PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “Extended”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 847 records · Page 47Linked to original sources

Role of physician extenders on the managed care team.

The use of physician extenders seems to be assured as health care reform efforts unfold at both the state and federal level. Movement to fixed budgeting and capitated reimbursement systems will encourage providers to be cost efficient whenever possible, and will accelerate the use of extenders as well as other lower cost allied professionals. As a spokesperson for Oregon's Sisters of Providence Health System said, "We have stopped investing in acute care. Our system is spending $30 million to ... establish ambulatory care settings. We need to prepare for increased numbers of patients in HMOs, more physicians who are employees, and the increased use of physician extenders." Proponents of physician extenders point to the fact that they charge less than physicians for similar services. Truly, several studies on the subject indicate that this assumption is correct. For example, a study from the Journal of Nurse Practitioners indicates that the cost of an office visit to see a nurse practitioner compared with a physician ranged from about 10% to 40% less depending on the nature of the visit (i.e., family, pediatric, gerontology, mental health, etc.). Another study has revealed that the average nurse practitioner in a family practice setting makes an annual salary of $43,600, compared to a family practice physician who makes over $110,000. While such statistics are compelling, they may not tell the entire story. For example, a study which compared APNs and primary care physicians indicated that the nurse practitioner saw fewer patients per week and spent significantly more time with each patient.(ABSTRACT TRUNCATED AT 250 WORDS)

Health Care Reform↗

Binding of longer peptides to the H-2Kb heterodimer is restricted to peptides extended at their C terminus: refinement of the inherent MHC class I peptide binding criteria.

MHC class I molecules usually bind short peptides of 8-10 amino acids, and binding is dependent on allele-specific anchor residues. However, in a number of cellular systems, class I molecules have been found containing peptides longer than the canonical size. To understand the structural requirements for MHC binding of longer peptides, we used an in vitro class I MHC folding assay to examine peptide variants of the antigenic VSV 8 mer core peptide containing length extensions at either their N or C terminus. This approach allowed us to determine the ability of each peptide to productively form Kb/beta2-microglobulin/peptide complexes. We found that H-2Kb molecules can accommodate extended peptides, but only if the extension occurs at the C-terminal peptide end, and that hydrophobic flanking regions are preferred. Peptides extended at their N terminus did not promote productive formation of the trimolecular complex. A structural basis for such findings comes from molecular modeling of a H-2Kb/12 mer complex and comparative analysis of MHC class I structures. These analyses revealed that structural constraints in the A pocket of the class I peptide binding groove hinder the binding of N-terminal-extended peptides, whereas structural features at the C-terminal peptide residue pocket allow C-terminal peptide extensions to reach out of the cleft. These findings broaden our understanding of the inherent peptide binding and epitope selection criteria of the MHC class I molecule. Core peptides extended at their N terminus cannot bind, but peptide extensions at the C terminus are tolerated.

Animals↗

Efficacy of extended lymphadenectomy in the noncurative gastrectomy for advanced gastric cancer.

BACKGROUND/AIMS: We retrospectively analyzed clinicopathologic data on 83 patients with advanced gastric cancer who underwent noncurative gastrectomy, with respect to the relation between the extent of lymphadenectomy and survival benefit. METHODOLOGY: These 83 patients were divided into 44 patients with limited or simple lymph node dissection (D0 in 14 and D1 in 30: Group A) and 39 patients with extended lymph node dissection (D2: Group B). RESULTS: The 1-year survival rate in Group B (82.1%) was significantly higher than in Group A (49.0%). However, the 3-year and 5-year survival rates did not significantly differ between Group A versus Group B, 39.7% versus 25.7% and 39.7% versus 20.5%, respectively. Median survival time after surgery with and without distant metastasis in Group B (21.5 months) was longer than in Group A (16.4 months), although not significant. CONCLUSIONS: While gastrectomy with extended lymphadenectomy did not contribute to improve long-term survival in patients with noncurable advanced gastric cancer, the utility of extended lymph node dissections may be relevant to improved locoregional control, at least in the prognosis within 1 year after surgery. Not only extended lymphadenectomy but also aggressive chemotherapy may be needed to improve the long-term survival for such patients.

Aged↗

Augmentation of osteoinduction with a biodegradable poly(propylene glycol-co-fumaric acid) bone graft extender. A histologic and histomorphometric study in rats.

