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PubMed2002

Removal of cartilage rings prevents graft stenosis in extended tracheal allotransplantation with omentopexy and immunosuppression: an experimental study.

BACKGROUND: One of the serious problems in longer size tracheal transplantation is severe stenosis of the graft, probably caused by an inadequate blood supply. We have previously reported that removal of some cartilage rings of the graft and omentopexy helps to provide sufficient blood flow to the graft mucosal tissue and results in satisfactory survival and non-significant graft stenosis in extended tracheal autotransplantation. However, it is unclear whether this method can be applied to extended tracheal allotransplantation that requires immunosuppression. In this report, we describe midterm results of extended tracheal allotransplantation with the technique. METHODS: Twenty-four adult mongrel dogs were used. In 18 dogs, a nine-cartilage-ring length of the trachea was allotransplanted when five cartilage rings of the graft were removed, leaving two rings intact at both ends of the graft for simple fixing to the recipient. Two artificial tracheal rings outside the graft and a stent inside the graft were used for maintaining the lumen width. Omentopexy was done for sufficient blood supply to the graft. FK 506 (0.1 mg/kg) was given on each day after the operation in Group A (n = 10), but was not given at all in Group B (n = 8). In Group C (n = 6), a nine-cartilage-ring length of the trachea, without removal of any cartilage ring, was transplanted into the recipient dog and covered with an omental pedicle flap. The same dose of FK 506 as that used in Group A dogs was given to Group C dogs. RESULTS: In Group A, 2 dogs died of graft stenosis within 9 weeks after surgery and 1 died of emaciation without tracheal stenosis. Seven dogs (70%) survived until time of killing. Among the 8 dogs in Group B, 6 died of graft stenosis within 9 weeks after surgery, with 1 dying of pneumonia and only 1 (13%) surviving for >1 year until killing. In Group C, all 6 dogs died of graft stenosis within 6 weeks after surgery. Survival at 16 weeks after surgery was 70% in Group A, 13% in Group B and 0% in Group C (p < 0.01, A vs B and C). No significant graft stenosis was found in 6 dogs and mild stenosis was found in 2 dogs at the time of death or killing in Group A (80%), whereas mild stenosis was found in only 2 dogs in Group B (25%) (p < 0.05). Mucosal blood flow of the graft in Group A was higher than that in Group C and was the same as that in Group B within 4 weeks after surgery; however, it remained unchanged to ultimately be higher than in Group B at 6 and 8 weeks after surgery. CONCLUSIONS: Removal of some cartilage rings, omentopexy and immunosuppression improved blood supply to the graft and resulted in good survival and non-significant tracheal stenosis in extended tracheal allotransplantation.

Animals↗
PubMed1975

Subtotal pharyngolaryngectomy conservation surgery for carcinoma of sinus pyriformis extending toward the larynx.

In newly developed surgery for pyriform sinus tumor extending toward the larynx, the supraglottic portion of the larynx and the vertical half of the larynx on the tumor side are included in the area of resection. The arytenoid and cricoid cartilages on the tumor side and the vertical half of the hypopharyngeal wall are resected. Three out of seven patients remain cured at the end of 5 years and this ratio is the same as that for total pharyngolaryngectomy for pyriform sinus tumor. The resulting voice is somewhat hoarse, however, verbal communication is not remarkably affected. It is concluded that in surgical repair for pyriform sinus tumor extending toward the larynx, subtotal pharyngolaryngectomy is the procedure of choice to preserve the laryngeal function and anticipate reasonable prospects for a cure.

Follow-Up Studies↗
PubMedDate not supplied

[Sonography of the larynx in childhood: new perspectives due to the use of computerized sonography. 1: Anatomy and method].

