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[Fertility disorders of potentially curatively treated tumor patients. Consequences for the choice of primary therapy and after care].

The risk of therapy-induced fertility disorders is increasingly determining the choice of primary treatment, but also the form of follow-up care in young tumour patients. By using modified surgical procedures, differentiated radiotherapy and the preferential use of cytostatic agents with less influence on fertility, disturbances of fertility and sexual activity in tumour patients can often be avoided or at least reduced. In the after-care of tumour patients, measures for detecting and treating fertility disorders are becoming ever more important. The physicians delivering aftercare need to concern themselves with the organic and psychosocial problems arising from such disorders.

Adult↗

The male genitourinary sphincter mechanism in the dog.

In an effort to locate and characerize a genital sphincter in the male posterior urethra, the intraluminal changes in urethral pressure under both sympathetic and parasympathetic stimulation were studied. It appears that the urethra has a specific genital sphincteric length corresponding to the supramontanal portion. The urethral length is seemingly under sympathetic control, so that backflow of semen does not occur during ejaculation. The urinary sphincter apparently involves the entire posterior urethra and is primarily under parasympathetic influence.

Angiotensin Amide↗

Neurologic control of prostatic secretion in the dog.

A model to record the volume of prostatic secretion was developed. The influence of both divisions of the autonomic nervous system on the prostate by pharmacologic stimulation and blockade, and by direct electrical nerve stimulation was observed. The prostate responded to parasympathetic stimulus by increasing secretion. Under sympathetic stimulation, the secretion collected in the acini and ducts was expulsed into the urethra by contraction of the smooth muscle fibers surrounding these structures. A correlation between these findings and the normal sexual function may be made: Early in the excitation phase there is parasympathetic activity with increased secretion. With onset of orgasm and emission, sympathetic activity initiates the contractile activity of the genital duct system and the prostatic muscular element. As a result, the secretion is transported to the prostatic urethra (emission) to be later ejaculated by the genital skeletal musculature of the perineum, mainly the ischiocavernosus and bulbospongiosus.

Angiotensin II↗