We investigated the feasibility of enhancing the regeneration of skeletal tissues by augmenting bone grafts with a composite biodegradable bone graft extender material based on the polymer poly(propylene fumarate), PPF. The material was mixed with autograft and allograft and placed directly into a cylindrical metaphyseal defect made in the rat tibia. These formulations were compared to defects without any graft material, autografts, allografts and PPF alone. Nine animals were included in each group. Animals were sacrificed at 1 and 4 weeks postoperatively. Implantation sites were then evaluated using histologic and histomorphometric methods. Results of this study showed that defects did not heal in sham operated animals. In the experimental groups, there was early new woven bone formation in the autograft group with near complete healing of the defect at four weeks. When PPF was used alone, gradual ingrowth of new bone was seen. Mixing of the PPF bone graft extender with either allograft or autograft material resulted in enhancement of new bone formation with both allo- and autograft. However, significantly more new bone formation than in the autograft group was only seen when the PPF bone graft extender was mixed with fresh autograft. Histomorphometry corroborated these findings. Results of this study suggest that a PPF-based material may be used to increase the volume of smaller amounts of bone grafts supporting the concept of "bone graft extenders" by application of engineered biodegradable porous scaffolds.

Absorbable Implants↗

Extended frontotemporal epidural approach to cavernous sinus: surgical anatomy and technique.

OBJECTIVE: To investigate the surgical technique of trans-frontotemporal extended epidural approach to the cavernous sinus. METHODS: A microsurgical study on the exposure and dissection of the cavernous sinus and its surrounding structures on cadavers was performed via an extended epidural approach with frontotemporal skull-base craniectomy. RESULTS: The extended epidural approach offered an appropriate exposure of the cavernous sinus with minimal brain retraction and nerve damage. CONCLUSIONS: The extended frontotemporal epidural surgical approach is superior to the routine intradural or combined epi- and intradural approaches. It is suitable for most of the cavernous sinus surgeries.

Brain Neoplasms↗

Extended resection of locally advanced (T4) stomach cancer.

INTRODUCTION: The surgical management of locally advanced (T4) stomach cancer remains controversial and many still question the benefits of an extended resection. The aims of this study were to examine the morbidity and mortality associated with extended resection and also to determine the survival benefit. MATERIALS AND METHODS: A retrospective review of all stomach cancer operations performed from 1989 to 1998 was carried out and the relevant case histories retrieved and analysed. RESULTS: Out of the 980 stomach cancer operations performed, 784 (80%) had tumour resection and 20 (2.5%) also had extended resection of adjacent involved organs. These 20 patients had a 10% postoperative morbidity and the operative mortality was 15%. The survival ranged from 2 to 35 months (median 17 months). CONCLUSIONS: Extended resection of T4 stomach cancer is feasible and carries an acceptable operative morbidity and mortality. However, there is poor survival benefit and it should only be performed in a selected group of patients.

Adult↗

Value of extended lymph node dissection in the treatment of gastric cancer.

Regional lymph node metastasis is a critical prognostic factor in gastric cancer, and extended lymph node dissection and routine microscopic examination of all resected nodes could potentially provide accurate information regarding lymph node status. On the other hand, the therapeutic value of extended lymph node dissection is controversial. While retrospective and prospective non-randomised comparative studies have shown that extended lymph node dissection significantly improves the survival rate, prospective randomised trials have failed to demonstrate the efficacy of extended dissection, although the number of patients in these studies was limited. The present review of the literature therefore considers the prognostic significance of regional lymph node metastases and the therapeutic efficacy of lymph node dissection performed for gastric cancer.

Clinical Trials as Topic↗

Analysis of fatalities in extended cab pickup trucks using an estimating equation method.

We compared the fatality risk for occupants of rear passenger seats in extended cab and crew cab pickup trucks to the fatality risk for front seat occupants of the same vehicles using the (US) Fatality Analysis Reporting System (FARS) for 1982-1997. A 10-digit truncated vehicle identification number was used to classify the pickup trucks. The data were analyzed with an estimating equation for data having few observations per stratum. We identified 549 extended cab pickup trucks with one or more occupants of rear passenger seats and one or more occupant deaths. Occupants of rear passenger seats had a fatality risk 43% lower than front seat occupants (95% confidence interval 32% to 52%), controlling for age, sex, and restraint use. Occupants of rear seats of extended cabs in compact pickup trucks did not experience any higher fatality risk (relative to front-seat occupants of the same vehicles) than rear seat occupants of extended cabs in full-size pickup trucks and large 4-door crew cabs.