We report on new perspectives in diagnostic ultrasound of the larynx, which has become possible by applications of computer sonography. To our knowledge no such comprehensive ultrasonic diagnostics in children are reported as yet in the area of larynx. All examinations were performed with a computed sonography system (Acuson 128). We used a linear transducer with a penetration corresponding to 5 MHz an a resolution corresponding to 10 MHz. The frame rate was around 25 Hz and thus enabled a good reproduction of dynamic processes. As we could show, it is possible to visualize all significant structures of the larynx including the thyroid cartilage, the vocal ligament, the vocalis muscle, the arytenoid cartilage and the piriform fossa. Of course the vestibular fold and the cervical musculature are also demonstrable. The high frame rate of the instrument anaibled a good reproduction of dynamic processes. The sonographic demonstration of anatomical structures is possible as well as a functional diagnosis.

Adolescent↗
PubMed2001

Bone or cartilage invasion by advanced head and neck cancer: intra-arterial supradose cisplatin chemotherapy and concomitant radiotherapy for organ preservation.

BACKGROUND: Invasion of bony or cartilaginous structures by advanced upper aerodigestive tract cancer has been considered an indication for surgery on the basis of historic experience of poor responsiveness to radiation therapy. At University of Tennessee-Memphis, patients with advanced head and neck cancer have been treated on a protocol of concomitant intra-arterial (targeted) cisplatin and conventional radiation therapy. OBJECTIVE: To compare the efficacy, in terms of disease control and survival, of this protocol in patients with T4 squamous cell cancers and invasion of bony or cartilaginous structures (group 1; n = 45) vs those with T4 disease but no bone or cartilage involvement (group 2; n = 90). DESIGN: Subset analysis of protocol database and retrospective chart review. METHODS: Treatment consisted of 4 weekly intra-arterial infusions of cisplatin (150 mg/m(2) per week), with simultaneous systemic neutralization by intravenous sodium thiosulfate (9 mg/m(2)), and concurrent radiation therapy at 180 rad (1.8 Gy) or 200 rad (2 Gy) per fraction to a planned total of 6600 to 7400 rad (66-74 Gy) to the primary site or overt nodal disease. Presence of bone or cartilage invasion was established by review of tumor diagrams of clinical findings and computed tomography or magnetic resonance imaging reports. RESULTS: Of 135 patients who had T4 disease and a minimum follow-up of 9 months (median, 40 months), 45 had clinical or radiologic evidence of bone (n = 29: mandible, 12; maxilla, 9; sphenoid, 3; hyoid, 6) and/or cartilage (n = 18: thyroid, 16; cricoid, 4) invasion (some patients had involvement of more than 1 site). The rate of complete response in group 1 (66.7%) was not significantly different from that in group 2 (71.1%) (chi(2) test, P = .79). The 2-year overall actuarial survival for group 1 (46.3%; 95% confidence interval, 30.3%-62.3%) was not significantly different (generalized Wilcoxon test, P = .36) from that of group 2 (36.9%; 95% confidence interval, 25.5%-48.4%). A marked trend was noted for higher response rates in cases of cartilage invasion (81.2%) than in those with bone invasion (58.6%) (P = .15). CONCLUSION: Equivalent efficacy of treatment in the 2 groups suggests that targeted chemoradiation can be a definitive therapeutic option in patients with advanced head and neck cancer invading bony or cartilaginous structures.

Adult↗
PubMed1999

Unusual chondrosarcoma of the larynx: CT findings.

A case of a large low-grade mixed clear-cell and conventional chondrosarcoma of the larynx is reported involving the paraglottic space, the cricoid and thyroid cartilage and characterized by an unusual long clinical course over 22 years, although multiple recurrences occurred without developing metastases. Computed tomography suggests diagnosis by detecting calcifications and adequately demonstrates the extension of the tumor. Innersurface and surface-rendering images document the airway stenosis in all directions. The unusual feature of this case consists in the peculiar histopathological differentiation of the observed chondrosarcoma showing a large clear-cell component.

Chondrosarcoma↗
PubMed1987

Sonographic anatomy of the larynx, with particular reference to the vocal cords.

Sonographic images of the vocal cords were obtained in 41 healthy human subjects using a phased array realtime ultrasound scanner. The thyroid cartilage provides the acoustic window for sonographic visualization of the vocal cords. The false vocal cords appear as hyperechoic structures, while the true vocal cords are seen as hypoechoic structures. The symmetry of movement of the vocal cords during respiration becomes apparent on examination in real time. Sonography may prove to be a potentially useful technique for the examination of the vocal cords.

