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At least 847 records · Page 47Linked to original sources
PubMed1999

[Economical consequences of intestinal nematodes infection in pigs].

The studies wers carried out in ZZD Kolbacz on 14 sows. The experimental groups control and treated consisted of 7 sows each. The sows were treated with Dectomax - 1 ml/33 kg of body weight. The efficacy of sows treatment's was verified with the Wllis-Schlaaf and McMaster method. The studies indicate, that subclinical infection of intestinal nematodes could influence the swine production. The piglets from treated with Dectomax sows were infected in 8% only; when all piglets from non treated sows were infected with nematodes. From treated sows 0.8 more piglet were obtained and the weight gain of litter was after 6 weeks 24.4 kg higher comparing with the control group.

Animals↗
PubMed1990

Pentoxifylline inhibition of procoagulant activity generated by activated mononuclear phagocytes.

When appropriately stimulated, monocytes are able to initiate blood coagulation through the membrane expression of tissue factor. This procoagulant activity is thought to play a role in activating coagulation in response to inflammatory stimuli in vivo. We found that pentoxifylline, a methylxanthine derivative already reported to regulate some monocyte functions, inhibits the procoagulant activity developed by U937 cells and monocytes in vitro in response to endotoxin. This effect was accompanied by an early increase in intracellular levels of cyclic AMP and was mimicked by compounds that induce an increase in the level of cyclic AMP levels. These results suggest that the suppressive effect of pentoxifylline occurs at least in part via an increase in intracellular cyclic AMP levels.

1-Methyl-3-isobutylxanthine↗
PubMedDate not supplied

[Gestational or essential hypertension in pregnant women limits the capacity to stock triglycerides by the placenta despite raised lipoprotein-lipase activity].

Placenta lipoprotein lipase (LPL) activity as well as serum VLDL and placenta lipids composition were determined in pregnant hypertensive women at term. 46 patients aged from 29 +/- 2 years with gravidic hypertension (HTA-G) and 38 patients with essential hypertension (HTA-E) aged 30 +/- 1 years were compared with 20 normotensive women aged 27 +/- 1 years. Serum triacylglycerols (TG) concentrations were 1.3-fold higher in the both hypertensive patients compared with controls. However, serum phospholipids (PL) and total cholesterol (TC) values were similar in the three groups. VLDL mass and their apolipoproteins, unesterified cholesterol (UC) and cholesteryl esters (CE) contents were significantly increased in hypertensive women compared with controls. In HTA-G and HTA-E patients, respectively. TG-VLDL concentrations were increased by +43% and +36% compared with those of controls (P < 0.01). In placenta, the values were lower 2.2- and 1.9-fold for TG, 2.8 and 2.5-fold for PL and two- and threefold for TC, in HTA-G and HTA-E patients than in controls. Placenta LPL activity was 2.7-fold higher in HTA-G and HTA-E patients compared with that of controls. In conclusion, although placenta LPL activity is higher it is not permit a decrease of serum TG-VLDL on the one hand, and an increase of placenta ability in TG storage on the other hand.

Adult↗
PubMedDate not supplied

[Fish proteins moderate triacylglycerols, activities of hepatic triacylglycerol lipase and tissue lipoprotein lipases in hypertensive and diabetic rats].