Accidents, Traffic↗

[Clinico-pathologic study on extended radical resection for rectal cancer].

OBJECTIVE: To justify clinico-pathologically the extended radical resection for rectal cancer. METHODS: Resected lymphatic specimens obtained by the triple approach in the radical resection for advanced rectal cancer was studied by routine pathological method. The outcome of this extended radical resection, guided by the route of lymphatic metastasis are presented in the justification. RESULTS: The incidence of lymphatic metastasis in advanced rectal cancer in the Chinese was 45.0%, with 44.0%, 14.0%, 10.0% and 9.0% in the upper 1, 2, 3 and the lateral third groups. Lymphatic metastasis from rectal cancer was related to the extent, depth and pathological type. The 5- and 10-year survival rates were 68.0% and 47.0%, which are much higher than those of the conventional radical resection. CONCLUSION: Extended radical resection for the rectal cancer, removing all the lymphatics, is able to prevent possible metastasis, thereby improving the survival rate significantly, This extended radical resection is an optimal type of operation.

Humans↗

[Long-term therapeutic effects of extended radical resection and radical resection of cancer of cardia and stomach fundus].

OBJECTIVE: To study the best range of radical resection in the treatment of cancer of the cardia and fundus of stomach. METHODS: 418 patients with cancer of the cardia and fundus of stomach underwent radical resection. Of them 192 were treated by extended radical resection (extended group), and 226 by radical resection (radical group). The 5-year and 10-year survival rates were followed up and compared in the two groups. RESULTS: Analysis failed to demonstrate significant difference between the two operations for TNM stage I and II (P > 0.05). For stage III, however, the 5-year and 10-year survival rates in the extended group increased by 14.2% and 15.9% as compared with those in the radical group (P < 0.05). The two groups survival rates were similar for stage IV (P > 0.05). CONCLUSIONS: To completely clean the lymph nodes of splenic hilus and artery and improve long-term survival rate, extended radical resection including spleen and body and tail of the pancreas should be recommended for stage III patients with cancer of the cardia and fundus of stomach when their serosa was involved or lymph node metastasis took place.

Cardia↗

Evidence-based practice: extending the search to find material for the systematic review.

BACKGROUND: Cochrane-style systematic reviews increasingly require the participation of librarians. Guidelines on the appropriate search strategy to use for systematic reviews have been proposed. However, research evidence supporting these recommendations is limited. OBJECTIVE: This study investigates the effectiveness of various systematic search methods used to uncover randomized controlled trials (RCTs) for systematic reviews. Effectiveness is defined as the proportion of relevant material uncovered for the systematic review using extended systematic review search methods. The following extended systematic search methods are evaluated: searching subject-specific or specialized databases (including trial registries), hand searching, scanning reference lists, and communicating personally. METHODS: Two systematic review projects were prospectively monitored regarding the method used to identify items as well as the type of items retrieved. The proportion of RCTs identified by each systematic search method was calculated. RESULTS: The extended systematic search methods uncovered 29.2% of all items retrieved for the systematic reviews. The search of specialized databases was the most effective method, followed by scanning of reference lists, communicating personally, and hand searching. Although the number of items identified through hand searching was small, these unique items would otherwise have been missed. CONCLUSIONS: Extended systematic search methods are effective tools for uncovering material for the systematic review. The quality of the items uncovered has yet to be assessed and will be key in evaluating the value of the systematic search methods.

Humans↗

Cementless S-ROM femoral component: effect of stem length on stability after extended proximal femoral osteotomy.

The extended proximal femoral osteotomy is becoming increasingly popular in revision total hip replacement. Our study was done to determine the femoral stem length required for stable fixation of a cementless femoral component after an extended proximal femoral osteotomy. Three lengths of the S-ROM femoral stem were implanted in paired cadaver femora and tested under torsional and axial loads. The results indicate that the standard (160 mm) and long (215 mm) stems do not provide adequate torsional stability after a 160 mm extended proximal femoral osteotomy. The extra-long (255 to 315 mm) stems provided significantly greater stability, suggesting that the extended proximal femoral osteotomy may need to be bypassed by more than 2 cortical diameters, especially when a flexible stem such as the S-ROM is used.

Arthroplasty, Replacement, Hip↗

Extended-duration low-molecular-weight heparin prophylaxis following total joint arthroplasty.

