cases of acquired lacrimal fistulae in seven patients, treated by EDCR without any external surgery was carried out. Cessation of epiphora and closure of fistula were considered, successful outcomes. All the nine fistulae closed, and all patients were relieved of their epiphora within two weeks of surgery. It can be concluded that EDCR is effective for treating an acquired lacrimal fistula.

Acute Disease↗
PubMed1980

Infectious sialodacryoadenitis and rat breeding.

The littering rate of female rats was significantly lowered when they had been exposed to sialodacryoadenitis early in pregnancy. Rats of 8 weeks or more of age were highly susceptible to contact infection, showing marked decrease in bodyweight gain, whereas those of 5-6 weeks of age were resistant.

Animals↗
PubMed1981

Diagnosis of sialodacryoadenitis virus infection of rats in a virulent enzootic outbreak.

In a natural outbreak of sialodacryoadenitis virus it was observed that the incidence of clinical signs in spontaneous-hypertensive rats was 100%, and that these signs were of a severity not observed before in other strains of rats. Rats free of the virus were introduced so that the progress of the disease could be studied under natural conditions of spontaneous spread from the enzootically-affected breeding colony. The pathogenesis of the infection in these Sprague-Dawley rats has been recorded over a period of 10 days after their introduction to the colony, and the results of extensive serological screening have shown that the antibody response of the spontaneous-hypertensive rats to the virus is lower than in other strains of rat.

Animals↗
PubMed1980

Isolation and properties of sialodacryoadenitis virus of rats.

Pathogenic agents were isolated from affected salivary glands of rats with sialodacryoadenitis (SDA) by means of intercerebral inoculation to newborn mice and inoculation to primary rat kidney cell cultures. The properties of these isolates, irrespective of the isolation techniques, were in general agreement with that of SDA virus strain 681, and they were identified as SDA virus. In addition to the known properties, following characteristics were noticed: (1) Particles of SDA virus bore two different long and short surface projections. (2) Some antigenic differences were observed between the present isolate 930-10 and the strain 681. (3) It was suggested that SDA virus grew better at 35 degrees C than at 31 degrees, 33 degrees, 37 degrees or 39 degrees C. (4) SDA virus did not propagate in DBT cells.

Animals↗
PubMed1980

Pathological observations on natural cases of sialodacryoadenitis of rats.

Pathological observations were carried out on 100 male rats of Sprague-Dawley strain obtained from 5 outbreaks of sialodacryoadenitis (SDA). In accordance with clinical and macroscopic findings, principal microscopic changes were found in the salivary (submaxillary and parotid) and Harderian glands. Lesions observed in these different glands were essentially similar to each other, and characterized by degenerative changes in the epithelial cells of the ducts and acini associated with marked and extensive serous inflammation in the interstice. Furthermore, squamous metaplasia of the ductal epithelia was a common feature to these glands in the late stage of the disease. Some differences, however, were detected between the changes of the salivary glands and those of the Harderian glands. Firstly, the ductal epithelial cells were affected at first and the acinous epithelial cells were damaged only secondarily in the active inflammatory process in the salivary glands, while both ductal and acinous epithelial cells were involved equally in the primary lesion in the Harderian glands. Secondly, the increase in connective tissue elements in the reparatory process was extremely marked in the Harderian glands as compared with the salivary glands. Consequently, in the lesion of Harderian glands in the late stage, original construction was almost indiscernible, and the ducts and acini were only recognized as disseminated islets in actively proliferated connective tissue elements.

Animals↗
PubMed1981

Acute orbital pseudotumors: classification and CT features.

Acute orbital pseudotumors are inflammatory lesions of unknown etiology that may affect part or, less often, all of the tissue within the orbit. A retrospective computed tomographic (CT) study of 16 patients demonstrated that these lesions occur in one of five specific anatomic patterns: anterior, posterior, diffuse, lacrimal, or myositic. The most common location was lacrimal followed by anterior pseudotumors. Posterior, most common location was lacrimal followed by anterior pseudotumors. Posterior, diffuse, and myositic pseudotumors were equally frequent. Localization on the basis of clinical features correlated with the CT localization. Illustrative cases of each of the five types are included. The role of CT in evaluating the therapeutic response is discussed.

Acute Disease↗
PubMed1988

Bilateral lacrimal duct cyst.

Reports of lacrimal gland cysts have been rare, and mostly of small, unilateral cysts of the palpebral lobes. An unusual case of bilateral, large acquired cysts of the orbital lobe of the lacrimal glands is presented. Pathologic examination showed chronic inflammation and fibrosis of the lacrimal gland structures. We suggest that prolapse of the lacrimal glands with obstruction of the lacrimal ducts, combined with chronic dacryoadenitis, led to cyst formation.

Adult↗
PubMedDate not supplied

Acute suppurative dacryoadenitis caused by a cysticercus cellulosa.

A case of acute suppurative dacryoadenitis caused by a cysticercus cellulosa in a male of 20 years is reported. The diagnosis was established by histopathologic examination of the cyst that escaped along with pus during drainage of the abscess. The abscess in the palpebral lobe of the lacrimal gland resulted from acute inflammation produced by the presence of an intact larva. There was no other focus of cysticercosis in the same eye, in the other eye, or anywhere else in the body. Postoperative recovery was uneventful and there were no sequelae. To our knowledge, this is the first case report of acute dacryoadenitis caused by a cysticercus cellulosa. As cysticercosis is still prevalent in the underdeveloped countries, it is to be kept in mind in the differential diagnosis of ocular and adnexal lesions in patients coming from these areas of the world.

Abscess↗