Adult↗
PubMedDate not supplied

Attachment of some internal laryngeal muscles at the base of the arytenoid cartilage.

The attachments of the lateral cricoarytenoid muscle, thyroarytenoid muscle and interarytenoid muscle at the base of the arytenoid cartilage were studied in six adult larynges. Fresh specimens were treated by the acetylthiocholine method, sections were made with a freezing microtome and stained with Van Gieson stain. The muscle fibres could thus be traced to their fibrous tendinous attachments. The extent of attachment of each muscle at the base of the arytenoid was traced and its relationship to the maximum concavity of the arytenoid articular facet was computed. The lateral cricoarytenoid muscle attachment extends anteromedially from the muscular process but falls short of the anterior border with a variation of 5,800M-7,800M. These variations are statistically significant. The thyroarytenoid and interarytenoid muscles' attachments show similar variations as described and discussed. The interpretation of these results is discussed and conclusions are drawn as regards the influence of these variations on the function of the glottis.

Arytenoid Cartilage↗
PubMedDate not supplied

[Forensic medical assessment of hemorrhages in hyaline cartilages of the larynx].

The diagnostic value of hemorrhages to hyaline cartilages of the larynx (CL), which is a sign of a trauma in the neck, were investigated. The application of term "hemorrhage" in respect to foci of reddish (brownish) coloring of the CL tissue was shown to be not always justifiable. Thus, genuine hemorrhages to the CL tissue are not altogether possible in children and teenagers owing to the original avascularity of their hyaline cartilage tissue; as for women, they are possible only in the dorsal CL sections. The reddish coloring results often from the imbibition of the CL tissue by hemoglobin at the places of contact of the cartilage surface with blood. Such false "hemorrhages" can occur not only in trauma but also in nonviolent death and also as artifacts of sectional examinations. It was established experimentally that 10 to 12 minutes are sufficient for postmortal hemorrhage to set on. The differential diagnosis should be made with due respect to the anatomic-and-physiological peculiarities of the dead and by applying the hyaline method.

Adolescent↗
PubMedDate not supplied

Imbrication reconstruction following partial laryngectomy.

Experience over a 16-year period with 38 patients who underwent partial laryngectomy with imbrication reconstruction is reviewed. We have found this technique to be an expeditious and highly successful means of eradicating T1 or T2 glottic cancer. The use of the patient's own full-thickness, adjacent normal tissue with imbrication of cartilage produces an adequate airway, an almost normal-appearing larynx, and a remarkable posttreatment voice quality, better results than from most cordectomies or vertical hemilaryngectomies. It is valuable as a salvage procedure after full-course radiation. Imbrication laryngoplasty is an alternative and a preferred modality for treatment of young people with early glottic carcinoma for whom the possible carcinogenic properties of radiation must be considered. The survival results are comparable with the more extensive vertical laryngectomies.

Glottis↗
PubMed1985

True vocal cord paralysis following intubation.

True vocal cord paralysis may follow endotracheal intubation and be the result of peripheral nerve damage. This damage can occur as the result of compressing the nerve between an inflated endotracheal tube cuff and the overlying thyroid cartilage. A series of anatomic dissections defined the likely site of injury to be at the junction of the vocal process of the arytenoid cartilage and the membranous true vocal cord approximately 6 to 10 mm below the level of the cord. Cuff pressures were monitored during anesthetics. Analysis of the results indicated that nitrous oxide diffuses into endotracheal tube cuffs causing a substantial increase in the intracuff pressure. We have concluded that true vocal cord paralysis which follows endotracheal intubation is usually temporary. The solution to the problem lies in its prevention and several methods are described whereby it may be avoided.

Adolescent↗
PubMed1975

Arytenoid vocal shunt in laryngectomized patients.