Patients undergoing total joint arthroplasty are predisposed to the development of venous thromboembolic disease, including deep venous thrombosis and pulmonary embolism. Despite a standard course of postoperative prophylaxis, orthopedic patients remain at significant risk for late venous thromboembolic complications, resulting in considerable morbidity and mortality. Since routine screening for asymptomatic deep venous thrombosis with duplex ultrasound has not been found to be effective, the practice of extended out-of-hospital prophylaxis with low-molecular-weight heparin after total joint arthroplasty has been proposed in order to better protect these patients from delayed venous thromboembolic events. Multiple controlled, randomized clinical trials have shown that extended-duration low-molecular-weight heparin therapy significantly reduces the incidence of asymptomatic venous thromboembolic events following total hip arthroplasty, although no similar benefit has been observed in patients undergoing total knee arthroplasty. There are currently no comparative studies assessing the efficacy of long-term venous thromboembolic prophylaxis with oral anti-coagulant agents. Extending low-molecular-weight heparin therapy is not associated with any increase in major bleeding complications, but it may result in more frequent minor bleeding episodes. In addition, the cost-effectiveness of prolonging low-molecular-weight heparin treatment has not yet been firmly established. Although there is evidence supporting the use of extended out-of-hospital low-molecular-weight heparin prophylaxis after total hip arthroplasty, this strategy has not gained widespread acceptance in North America because of concerns regarding its adverse effects, cost-effectiveness, and uncertain patient compliance. There is general agreement that prophylaxis is needed after hospital discharge, and a minimum of 10 to 14 days of prophylaxis has been shown to be both safe and effective. However, further studies are necessary to determine the optimal duration of treatment.

Anticoagulants↗

[The evolution of threshold values of air conduction in the extended high frequency range (9-18 kHz) in patients suffering from the pulmonary tuberculosis treated with combination of SM, INH, RFM, and PZA].

The evolution of threshold values of air conduction in the extended high frequency range (9-18 kHz) at patients suffering from the active pulmonary tuberculosis treated with the combined therapy (SM, INH, RFM, PZA). There were audiologically examined 13 patients (the average age 41.2) suffering from the active pulmonary tuberculosis and treated with the combined therapy (SM, INH, RFM, PZA). In 13 tuberculosis patients the full range of audiometric tests and measurements including: the pure tone audiometry, acoustic impedance and the extended high frequency range threshold audiometry (9-18 kHz) have been applied before starting the treatment with SM, INH, RMP and PZA and in the two months later--after its completion. The reference group was composed of 10 audiologically healthy individuals (the average age 40.2). A significant hearing loss with respect to air conduction within the extended range of high frequencies (9-17 kHz) was stated. The said hearing pathology can be diagnosed at earlier stages by the use of the extended high frequency range audiometry than through applying methods of conventional audiometry.

Adult↗

[A clinical evaluation on reconstruction in extended partial laryngectomy for transglottic cancer].

OBJECTIVE: Transglottic cancer has been a definite indication for total laryngectomy in decades, compromising function of the larynx. The purpose of this study is to present a new radical surgery of extended partial laryngectomy and reconstruction to restore the essential function of larynx. METHODS: Forty-one cases of transglottic cancer were treated by extended vertical laryngectomy (26/41), extended frontolateral laryngectomy (5/41) and subtotal laryngectomy (10/41); the defects of larynx were reconstructed by rotary door myocutaneous flap in twenty-seven cases, by sternohyoideus flap in seven cases, by osteomuscular flap in five cases and by sternocleidomastoid flap in two cases. RESULTS: The 3 and 5 year survival rates were 85.7% (30/35) and 74.1% (20/27) respectively, those for stage III were 84.6% (22/26) and 76.2% (16/21), for stage IV were 3/4 and 1/2 respectively. All cases resumed acceptable voice, 92.7% (38/41) and enjoyed satisfactory phonation. The over-all decannulation rate was 87.8% (36/41), those with rotary door myocutaneous flap was 96.3% (26/27), with sternohyoideus flap was 5/7, with osteomuscular flap was 4/5 and with sternocleidomastoid flap was 1/2. All patients had normal swallow function. CONCLUSION: Extended partial laryngectomy is a kind of radical operation in selected cases of transglottic cancer. The method of reconstruction with rotary door myocutaneous flap can improve curative effect and the essential functions of the larynx.

Adult↗

Treatment of telangiectasia using the multi-pass technique with the extended pulse width, pulsed dye laser (Cynosure V-Star).