Fish proteins effect compared with casein was determined on triacylglycerols (TG) metabolism and activities of hepatic triacylglycerol lipase (HTGL) and tissue lipoprotein lipases (LPL), in SHR and diabetic SHR. Two groups of rats (n=24) were fed, 2 months, diet containing 20% casein (CAS) or 20% fish proteins (FP). One month before sacrifice, diabetes was induced in one group of rats by a single intraperitoneal injection of streptozotocin (STZ) (60 mg/kg of body weight). FP vs. CAS showed a significant decrease of TG concentrations in plasma (-41%) and liver (-66%), in SHR-STZ. VLDL-LDL mass, which represented the amount of apolipoproteins, TG, phospholipids (PL), unesterified cholesterol (UC), and cholesteryl esters (CE), decreased by 21 and 16% with FP vs. CAS, in SHR and SHR-STZ, respectively, and was concomitant with its low TG. Indeed, TG values was 1.35- and 1.82-fold lower in SHR and SHR-STZ, respectively. In HDL2, a TG diminution of 13% was noted, in SHR with FP vs. CAS. In SHR-STZ with FP, TG and PL were enhanced by 11% and 27%, respectively compared to SHR. HTGL activity decreased by 22% in SHR fed FP compared to those fed CAS. In SHR-STZ with CAS vsSHR, this activity was decreased by 21%. LPL activity in heart was enhanced by 19% in SHR-STZ vs. SHR with FP, when that of muscle was diminished 1.5-fold in SHR with FP vs. CAS and 1.8-fold in SHR-STZ vs. SHR with CAS. Adipose LPL activity was 1.36-fold higher in SHR with FP than CAS. In conclusion, it appears that fish proteins have a hypotriglyceridemic effect, which the mechanism can differ in SHR or SHR-STZ. It may be of interest to propose these fish proteins as lipid metabolism regulator in diseases with hypertriglyceridemia.

Animals↗
PubMed2006

An experimental manipulation of life-history trajectories and resistance to oxidative stress.

Optimal investment into life-history traits depends on the environmental conditions that organisms are likely to experience during their life. Evolutionary theory tells us that optimal investment in reproduction versus maintenance is likely to shape the pattern of age-associated decline in performance, also known as aging. The currency that is traded against different vital functions is, however, still debated. Here, we took advantage of a phenotypic manipulation of individual quality in early life to explore (1) long-term consequences on life-history trajectories, and (2) the possible physiological mechanism underlying the life-history adjustments. We manipulated phenotypic quality of a cohort of captive zebra finches (Taeniopygia guttata) by assigning breeding pairs to either an enlarged or a reduced brood. Nestlings raised in enlarged broods were in poorer condition than nestlings raised in reduced broods. Interestingly, the effect of environmental conditions experienced during early life extended to the age at first reproduction. Birds from enlarged broods delayed reproduction. Birds that delayed reproduction produced less offspring but lived longer, although neither fecundity nor longevity were directly affected by the experimental brood size. Using the framework of the life-table response experiment modeling, we also explored the effect of early environmental condition on population growth rate and aging. Birds raised in reduced broods tended to have a higher population growth rate, and a steeper decrease of reproductive value with age than birds reared in enlarged broods. Metabolic resources necessary to fight off the damaging effect of reactive oxygen species (ROS) could be the mechanism underlying the observed results, as (1) birds that engaged in a higher number of breeding events had a weaker red blood cell resistance to oxidative stress, (2) red blood cell resistance to oxidative stress predicted short-term mortality (but not longevity), and (3) was related with a parabolic function to age. Overall, these results highlight that early condition can have long-term effects on life-history trajectories by affecting key life-history traits such as age at first reproduction, and suggest that the trade-off between reproduction and self-maintenance might be mediated by the cumulative deleterious effect of ROS.

Aging↗
PubMed2006

Effects of N-acyl-2-hydroxymethyl aziridines on in vitro proliferative responses of human lymphocytes stimulated by mitogens.

Aziridines have been shown to possess marked immunotropic activity. The aim of this work was to study the in vitro effects of different concentrations of three novel aziridines, 2-hydroxy-methyl-1-(N-phtaloylglycyl) aziridine (aziridine 1), 2-hydroxy-methyl-1-(N-phtaloylalanyl) aziridine (aziridine 2) and 2-hydroxy-methyl-1-(N-phtaloylphenylalanyl) aziridine (aziridine 3), on the proliferative responses of human lymphocytes stimulated by mitogens (concanavalin A (Con A) and lipopolysaccharide (LPS)), and interleukin-2 (IL-2), interleukin-6 (IL-6) secretion. The results showed that aziridines 1 and 3 significantly stimulated the resting and Con A or LPS lymphocyte proliferation at concentrations between 1 micromol/l and 1 mmol/l, in a dose-dependent manner, the action of aziridine 3 being the highest. They also increased IL-2 and IL-6 secretion. However, aziridine 2 had no effect on the resting lymphocyte proliferation in the absence of mitogens, at any concentration used, reduced Con A-stimulated T lymphocyte proliferation and LPS- stimulated B lymphocyte proliferation in a dose dependent manner and diminished IL-2 and IL-6 production. None of the three aziridines affected cell viability. In conclusion, the three aziridines used in this study displayed immunomodulatory properties. Aziridines 1 and 3 are potentially immunostimulant while aziridine 2 is immunosuppressive and could be used to provide nonspecific cell-mediated immune responses.