A method is presented for forming short, mucosa-lined vocal shunt in cases of supracricoid laryngectomy with preservation of one or two arytenoids, or the interarytenoid fold alone. On the basis of radiologic and particularly radiocinematographic examinationion of the anterior pharyngeal wall is of paramount importance. In cases of complete absence of leakage, said wall lies in the plane of the arytenoids or somewhat posteriorly. After simple supracricoid laryngectomy it is possible to prevent aspiration also by translocation of the anterior pharyngeal wall into the plane of the cricoid cartilage plate. The clinical experience with this supracricoid shunt is still scanty. Of 25 cases with the arytenoid vocal shunt, phonation was possible in 22 cases under the expiratory pressure of 20-45 cm H2O; in one under the more elevated pressure, and in the last two the result is still not known. Loudness of speech was 70-100 db and its comprehensibility 73-90 percent. Complete absence of leakage was observed in 17 cases, "practical" prevention of aspiration (some drops of thin fluids, no saliva) in seven cases, profuse leakage in one case (ceased after correction), In the last 10 consecutive cases the problem of aspiration was completely eliminated. Advantages and disadvantages of our own method in comparison with Asai's method have been presented.

Deglutition↗
PubMed1991

Subtotal laryngectomy with crico-hyoido-epiglotto-pexy for the treatment of extended glottic carcinomas.

We first described subtotal laryngectomy with crico-hyoido-epiglotto-pexy in 1974. This procedure is a modification of Majer's operation and results in the complete resection of the intact thyroid cartilage. The epiglottic petiole, the false cords, the true cords, and one arytenoid are also excised, along with the paraglottic space. The pharynx is closed by suturing the cricoid to the epiglottis and the hyoid bone. The neoglottis is occluded during deglutition by the epiglottis and the base of tongue, which come into contact with the remaining arytenoid. Postoperative hospitalization lasts approximately 3 weeks, and patients have a strong but deep voice. Between 1972 and 1985, we treated 104 patients with stage T2 and T3 lesions of the glottis using this method. A retrospective analysis showed that the overall survival rate of patients was 86% at 3 years and 75% at 5 years. Five patients experienced local recurrence. Seven patients had recurrences in the neck, and eight developed second primaries. Thirteen patients were lost to follow-up or developed intercurrent disease. Patients with T3NO lesions were treated with unilateral prophylactic neck dissection, and positive nodes were found in 23% of cases. We believe that the high proportion of positive nodes justifies routine prophylactic neck dissection in these patients. Because our operation is associated with good local control (5% recurrence rate), we propose that, for the treatment of extended glottic cancers, it replace transcartilaginous procedures that are associated with much higher recurrence rates.

Carcinoma, Squamous Cell↗
PubMed1977

Throat-skeleton fractures by strangulation.

The frequency of throat-skeleton fractures was investigated in a series of 30 unselected cases of strangulation. Less than half of the victims showed fractures. From the data obtained, it seems to prove that this is a connection between the frequency of fractures and the age of the victims. The radiological investigation shows that this connection is based on the degree of ossification of the throat-skeleton. This ossification starts often already at early age and should be considered as a process of ageing. Notwithstanding the irregular occurrence of throat-skeleton fractures, these injuries are obviously of a vast diagnostic value.

Adolescent↗
PubMed1988

Cricoarytenoid arthritis may be a case of emergency.

Cricoarytenoid arthritis is a frequent complication of rheumatoid arthritis. In most cases it is an insidious, progressive disorder which does not produce early symptoms. A bilateral fixation can lead to a considerable stenosis; exertional dyspnoea, however, may not be noted because mobility of most patients is restricted. We report a case of severely symptomatic cricoarytenoid arthritis in a women known to have myasthenia gravis and rheumatoid arthritis. Initially exacerbation of the myasthenia gravis, leading to severe inspiratory insuffiency was suspected. On indirect laryngoscopy, however, the correct diagnosis was made. Early diagnosis might have prevented an emergency in our patient.

Aged↗
PubMedDate not supplied

Iatrogenic fractures of the hyoid bone and the thyroid cartilage. A case report.

A case of fracture of the hyoid bone and the thyroid cartilage is reported as a complication to resuscitation. This gave rise to many forensic as well as police investigations and stresses the importance of detailed information at medicolegal autopsies as regards the resuscitation carried out.

Fractures, Bone↗