BACKGROUND: The pulsed dye laser (PDL) has been used for the treatment of facial and leg telangiectasia, where it provides safe and effective treatment. Often, a single treatment with the PDL can provide acceptable vessel clearance. Unfortunately, the hallmark of PDL treatment is transient purpura, which can be cosmetically unacceptable to patients. A new class of PDL has been developed in an effort to reduce this transient side effect while maintaining both safety and efficacy. OBJECTIVE: To evaluate the ability of multi-pass treatment for telangiectasia with extended pulse width (40 ms) PDL to provide effective, single-treatment vessel treatment without inducing purpura. METHODS: A total of 40 patients presenting with facial or leg telangiectasia were treated with the extended pulse width PDL (595 nm), used in conjunction with refrigerated air-cooling (SmartCool; Cynosure). Treatment was given using a pulse width of 40 ms and fluences at or below the purpuric threshold (less than 16 J/cm(2)) and with high-flow air cooling at -4 degrees C. Up to three passes were given until vessel disappearance or intravascular coagulation was observed. A second treatment was done, where needed, 4-8 weeks following the initial treatment. Patients were evaluated 4, 8, and 12 weeks after the final treatment. RESULTS: Following a single treatment, 70% of facial and 80% of leg vessels exhibited at least 75% clearance. After two treatments, 14/20 leg vessels cleared at 75-100%. In all cases, vessel clearance was associated with transient purpura lasting less than 7 days. Hyperpigmentation occurred in 5% of facial vessels and 55% of leg veins. Sub-purpuric doses did not provide acceptable single-treatment clearance. CONCLUSIONS: Extended pulse width dye lasers significantly increase the threshold for purpura, allowing higher fluences to be employed. For the goal of single treatment vessel clearance, the extended pulse duration provided acceptable, single-treatment improvement but only in the presence of purpura. While additional, non-purpuric treatments may provide acceptable outcomes, additional improvements will be necessary to provide consistent, effective, single-treatment clearance of telangiectasia without generalized purpura.

Face↗

[Benefits of extended lymphadenectomy in patients with gastric carcinoma with metastasis to second level lymph nodes. An Italian multicenter study].

The actual benefit of extended lymphadenectomy in terms of survival in the surgical treatment of gastric cancer is still a debated issue. The aim of this non-randomized prospective multicentre study was to evaluate long-term survival in a group of patients with involvement of the second level lymph nodes, which would not have been removed with a limited lymphadenectomy. From 1991 to 1997, 451 patients with primary gastric cancer underwent curative resection with extended lymphadenectomy in three italian surgical departments. Lymph node stations were removed and classified according to the rules of the Japanese Research Society for Gastric Cancer; in all cases, retrieval of the lymph nodes was performed by the surgeon on the fresh specimen. Metastases to lymph node stations 7-12 were found in 126 patients out of 451 (27.9%). A mean number of 13 +/- 9 positive lymph nodes (range: 1-42) was found in these cases. Lymph node stations 7 and 8 showed the highest incidence of metastases (61.1% and 44.4%, respectively). Morbidity and mortality rates were 17.1% and 2% in 451 cases treated by extended lymphadenectomy, and 21.4% and 3.2%, respectively, in 126 cases with involvement of second level lymph nodes. In this group of patients, the five-year survival rate was 32 +/- 4%. Multivariate analysis, identified depth of invasion (P < 0.0001, relative risk (RR) 2.4) and the number of positive lymph nodes (P < 0.001, RR 1.6) as significant predictors of a poor prognosis. Japanese-type extended lymphadenectomy is associated with low morbidity and mortality rates if performed in specialised centres. The incidence of metastases in lymph node stations removed with this technique is by no means negligible. This procedure could be beneficial as regards long-term survival even in patients with involvement of regional lymph nodes.

Adult↗

Extended role of the nurse in ICU.

A popular definition of a nurse's extended role is a procedure that is not covered in basic training and for which further training is needed (Rowden, 1987). Nurses' past need for certification and the concept that certain procedures are part of an extended role negates nurses' professionalism. Many nurses fear that the UKCC's abolishment of certification for extended role procedures will open the floodgates for unsafe practice and strip the profession of its protection. This survey analysed what procedures intensive care nurses were performing, how responsibility was related to status, whether certain procedures were classified as extending their role and how staff related these procedures to patient care, staffing levels and professionalism.

Humans↗