Aziridines↗
PubMedDate not supplied

Time course of changes in rat pancreatic synthesis rates and retention thresholds of four hydrolases during consumption of a low-protein followed by a balanced diet.

Synthesis rates of pancreatic amylase, trypsinogen 2 (Tg2), chymotrypsinogen 1 (Chtg1), and lipase, were measured in control rats fed a 20% protein diet for 46 days and in malnourished rats fed a 5% protein diet for 23 days (protein malnutrition) followed by refeeding a balanced diet for 23 days. In the control group, a progressive pancreatic maturation (namely an increase in hydrolase synthesis per gram of tissue) appeared with age. In the malnourished group, pancreas maturation of the four hydrolases was inhibited. Synthesis rates of the four hydrolases were reduced to a lesser extent from day 2 of protein malnutrition. With continued protein malnutrition, Tg2 synthesis rates remained steady, whereas the lipase synthesis rate continued to decrease and Chtg1 and amylase rates started to increase. As soon as refeeding was initiated, an important enhancement in synthesis was observed. The synthesis rates of Tg2, Chtg1, and amylase actually showed a rebound effect, then decreased with the refeeding time to reach control values, except for Chtg1, which remained higher than control values throughout the refeeding phase. Lipase synthesis rate rose more slowly and reached the control values only after 9 days of refeeding. The retention threshold (pancreas tissue versus pancreatic secretion) values showed that the storage levels were different from one hydrolase to the other and were variable with age in the control group, and with protein malnutrition and refeeding times in the malnourished group. In the control group, a preferential secretion of newly synthesized enzymes was observed in young rats, whereas with age, the proportion of newly synthesized hydrolases excreted decreased slowly.(ABSTRACT TRUNCATED AT 250 WORDS)

Amino Acids↗
PubMedDate not supplied

[Results of experimental studies of the possibility of using low temperature in the treatment of retinopathy of prematurity].

The purpose of the paper was to study whether the use of cryotherapy can cause decrease of angiogenic activity of the primary avascular retina in kittens with oxygen induced retinopathy. The studies showed that after cryotherapy comes to a considerable decrease of angiogenic activity of this part of the retina. It indicates that cryotherapy should arrest the development of more advanced stages of retinopathy of prematurity.

Animals↗
PubMedDate not supplied

[Pathogenesis of retinal neovascularization].

Presented are the causes and actual opinions on the pathogenesis of retinal neovascularization. The ischaemic hypothesis of neovascularization is particularly discussed; it is commonly accepted to day as the most probable hypothesis.

Arteriovenous Malformations↗
PubMedDate not supplied

[Choroid ischemia syndrome].

Presented are the ischemic changes of the choroid on the basis of observation of patients treated in our Department in the course of the last years. In dependence on the advancement of the ischemic changes one can see 3 various types of signs at the fundus. It seems that the most proper name for these changes would be "the choroidal ischaemia syndrome". It is namely a complex of various fundus changes connected by a common pathogenesis but with various kind of causes.

Adolescent↗
PubMed1991

[Parosteal sarcoma of the radius in the course of etretinate therapy].

A parosteal osteosarcoma of the right radius has developed in a patient treated for a long time by etretinate (total dose: 73 g). If brachial ossifications have been reported to etretinate in 2 cases, they were benign tumours; so coincidence is possible in our case. Nevertheless, a relation between the tumour and the treatment cannot be excluded and justify the report of this observation.

Bone Neoplasms↗
PubMed1991

[Dubowitz syndrome].

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Abnormalities, Multiple↗