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PubMed2004

[Treatment of iron-deficiency anaemia with ferrous gluconate].

Twenty women with iron-deficiency anaemia were treated. The distribution of women was as follow: 16 women with metrorrhagia and 4 pregnant women. According the stage of anaemia - 6 of them with slight anaemia, 12 - moderate, 2 of them with severe anaemia. Diagnosis of iron-deficiency anaemia was done on the base of clinical and laboratory dates, including Hb, Er, Fe and Fe-binding capacity measured in periphery blood. "Tot'hema" was prescribed twice daily. Control laboratory investigations were done on 24 and 72 hours. Receiving dates confirmed excellent GI absorption, which guarantee "Tot'tema" efficacy. Reported on all cases very good therapeutic effect and excellent tolerability of "Tot'tema", without side effects.

Adult↗
PubMed1990

Several aspects of red blood cell engineering: potential therapeutic applications.

Erythrocytes can be used to entrap drugs, enzymes or other molecules with active properties, with various encapsulation procedures. The method of internalization we are using includes an hypotonic dialysis step. Carrier erythrocytes survival depends on the dialysis process and the carried molecule. Research has led us to perform preclinical trials on animals for several drugs and enzyme therapies and for the improvement of oxyphoric capacity of erythrocytes. There exist many potential clinical applications for each kind of internalized molecules.

Animals↗
PubMedDate not supplied

[Electron structure of the active center of paramagnetic hemoproteins from the data of low-temperature magnetic circular dichroism. High-spin ferric derivatives].

The temperature dependences of magnetic circular dichroism (MCD) spectra of the high-spin fluoride complexes of metmyoglobin, methemoglobin and horse-radish ferriperoxidase have been studied and analysed in spectral region 250-1100 nm at temperatures from 2 to 300 K. Upon lowering of the temperature the increase of the MCD intensity was observed over all spectral regions studied, indicating the presence of the so called C-type effects. In contrast to other paramagnetic hemoproteins studied previously the significant changes of the shape of MCD spectra of fluoride complexes in the near UV B (pi--pi*)-band (Soret band) was observed at the lowest temperatures. The changes are explained by the superposition of effects of two types: the usual C-type effects which have the shape of absorption dispersion and of the derivative shape CA-type effects. The CA-type effects in the Soret band were analysed in terms of the theoretical model suggested previously. The data are in qualitative agreement with the prediction of the model. New information on the energies of the 4E and 4A2 excited states of the heme iron, on the orbital contribution into ground state paramagnetism and on the value of the pi--d pi-splitting, typical for B(pi--pi*)-state and ground Kramers doublet, were obtained on the basis of quantitative analysis of the MCD temperature dependences. The parameter D of zero-field splitting was estimated from MCD spectra and its value (6 cm-1) agrees well with that obtained by other methods.

Animals↗
PubMed1986

Ferritin versus ferrous sulphate preparations: a controlled study in sideropaenic patients.

A double-blind study was carried out in 54 patients requiring iron therapy to compare the effects of orally administered bivalent and trivalent iron over a period of 12 weeks. Patients were allocated at random to receive ferrous sulphate (100 mg/day), ferritin (80 mg/day as Fe3+) or a combination of ferritin (80 mg Fe3+/day), folinic acid and vitamin B12 coenzyme. Haematological measurements made before and during treatment showed that, whilst there were significant improvements in all of the parameters studied with both the bivalent and trivalent forms of iron, the results were more progressive and consistent with the two ferritin preparations, indicating that ferritin is clinically effective as a physiological iron donor in sideropaenic conditions.

Adolescent↗
PubMed1977

Increased survival from acute Salmonella gallinarum infection in chicks given diets with high levels of some forms of iron.

Amounts exceeding 100 ppm of extra dietary iron as the ferric salts of ethylenediaminetetra-acetic acid (FeE) or nitrilotri-acetic acid (FeN) produced highly significant increases in survival among chicks infected with 10(6.4) living Salmonella gallinarum strain 9. Additional dietary iron (400 ppm) as the sulphate or chloride salts (or as ferric fructose) lacked activity comparable with FeE or FeN except when 0.2 per cent of NaE was also present in the diet. FeE iron (600 ppm) also diminished the severity of several of the pathological reactions which occur in chicks during the acute stage of experimental fowl typhoid. The enhanced survival and decreased severity of the pathological changes in infected chicks were associated with large reductions in the numbers of viable salmonellae in the spleen at the height of the acute infection.

Animals↗